Maastricht University Medical Center

This study tests a new, gentler steroid eye drop plan after corneal transplant surgery. The goal is to prevent rejection while reducing side effects like high eye pressure. About 342 adults getting a DMEK transplant will be followed for two years to see if a milder steroid works …

This study tests a new drug called CP-506, which becomes active only in low-oxygen areas of solid tumors. It is given alone or with chemotherapy (carboplatin) or immunotherapy. The goal is to find safe doses and see if it helps shrink tumors in adults with advanced cancers. About…

This study looks at a serious condition called TMA, where small blood clots damage the kidneys and brain. Researchers want to see if a new lab test can better identify which patients have a specific immune system problem causing their illness. The goal is to help doctors choose t…

This study is testing whether a blood test can find tumor DNA in people with cancer. If successful, it could lead to a less invasive way to diagnose cancer compared to current methods like biopsies. The study will include 40 adults newly diagnosed with breast, colorectal, lung, o…

This study tests whether a newer PET tracer, 68Ga-FAPI-46, finds more cancer spots than the standard tracer in people with ER-positive breast cancer. About 20 women with advanced or recurrent breast cancer will get both types of scans. The goal is to see if the new tracer leads t…

This study tests whether a diet tailored to a person's unique metabolism can prevent type 2 diabetes better than standard dietary advice. Researchers will group 240 overweight or obese adults by their metabolic type and give them a personalized 12-month diet plan. The goal is to …

This study tests a surgery called lymphaticovenous anastomosis (LVA) to see if it reduces chronic swelling (lymphedema) in cancer survivors. About 110 people with swelling in one arm or leg after cancer treatment will be randomly assigned to receive either LVA or a sham surgery. …

This study looks at how a week of either eating less or exercising daily affects prostate tumor growth and muscle health in 45 men with prostate cancer. Researchers will measure protein building in tumors and muscles to see which approach works better. The goal is to find lifesty…

This study looks at how healthy young adults process protein from whole foods like beef patties. Twenty people aged 18-35 will eat different amounts of protein (1, 2, or 4 patties) in a random order. Researchers measure how much protein the body uses over 24 hours. The goal is to…

This study looks at how often you should get up and walk during long periods of sitting to help your thinking and blood sugar. Researchers will have 33 young adults who sit a lot try four different routines: sitting non-stop, walking 1 minute every 10 minutes, walking 3 minutes e…

This study tests whether a daily ketogenic supplement taken in the evening for 4 weeks can safely shift overnight metabolism in healthy but overweight adults aged 60-80. Researchers will measure how the body burns fuel during sleep and check muscle cell function. The goal is to u…

This study collects biological samples and medical information from 3600 people visiting a genetics clinic. The goal is to store these materials for future research to better understand how genes work and what causes genetic diseases. Participants must be new patients at the clin…

This study looks at whether adding febuxostat (a gout medicine) to the standard lung cancer drug osimertinib can increase the amount of osimertinib that reaches the brain. It involves 7 adults with a specific type of advanced lung cancer who are already taking osimertinib. Resear…

This study will look at medical records from 600 adults with liver cirrhosis to understand how often they visit doctors, get scans, or have procedures. The goal is to find patterns in healthcare use and see what factors, like mental health, play a role. No new treatments are bein…

This study aims to accurately measure how many calories critically ill patients burn each day using a safe, non-invasive method called doubly labeled water. About 50 adults in the ICU who are expected to stay at least 5 days will provide urine samples to track energy use. The goa…

This study looks at whether taking a ketone supplement before and during exercise changes how the body burns carbohydrates. Twenty trained cyclists will do a 3-hour workout while drinking carbs with either a ketone supplement or a placebo. The goal is to see if ketones alter the …

This study looks at whether eating wild blueberries for several weeks can improve brain function in adults aged 60-75 who are overweight. Researchers will measure blood flow in the brain and how well the brain responds to insulin using MRI scans. Participants will eat either blue…

This study aims to understand why some people have unexplained bleeding that standard tests cannot diagnose. Researchers will study blood samples and ask participants about their symptoms and quality of life. The goal is to find the causes of this bleeding disorder and improve ca…

This study looks at whether giving critically ill patients more protein (1.3 grams per kilogram of body weight per day) helps their muscles grow or maintain strength better than the standard amount (0.8 grams). The study will include 26 adults who are on breathing machines in the…

This study tests a new way to decide which patients with a narrowed neck artery need surgery to prevent a stroke. The standard method looks mainly at how narrow the artery is, but the new method uses an MRI scan to find unstable plaques that are more likely to cause a stroke. Abo…