Can a birth tissue patch boost tear duct surgery success?
NCT ID NCT06226181
First seen Sep 04, 2026 · Last updated Sep 04, 2026
Summary
This trial compares two versions of a surgery called external dacryocystorhinostomy, which creates a new drainage path for a blocked tear duct. Half of the participants receive the standard surgery, while the other half receive the surgery plus a piece of amniotic membrane placed at the surgical site. Researchers will measure how well each approach relieves watery eyes and keeps the duct open. The study enrolls adults with nasolacrimal duct obstruction who can undergo general anesthesia.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Amniotic membrane placed at the surgical site during dacryocystorhinostomy
- What this could lead to
- If it works, adding amniotic membrane could make tear duct surgery more successful and reduce the need for repeat procedures.
- What could go wrong
- This is a small, early-stage trial with only 22 participants, so results may not apply broadly. The membrane could also fail to improve outcomes or cause healing issues.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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22 people
The number who actually took part.
- Started
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Jan 2024
- Finished
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Mar 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients over 18 years old * Diagnosis of Nasolacrimal Duct Obstruction or Score ≥ 2 on the Munk Scale * Patients able to undergo general anesthesia * Patients able to keep follow-up * Patients willing to participate in the study and signed informed consent Exclusion Criteria: * Patients with ocular surface diseases that affect surgical outcomes, such as blepharitis, lacrimal punctum epithelization, kissing punctae, facial nerve palsy, allergic conjunctivitis, etc * Patients with eyelid malpositions * Patients diagnosed with systemic inflammatory diseases, such as granulomatosis with polyangiitis, sarcoidosis, etc * Previous history of facial trauma with nasal bone fractures * Pregnancy and lactation
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Institiuto de Oftalmología Fundación Conde de Valenciana
Mexico City, Mexico City, 06800, Mexico
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