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Virtual reality game could revolutionize vision testing for retinal disease patients

NCT ID NCT04289571

Knowledge-focused Sponsor: National Eye Institute (NEI) Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 11, 2026 · Updated 4 times

Summary

This study is testing whether a virtual reality (VR) tool can better measure how retinal disease affects a person's ability to move through spaces. About 165 people aged 5 and older with retinal disease and healthy volunteers will use a game controller to navigate VR obstacle courses. Researchers will compare VR results with standard eye exams and questionnaires to see if the VR tool provides a more accurate and easier way to assess functional vision.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

About 165 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2023

Expected to finish

Dec 2030

An estimate. End dates often move.

Lead sponsor

A government research agency

The lead sponsor is the US National Institutes of Health.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

5 to 120 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

* INCLUSION CRITERIA: To be eligible, the following inclusion criteria must be met. 1. For the NEI site: Participant must be five years of age or older. 2. For the USyd site: Participant must be thirteen (13) years of age or older. 3. Participant (or legal guardian) must understand and be willing to sign the protocol s informed consent document. 4. Participant must be able to cooperate with the testing required for this study. 5. Participant must be able to read and speak English. a. If participant is a minor, their parent or legal guardian must be able to read and speak English. 6. For healthy volunteers only: 1. Participant must not have retinal disease in either eye. EXCLUSION CRITERIA: A participant is not eligible if any of the following exclusion criteria are present. 1. Participant is in another investigational study and actively receiving study therapy. 2. Participant is unable to comply with study procedures. STUDY EYE ELIGIBILITY CRITERIA: The participant must have at least one eye meeting all inclusion criteria. STUDY EYE INCLUSION CRITERIA: 1. Healthy Volunteers Only a. Study eye must have visual acuity of 20/20 or better, with or without correction (e.g., glasses or contact lens). 2. Participants with Retinal Disease Only 1. Study eye must have retinal disease, defined as retinal dysfunction and/or degeneration as previously established by standard clinical methods including perimetry, ERG and imaging.

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Conditions

The condition(s) this trial relates to.

cone-rod dystrophy retinitis pigmentosa

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cone-rod degeneration Rod-cone degeneration

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites in 2 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • National Institutes of Health Clinical Center

    RECRUITING

    Bethesda, Maryland, 20892, United States

  • University of Sydney

    RECRUITING

    Sydney, Australia

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