Can light zap eyelid mites? new trial investigates
NCT ID NCT07169461
First seen Jun 26, 2026 · Last updated Jul 14, 2026 · Updated 2 times
Summary
This study tests two types of light therapy—low-level light and intense pulse light—to kill Demodex mites that cause eyelid inflammation (blepharitis). 88 adults with confirmed mite infections will receive one of four treatments: sham, blue light alone, IPL alone, or both. All will also do warm compresses and lid scrubs. The main goal is to see if mite counts drop after one month.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Low-level light therapy (blue light) and intense pulse light (IPL) devices
- What this could lead to
- If successful, this could offer a non-drug, non-invasive way to control Demodex mites and improve symptoms of blepharitis.
- What could go wrong
- This is a small, early-stage trial with only 88 people. The treatments may not work better than sham therapy, and results may not apply to everyone with the condition.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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88 people
The number who actually took part.
- Started
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Feb 2025
- Finished
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May 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. All patients who received a definite diagnosis of demodex blepharitis based on cylindrical dandruff at the base of the lashes and the presence of at least one alive demodex mites on eyelid margin by microscopy 2. Age \>18 years. 3. Patients who can understand and follow the study instructions and can adhere to the scheduled follow-up plan. Exclusion Criteria: 1. Patients who received previous treatment IPL or LLLT 2. Poor compliance with eyelid scrubbing using tea tree oil (TTO) 3. Dead demodex mite on lash. 4. Contraindication of IPL: Skin Fitzpatrick scale V/VI, patients with pigmented lesions on the treatment area (Eyelid, Cheek). 5. Pregnancy or breastfeeding. 6. Active Skin disease: facial skin cancer, graft-versus-host disease, systemic lupus erythaematosus 7. Active eye infection: recurrent herpes simplex 8. Other lid disease ocular trauma, ocular deformity scar, exophthalmos, eyelid insufficiency 9. Patients with pigmented lesion on area of treatment.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Chulalongkorn University
Pathum Wan, Bangkok, 10330, Thailand
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Other studies related to the condition(s) this trial covers.