Maastricht University Medical Center

This study is for adults with solid tumors that have certain genetic features (HRD/FAD) or are growing despite immunotherapy. The experimental drug CP-506 is designed to activate only in low-oxygen areas of tumors, potentially killing cancer cells while sparing healthy tissue. Th…

This study tests a new, gentler steroid eye drop plan after corneal transplant surgery. The goal is to prevent rejection while reducing side effects like high eye pressure. About 342 adults getting a DMEK transplant will be followed for two years to see if a milder steroid works …

This study is testing whether a blood test can find tumor DNA in people with cancer. If successful, it could lead to a less invasive way to diagnose cancer compared to current methods like tissue biopsies. The study will enroll 40 adults with newly diagnosed breast, colorectal, l…

This study is testing a new blood test (the HMEC test) to see if it can better identify which patients with thrombotic microangiopathy (TMA) have a specific immune system problem driving their disease. TMA is a severe condition that damages kidneys and the brain. The researchers …

This pilot study compares two types of PET scans in 20 women with ER-positive breast cancer. The standard tracer (18F-FDG) sometimes misses cancer spread in this subtype. The new tracer (68Ga-FAPI-46) targets a protein on tumor-supporting cells and may find more lesions. Research…

This study tests whether a diet tailored to a person's unique metabolism can prevent type 2 diabetes better than standard dietary advice. Researchers will group 240 overweight or obese adults by their metabolic type and give them a personalized 12-month diet plan. The goal is to …

This study tests a surgery called lymphaticovenous anastomosis (LVA) to see if it reduces chronic swelling (lymphedema) in cancer survivors. About 110 people with swelling in one arm or leg after cancer treatment will be randomly assigned to receive either LVA or a sham surgery. …

This study tests a precise method called doubly labeled water to measure how much energy critically ill patients use. By collecting urine samples, researchers hope to better tailor nutrition to each patient's needs. The goal is to improve recovery and reduce complications like in…

This study tests whether giving critically ill patients more protein in their tube feed (1.3 grams per kg of body weight per day, instead of the standard 0.8 grams) can help their muscles build protein and reduce wasting. Twenty-six adults on ventilators in the ICU will be random…

This study is building a biobank of genetic samples and medical information from 3600 patients visiting the Clinical Genetics department in Maastricht. Researchers will use the stored data to compare genes and discover unknown functions. The goal is to better understand how genet…

This study looks at whether eating wild blueberries every day for a few months can improve blood flow and insulin sensitivity in the brains of older adults (ages 60-75) who are overweight. Researchers will use MRI scans to measure brain function and simple iPad tests to check thi…

This study looks at how a week of either eating less or exercising daily affects prostate tumor growth and muscle health in 45 men with prostate cancer. Participants will be assigned to a reduced-calorie diet, daily exercise with mild diet changes, or their usual routine. After 7…

This study tests a new way to decide which patients with a narrowed neck artery need surgery to prevent a stroke. The standard method mainly looks at how narrow the artery is, but the new method uses an MRI to find unstable plaques that are more likely to cause a stroke. About 61…

This study looks at how often young adults who sit a lot should take short walking breaks to help their thinking and blood sugar. Researchers will compare sitting for 4.5 hours straight with taking walks of different lengths and frequencies. The goal is to find the best pattern f…

This study looks at whether a special ketogenic drink taken each evening for 4 weeks can shift how the body uses energy during the night in healthy but overweight older adults (ages 60-80). Researchers will measure changes in metabolism and muscle cell health. The goal is to unde…

This study reviews medical records of 600 adults with liver cirrhosis to see how often they visit doctors, get scans, or undergo procedures. Researchers want to understand what factors, like mental health, affect healthcare use. The goal is to find ways to improve care for people…

This study looks at how healthy young adults process protein from whole foods like beef patties. Twenty people aged 18-35 will eat different amounts of protein (1, 2, or 4 patties) in a random order. Researchers measure how much protein the body uses over 24 hours. The goal is to…

This study looks at whether adding febuxostat (a gout medicine) to the standard lung cancer drug osimertinib can increase the amount of osimertinib that reaches the brain. It involves 7 adults with a specific type of advanced lung cancer who are already taking osimertinib. Resear…

This study looks at whether taking a ketone supplement before and during exercise changes how the body burns carbohydrates. Twenty trained cyclists will do a 3-hour workout while drinking carbs with either a ketone supplement or a placebo. The goal is to see if ketones alter the …

This study aims to understand why some people have unexplained bleeding that standard tests cannot diagnose. Researchers will study blood samples and ask participants about their symptoms and quality of life. The goal is to find the causes of this bleeding disorder and improve ca…