Maastricht University Medical Center

This early-phase trial tests a new drug called CP-506 in adults with solid tumors that have low oxygen levels. The drug is given alone or with chemotherapy (carboplatin) or immunotherapy. The goal is to find safe doses and see if it helps control the disease. About 126 participan…

This study tests whether using a person's genetic information to select psychiatric medications leads to better recovery than standard prescribing. About 2,500 adults with mood, anxiety, or psychotic disorders will be randomly assigned to either genetics-guided treatment or usual…

This study aims to improve diagnosis of thrombotic microangiopathy (TMA), a life-threatening condition where small blood clots damage organs like the kidneys and brain. Researchers will test a new blood test (HMEC test) in 42 adults to see if it can better identify which cases ar…

This study tests whether a newer PET tracer, 68Ga-FAPI-46, can find more cancer spots than the standard tracer in people with ER-positive breast cancer. About 20 women with advanced or recurrent breast cancer will get both types of scans. The goal is to see if the new tracer lead…

This study tests whether a diet tailored to a person's unique metabolism (called a 'metabotype') can prevent type 2 diabetes better than standard dietary advice. Researchers will enroll 240 overweight or obese adults who are at risk for diabetes. Participants will follow either a…

This study looks at how healthy young adults aged 18-35 process protein from whole foods like beef patties. Twenty participants will eat different amounts of minced beef (1, 2, or 4 patties) on separate days. Researchers measure how much protein is burned for energy over 24 hours…

This study tests whether drinking a ketone supplement before and during a 3-hour bike ride changes how the body uses carbohydrates for fuel. Twenty trained cyclists will complete two exercise sessions, once with the ketone drink and once with a placebo, to compare sugar burning r…

This study collects blood or tissue samples and medical information from 3600 people visiting a genetics clinic. The goal is to store these materials for future research to better understand how genes work and what causes genetic diseases. Participants must be new patients at the…

This study looks at whether eating wild blueberries every day for several months can improve brain function in older adults. Researchers will measure blood flow and insulin sensitivity in the brain using MRI scans, and test thinking skills with iPad games. The study involves 36 o…