National Eye Institute (nei)

This early-stage trial tests if replacing damaged eye cells with lab-grown stem cells can help people with dry age-related macular degeneration and geographic atrophy. About 20 adults aged 55 and older will receive a transplant of their own reprogrammed cells into one eye. The ma…

This study tests whether metformin, a pill used for diabetes, can safely slow vision loss in people with ABCA4 retinopathy (including Stargardt disease). About 56 participants aged 12 and older will take metformin daily for 24 months. Researchers will measure changes in the retin…

This study looks at how well people see in the dark to learn more about retinal diseases like retinitis pigmentosa and Stargardt's disease. Researchers will compare healthy volunteers and people with retinal disease to see if dark adaptation tests can detect and track disease sev…

This study helps doctors at the National Eye Institute examine people with eye diseases to see if they can join other research studies. No treatment is offered. People of all ages with various eye conditions, including genetic disorders, may take part. Tests include eye exams, bl…

This study aims to learn more about different eye diseases by observing and treating up to 1,000 people over several years. Participants receive standard care, including exams, tests, and treatments, while researchers track how the diseases progress and may be inherited. The goal…

This study is looking for genes that cause inherited eye diseases. Researchers will collect medical history, eye exams, blood, and other samples from up to 1,500 people with known or suspected inherited eye conditions and their relatives. The goal is to better understand these di…

This study aims to uncover the genetic causes of microphthalmia, anophthalmia, and uveal coloboma (MAC) — rare eye conditions that can lead to vision loss or blindness. Researchers will collect DNA samples and medical information from 600 people with MAC and their close relatives…

This study collects skin, hair, blood, saliva, or urine samples from people with certain eye diseases (like macular degeneration) and healthy volunteers. Researchers will turn these cells into stem cells in the lab to study how the diseases develop and to test potential new drugs…

This study aims to expand a large collection of DNA samples and eye health information from people with rare inherited eye diseases, such as aniridia, Best disease, and albinism. Researchers will use this data to better understand the genetic causes of these conditions and to hel…

This study aims to understand how healthy brains process sights and sounds. Researchers will use brain scans, eye tracking, and computer tasks to measure perception, memory, and attention. Up to 10,200 participants aged 13-65 with normal vision and hearing can join, either online…

This study tests whether a virtual reality (VR) tool can better measure how retinal disease affects a person's ability to move around. People aged 5 and older with retinal disease and healthy volunteers will navigate obstacle courses in VR while researchers track their accuracy a…

This study tests a special imaging technique called adaptive optics to take super-detailed pictures of the retina. Researchers hope this can help find eye diseases earlier, before serious damage occurs. Up to 1,000 people aged 12 and older, with or without eye disease, will parti…

This study follows people aged 10 and older with Stargardt-like macular dystrophy (STDG3) caused by ELOVL4 gene changes. Over three years, researchers will track vision and retinal health using eye exams, imaging, and light tests. The goal is to learn how the disease progresses n…

This study follows people with spinocerebellar ataxia type 7 (SCA7) for up to 5 years to learn how the disease affects vision, coordination, and the brain. Participants aged 12 and older will have yearly eye exams, neurological tests, and brain scans. No treatments are tested; th…

This study collects blood, tissue, and health information from people with and without retinal diseases like age-related macular degeneration and diabetic retinopathy. The goal is to create a research database to help scientists understand why some people get eye diseases and oth…

This study looks at whether certain genes make some people more likely to get eye damage from the drug Plaquenil, used for autoimmune diseases like lupus. Researchers will compare people who have had eye damage with those who haven't, using blood tests and eye exams. No treatment…

This study aims to find the genetic causes of inherited eye diseases by analyzing the DNA of 2,000 people, including affected individuals and their family members. Participants provide a blood or saliva sample for whole exome or whole genome sequencing. The goal is to discover ne…

This study aims to find the genes that cause inherited eye diseases by examining people and their family members who have these conditions. Participants will undergo an eye exam, blood or saliva tests, and genetic testing. The goal is to better understand these diseases and impro…