Could Lab-Grown eye cells restore sight in dry AMD?
NCT ID NCT04339764
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage trial tests whether transplanting lab-grown retinal cells into the eye is safe for people with geographic atrophy from dry age-related macular degeneration. Twenty participants aged 55 and older will receive a transplant of their own reprogrammed cells into one eye. The study will monitor safety and vision changes over several years.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
iPSC-derived retinal pigment epithelium cells
What this could lead to
If successful, this could point toward a cell-replacement therapy to slow or stop vision loss from geographic atrophy in dry AMD.
What could go wrong
This is an early phase I/IIa trial with only 20 participants, so safety and effectiveness are not yet proven. Surgery inside the eye carries risks like infection or retinal detachment, and participants must take immunosuppressants long-term.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Johns Hopkins University
NOT_YET_RECRUITINGBaltimore, Maryland, 21205, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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National Institutes of Health Clinical Center
RECRUITINGBethesda, Maryland, 20892, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••