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Pill or IV? small study tests safer sedation for Seniors' eye surgery

NCT ID NCT07154147

Knowledge-focused Sponsor: University of California, San Francisco Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study tested whether giving a sedative pill (alprazolam) before cataract surgery works as well as IV sedation (midazolam) in adults 65 and older. Twenty participants were randomly assigned to one of the two approaches, and researchers measured how well their thinking and memory recovered after surgery. The goal was not to declare a winner, but to see if a larger, more definitive study is possible.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Alprazolam (Xanax) and midazolam (Versed)
What this could lead to
If successful, this pilot could pave the way for a larger study that helps determine the safest sedation method for older adults during cataract surgery.
What could go wrong
This is a very small pilot study with only 20 participants, so results may not apply broadly. It is designed to test feasibility, not to prove which sedation method is better.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

20 people

The number who actually took part.

Started

Aug 2025

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

65 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. ≥ 65 years old 2. Capable of providing informed consent and completing the study procedures in English 3. Able to provide consent for oneself 4. Able to follow directions 5. Able to climb one flight of stairs without stopping to rest 6. Have a new diagnosis of cataract disease 7. Plan on having cataract surgery on their eye within the next 6 months Exclusion Criteria: 1. History of prior cataract surgery 2. Admission to the hospital within the past 30 days 3. Difficulty being sedated during other minor outpatient procedures or imaging studies 4. Allergy or resistance to local anesthetic agents 5. Cannot lay flat without having symptoms (i.e., difficulty breathing, severe back pain, etc.) 6. History of severe anxiety requiring routine use of benzodiazepines 7. Patient undergoing cataract surgery in combination with any other ophthalmologic procedure 8. Patient requiring general anesthesia during cataract surgery due to the underlying characteristics of the existing cataract and/or anticipated complexity of the planned procedure

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Conditions

The condition(s) this trial relates to.

cataract Patient Satisfaction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cataract surgery Cognition function Older adults Perioperative care Sedation

Contacts and locations

Locations

  • UCSF Wayne and Gladys Valley Center for Vision, Mission Bay

    San Francisco, California, 94117, United States

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