Nightly ketogenic drink may rev up overnight metabolism in seniors

NCT ID NCT07395973

Knowledge-focused Sponsor: Maastricht University Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether taking a ketogenic nutritional supplement every evening for 4 weeks can change how the body burns energy overnight and affect muscle health. Researchers will study 14 healthy but overweight adults aged 60-80 who are not very active. Participants will either get the ketogenic drink or a non-ketogenic control drink, and their metabolism and muscle function will be measured.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: ketogenic nutritional supplement
What this could lead to: If successful, this could point toward a simple dietary strategy to improve metabolic health and muscle function in older adults.
What could go wrong: This is a very small, early-stage study with only 14 participants. It is designed to measure metabolic changes, not to treat any disease, so results may not lead to a clear health benefit.

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Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 14 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2025

Expected to finish

Oct 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

60 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged 60-80 years * Body mass index (BMI) 25-35 kg/m2 * Sedentary lifestyle (not more than 2 hours of structured physical activity per week in the past 3 months) * Stable dietary habits (no weight loss or gain \> 5 kg in the past 3 months) * Healthy (as determined by dependent physician based on medical questionnaire) * Regular sleeping habits (7-9h of daily sleep) Exclusion Criteria: * Type 2 diabetes * Participants with active congestive heart failure and/or severe renal and or liver insufficiency * Uncontrolled hypertension * Alcohol consumption of \>3 servings per day for men and \>2 servings per day for women * Unstable body weight (weight gain or loss \> 5 kg in the last 3 months) or intention to lose weight * Participants who are on an intermittent fasting diet * Previous enrolment in a clinical study with an investigational product during the last 3 months or as judged by the investigator which would possibly hamper our study results * Significant food allergies/intolerance (seriously hampering study meals or study product) * Participants who do not want to be informed about unexpected medical findings * Blood donation during or within 2 months prior to the study * Disturbances in circadian rhythm determined with the follow criteria: * Extreme early bird or extreme night person (score ≤30 or ≥70 on MEQ-SA questionnaire) * Heavily varying sleep-wake rhythm * Night shift work during last 3 months * Travel across \> 1 time zone in the last 3 months * High daily caffeine intake \> 400mg (more than 4 cups of coffee or energy drinks)

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Overweight and obesity

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

1 site. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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A doctor treating you

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Nightly ketogenic drink may rev up overnight metabolism in seniors

What the study statuses mean