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Can plant extracts on a gauze tame eyelid bacteria?

NCT ID NCT07759180

Disease control Sponsor: Azienda Ospedaliera OO.RR. S. Giovanni di Dio e Ruggi D'Aragona Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time

Summary

This trial investigates whether a sterile gauze infused with natural plant extracts can reduce bacteria on the eyelid margin in people with bilateral anterior blepharitis. Each participant receives the plant-based gauze on one eye and a standard gauze on the other, allowing direct comparison. The study measures bacterial load before and 20 minutes after cleansing, and also assesses comfort and tolerability. The goal is to see if the natural extracts offer added microbiological benefits beyond mechanical cleansing alone.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
A sterile gauze impregnated with natural plant extracts (sodium hyaluronate, Echinacea angustifolia, bromelain, ammonium glycyrrhizate, tocopherol)
What this could lead to
If effective, this could offer a natural, well-tolerated option for managing blepharitis symptoms and reducing bacterial load.
What could go wrong
This is a small, single-application study, so results may not reflect long-term use. The effect on bacteria may be modest, and individual responses can vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

38 people

The number who actually took part.

Started

Feb 2023

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18 years or older. * Clinical diagnosis of bilateral anterior blepharitis confirmed by slit-lamp examination. * Presence in both eyes of eyelid-margin inflammation associated with at least two of the following clinical signs: eyelid-margin hyperemia; eyelash crusting or collarettes; scaling or debris at the base of the eyelashes; lash abnormalities; mucocutaneous inflammation. * Presence of at least one associated symptom, including burning, itching, foreign-body sensation, tearing, or ocular irritation. * Ability and willingness to provide written informed consent. Exclusion Criteria: * Active ocular infection other than anterior blepharitis. * Predominantly posterior blepharitis requiring specific treatment. * Clinically evident Demodex infestation. * Ocular surgery within the previous 3 months. * Contact lens wear. * Use of topical or systemic antibiotics, antiseptics, or corticosteroids within the previous 4 weeks. * Ocular trauma. * Autoimmune disease or immunodeficiency. * Pregnancy or breastfeeding. * Known hypersensitivity to any component of the study products.

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Conditions

The condition(s) this trial relates to.

blepharitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Blepharitis

Contacts and locations

Locations

  • Azienda Ospedaliera Universitaria OO.RR. S. Giovanni di Dio e Ruggi D'Aragona

    Salerno, Campania, 84125, Italy

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