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Eye study seeks clues to cell loss after lens surgery

NCT ID NCT04174924

Knowledge-focused Sponsor: Maastricht University Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at why some people lose cells on the inner surface of their cornea after having a special lens implant for severe nearsightedness. Researchers compared fluid and tear samples from 126 patients having lens removal or routine cataract surgery. The goal was to see if inflammation in the eye plays a role in this cell loss.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help doctors understand why some patients lose eye cells after lens implants, potentially leading to better monitoring or prevention strategies.
What could go wrong
This is an observational study, not a treatment trial. It may not find clear answers, and any findings would need further research before changing practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

126 people

The number who actually took part.

Started

Jul 2020

Finished

May 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Two groups will be included to compare endothelial cell loss due to inflammation in affected (i.e. iris-fixated \[IF\] phakic intraocular lens \[pIOL\] implanted) versus healthy (i.e. scheduled for regular cataract surgery) eyes.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age over 18 * Cataract in one or both eyes, or indication for pIOL explantation * Informed and having given informed consent. Exclusion Criteria: * Insufficient understanding of the Dutch language to comply with study procedures * Inability to complete follow-up or comply with study procedures * Non-routine cataract surgery * Cognitive or behavioral conditions that might interfere with surgery * Patients with ocular comorbidities such as * Women who are pregnant or nursing their child * Immune-compromised patients (e.g., systemic corticosteroid use, leukaemia) * Factors that increase the risk of complicated surgery

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Conditions

The condition(s) this trial relates to.

cataract

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cataract Phakic intraocular lens explantation

Contacts and locations

Locations

  • Maastricht University Medical Centre

    Maastricht, Limburg, 6202 AZ, Netherlands

More trials for these conditions

Other studies related to the condition(s) this trial covers.