National Eye Institute (nei)

This early-stage trial is testing the safety of a new procedure for advanced dry macular degeneration, a leading cause of vision loss. Researchers take a small blood sample from a patient, turn those cells into new retinal cells in a lab, and then transplant them back into the pa…

This study is testing if the oral diabetes medication metformin is safe and can slow down the progression of ABCA4 retinopathy, a genetic eye disease that causes vision loss. It will involve about 56 participants aged 12 and older who have the disease. Participants will take metf…

This study aims to understand how healthy brains turn signals from our eyes and ears into what we see, hear, and think. Researchers will recruit up to 10,200 participants, many of whom will complete online tests, while others will have in-person sessions involving brain scans and…

This study aims to learn more about the genes that cause inherited eye diseases. Researchers will collect health information, eye exam data, and genetic samples from 1,500 people who have these conditions or are their unaffected relatives. The goal is to build a detailed database…

This study aims to understand why some people develop serious eye damage from Plaquenil (hydroxychloroquine), a drug used for lupus and arthritis, while most do not. Researchers will compare the genes of people who have experienced this eye damage with those who have taken the dr…

This study aims to learn how a rare genetic disease called SCA7 changes a person's vision and brain function over time. Researchers will follow 25 people with SCA7 for at least five years, performing regular eye exams, brain scans, and neurological tests. The goal is to gather de…

This study aims to identify the specific genes that cause inherited eye diseases like cataracts, glaucoma, and retinal degeneration. Researchers will examine families with a history of these conditions, performing detailed eye exams and collecting blood or saliva samples for gene…

This study aims to discover the genetic causes of inherited eye diseases by analyzing the DNA of 2,000 people. It will include both people with an eye condition and their unaffected family members. Researchers will use advanced genetic sequencing on blood or saliva samples to ide…

This National Eye Institute study aims to better understand how various eye diseases develop and progress over time. Researchers will observe and provide standard medical care to 1,000 participants with diagnosed or suspected eye conditions for up to five years. The study focuses…

This study aims to understand how a rare inherited eye disease called Stargardt-like macular dystrophy (STDG3) changes over several years. Researchers will observe up to 25 people with a specific genetic mutation, tracking their vision and eye health through regular exams and ima…

This study aims to understand the genetic causes of a group of rare eye conditions known as MAC, which can lead to vision problems including blindness. Researchers will enroll 600 people, including those with MAC and their unaffected family members, to collect medical information…

This study is testing a new, very detailed camera system called adaptive optics to take pictures of the retina at the back of the eye. Researchers want to see if these super-clear images can help doctors find and understand eye diseases much earlier than is currently possible. Th…

This study aims to understand and eventually find treatments for serious eye diseases that can lead to blindness, like macular degeneration. Researchers will collect simple samples like hair, skin, or blood from people with these conditions and from healthy volunteers. In the lab…

This study is testing a new virtual reality (VR) tool to see if it can accurately measure how retinal diseases affect a person's ability to move around. Researchers will have participants with vision loss and healthy volunteers navigate VR obstacle courses and compare the results…

This study aims to understand how retinal diseases affect vision, especially in low light. Researchers will measure how well 500 participants, including healthy people and those with conditions like retinitis pigmentosa, can see in the dark. The goal is to see if these dark-adapt…

This study is creating a research database by collecting health information and physical samples from people with and without eye diseases. Researchers will follow 650 participants over time, including those with conditions like macular degeneration and diabetic retinopathy, as w…

This National Eye Institute study screens people with various eye conditions to determine if they qualify for other research studies. Participants undergo eye exams, vision tests, and other evaluations, but receive no treatment through this study. The goal is to match people with…