National Eye Institute (nei)

This study tests whether the diabetes drug metformin is safe and can slow vision loss in people with ABCA4 retinopathy (Stargardt disease), a genetic condition that causes progressive blindness. About 56 participants aged 12 and older will take metformin daily for 24 months, with…

This study tests whether transplanting lab-grown eye cells can help treat geographic atrophy, a severe form of dry age-related macular degeneration that causes blind spots. About 20 people aged 55 and older will receive a transplant of their own stem-cell-derived retinal cells in…

This study aims to find the genes that cause a group of rare eye conditions called MAC (microphthalmia, anophthalmia, and uveal coloboma), which can lead to vision loss or blindness. Researchers will collect DNA samples and medical information from 600 people with MAC and their c…

This study aims to learn how well people with retinal diseases (like retinitis pigmentosa and Stargardt's disease) see in the dark compared to healthy volunteers. Researchers will use special vision tests and eye exams to see if dark adaptation can help detect and track these dis…

This study aims to discover the genes that cause inherited eye diseases by studying people with these conditions and their family members. Participants will provide blood, tissue, and other samples, and undergo various eye tests. No treatment is given; the goal is to gather knowl…

This study collects skin, hair, blood, urine, or saliva samples from people with certain eye diseases (like macular degeneration) and from healthy volunteers. Researchers will turn these cells into stem cells in the lab to study how the diseases develop and to test potential new …

This study is testing whether a virtual reality (VR) tool can better measure how retinal disease affects a person's ability to move around. Researchers will ask people with retinal disease and healthy volunteers to navigate obstacle courses in VR while wearing goggles or using a …

This study tests a special camera called adaptive optics to take detailed pictures of the retina, the light-sensitive part at the back of the eye. Researchers want to see if this method can find eye diseases earlier than standard exams. About 1,000 people aged 12 and older, inclu…

This study looks at whether certain genes make some people more likely to develop eye damage from the drug Plaquenil, used for autoimmune diseases like lupus. Researchers will compare people who have had eye damage with those who haven't, using blood tests and eye exams. No treat…

This study aims to identify the genetic causes of inherited eye diseases by analyzing the DNA of up to 2,000 participants, including affected individuals and their family members. Researchers will use whole exome or whole genome sequencing to find new or known gene mutations. The…

This study aims to learn more about eye diseases by observing and providing standard treatment to up to 1,000 people over 5 years. Participants will have regular eye exams, tests, and may receive medications or procedures as part of their routine care. The goal is to better under…

This study follows people with spinocerebellar ataxia type 7 (SCA7), a genetic disease that causes problems with coordination, balance, speech, and vision. Researchers want to track how the disease progresses over 5 years by doing eye tests, brain scans, and neurological exams. T…

This study follows people aged 10 and older with Stargardt-like macular dystrophy caused by ELOVL4 gene changes. Over three years, researchers will track vision and retinal health using eye exams, imaging, and light tests. The goal is to learn how the disease naturally progresses…

This study collects blood, tissue, and health information from 650 people with and without retinal diseases like age-related macular degeneration and diabetic retinopathy. The goal is to build a database and biobank for future research, not to provide treatment. Participants will…

This study aims to expand a large repository of DNA samples and eye health information from people with rare inherited eye diseases, such as aniridia, Best disease, and albinism. Researchers will collect saliva or blood samples and eye exam data from up to 1,000 participants of a…

This study aims to find the genes that cause inherited eye diseases by examining people and their family members who have these conditions. Participants will undergo an eye exam, blood or saliva tests, and genetic testing. The goal is to better understand these diseases and impro…

This study aims to understand how healthy brains process what we see and hear. Researchers will use brain scans, eye tracking, and other tests to measure brain activity. Participants must be 13-65 years old with good vision and hearing. The study involves online or in-person sess…

This study helps doctors at the National Eye Institute examine people with eye diseases to see if they can join other research studies. No treatment is given here. People of all ages with various eye conditions may take part. Tests include eye exams, blood tests, and imaging to e…