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This early-phase trial tests a single injection of ASP2020, stem cells turned into retinal cells, placed under the retina in people with Stargardt disease or similar inherited macular dystrophies. The main goal is to check safety and tolerability, while also looking for signs tha…

This trial tests a gene therapy called SPVN20, given as a single injection into the eye, for people with advanced rod-cone dystrophy, a genetic condition that causes progressive vision loss. The study includes adults with a confirmed genetic diagnosis and some remaining cone cell…

This Phase 3 trial tests an oral drug called gildeuretinol acetate (ALK 001) in 230 people aged 8 to 45 with Stargardt disease, a genetic condition that causes progressive vision loss. Participants take the drug or a placebo daily for 24 months. The goal is to see if the drug can…

Researchers are testing a new treatment called PAL-222 for people with neovascular age-related macular degeneration (AMD) whose disease has not responded to existing therapies. The study will enroll up to 10 adults aged 18 to 85 with this condition. Each participant will have a s…

This study tests a drug called felzartamab in people who received a kidney transplant and later developed microvascular inflammation (MVI), a type of injury to small blood vessels in the new kidney that can lead to serious problems. The trial includes 81 participants who will rec…

This phase 3 trial tests whether an experimental drug called MK-8748 can treat diabetic macular edema (DME), a condition where fluid builds up in the retina and blurs vision. About 960 adults with DME will receive either MK-8748 or the standard treatment aflibercept via eye injec…

Researchers at Huashan Hospital are studying a practical management model for Chinese patients with neuromyelitis optica spectrum disorder (NMOSD) who receive satralizumab. The study follows about 100 patients aged 12 and older who test positive for AQP4 antibodies and have had r…

This study tests a new medicine called tiespectus (EYE201) for wet age-related macular degeneration, a leading cause of vision loss. About 960 people will receive either tiespectus or the standard treatment aflibercept via eye injections. The goal is to see if tiespectus can impr…

This study tests a single injection into the eye of a new drug (SAR446597) for people with geographic atrophy, a progressive form of age-related macular degeneration that causes vision loss. About 104 participants aged 60 and older will be followed for 2 years, with an optional 3…

This study tests two ways to treat proliferative diabetic retinopathy, a serious eye problem caused by diabetes. One group gets eye injections of faricimab plus laser treatment; the other gets vitrectomy surgery with laser. Researchers will track vision and how many extra treatme…

This phase 3 trial tests two injectable drugs, pozelimab and cemdisiran, alone or together, to slow the growth of geographic atrophy—an advanced form of dry age-related macular degeneration that causes central vision loss. About 975 participants will receive either the drugs or a…

This study tests two types of modified spectacle lenses designed to slow the progression of myopia (nearsightedness) in children aged 6 to 13. Over one year, researchers will measure changes in the back of the eye (choroid), eye length, and prescription strength. The goal is to s…

This study tests two types of daily disposable contact lenses designed to slow the progression of myopia (nearsightedness) in children aged 7 to 12. Over two years, 126 Hong Kong Chinese children will wear either a special lens or a standard single-vision lens, with their eyes me…

This study tests whether tofacitinib, a drug already used for rheumatoid arthritis, is safe and helpful for people with Sjogren's disease. About 60 adults with mild-to-moderate Sjogren's will take the pill twice daily for 28 weeks. Researchers will track side effects and measure …

This study tests a one-time gene therapy called surabgene lomparvovec (Sura-vec) for diabetic retinopathy, a common eye problem from diabetes that can lead to blindness. About 576 adults with moderate-to-severe non-proliferative diabetic retinopathy will receive either the gene t…

This early-stage trial tests a new oral drug called OCT-980 for people with a specific inherited eye disease (autosomal dominant retinitis pigmentosa) that causes gradual vision loss and blindness. The study first gives a single dose to healthy volunteers to check safety, then mu…

This phase 3 trial tests whether a new drug called ABP 938 works as well as the approved treatment Eylea HD for wet age-related macular degeneration, a leading cause of vision loss. About 304 people aged 50 and older with untreated wet AMD will receive injections of either drug i…

This study tests a second-generation travoprost implant placed inside the eye to lower pressure in people with open-angle glaucoma or ocular hypertension. About 610 participants will receive either the implant, timolol eye drops, a sham procedure, or placebo drops. The main goal …

Researchers compare two versions of corneal crosslinking to treat corneal neovascularization, a condition where abnormal blood vessels grow into the clear front surface of the eye. Both versions use riboflavin eye drops followed by ultraviolet A light, but one shines the light fo…

This study tests whether a 6-week self-management program, done with a caregiver's help, can improve diabetes control and thinking skills in adults aged 55+ who have both diabetes and mild cognitive impairment. About 309 participants will attend weekly group sessions and provide …

This Phase 3 trial tests an oral drug called nizubaglustat (AZ-3102) in people aged 4 and older with Niemann-Pick type C disease, GM1 gangliosidosis, or GM2 gangliosidosis. The study lasts 18 months and compares the drug to a placebo to see if it is safe and can slow disease prog…

This study tests whether the drug nerandomilast can slow lung scarring in people with autoimmune diseases like rheumatoid arthritis or scleroderma. About 400 adults whose lung function hasn't improved with standard treatment will take either nerandomilast or a placebo twice daily…

Researchers are testing a new eye drop called NT-101 in people with wet age-related macular degeneration, a condition where abnormal blood vessels leak fluid into the retina and damage central vision. The trial enrolls 66 adults aged 50 and older who have active leaking vessels u…

This phase 3 trial tests whether taking darovasertib and crizotinib after standard treatment can delay or prevent uveal melanoma from returning. The study enrolls adults with high-risk, non-metastatic uveal melanoma who have completed local therapy such as surgery or radiation. P…

This study tests a gene therapy called ABBV-RGX-314 for people with wet age-related macular degeneration (AMD), a leading cause of vision loss. The goal is to see if a single treatment can reduce the need for frequent eye injections while keeping vision stable. About 561 adults a…

This phase 2 trial is testing a drug called tebentafusp in 19 people with a rare eye cancer (uveal melanoma) that has spread to the liver. Participants receive weekly infusions for 6 months, then may have surgery to remove any remaining tumors. The goal is to see if the drug can …

This study is for people who have both an autoimmune disease (like rheumatoid arthritis, lupus, or multiple sclerosis) and an advanced cancer that has spread or cannot be removed by surgery. It tests the safety and effectiveness of the immunotherapy drug nivolumab, given alone or…

This early-stage trial tests a personalized cell therapy called lifileucel for people with advanced uveal melanoma (a rare eye cancer) or certain sarcomas (connective tissue cancers). The treatment involves removing immune cells from the patient's tumor, growing them in a lab, an…

This study tests whether special research glasses can reduce the difference in prescription between the two eyes in children aged 6 to 13 with myopic anisometropia (when one eye is much more nearsighted than the other). Twenty children will wear the study glasses and have their e…

This study tests a cell therapy called OpRegen for people with geographic atrophy, an advanced form of dry age-related macular degeneration that causes blind spots. About 60 participants will receive a one-time injection of retinal cells under the retina during eye surgery. The m…

This study tests a gel stent implant designed to lower eye pressure in people with glaucoma. About 130 adults aged 45 and older will receive the stent through one of two surgical methods. Researchers will check safety and how well the stent reduces eye pressure over 12 months.

Researchers are observing whether a tiny implant that releases travoprost can be safely placed inside the eye during an office visit. The implant is designed to lower eye pressure in people with open angle glaucoma or ocular hypertension. The study follows 30 participants to see …

This early-stage trial tests an experimental drug called RO7663498, given as an injection into the eye, for people with diabetic retinopathy. The main goal is to check safety and how the drug moves through the body. About 30 participants will receive multiple doses to see if it i…

This study follows people who already received an eye injection of JNJ-81201887 or a sham in earlier studies for geographic atrophy, a form of advanced age-related macular degeneration that causes vision loss. The goal is to check long-term safety, including side effects and eye …

This study looks at whether giving free reading or distance glasses to older adults in rural areas can slow down memory and thinking problems. About 964 people aged 60-79 with poor eyesight but normal hearing and memory will take part. Half will get glasses, and the other half wi…

This early-stage trial tests an experimental drug called RO7823653, given as an eye injection alone or with an approved drug (faricimab), for people with diabetic macular edema—a condition where diabetes causes fluid buildup and vision loss in the center of the eye. The study wil…

This study tests an experimental gene therapy called ASP2767 in people with open-angle glaucoma, a common eye disease that damages the optic nerve and can lead to vision loss. The therapy uses a harmless virus to deliver genes into the eye, helping retinal nerve cells produce pro…

This study tests a gene therapy for GM1 gangliosidosis, a fatal disorder that destroys nerve cells. The therapy uses a harmless virus to deliver a working gene, helping the body produce a missing enzyme. Up to 54 children with Type I (ages 6-12 months) or Type II (ages 1-12 years…

This phase 3 trial tests whether adding surgery (vitrectomy, clot-busting drug, and gas bubble) to standard anti-VEGF injections can improve vision more than injections alone for people with a macular bleed from wet AMD. About 210 participants across Europe will be randomly assig…

This study tests a drug called ravulizumab in about 19 Chinese adults with a rare autoimmune disease called NMOSD. The goal is to see if it can reduce the number of disease attacks (relapses) and slow disability. Participants must have had at least one attack in the past year and…

This study tests whether injecting the antibiotic moxifloxacin directly into the cornea can help treat bacterial eye infections that don't improve with standard antibiotic drops. About 60 adults with stubborn corneal infections will receive either the injection plus drops or drop…

This study tests an experimental drug called ONL1204, given as an eye injection, to see if it can slow the growth of blind spots in people with geographic atrophy, an advanced form of dry age-related macular degeneration. About 324 adults aged 55 and older will receive either the…

This study tests a gene therapy called ATSN-201 in males aged 6 and older with X-linked retinoschisis, a genetic eye condition that leads to vision loss. The therapy delivers a working copy of the RS1 gene to the retina. The trial has three parts: first, finding the right dose; s…

This study tests a drug called tebentafusp in people with a specific type of advanced eye cancer (uveal melanoma) that has spread to other parts of the body. The drug is designed to help the immune system attack cancer cells. Researchers will also use a blood test to measure tumo…

This study tests a new eye injection called KIO-104 for people with macular edema, a condition where fluid builds up in the eye and blurs vision. About 28 adults will receive multiple doses to see if the drug is safe and helps reduce swelling. The goal is to find a steroid-free o…

This early-stage study tests a new drug called SAR448501 (DR-0201) in 62 adults with lupus or rheumatoid arthritis. The drug is a bispecific antibody designed to target the immune system. The main goal is to check safety and find the right dose, not yet to prove it works. Partici…

This Phase 2 trial tests FWY003, an experimental drug, in 272 people with geographic atrophy (a form of advanced age-related macular degeneration). The goal is to see if different doses can slow the growth of damaged areas in the eye and preserve vision. Participants receive eith…

This phase 2 trial is testing whether an experimental drug called DDY391 can reduce disease activity and improve symptoms like dryness, pain, and fatigue in people with Sjögren's disease. About 344 participants will receive either DDY391 at one of three dose levels or a placebo f…

This early study tests a new treatment called azercabtagene zapreleucel (azer-cel) for people with B-cell mediated autoimmune disorders like multiple sclerosis and neuromyelitis optica. The treatment uses a patient's own immune cells that are modified in a lab to target and destr…

This study tests a new gel made from donated amniotic membrane to treat large macular holes, a condition that blurs central vision. The gel is injected into the eye during surgery to help close the hole. Researchers will compare this method to the standard flap technique in 26 ad…

This phase 3 trial tests whether belimumab (Benlysta) can stabilize or improve lung function in adults with interstitial lung disease caused by connective tissue diseases like rheumatoid arthritis or lupus. About 440 participants will receive either belimumab injections or a plac…

This Phase 2 trial tests an experimental drug called EYE103 (Restoret) in 160 people with wet age-related macular degeneration or macular edema from a branch retinal vein occlusion. Participants receive three eye injections of either a low or high dose of EYE103, spaced four week…

This phase II trial is testing a combination of three drugs—zanubrutinib, rituximab, and methotrexate—given through the vein and directly into the eye, for people newly diagnosed with primary intraocular lymphoma, a rare cancer of the eye. The goal is to see if this regimen can i…

This phase 3 trial is testing whether giving men with metastatic prostate cancer half the standard dose of certain hormone therapies (called ARPIs) can be just as effective as the full dose, while causing less fatigue and fewer treatment stoppages. About 1,500 men with prostate c…

This study tests a toric add-on lens placed in the eye to correct high astigmatism in people who have already had a corneal transplant and cataract surgery. The goal is to reduce blurry vision from astigmatism without removing the original lens. About 40 participants will be foll…

This Phase 2 trial tests whether Lacripep eye drops can help the cornea heal faster and more smoothly after PRK laser eye surgery. 88 active-duty military members and their dependents will receive Lacripep in one eye and a placebo in the other. The study measures corneal thicknes…

This Phase 3 trial tests a gene therapy called FLT201 for adults with Gaucher disease type 1. The goal is to see if a single dose can keep blood counts stable so patients can stop their regular enzyme replacement or substrate reduction therapy. The study will enroll 45 people who…

This study tests an oral medication called BI 1815368 in 300 adults with center-involved diabetic macular edema, a common cause of vision loss in diabetes. Participants take tablets twice daily for about 11 months, and doctors compare vision changes between those on the drug and …

This early-stage trial tests whether adding special cells (DUOC-01) into the spinal fluid is safe for children with inherited metabolic diseases that damage the brain. Participants are ages 1 week to 21 years and are already receiving a standard umbilical cord blood transplant. T…

This trial tests whether people with newly diagnosed glaucoma can better control their eye pressure by measuring it at home and sharing the readings with their doctor. Participants either use a home device plus a smartphone app to guide treatment, or receive standard care with a …

This early-stage study tests a stem cell therapy called ASP7317 for people with geographic atrophy, the advanced form of dry age-related macular degeneration that causes central vision loss. The treatment involves injecting special cells under the retina to replace damaged ones. …

This study tests a new medicine called BI 3812465 for people with diabetic macular edema, a condition that causes swelling in the center of the eye and can lead to vision loss. The trial has two parts: first, a small group gets low to high doses to check safety, then a larger gro…

This study tests an experimental drug called ADX-038 in 240 people with geographic atrophy, a form of advanced age-related macular degeneration that causes blind spots. The drug is given as a shot under the skin and is compared to a placebo to see if it can slow the loss of a key…

This early-phase trial tests a new gene therapy called VG801 for Stargardt disease, a genetic condition that causes vision loss. Fifteen people aged 6 and older will receive a single injection under the retina. The main goal is to check safety, but researchers will also measure a…

This phase 2 trial is testing whether N-acetyl cysteine (NAC) eye drops can reduce oxidative stress in the eyes of people with Fuchs endothelial corneal dystrophy (FECD), a condition that often leads to corneal transplant. The study will enroll 45 adults with advanced FECD who ar…

This study tests a new drug called BNT326, given alone or with other cancer immunotherapies, in about 980 adults with advanced solid tumors that have spread or come back after prior treatment. The goal is to find the best dose and see if it is safe and effective. It is an early-s…

This early-phase study tests a new drug called DSB2455 in adults with advanced cancers (breast, ovarian, prostate, pancreatic, or brain metastases) that have a specific DNA repair problem. The main goals are to check safety and see if the drug shrinks tumors. About 180 participan…

This study tests whether photobiomodulation (PBM), a light-based therapy delivered by the Valeda system, can safely improve vision in people with dry age-related macular degeneration (AMD). Researchers will collect data from 500 participants in routine clinical practice across Eu…

This study is testing a refillable eye implant that delivers the drug ranibizumab to treat wet age-related macular degeneration (AMD). The main goal is to see if the implant affects the cells on the inner surface of the cornea. About 188 people with wet AMD will receive the impla…

This study looks at whether taking a supplement containing lutein, zeaxanthin, and meso-zeaxanthin can increase carotenoid levels in the skin, which may be linked to eye health. About 60 adults aged 18 to 50 will be randomly assigned to receive the supplement or a placebo for 12 …

This study follows people with wet age-related macular degeneration who received an injection of SKG0106, an experimental gene therapy, in an earlier trial. Researchers will track their eye health, vision, and any side effects for up to 5 years after the injection. The goal is to…

This early-stage trial is testing a new drug called cizutamig in 38 adults with active, moderate-to-severe thyroid eye disease. The main goal is to see if the drug is safe and tolerable, while also checking how the body processes it and whether it shows any signs of helping the c…

This study is checking the long-term safety of a small implant placed in the eye that slowly releases medicine to treat wet age-related macular degeneration, a condition that can cause rapid vision loss. About 1,000 people who have already used the implant in earlier studies will…

This trial tests whether QRX003, a lotion applied to the skin, can reduce the redness, scaling, and itch caused by Netherton syndrome, a rare genetic condition. Participants apply the lotion twice daily for 3 months and visit the clinic every 4 to 6 weeks for checkups. The study …

This study follows 30 people with Alagille syndrome who are taking odevixibat (Bylvay) in their daily lives. The goal is to see if the drug helps them avoid serious surgeries like liver transplant or bile duct repair over the long term. Researchers will also track weight, height,…

This study will follow 30 people with Alagille syndrome who are taking odevixibat in their daily lives. The goal is to see how safe the drug is over the long term by tracking any side effects. It is not testing if the drug works, but rather monitoring its real-world safety.

This trial tests whether QRX003 lotion, applied to the skin, can safely reduce the severity of Netherton syndrome, a rare genetic condition causing red, scaly skin and intense itching. Researchers will enroll about 20 people aged 14 and older who have the condition. Participants …

This study tests a combination of darolutamide, hormone therapy, and a lower dose of the chemotherapy drug docetaxel in men with metastatic hormone-sensitive prostate cancer. The goal is to see if this approach can keep PSA levels very low (below 0.2 ng/mL) at 24 weeks while redu…

This Phase 3 study tests whether telitacicept, a biologic drug given as a shot, can reduce disease activity in adults with active primary Sjögren's disease. About 250 participants will receive either telitacicept or a placebo for 48 weeks. The main goal is to see if the drug impr…

This study tests a new gene therapy called VV-14305, given as an injection around the eye, for people with moderate to severe thyroid eye disease. The trial will include 110 adults and is split into two parts: first to check safety, then to compare the treatment against a sham in…

This phase 3 trial compares an experimental drug, tabirafusp tedromer, against the standard treatment aflibercept for people with diabetic macular edema (DME), a leading cause of vision loss in diabetes. About 910 adults with DME will receive injections into the eye and be follow…

This study tests whether GAL-101 eye drops can slow the growth of geographic atrophy, a form of advanced age-related macular degeneration that causes blind spots. About 110 adults aged 55 and older with early-stage atrophy will use the drops or a placebo daily for up to two years…

This study tests an experimental oral drug called VMD-102 in people with advanced solid tumors, including liver, lung, kidney, skin (uveal melanoma), and colorectal cancers that have not responded to standard treatments. The drug works by blocking a specific protein (PKC epsilon)…

This study compares two surgical approaches for Fuchs endothelial dystrophy, a condition that clouds the cornea. One is a full corneal transplant (DMEK), the other is a simpler procedure that removes only the diseased cells (DSO) plus Ripasudil eye drops to help healing. 60 parti…

This study tests a device called PRIMA, which is implanted under the retina to help people with inherited retinal diseases like Stargardt disease and retinitis pigmentosa see better. The trial will enroll 5 adults with severe central vision loss and measure improvements in visual…

This Phase 3 trial tests whether privosegtor, a neuroprotective drug, can improve vision recovery in people having their first episode of optic neuritis. About 210 adults aged 18 to 50 will receive either privosegtor or a placebo, both alongside standard steroid treatment. The ma…

This study looks at whether giving satralizumab early during an attack of neuromyelitis optica spectrum disorder (NMOSD) can improve recovery and reduce long-term disability. Researchers will follow 50 adults with NMOSD who receive satralizumab as part of their routine care, trac…

This clinical trial tests whether an oral medication called linsitinib can reduce eye bulging (proptosis) in people with moderate to severe active thyroid eye disease (TED). Participants will take either linsitinib or a placebo twice daily for 24 weeks. The main goal is to see if…

This trial compares two phacoemulsification systems used in cataract surgery to see which removes the cataract more efficiently and leads to better early recovery. Each participant will have one eye treated with the UNITY VCS system and the other with the Centurion system, allowi…

This trial tests whether a new surgical procedure, called Innovative Tube Trabeculectomy, can better control eye pressure in people with advanced glaucoma that hasn't responded to other treatments. The new technique uses a deeper tunnel, a special suture, and a small tube to impr…

This Phase 3 trial tests pegtibatinase, an enzyme given as a shot, in 70 people aged 12–65 with classical homocystinuria. The goal is to see if it safely lowers high homocysteine levels when added to standard care. Participants receive either the drug or a placebo for 24 weeks.

This study tests a new drug called tiespectus (MK-8748) against the current standard treatment, aflibercept, for people with wet age-related macular degeneration (AMD). About 960 participants will receive injections into the eye and be followed for a year to see if tiespectus can…

This early-stage trial tests a single injection of AXV-101 gene therapy into one eye of 12 children and teens (ages 4-17) with Bardet-Biedl syndrome type 1, a rare genetic condition that causes progressive vision loss. The main goal is to check safety and find the right dose, whi…

This study tests whether Systane PRO Preservative Free eye drops are as effective as Blink Triple Care Preservative Free in relieving dry eye symptoms. Adults with mild to moderate dry eye will use one of the two drops four times a day for 30 days. Researchers will measure change…

This early-stage trial tests a new drug called OCU200, given as an injection into the eye, for people with diabetic macular edema (swelling in the center of the retina caused by diabetes). The study will include 24 participants and will primarily check for safety and side effects…

This study tests if a device that delivers mild electrical pulses to the eye (transcorneal electrical stimulation) can safely slow the progression of geographic atrophy, an advanced form of age-related macular degeneration that causes vision loss. About 70 people aged 60 and olde…

This study tests NOV05, a water-free tacrolimus eye drop, in 20 adults with active non-infectious anterior uveitis. Participants receive either a high or low dose for 6 weeks. The goal is to see if it safely controls inflammation and reduces the need for steroid eye drops.

This phase 4 trial will test the drug faricimab (Vabysmo) in 64 people with wet age-related macular degeneration (AMD). Participants will receive eye injections every 4 weeks for 4 doses, then a treat-and-extend schedule based on disease activity. The study also measures biomarke…

This early study tests a new treatment called CD19/BCMA CAR-T for people with severe autoimmune diseases like lupus and Sjögren's syndrome that haven't improved with standard care. The treatment involves taking a patient's own immune cells, modifying them to target specific immun…

This study tests a drug called AMG 732 in 30 adults with thyroid eye disease who either did not respond to treatment or saw their symptoms return after a previous study. The main goal is to see if the drug can reduce eye bulging by at least 2 millimeters without worsening the oth…

This study tests a community-designed strategy to deliver preventive chemotherapy to mobile and migrant populations in Nigeria, who often miss treatment for neglected tropical diseases like river blindness and schistosomiasis. Researchers will work with communities to map migrati…

This phase 3 study tests a single injection of Ixo-vec gene therapy against standard aflibercept injections in 284 people with wet AMD. The goal is to see if Ixo-vec can maintain or improve vision while reducing the need for repeated eye injections. Participants must be at least …

This clinical trial compares two ways to place a glaucoma drainage device during surgery: one in the front chamber of the eye and one in a small space behind it. The goal is to see which method causes less loss of important cells on the inner surface of the cornea. The study invo…

This study is checking whether a small metal implant called the Hydrus Microstent stays in the right place after being placed during cataract surgery. The implant is designed to help drain fluid from the eye and lower pressure in people with open-angle glaucoma. Researchers will …

This study compares two standard treatments for bleeding internal hemorrhoids: hemorrhoidal artery embolization (HAE) and rubber band ligation (RBL). HAE uses a catheter to block blood flow to the hemorrhoid with tiny particles or coils, while RBL uses rubber bands to cut off cir…

This study tests whether faricimab (Vabysmo), an FDA-approved eye injection for other retinal diseases, can safely treat abnormal blood vessel growth in the eye caused by presumed ocular histoplasmosis syndrome. About 25 adults with this condition will receive an initial injectio…

This trial studies whether giving anti-seizure medication to comatose patients who have brain seizure activity after cardiac arrest can improve their recovery. Participants are randomly assigned to receive either standard care alone or standard care plus a stepwise anti-seizure t…

This early-stage trial tests a new medicine called EYC-0305, given as an eye injection every 24 weeks, in 30 people aged 50 and older with wet age-related macular degeneration (AMD). The main goal is to check if the treatment is safe and tolerable. Researchers will also measure h…

This phase 3 trial tests whether the drug tebentafusp can prevent uveal melanoma from coming back in high-risk patients after their initial treatment. About 290 people with a specific genetic marker (HLA-A*02:01) will either receive weekly infusions of tebentafusp or be observed …

This study tests whether injecting a person's own bone marrow stem cells into or near the eye can help treat various retinal and optic nerve diseases, including age-related macular degeneration, retinitis pigmentosa, and glaucoma. Participants receive stem cell injections via dif…

This study compares two types of corneal transplants—PKP and DSAEK—in 334 adults aged 50+ with advanced bullous pseudophakic keratopathy, a condition where the cornea swells and blurs vision. Participants are randomly assigned to one procedure and followed for 2 years to see whic…

This study tests whether Miebo eye drops, used for one month before and 1.5 months after LASIK surgery, can reduce dry eye symptoms in people who already have dry eye disease. One hundred adults will use the drops four times daily. The goal is to see if eye dryness after surgery …

This study tests a new gene therapy for children with a severe inherited bone disease called osteopetrosis. The therapy uses the child's own blood stem cells, modified to fix the genetic defect, and then returned to the body. The goal is to improve blood cell production and survi…

This study looks at switching people with wet age-related macular degeneration (AMD) to a higher dose (8 mg) of the drug aflibercept. The goal is to see if it can extend the time between eye injections while still controlling the disease. Researchers will compare injection interv…

This early-stage study tests a new drug (GSK5926371) in people with lupus and similar autoimmune diseases. The drug is designed to target and calm specific immune cells that attack the body. The main goal is to check if the drug is safe and how the body handles it, with 54 adults…

This study looks at 100 people with wet age-related macular degeneration (AMD) who have been getting regular eye injections with older drugs. They will switch to a newer drug called faricimab. The goal is to see if faricimab can extend the time between injections, meaning fewer t…

This study tests a single injection of CTx001 gene therapy into the eye for people with geographic atrophy, a form of advanced age-related macular degeneration that causes vision loss. The trial involves 75 participants and will monitor safety and whether the treatment can slow d…

This study tests a gene therapy called ZVS203e for people with retinitis pigmentosa caused by a specific RHO gene mutation. The therapy is injected into the eye and uses a harmless virus to deliver a gene-editing tool. The trial includes 18 adults and will check safety and whethe…

This study tests a new drug called epcoritamab, given with two other drugs (lenalidomide and rituximab), for people whose primary CNS lymphoma has returned or stopped responding to treatment. The goal is to see if this combination can shrink or control the cancer. About 60 adults…

This study tests a two-step treatment for corneal neovascularization, where abnormal blood vessels grow on the clear front part of the eye. First, doctors use a fine needle with heat to seal off the vessels, then inject a drug called bevacizumab to prevent regrowth. The trial wil…

This study tests a tiny implant called MINIject s+ to help drain fluid and lower eye pressure in people with open-angle glaucoma. About 60 adults will receive the implant during surgery, and researchers will check if it is placed correctly and is easy for surgeons to use. The goa…

This trial investigates whether people with diabetic macular edema can safely monitor their vision and eye health at home instead of making frequent hospital visits. Participants use a home vision tester and a portable eye scanner every four weeks, with results sent to their doct…

This study tests a new treatment made from donor immune cells (CAR-NK cells) that are designed to attack two targets on melanoma cells. It is for adults with advanced melanoma that has spread or cannot be removed and has not responded to standard therapies. The goal is to find a …

This early-stage trial is testing a brain implant designed to create artificial vision in people who are blind. Five participants will have a wireless device surgically placed in the part of the brain that processes vision. The study will check if the device is safe and whether i…

This study is testing ten different surgical methods to repair full-thickness macular holes, a condition that blurs central vision. 120 adults will be randomly assigned to one technique during vitrectomy surgery. The main goal is to see which method closes the hole most often and…

This study tests a new multifocal lens (LuxHighAdd) for cataract surgery, comparing it to a standard monofocal lens. About 57 people aged 50+ with cataracts in both eyes will receive the lens in both eyes. The goal is to see if the new lens improves near vision without harming di…

This study tests a new treatment called Modified Zipper Therapy for people with a rare disease called NMOSD. It combines standard treatments with a drug called eculizumab to help patients recover better from sudden attacks. About 198 adults will take part to see if this approach …

This study tests an oral drug called sparsentan in 67 children with certain kidney diseases that cause protein to leak into urine. The goal is to see if the drug safely reduces protein levels over 108 weeks. Participants must have a certain level of kidney function to join.

This study tests whether a purine-rich diet can lower disease markers in people with AICA-ribosiduria, a rare genetic condition causing severe disability and epilepsy. Ten participants will follow a diet with 160 mg of purines per day. Early results in one patient showed promise,…

This study tests a new medicine called AVT29 against an approved drug, Eylea HD, for people with diabetic macular edema (DME), a leading cause of vision loss in diabetes. About 256 adults with DME will receive either AVT29 or Eylea HD to see if AVT29 works just as well at improvi…

This study compares two small implants (XEN-63 and PRESERFLO) placed during a quick surgery to lower eye pressure in adults with open-angle glaucoma. About 166 participants will be randomly assigned to one implant and followed for 2 years. The goal is to see if PRESERFLO works as…

This study tests an oral medication called tofacitinib in 8 people with moderate-to-severe thyroid eye disease who did not improve with or could not take steroids. The drug works by blocking inflammation pathways. Researchers will check if it reduces eye bulging and other symptom…

This early-stage study tests a new medicine called FLQ-101 in 18 premature babies born at 26-27 weeks who are at high risk for retinopathy of prematurity (ROP), an eye disease that can cause blindness. The main goal is to check if the drug is safe and how it works in the body. Re…

This study tests a new type of eyeglass lens designed to slow down nearsightedness (myopia) in children aged 6 to 14. The new lens is compared to an older version to see which works better. Each child will wear both lenses over a year, and researchers will measure eye growth and …

This early-stage trial tests a single injection of a gene therapy called RTx-021 in the eye of people with Stargardt disease, a genetic condition that causes vision loss. Up to 18 participants will receive different doses to check safety and tolerability. Researchers will monitor…

This study is testing a special laser called ELIOS to treat glaucoma at the same time as cataract surgery. The laser creates tiny channels in the eye to help fluid drain and lower eye pressure. About 46 adults with both cataracts and open-angle glaucoma will take part. The goal i…

This early-stage trial tests the safety of a new drug called ZM-02, given as an injection into one eye, in 12 adults with retinitis pigmentosa—a genetic condition that causes gradual vision loss. The main goal is to check for side effects, not to cure the disease. Researchers wil…

This study compares a new ambulatory (same-day) stroke care model to standard hospital care for patients aged 60 and older who have had a mild stroke or transient ischemic attack (TIA). Participants receive a full neurological assessment and treatment plan on the same day and the…

This Phase 3 trial tests an injection called MHB018A for people with chronic moderate-to-severe thyroid eye disease. The drug targets a protein linked to inflammation and eye bulging. About 150 adults will receive either the drug or a placebo every 4 weeks for 6 months. The main …

This study tests whether a tiny drainage device called the Preserflo MicroShunt can lower eye pressure as well as the standard trabeculectomy surgery in adults with open-angle glaucoma. One hundred participants will be randomly assigned to receive one of the two procedures and wi…

This early-phase trial is testing a new treatment called KN5601, which uses a patient's own immune cells (NK cells) that have been engineered to target and destroy harmful B cells. The goal is to see if it is safe and can help children aged 5 and older with rheumatic diseases lik…

This Phase IIb trial tests a retinal implant (CPCB-RPE1) in 24 people with advanced dry age-related macular degeneration (geographic atrophy). Participants are randomly assigned to receive the implant or a sham procedure. The study measures changes in retinal sensitivity and visu…

This study tests whether taking nicotinamide riboside (a vitamin B3-like supplement) can help preserve vision in people with a detached retina affecting the macula (central vision). Participants take the supplement or a placebo daily for 20 weeks, starting at diagnosis. The goal …

This study tests whether giving enzyme replacement therapy to fetuses with certain rare genetic diseases (like MPS I, Gaucher, or Pompe) before birth is safe and feasible. About 10 pregnant participants will receive the treatment through the umbilical vein. The goal is to see if …

This study tests whether clemastine fumarate, a drug originally approved for allergies, can help repair nerve damage in people with acute optic neuritis (inflammation of the optic nerve). About 90 participants will receive either clemastine or a placebo for 9 months. Researchers …

This study tests whether a weak electrical current applied to the eye's surface can improve vision in people with open-angle glaucoma. Fifty adults with worsening vision loss will receive either real or sham stimulation over several sessions. The goal is to see if this safe, non-…

This study is testing whether adding eculizumab to standard steroid therapy helps people having an acute attack of neuromyelitis optica spectrum disorder (NMOSD). Researchers will follow 200 patients in China, comparing those who get eculizumab plus steroids to those who get ster…

This Phase 3 trial tests faricimab (Vabysmo) in 50 people with a type of age-related macular degeneration called polypoidal choroidal vasculopathy (PCV). The goal is to see if a personalized treat-and-extend schedule can keep the eye healthy while allowing longer breaks between i…

This early-phase trial is testing an oral drug called Kamuvudine-9 (K9) in 10 adults with diabetic macular edema, a condition that causes vision loss. The study aims to see if K9 is safe and whether it improves vision compared to a placebo. Participants will take either K9 or pla…

This study is testing whether providing free glasses to older adults in India who need them can slow down age-related cognitive decline. Over 800 people aged 60 and older with uncorrected vision problems will be randomly assigned to receive glasses or not. Researchers will track …

This study tests a gene therapy called GS010 for people with Leber hereditary optic neuropathy (LHON), a genetic condition that causes rapid vision loss. Researchers will give the treatment as an injection into the eye at two different doses to see if it improves vision and mitoc…

This study looks at how well a higher dose (8mg) of the drug Aflibercept (Eylea) works in the first two months for people with wet age-related macular degeneration, a leading cause of vision loss. Researchers will track fluid changes in the retina and vision improvements in 50 pa…

This study tests a redesigned inserter for the travoprost implant, a tiny device placed inside the eye to lower pressure in people with open-angle glaucoma or ocular hypertension. About 30 adults will receive the implant using the updated inserter. The main goal is to see if doct…

This study compares two common procedures—CSF shunting and dural venous sinus stenting—to see which better preserves vision in adults with idiopathic intracranial hypertension (IIH) who are at risk of permanent sight loss. About 80 participants will be randomly assigned to one of…

This study tests a free rideshare program (PRONTO-EYE) to help diabetic retinopathy patients with Medicaid get to their eye appointments. Researchers will see if offering transportation helps patients attend visits more regularly. The pilot includes 60 English-speaking adults who…

This study tests a new gene therapy called KB801 for people with stage 2 or 3 neurotrophic keratitis, a rare eye disease where the cornea cannot heal itself. The treatment uses a harmless virus to deliver nerve growth factor directly to the eye. About 60 participants will receive…

This study tests a 16-week inclusive exercise program called PACE for adults with intellectual disability. Participants will attend fitness classes, meet with coaches, and use a web dashboard to set goals. The trial includes 376 people and will measure daily steps and moderate-to…

This early-phase study tests a new treatment called TI-0032-III for people with severe autoimmune diseases like lupus and scleroderma that haven't improved with standard care. The treatment uses a special injection to create CAR-T cells inside the body, which then target and dest…

This phase 3 study tests whether low-dose atropine eye drops (0.025% and 0.05%) can slow the progression of myopia (nearsightedness) in children and teens aged 3 to 17. About 234 participants across Europe will use the drops once nightly for 2 years. The goal is to see if these d…

This study tests whether stingless bee honey (Kelulut honey) can help young people with juvenile open-angle glaucoma. Sixty participants will either take 30 grams of honey daily for three months or receive no honey. Researchers will measure changes in inflammation, eye nerve thic…

The DYMOND study is testing a digital app called TrackSight that may slow myopia (nearsightedness) in children aged 6 to 12. The app uses eye-tracking to keep central vision clear while slightly blurring the edges of the screen, based on principles that influence eye growth. Abou…

This study tests whether an oral drug called dimethyl fumarate (Tecfidera) can safely slow the growth of geographic atrophy, a form of advanced age-related macular degeneration that causes vision loss. About 90 adults aged 55–85 with geographic atrophy will take the drug for 12 m…

This study tests whether combining a laser vision correction (PRK) with corneal cross-linking improves eyesight and corneal shape better than cross-linking alone in people with keratoconus, a condition that thins and bulges the cornea. Fifty adults aged 18-40 with mild to moderat…

This study tests whether a custom-made lens implanted during cataract surgery can better correct vision in people with irregularly shaped corneas. Fifteen adults with significant astigmatism will receive the special lens. The goal is to reduce total astigmatism and improve visual…

This study tests whether high-dose atorvastatin (a statin drug) can improve vision in people with intermediate age-related macular degeneration (AMD). Researchers will measure how quickly participants' eyes adjust to darkness and track changes in fatty deposits (drusen) in the re…

This study tests a new gene therapy called LY-M001 for adults with Gaucher disease type 1, a genetic disorder that causes organ damage and other health problems. The therapy uses a harmless virus to deliver a working copy of the GBA1 gene to liver cells, aiming to restore the mis…

This study tests whether a daily supplement called BrudyGlauco (containing DHA and citicoline) can help protect eyesight in people with glaucoma. About 108 participants will take either the supplement or a placebo for 12 months. The goal is to see if it slows vision loss and impr…

This study tracks 50 children and adults with non-malignant disorders like immune deficiencies and anemias who receive a stem cell transplant after a reduced-intensity chemotherapy regimen. The goal is to see if this approach improves survival and reduces severe graft-versus-host…

This early-stage trial tests a new implant called PVEK for people with corneal swelling from Fuchs' dystrophy or pseudophakic bullous keratopathy. The implant uses a collagen scaffold with human corneal cells to replace damaged tissue. About 15 participants will receive the impla…

This study tests whether low-dose atropine eye drops (0.025%) can safely slow the progression of myopia (nearsightedness) in children aged 5 to 10. Over two years, 144 children will receive either the active drops or a placebo. The goal is to see if the drops reduce how quickly t…

This study compares two surgical options—iStent inject and goniotomy with Kahook Dual Blade—performed during cataract surgery in 100 people with open-angle glaucoma. The goal is to see which method better lowers eye pressure and reduces the number of daily eye drops needed. Both …

This study tests a new surgical technique for people with macular holes that didn't close after standard treatment. Surgeons take a small piece of the patient's own eye tissue (Tenon's capsule) and use it as a patch to plug the hole. Twenty participants will be followed for 3 mon…

This study tests whether taking krill oil capsules daily for 3 months can reduce drusen (fatty deposits) in the eyes of people with early or intermediate dry age-related macular degeneration (AMD). 24 adults will receive either krill oil or a placebo. The main goal is to see if t…

This study tests whether special spectacle lenses can slow the progression of myopia (nearsightedness) in children aged 6 to 8. About 150 kids will wear either the test lenses or regular lenses for up to 3 years. Researchers will measure changes in eye focus and eye length to see…

This study tests special spectacle lenses designed to slow the progression of nearsightedness (myopia) in Chinese children. About 175 children who completed a prior study will wear the lenses for 12 months. Researchers will measure changes in eye length to see if the lenses help …

This Phase 3 trial tests a new eye drop called PRO-232, which combines an antibiotic (moxifloxacin) and a steroid (dexamethasone) in one bottle. It aims to see if this single drop works as well as using two separate drops to prevent infection and control inflammation after catara…

This study tests a new treatment for people who have lost vision in both eyes due to severe burns or rare eye diseases. Doctors take a small sample of cells from the inside of the patient's cheek, grow them into a thin sheet in the lab, and then transplant that sheet onto the dam…

This study is testing a less intense chemotherapy and radiation regimen before a stem cell transplant for children and young adults up to age 55 with non-cancerous blood disorders like immune deficiencies, anemias, and metabolic diseases. The goal is to see if this gentler prepar…

This study looks at how safe and effective DMEK (a type of cornea transplant) is for people who have already had eye surgeries like vitrectomy or glaucoma surgery. Researchers will track serious complications and vision improvement over 12 months in 80 participants. The goal is t…

This study tests a new drug called ANXV in 12 adults with eye diseases from diabetes or blocked retinal veins. The main goal is to check if ANXV is safe and if it can improve vision or reduce the need for other treatments. Participants receive ANXV as a 30-minute infusion for 5 d…

This study tests two ways to treat retinoblastoma, a childhood eye cancer, while trying to save the eye and vision. One part compares two types of artery-directed chemotherapy (one with two drugs, one with one) to see which better preserves the eye. The other part looks at how we…

This early study tests a special contact lens that slowly releases steroid medicine directly to the eye. It is for people with recurrent cystoid macular edema, a condition causing swelling in the back of the eye. The goal is to see if the lens is safe, comfortable, and a practica…

This study tests whether a handheld, ultra-widefield eye scanner (OCT) can accurately identify preterm infants with severe retinopathy of prematurity (ROP), a condition that can harm vision. The scanner takes detailed images of the retina without touching the eye, potentially red…

Uveitis is an inflammation inside the eye that can cause permanent vision loss in children, often without symptoms. This study compares a high-resolution, non-contact eye scan called AS-OCT with the standard slit-lamp eye exam in 300 children aged 2 to 16 who attend a pediatric u…

Researchers are testing whether advanced eye imaging, called OCT and OCT angiography, can detect glaucoma earlier and predict how it will progress. The study includes people with glaucoma, those suspected of having it, and healthy volunteers. Participants undergo detailed eye sca…

Researchers are testing three different visual field grids to see which one best detects central vision loss in people with early glaucoma and reduced retinal nerve thickness. The study compares the standard 10-2 and 24-2c tests with the G1 Octopus grid. About 16 glaucoma patient…

This trial tests whether adding an AI analysis of eye photos, an eye pressure check, and a virtual reality visual field test to standard diabetic eye screening can help detect glaucoma. About 2,000 people with diabetes who are already getting AI-based screening for diabetic eye d…

This study is testing a new, noninvasive imaging device called HH-SECTR to see inside the eyes of premature infants with retinopathy of prematurity (ROP), a condition that can affect vision. The goal is to see if this technology can provide clearer, more detailed images of the re…

This study tests whether an artificial intelligence (AI) model can accurately diagnose thyroid eye disease, assess its activity and severity, and predict its outcome using specialized MRI scans of the eye socket. Researchers will enroll 1200 people, including patients with thyroi…

This pilot study tests a new, portable device called the World Sight Foundation Field Machine (WSFFM) for measuring visual field loss in glaucoma patients. The WSFFM is compared to the standard Humphrey Visual Field analyzer to see if it can accurately detect glaucoma damage. If …

This study is testing a home-based eye-tracking system called AVIGA to see if it can detect when wet age-related macular degeneration (AMD) comes back. Sixty adults aged 50-99 who are being treated for wet AMD will use the AVIGA device at home, and its accuracy will be compared t…

This study looks at whether a new set of international criteria can accurately diagnose optic neuritis—a condition that causes sudden vision loss—in Chinese patients. Researchers will enroll 500 people with acute or subacute vision loss and compare the criteria's results against …

This study is testing a new blood test that looks for fetal cells in the mother's blood to detect genetic conditions like Down syndrome. The test will be compared to standard diagnostic methods such as amniocentesis or newborn testing. The study involves 1,000 pregnant individual…

This study tests a smartphone app that uses artificial intelligence to detect 16 different eye diseases from photos taken with the phone. The AI works entirely on the device, so no internet is needed. Researchers will compare its accuracy to eye doctors and see if non-medical use…

This study will enroll 500,000 people with high myopia and cataracts to develop an artificial intelligence model that helps doctors calculate the correct lens power and grade cataracts more accurately. The goal is to improve vision outcomes and reduce complications after surgery.…

This study tests a new eye imaging device (VG200D OCT) that takes detailed pictures of the retina. It compares these images to standard dye-based images (FA/ICGA) to see if the new device works just as well. About 30 adults with retina problems will take part. The goal is to see …

This study tests whether using telehealth tools like eye scans and pressure checks can find undiagnosed glaucoma earlier than just giving people information. It includes 2,000 Black and Hispanic adults and people with diabetes who are at higher risk. The goal is to see if remote …

This study tests a new 3D ultrasound probe to see tiny blood vessels inside fatty plaques in the neck arteries. These vessels can make plaques more likely to rupture and cause a stroke. Ten people who already had a standard ultrasound will get this new 3D scan with a contrast dye…

This study tests whether an AI software can help doctors spot diabetic retinopathy (an eye disease caused by diabetes) earlier. About 340 adults with type 2 diabetes who have not been diagnosed with eye disease will be randomly assigned to get either standard care or standard car…

This study tests whether an artificial intelligence (AI) program can help spot glaucoma, a leading cause of blindness, in people with diabetes. About 1,040 adults with diabetes will have their eye photos checked by either the AI or a human grader to see which method finds glaucom…

This study tests whether a nightly drop of low-dose atropine in both eyes can delay the start of nearsightedness in children aged 6–11 who are not yet nearsighted. Over 600 kids will be randomly assigned to get either the atropine drops or placebo drops for two years. The main go…

This trial tests whether a wearable device that tracks and reminds children to spend more time outdoors can help prevent nearsightedness (myopia). Primary school students with adequate hyperopic reserve—a natural buffer against myopia—will be randomly assigned to either a program…

This trial tests whether combining auricular acupressure (small seeds placed on the ear) with defocus spectacle lenses can slow the progression of nearsightedness (myopia) in primary school children. About 358 students in grades 1-4 with premyopia or myopia will be randomly assig…

This trial tests whether auricular acupressure—small adhesive patches with seeds placed on specific ear points—can prevent myopia in children who are at higher risk. Primary school students in grades 1-4 with insufficient hyperopic reserve (a sign they may become nearsighted) wil…

This study tests whether eating goji berries five days a week for six months can lower the risk of age-related macular degeneration (AMD) in people aged 65 to 95. Participants will eat 14 grams of goji berries or a fiber supplement and have their eye health, gut bacteria, and oth…

This trial tests whether a community-based screening program using advanced eye imaging (OCT, fundus photography, and pressure checks) can prevent vision loss from age-related macular degeneration, diabetic retinopathy, and glaucoma better than simple vision tests alone. About 60…

This study tests whether an oral blood pressure drug, propranolol, can prevent severe eye disease (retinopathy of prematurity) in extremely premature infants. About 276 babies born before 28 weeks and weighing under 1250 grams will receive either propranolol or a placebo. The goa…

Cataracts cloud the eye's lens and blur vision, and presbyopia makes it hard to focus up close after age 50. Researchers are testing an intraocular lens with a virtual aperture optic, implanted during cataract surgery, to see if it improves vision at distance, intermediate, and n…

This study looks at whether disulfiram (Antabuse), a drug used for alcohol use disorder, can improve vision in people with retinal degeneration (like macular degeneration or retinitis pigmentosa). Researchers believe it may calm overactive cells in the retina. The study involves …

Researchers are testing a robotic surgical system called Luca for people who need vitreoretinal surgery to treat conditions such as vitreous hemorrhage and macular pucker. The study enrolls up to 15 adults aged 18 to 85 who are scheduled for this type of eye surgery. Doctors use …

This study tests a disposable silicone device that clips onto eyeglasses to trap moisture around the eyes. Thirty-five adults with mild to moderate dry eye will wear it for two hours. Researchers will measure tear film stability, tear volume, and symptom changes before and after …

Researchers are testing an experimental oral drug called BGE-102 in adults with diabetic macular edema, a condition where fluid leaks into the center of the retina and blurs vision. The trial enrolls about 180 people with type 1 or type 2 diabetes and center-involved DME. Partici…

This study tests a small device called the VisAbility™ Micro Insert System, which is placed in the eye to help people with presbyopia (age-related trouble seeing up close) read without glasses. It involves 33 adults aged 45 to 60 and will track safety and vision improvement over …

This phase 3 study tests whether ianalumab, given as a monthly injection, can reduce dry mouth and other symptoms in people with Sjögren's disease who have a high symptom burden. About 570 adults will receive either the drug or a placebo for 52 weeks. The main goal is to see if t…

This study tests whether phentolamine eye drops can improve vision in low light for people who had laser eye surgery and now see glare, halos, or starbursts at night. About 200 adults will use the drops or a placebo every evening for two weeks. The main goal is to see if more peo…

This trial tests whether Daydrop Triple Action eye drops can relieve symptoms of allergic conjunctivitis, such as itching, redness, and tearing. The drops contain ectoine, hyaluronic acid, and carboxymethylcellulose, which are meant to hydrate and protect the eye surface. About 4…

This study compares two types of artificial lens implants used in cataract surgery: the Clareon TruPlus and the Tecnis Eyhance. Researchers want to see which lens gives better vision at different distances and how satisfied patients are. The study involves 70 adults with cataract…

This study tests whether licaminlimab eye drops can reduce eye discomfort in people with dry eye disease who have a specific gene variant. About 160 participants will use the drops three times daily for 29 days. The goal is to see if this targeted approach works better than a pla…

This study tests a new type of artificial lens (LuxBoost) for people having cataract surgery. The goal is to see if it improves vision at far, middle, and close distances compared to a standard lens. About 58 adults aged 50 and older with cataracts in both eyes will take part.

This study tests whether atropine eyedrops help reduce pain and inflammation after a type of eye surgery called vitrectomy. About 62 adults having this surgery will receive atropine or a placebo. Researchers will measure pain scores and signs of eye swelling to see if atropine ma…

This trial tests whether a combination of pain education, guided imagery, and paced breathing—called the STEIN Protocol—can help people undergoing awake cataract surgery need less pain and anxiety medication. Participants wear open-ear headphones that play audio prompts every few…

This study tests a special lens used during cataract surgery to see how well it improves vision. About 130 adults with cataracts will get the lens and have their eyesight checked afterward. The goal is to make sure the lens is safe and helps people see more clearly.

This study looks at the best way to fix a detached retina, a serious eye problem that can cause vision loss. It compares doing one surgery (vitrectomy) alone versus doing it together with cataract surgery at the same time. The goal is to see which approach gives better vision, fe…

This study looks at whether people who already wear INFUSE One-Day multifocal contact lenses for presbyopia (age-related blurry near vision) feel more comfortable and see better after switching to DAILIES TOTAL1 multifocal lenses. About 30 satisfied lens wearers, aged 40 and olde…

This study looks at whether a visual rehabilitation program can ease anxiety and depression in people with advanced age-related macular degeneration (AMD). Twenty-two participants will attend five group sessions over 60 days, learning skills like coin recognition, using voice ass…

This early study tests a new spring made from surgical stitches to help people with facial nerve palsy close their eyelid. The spring is placed under the skin near the eyelid center, without attaching to bone. Ten adults who cannot blink due to nerve damage will try it, aiming to…

This study tests whether rinsing the inner eyelids and eye surface with a special device can lower inflammation and improve symptoms in people with dry eye disease. Researchers will measure changes in a marker of inflammation called MMP-9 in 33 participants. The goal is to see if…

This study tests a new lubricating eye drop called ABR2 in 40 adults with dry eye syndrome. The goal is to check if the drop is safe and tolerable when used for up to 28 days. Participants first receive a single drop in one eye, then use the drop at least twice daily for a month.…

This study tests whether a daily astaxanthin supplement can reduce digital eye strain in children aged 6–18 who use electronic devices. Seventy children with mild to moderate eye strain will take either astaxanthin or a placebo for 24 weeks. The goal is to see if the supplement i…

This study tests a new, gentler way to remove cataracts (cloudy lenses) using high-frequency pulsed vacuum instead of the usual ultrasound. The goal is to see if it causes less damage to the eye's inner lining, leading to faster recovery and fewer risks. Sixty adults with catarac…

This study tests whether adding acupuncture or a mild nerve stimulation device to an exercise program can reduce fatigue in people with Sjögren's syndrome. About 174 adults with long-term fatigue will be randomly assigned to one of three groups: exercise alone, exercise plus acup…

This study looks at whether using a stress ball during cataract surgery can lower patients' pain and fear and increase their satisfaction. About 60 adults having their first cataract surgery will be asked to squeeze a stress ball during the procedure. Researchers will measure pai…

This study looks at whether adding early nurse and psychologist support after a retinitis pigmentosa (RP) diagnosis helps patients feel better emotionally. RP is a rare, progressive eye disease, and the diagnosis can be upsetting. Eighty newly diagnosed adults will get either sta…

This study looks at whether repairing blocked leg blood vessels within 48 hours helps heal foot ulcers in people with type 2 diabetes faster than waiting for a scheduled procedure. About 200 adults with diabetic foot sores will be randomly assigned to early or standard treatment.…

This study tests whether a standard cosmetic treatment for eye wrinkles (Tixel) can also improve symptoms and signs of dry eye disease. 36 adults with mild to moderate wrinkles and dry eyes will receive either real Tixel or a sham treatment. The goal is to see if the treatment is…

This study tests whether TheaLoz Duo eyedrops can protect the eyes of people who play handheld console or computer games for at least 2 hours daily. 28 participants with mild dry eye symptoms will use the drops for one month and no drops for another month, in random order. Resear…

This study compares standard monofocal intraocular lenses (IOLs) with enhanced monofocal IOLs in 461 people having cataract surgery. The goal is to see if the enhanced lenses improve vision at intermediate distances, like reading a computer screen, while maintaining good distance…

This study tests whether a drug called TRYPTYR (Acoltremon) can improve quality of life and work ability in adults with chronic dry eye disease. About 40 participants who are unhappy with their current treatment will use the eye drops for one month. Researchers will measure chang…

This study compares having cataract surgery on both eyes the same day versus waiting weeks between surgeries. Researchers want to see if same-day surgery is just as safe, costs less, and improves quality of life. About 242 adults in France with cataracts in both eyes will take pa…

This early-stage trial tests whether insulin eye drops are safe for people with glaucoma and other optic nerve conditions. Researchers at Stanford will give different doses of insulin drops to 52 participants for 1-2 months. The main goal is to check for side effects, but they wi…

This study looks at whether a new cyclosporin eye drop (Vevizye®) can reduce inflammation and dryness in people with moderate to severe dry eye disease who still have symptoms after using artificial tears. About 25 adults with chronic dry eye and visible eye redness will use the …

This study aims to learn more about eye diseases by observing and providing standard care to up to 1,000 people over 5 years. Participants receive regular eye exams, tests, and treatments as needed. The goal is to better understand how eye diseases progress and are inherited, not…

This study aims to uncover genetic changes that cause autoimmune diseases in people native to Peru. Researchers will collect blood, urine, and stool samples from 300 participants, including patients with conditions like lupus and rheumatoid arthritis, their family members, and he…

This study follows 100 adults with diabetic eye disease who are already receiving standard anti-VEGF injections for swelling in the center of the retina. Researchers will use advanced vision tests and imaging to track changes over time. The goal is not to test a new drug, but to …

This study follows 25 people aged 10 and older with Stargardt-like macular dystrophy (STDG3), a rare inherited eye disease that causes vision loss. Over three years, researchers will measure changes in the retina using eye exams, imaging, and vision tests. The goal is to understa…

This observational study looks at whether different eyeglass prescriptions change how close teenagers hold objects during everyday tasks. It includes 100 adolescents aged 12-17, both with and without myopia. Participants wear motion-capture and eye-tracking gear while performing …

This study aims to uncover the genetic causes of a group of eye conditions called MAC (microphthalmia, anophthalmia, and uveal coloboma), which can lead to vision loss or blindness. Researchers will collect DNA samples from 600 people—both those with MAC and their close relatives…

This study aims to learn more about diseases that affect the salivary glands, which produce saliva. Researchers will collect medical data, blood, saliva, and tissue samples from people with these conditions, their relatives, and healthy volunteers. The goal is to better understan…

This study follows 300 people with Sjogren's disease (or symptoms) over time to learn how the condition starts and progresses. Participants undergo exams, saliva and tear tests, and questionnaires during several visits. No treatment is given; the goal is to gather data and sample…

Researchers are building a global registry to collect patient-reported surveys, genetic test results, and medical records from people with Charcot-Marie-Tooth disease and related inherited neuropathies. The study is open to children and adults with a confirmed or suspected diagno…

This study aims to find out why 20-40% of people with wet age-related macular degeneration (AMD) don't respond well to standard anti-VEGF injections. Researchers will collect fluid from inside the eye of 117 patients and compare those who respond well to treatment with those who …

This study collects skin, hair, blood, urine, or saliva samples from people with certain eye diseases (like macular degeneration) and from healthy volunteers. Researchers will turn these samples into stem cells in the lab to study how the diseases develop and to test potential ne…

This study looks at whether certain genes make some people more likely to develop eye damage from the drug Plaquenil, which is used for autoimmune diseases like lupus and rheumatoid arthritis. Researchers will compare people who have had eye damage from Plaquenil with those who h…

Researchers at a German university eye hospital collect and anonymize data from about 10,000 people with glaucoma, ocular hypertension, or suspected glaucoma. They study how often patients should return for check-ups and which treatments best lower eye pressure for each person. T…

This study follows people with a rare genetic condition called DICER1 syndrome, which raises the risk of certain childhood cancers like pleuropulmonary blastoma. Researchers will collect medical histories, genetic samples, and tissue from up to 1,500 participants and their relati…

This study will follow 450 people with diabetes (and some without) for several years to track how their eyes change. Researchers will use advanced eye tests like visual field analysis, contrast sensitivity, and retinal imaging to see which measurements best show disease progressi…

Researchers at the University of Miami are studying whether advanced eye imaging devices can reveal useful information about the eye in health and disease. The study has two parts: one observes the eyes of healthy people and people with conditions such as multiple sclerosis, dry …

This study screens people with eye diseases to see if they can join other research studies at the National Eye Institute. No treatment is given. Participants undergo eye exams, blood tests, and other procedures to diagnose or evaluate their condition. The goal is simply to determ…

This study follows people with rare genetic disorders that cause harmful substances to build up in the body, leading to brain damage. Researchers will monitor up to 200 participants over time using exams, surveys, and lab tests. The goal is to better understand how these diseases…

This study looks at the structure of children's eyes using MRI and standard eye exams. The goal is to understand why some kids respond better to myopia treatments than others. By collecting detailed images and measurements from 100 children, researchers hope to pave the way for m…

This study follows up to 10 children under 2 years old with acid sphingomyelinase deficiency (ASMD) who are already receiving olipudase alfa (Xenpozyme®) as part of their routine care. Researchers will monitor side effects and immune responses over 1 to 3 years. No new treatment …

This study is a long-term registry that follows over 1,200 people with Gaucher disease worldwide. It collects real-world data on how the disease progresses and how different treatments, including velaglucerase alfa, work over time. No new drugs are being tested; instead, particip…

This study is the first time the experimental drug ARO-033 is being given to humans. Its main goal is to check the safety and tolerability of single and multiple doses in healthy adult volunteers. Researchers will also measure how the drug moves through the body. This is an early…

This observational study will follow 2000 adults with type 2 diabetes to see how their eating habits, body composition, and grip strength change over time. Researchers hope to identify patterns that could help improve care. Participants must be 18 or older and able to complete ba…

This study follows 2,800 unpaid caregivers of people with chronic conditions like diabetes or inherited disorders. Researchers will survey and interview caregivers over up to 5 years to track changes in their health, stress, and social support. The goal is to understand how careg…

Researchers at the University of Trieste are studying how the vitreous gel inside the eye changes after cataract surgery. They will take detailed OCT scans of 15 adults before and after the procedure, focusing on the back of the vitreous and where it meets the retina. By comparin…

This study aims to learn more about the genetics and natural history of autoinflammatory diseases, which cause repeated fevers and inflammation. Researchers will study up to 5,000 people, including patients, their relatives, and healthy volunteers. Participants provide blood and …

This trial asks whether offering a small financial reward encourages more people to complete a follow-up telephone survey as part of a glaucoma screening program. About 2,000 participants will be randomly assigned to receive a $5 gift card, entry into a monthly $100 drawing, or n…

This study tests whether immune cells called monocytes from people with the atrophic form of age-related macular degeneration (AMD) survive longer on retinal cells than monocytes from healthy people. Researchers will collect blood samples from 80 participants, extract monocytes, …

This study is testing a new non-invasive device that uses laser speckle to measure blood flow and structure inside the eye. Researchers will compare these images with standard vision tests in 500 people with various retinal conditions. The goal is to see if this technology can be…

This study is creating a large collection of health information and biological samples (like blood, saliva, and eye tissue) from people with and without retinal diseases. Researchers aim to use this database to better understand conditions like age-related macular degeneration an…

This international study aims to collect genetic and health information from 1,500 people with rare inherited retinal diseases like retinitis pigmentosa. It has two parts: a registry to gather genetic and vision data, and a natural history study that follows participants over tim…

This study collects extra blood, urine, and tumor samples from children and adults with certain cancers to build a large tissue repository. Researchers will analyze these samples to learn more about the genetic and molecular makeup of these tumors. The goal is to support future s…

This study observes 75 adults aged 55 and older with geographic atrophy (a late stage of age-related macular degeneration) to see how the condition progresses over a short time. Researchers will measure changes in eye structure and function, and explore links to genetics and life…

This study follows 200 people with Gaucher disease over many years to learn how the condition affects the body long-term, including the nervous system, liver, and spleen. It also looks at how well current treatments like enzyme replacement therapy work over time. No new treatment…

This study follows people with glaucoma and healthy volunteers for 10 years, using brain MRI scans to compare how brain regions connect and how brain volume changes over time. The goal is to test whether glaucoma damages the entire central nervous system, not just the visual path…

Researchers are investigating whether narrowing of the ophthalmic artery, which supplies blood to the eye, contributes to geographic atrophy, an advanced form of dry age-related macular degeneration. The study will use a noninvasive imaging technique called PC-CTA to measure arte…

This early-stage study is testing a new oral drug called SK-09 in 72 healthy adults to see if it is safe and how the body processes it. The study is split into two parts: one where participants get a single dose, and another where they get multiple doses. No one knows who gets th…

This study compares measurements from two biometers—devices that use light to measure the eye's internal structures—to see if they agree. The measurements are important for calculating the correct lens power before cataract surgery. The study includes people with healthy eyes, ke…

This study tests a modified P200TE imaging device to see how well it captures images of the retina in people with posterior segment eye diseases, such as age-related macular degeneration, glaucoma, and diabetic retinopathy. Researchers will collect images from 50 adults with thes…

This study aims to find out how often exocrine pancreatic insufficiency (EPI) occurs in people with Alagille syndrome who have had a liver transplant. About 30 participants aged 7 to 50 will eat a high-fat diet and collect stool samples for lab testing. The results will help doct…

This study looks at how nearsightedness (myopia) and other vision problems affect the quality of life of Swedish children and teens. Researchers will translate a vision questionnaire into Swedish and test it on 300 healthy kids aged 0-17. Participants will get a full eye exam and…

This study is testing whether a simple vision screening program in general practice can help detect vision loss early in adults over 70 who have at least one chronic condition. Participants will have three vision tests done by their GP or nurse, then visit a collaborating opticia…

This study looks at how well people with retinal diseases like retinitis pigmentosa and Stargardt's disease see in the dark. Researchers want to find out if measuring dark adaptation can help detect and track these conditions. Healthy volunteers and people with retinal disease ag…

This study follows 60 women with neuromyelitis optica spectrum disorder (NMOSD) who received UPLIZNA during pregnancy or within 6 months before conception. Researchers will collect data on pregnancy outcomes, including birth defects, preterm birth, and infant development over 10 …

This study looks at whether a person's dominant eye influences how well their eyes can work together to see a single image, a skill called fusional vergence. Researchers will measure eye fusion in 60 healthy adults aged 18 to 35, comparing results when testing the dominant versus…

This study follows 90 children and adults with Stargardt disease or similar inherited eye conditions to see how their vision changes over 2 years. Participants will have regular eye exams and imaging every 6 months. No treatment is given—the goal is to better understand the natur…

This study investigates whether specialized visual function tests can detect early changes in people with early or intermediate age-related macular degeneration (AMD). Researchers will follow 120 adults with good visual acuity but early signs of AMD, using tests like microperimet…

This study investigates whether a blood marker called anti-Müllerian hormone (AMH) can predict future infertility in children and adolescents who have undergone cancer treatment. Many young patients recover normal menstrual cycles or puberty after chemotherapy, but their ovarian …

This study follows people with rare inherited forms of kidney stones and chronic kidney disease, such as primary hyperoxaluria, cystinuria, and Dent disease, to learn how these conditions develop over time. Researchers will measure markers of inflammation in blood and urine and t…

This study creates a global registry for people with mitochondrial disorders—rare diseases that affect energy production in cells. By collecting health data from 6,000 participants worldwide, researchers aim to understand how these diseases progress and identify the best ways to …

This study looks at 200 highly myopic adults in France, the Netherlands, and Spain to understand why some develop a condition called posterior staphyloma, where the back of the eye bulges outward. Researchers will analyze blood samples and eye images to find genetic and molecular…

This observational study is measuring the eye length of 30,000 Chinese children aged 3 to 18 years to create standard growth charts for healthy eyes. Researchers will follow each child for three years with yearly check-ups. The goal is to better understand how eyes grow and when …

This observational study explores whether personality traits, such as neuroticism, are linked to the eye side effects that some people experience from glaucoma medications. Researchers will ask adults with glaucoma to complete a personality questionnaire and will review their med…

This study follows adults with age-related cataracts who receive different types of intraocular lenses (IOLs) during surgery—either the same bifocal lens in both eyes or a mix of bifocal, EDOF, and monofocal lenses. Researchers will track how well patients adapt to their new visi…

This study tracks 90 coma patients in intensive care to see if their body's natural daily rhythms (like sleep-wake cycles) return as they wake up. Researchers will measure behavior, eye movements, temperature, and urine biomarkers every few hours. The goal is to better understand…

This study follows people with a genetic condition called OPA1-associated optic atrophy, which causes gradual vision loss. Researchers will use a battery of eye exams—including vision charts, contrast sensitivity, and retinal imaging—to see how the disease changes over time. The …

This study follows 100 children ages 4 to 8 who currently have perfect vision to see who develops nearsightedness (myopia) over 2 to 5 years. Researchers will track eye measurements and daily habits to uncover why some children become nearsighted while others don't. The goal is t…

This study aims to understand why some patients with severe dry eye syndrome improve with autologous serum eye drops while others do not. Researchers will analyze the protein makeup of the drops from 68 participants over 6 months. The goal is to identify which proteins are linked…

This study analyzes blood and aqueous humor (eye fluid) from 250 people with type 1 choroidal neovascularization—a cause of vision loss—and from controls without the condition. Researchers measure biomarker levels and check whether they correlate with how well patients respond to…

This study follows 800 children born with eye malformations like microphthalmia, anophthalmia, aniridia, or anterior segment defects. Researchers will track their vision, brain development, and overall health for up to 10 years to better predict outcomes. No new treatments are be…

This study aims to find biological markers (biomarkers) in blood, tears, and eye cells from 110 adults with seven rare eye diseases. Researchers will compare these markers between patients and healthy controls to see if they differ and if they relate to disease symptoms. The goal…

This study looks at the bacteria, fungi, and viruses living on the skin, in the gut, and in the mouth of people with Netherton syndrome, a rare condition that damages the skin barrier and often causes allergies. Researchers will compare these microbes to those of healthy voluntee…

This study tests whether advanced MRI scans that map the brain's structural and functional connections can better predict neurological recovery in coma patients after cardiac arrest than standard methods. Researchers will scan 263 adults who remain unconscious at least 72 hours a…

This study is looking at how well current classification criteria can diagnose primary Sjögren's syndrome, a rare autoimmune disease. Researchers will compare the criteria against diagnoses made by expert doctors. The goal is to improve diagnostic accuracy for this condition.

This study is analyzing inflammatory markers in the blood and spinal fluid of 300 people who are being checked for multiple sclerosis (MS). The goal is to see if certain markers can help doctors tell MS apart from other autoimmune diseases that affect the brain and spinal cord. R…

This pilot study is testing how well children aged 6 to 16 adapt to Essilor Stellest myopia-control spectacle lenses. The goal is to see if kids find them comfortable and easy to wear in real life, which is important for long-term use. Fifty children with progressive myopia will …

This study follows 50 people with advanced glaucoma for three years, using a special eye scan (OCT angiography) to measure blood flow around the optic nerve. Researchers want to see how these scans compare with standard vision tests in tracking the disease. The goal is to better …

This study will compare how well patients see after three types of corneal transplants: DSAEK, UT-DSAEK, and DMEK. Researchers will follow 1,000 people who had surgery for Fuchs' endothelial corneal dystrophy or pseudophakic bullous keratopathy. They will measure vision, cell cou…

This study aims to discover new genes that may cause certain cancers to run in families. Researchers will collect blood samples and health information from 1,500 people in families where multiple members have had cancer, especially childhood cancers. The goal is to build a regist…

This study investigates the specific cognitive strengths and weaknesses of children and adults with Sturge-Weber Syndrome (SWS), a rare condition affecting blood vessels in the brain, skin, and eyes. Participants complete a series of tests measuring memory, attention, language, a…

This study uses a special eye scan (OCT angiography) to take detailed pictures of blood vessels in the back of the eye. Researchers will follow about 1,050 people with retinal diseases like diabetic retinopathy and healthy volunteers to see how these images can help detect early …

This study follows 100 women with neuroimmune diseases (like multiple sclerosis or myasthenia gravis) through pregnancy and up to five years after. Researchers will track disease activity, pregnancy complications, and baby health to learn how these conditions affect fertility and…

This study is following 1,500 adults aged 55 and older to learn how early age-related macular degeneration (AMD) turns into the advanced form that can cause vision loss. Researchers will use eye imaging, genetic tests, and other measurements to find clues that predict progression…

This study watches how vision changes over two years in 50 people aged 65-90 with geographic atrophy (a form of dry age-related macular degeneration) who are already taking the drug pegcetacoplan. Researchers will use a special vision test that maps light sensitivity near damaged…

This study looks at three drugs (bevacizumab, ranibizumab, and aflibercept) used to treat age-related macular degeneration (AMD), a leading cause of blindness in older adults. Researchers will analyze costs and quality of life for 600 patients in France to see which treatment off…

This study is for people with rare kidney diseases like Minimal Change Disease, Focal Segmental Glomerulosclerosis, and Membranous Nephropathy. Researchers will collect health information and biological samples from 1,200 participants over many years. The goal is to better unders…

This study checks if a French version of the MEPS/MEPI elbow score works well for children aged 4 to 17. It includes kids with and without elbow injuries to see if the score accurately measures elbow pain and function. The goal is to make sure doctors can use this tool reliably i…

This study helps people with certain kidney diseases (like nephrotic syndrome and FSGS) find clinical trials that match their specific disease profile. Researchers analyze participants' molecular data to recommend targeted therapies in ongoing trials. The goal is to improve treat…

This study follows 60 children aged 7-12 for three years to measure their daily visual environment, including how far they look, light brightness and color, and eye movements. Researchers want to find which factors most influence the development and worsening of nearsightedness (…

This study is following 5,000 adults aged 65 and older to learn how eye diseases develop and progress over time. Researchers will collect detailed health information, eye exams, and biological samples to build a comprehensive database. The goal is to create a personalized risk pr…

This study follows 2000 adults who are in a coma or have disorders of consciousness after serious brain injuries like stroke, cardiac arrest, or trauma. Researchers collect medical records and later interview survivors or their caregivers about physical and emotional recovery. No…

This study collects fluid and blood samples from 260 people with age-related macular degeneration, diabetic retinopathy, or retinal detachment, plus healthy controls. Researchers will analyze proteins in these samples to identify markers that could help diagnose or track these ey…

This study is looking at whether GLP-1 receptor agonists—drugs used for type 2 diabetes and obesity—can also improve dry eye disease. Researchers will measure changes in tear stability and eye surface health in 100 patients who have not taken these drugs before. The goal is to un…

This study is testing whether a smartphone app called Acuvera Capture can record eye test results as accurately as the traditional paper method. Researchers will compare the two methods in 90 adults with different levels of vision, from normal to low vision. The goal is to see if…

This study looks at how silicone oil, used to hold the retina in place after a retinal detachment, affects the retina's electrical activity. Researchers will measure these signals in 50 people who had surgery for a detached retina. The goal is to better understand how the oil imp…

This study looks at whether polishing the inner layer of the cornea before injecting new cells helps remove tiny bumps called guttae in people with Fuchs endothelial corneal dystrophy. Twenty adults scheduled for corneal transplant will have half their cornea polished and the oth…

This registry collects information from people with inherited retinal diseases, like retinitis pigmentosa and Stargardt disease. Participants share their symptoms, family history, and genetic test results online. The goal is to help researchers understand these rare diseases and …

This study looks at how artificial intelligence (AI) can help emergency call operators quickly identify life-threatening situations like cardiac arrest, stroke, or severe breathing problems. Researchers will analyze millions of past emergency calls to train AI models to recognize…

This study looks at how common tooth staining is in children who had very high bilirubin levels (jaundice) early in life. Researchers will check 120 children with certain liver conditions to see if their teeth are discolored and whether that affects their daily life. The goal is …

This study is observing 300 children under 18 with uveitis, an eye inflammation condition. Researchers want to learn how common different types of uveitis are and what treatments children receive. Participants have one visit with their doctor, and some will have their medical rec…

This study uses a special PET scan to look at dopamine pathways in the brains of people who are in a coma after a severe head injury. Researchers will compare three groups: coma patients, patients who have recovered from coma, and healthy volunteers. The goal is to understand how…

This study is looking for a better way to track disease activity in people with primary Sjögren's syndrome, a chronic autoimmune disease that causes dryness and can affect organs. Researchers will test a new blood marker called anti-Ro/SSA IgE in 185 participants to see if it is …

This study is looking at how genes relate to the different forms of Fuchs corneal endothelial dystrophy, a common eye disease that affects the cornea. Researchers in France will enroll 500 people who need corneal transplant surgery. They will analyze blood samples for genetic mar…

This research study aims to learn more about children born with small or missing eyes (Microphthalmia, Anophthalmia, and Coloboma, or MAC) and how genetic changes may cause these conditions. Researchers will collect medical histories, saliva, and blood samples, and perform physic…

This study uses a special camera called an adaptive optics scanning laser ophthalmoscope to take incredibly detailed pictures of the retina, the light-sensitive layer at the back of the eye. Researchers will compare images from healthy people and those with eye diseases like Star…

This study creates a Canadian registry for children under 18 with Alagille syndrome or genetic intrahepatic cholestasis, rare liver conditions that cause bile buildup. Researchers will collect health data from medical records over time to understand how these diseases progress an…

This study looks at people with retinitis pigmentosa and similar eye diseases who already use a device called OkuStim® that sends mild electrical pulses to the eye. Many patients report temporary improvements in vision right after treatment, but these haven't been measured in a s…

This study is observing how doctors manage complicated infections of the ears, nose, throat, and neck in both children and adults. Researchers will track standard treatments like surgery or medication to understand current practices. No new treatments are being tested; the goal i…

This study is collecting medical information and biological samples (like blood, urine, and kidney tissue) from 300 people with FSGS or MCD who have had or will have a kidney transplant. The goal is to build a research biobank called RESOLVE to help scientists study why these dis…

This study collects tear samples from 300 people with dry eye, infectious keratoconjunctivitis, mucous membrane pemphigoid, or allergic conjunctivitis. Researchers will analyze the proteins and metabolites in tears to create a unique fingerprint for each condition. The goal is to…

This study tests two advanced eye imaging techniques—central microperimetry and radial OCT—to see if they can more accurately measure the progression of geographic atrophy, a severe form of age-related macular degeneration that can lead to blindness. Researchers will follow 80 ad…

This study compares two new ultrawide field cameras (Clarus and Optos) to the standard Spectralis camera for taking pictures of the back of the eye in people with inherited retinal diseases. Fifty adults will have their eyes dilated and photographed with all three cameras. The go…

This study aims to find better ways to detect lung scarring (interstitial lung disease) early in people with connective tissue diseases like scleroderma or rheumatoid arthritis. Researchers will analyze tiny particles in the blood called extracellular vesicles and use AI to exami…

This study aims to find genetic mutations in the brain that cause drug-resistant epilepsy in children. Researchers will compare DNA from blood and brain tissue, including samples from special electrodes placed in the brain. The goal is to better understand the root causes of thes…

This study looks at whether using a liquid called perfluorocarbon (PFCL) during retinal detachment surgery changes how the retina shifts after reattachment. About 292 adults with a detached retina that affects central vision will be randomly assigned to surgery with or without PF…

This study collects information from up to 250 patients with lysosomal storage diseases (like certain forms of MPS, Pompe, Gaucher, and Wolman disease) to understand how these conditions develop and respond to treatments given before birth. Researchers will track symptoms, lab re…

This study aims to understand how glaucoma impacts quality of life by asking 5000 adults with glaucoma to fill out questionnaires about their symptoms and daily activities. The questionnaires are given before treatment or surgery and again 3 to 6 months after. The goal is to lear…

This study is testing new eye exams to see if they can better track early age-related macular degeneration (AMD). Researchers will measure how quickly the eye adapts to darkness in 150 healthy volunteers and people with early AMD. The goal is to find reliable ways to measure dise…

This study enrolls 25 people with severe retinal diseases like retinitis pigmentosa and Stargardt disease to test new ways of measuring visual function. Researchers will evaluate how well participants can perform various vision tests, such as navigating obstacles or detecting lig…

This pilot study is measuring prednisolone levels in 120 people with inflammatory diseases like thyroid eye disease, vasculitis, COPD, asthma, and others. Participants take high-dose prednisolone as part of their routine care, and researchers take timed blood samples to see how t…

This study follows 15,000 people who had a retinal artery occlusion, or 'eye stroke,' to track their long-term risk of heart attack, stroke, and death. Researchers will analyze medical records from a Korean national database to see how different treatments, like blood thinners an…

This study aims to find new genes that may cause a hereditary risk for uveal melanoma, a rare eye cancer. Researchers will analyze the DNA of 50 patients with this cancer to identify unknown genetic changes. The goal is to improve screening and surveillance for families affected …

This study takes skin or blood cells from 20 people with eye malformations and turns them into stem cells, which are then grown into tiny 3D eye-like structures (organoids) in a dish. Researchers will study these mini eyes to understand what goes wrong during development and test…

This study compares two different machines used during cataract surgery to see which one uses less ultrasound energy. The researchers will measure the total energy delivered into the eye while removing the cloudy lens. Thirty adults with cataracts in both eyes will take part, wit…

This study follows 132 adults having glaucoma surgery to see how their quality of life changes over six months. Patients fill out a questionnaire about vision-related daily activities before and after surgery. The goal is to compare different surgical techniques from the patient'…

This study will review medical records of 300 diabetes patients at a hospital in Da Nang, Vietnam, to see how many have diabetic retinopathy—a condition that can harm vision. Researchers will also look for factors that make the disease more likely. No new treatment is being teste…

This study follows 100 people with type 2 diabetes who have moderate to severe diabetic retinopathy, a condition that can lead to vision loss. Researchers will use advanced eye scans and imaging to track changes in the retina over two years. The goal is to find better ways to pre…

This study follows 600 people with birdshot chorioretinopathy, a rare inflammatory eye disease, to better understand its features and causes. Researchers will use imaging, vision tests, and quality-of-life surveys to track the disease over time. They will also analyze DNA to find…

This study is testing whether a special eye scan (OCT) can accurately measure inflammation inside the eye for people with uveitis. Researchers will scan the eyes of 1500 patients and compare the results to standard exams. The goal is to find a faster, painless way to track diseas…

This study tracks 400 adults with cataracts to see how three different toric intraocular lenses rotate after surgery. Rotation is measured at several follow-up visits over three months. The goal is to find which lens stays most stable and help doctors choose the best option for e…

This observational study will follow 1,000 people with type 2 diabetes for one year to see if changes in the eye's blood vessels and tissues can predict worsening diabetic retinopathy and related heart problems. Researchers will use advanced imaging and medical records to track e…

This study looks at how different types of artificial lighting affect how well people see after having presbyopia (age-related blurry near vision) corrected with special extended-depth-of-focus lens implants. Researchers will measure the minimum light needed for clear distance vi…

This study is creating a large database of genetic and physical information from 3100 children with craniofacial abnormalities, such as craniosynostosis and Pierre Robin sequence. Researchers will analyze this data to understand why these conditions vary so much from person to pe…

This study aims to understand the full burden of 9 rare skin diseases—including physical, emotional, social, and financial challenges—on patients and their families. Researchers will use special questionnaires to track how these conditions affect daily life and care needs. About …

This study looks at whether special vision training can improve how people with central vision loss from macular degeneration see and move their eyes. Researchers will train 60 adults aged 18 to 89 with severe vision loss to better detect and discriminate visual patterns. The goa…

This study looks at how often people with cystic fibrosis and diabetes develop complications like eye, kidney, and nerve problems. Researchers will also check blood pressure and cholesterol. The goal is to better understand these risks in a diverse group of 200 adolescents and ad…

This study uses a non-invasive eye tracker to measure how well people with Thyroid-Associated Ophthalmopathy (TAO) can move their eyes and pay attention to faces. Researchers will compare 100 participants, including patients and healthy volunteers, to see if the disease causes me…

This study looks at how small fiber neuropathy (nerve damage causing pain, burning, and numbness) impacts the quality of life and medical costs for people with Sjögren's syndrome. Researchers will follow 100 adults with Sjögren's to measure their symptoms, daily functioning, and …

This study is creating a large registry and tissue bank for people with mitochondrial disorders. Researchers will collect medical information and samples from up to 1,000 participants, including those diagnosed with or suspected to have a mitochondrial disease. The goal is to gat…

This study looks at a hand-held laser used during cataract surgery to see if it keeps the risk of capsule tears below 2%. Researchers will review medical records of 446 adults who had cataract surgery with this laser as part of their regular care. The goal is to confirm how safe …

This study compares lying on your back for 1 day versus 5 days after a specific type of corneal transplant (DMEK) for Fuchs dystrophy. Researchers want to see if a longer period helps the transplant stay attached and reduces the need for extra procedures. About 102 participants w…

This study looks at how short periods of high oxygen affect blood flow in the brains of ICU patients on breathing machines. Researchers will briefly increase the oxygen given through the ventilator and use ultrasound to monitor brain artery blood flow. The goal is to understand t…

This study looks at how glaucoma affects sleep, mood, alertness, and thinking by changing how the eye responds to light. Researchers will compare 120 adults with glaucoma to healthy volunteers aged 45-75. Participants will wear a sleep tracker and visit a lab to test their thinki…

This study will test 10,000 people in Cambodia for 57 different infectious diseases, including dengue, flu, and malaria. Researchers want to understand how these diseases spread and who is at risk. The goal is to give local health authorities the information they need to create b…

This study aims to understand what causes Visual Snow Syndrome (VSS), a condition where people see constant flickering dots across their vision. Researchers will use brain scans and visual tests to find which brain pathways are involved. About 100 adults with VSS, migraine, or he…

This study is a registry that collects health information from people in Switzerland who have neuromuscular disorders like SMA, DMD, BMD, and others. It aims to track symptoms, treatments, and outcomes over time to help researchers and doctors improve care. No new treatments are …

This registry enrolls pregnant women or those planning pregnancy who have autoimmune diseases like lupus or rheumatoid arthritis. Researchers at Duke University will track health data to find ways to improve outcomes for mothers and babies. The goal is to better understand risk f…

This study is testing a new optical biometer called Helioscope that measures key eye dimensions in people with cataracts. The goal is to see if it can accurately measure the eye's shape and length, which helps surgeons pick the right lens implant during cataract surgery. About 10…

This study tests a new digital guidance system that helps surgeons place toric lenses more accurately during cataract surgery. Researchers will compare the system's alignment calculations to standard methods and check vision and astigmatism one month after surgery. The study invo…

This registry follows 1,500 women with multiple sclerosis (MS) or related conditions through pregnancy and after childbirth. Researchers will track relapses, use of disease-modifying drugs, and outcomes for both mothers and children. The goal is to better understand how MS and it…

This study is testing whether a special type of MRI scan can predict how children with retinoblastoma, a rare eye cancer, will respond to chemotherapy delivered directly to the eye. Researchers will scan 60 children before treatment and check if the scan results match their respo…

This study is testing whether a special type of MRI, called resting-state fMRI, can predict how well people with optic neuritis (inflammation of the optic nerve) will recover their vision. Researchers will scan 200 patients and track their vision over 6 months. The goal is to see…

This study uses MRI scans to look at how the brain's visual networks change in people with inherited retinal diseases. Researchers will scan 200 patients before and after they receive treatments like retinal implants or optogenetics. The goal is to understand how the brain adapts…

This study looks at how natural cannabis compounds (phytocannabinoids) affect immune cells from 100 people with chronic inflammatory diseases like rheumatoid arthritis, lupus, and Crohn's disease. Researchers will take a blood sample and expose the cells to different cannabis ext…

This study tests a new tool called PRECOM that uses brain wave signals to predict whether coma patients after cardiac arrest will wake up within three months. Researchers will enroll 100 adults in French ICUs and compare the tool's predictions to actual outcomes. The goal is to i…

This study gathers health data from 7,000 people with multiple sclerosis (MS) and related conditions. The goal is to use this information to train artificial intelligence (AI) tools that can help doctors diagnose MS earlier and predict how the disease will progress. No new treatm…

This study aims to create a database of eye images using a new holographic Doppler laser device. The goal is to better visualize and measure blood flow in the retina and choroid, which is important for diagnosing eye diseases. About 123 adults, both with and without eye condition…

This study looks at whether sinusitis (sinus infection) is common in people with wet age-related macular degeneration (AMD) who need many eye injections. Researchers will screen 200 participants for sinusitis and treat it if found. They will then check if sinusitis treatment redu…

This study looks at how color vision changes over time in people with inherited retinal diseases (IRDs). Researchers will study 200 participants, including those with IRDs and healthy volunteers, to see how color vision loss relates to changes in the retina's structure. They are …

This study looks at whether a special eye scan can detect early blood flow changes in the retina of people with pseudoxanthoma elasticum (PXE), a rare genetic disease that can cause vision loss. Researchers will compare 30 PXE patients with 30 healthy volunteers matched by age an…

This study looks at whether damage to the glycocalyx, a protective lining inside blood vessels, is linked to glaucoma. Researchers will compare 50 people with glaucoma to 50 without, using a non-invasive device to measure this lining under the tongue. The goal is to see if blood …

This study is looking at tiny changes on the surface of eye cells in people with severe dry eye. Researchers will compare these cells before and after treatment starts, and also compare them to people without dry eye. The goal is to better understand what happens in the disease, …

This study looks at two treatments made from patients' own blood—autologous serum and growth factor-rich plasma—to see which helps heal the cornea better in people with aniridia, a rare eye condition. Researchers will test these treatments on corneal cells in the lab, using blood…

This study follows 1,000 myopic children in Europe for 5 years, measuring their eye growth every 6 months. The goal is to understand how nearsightedness progresses in this population, since most research has been done in Asia. Participants will have regular eye exams, including a…

This study is testing a scoring system called the SUCCESS Score to see if it can predict which people with Fuchs dystrophy will need a cornea transplant after cataract surgery. Researchers will follow 250 adults who have both Fuchs dystrophy and cataracts. The goal is to improve …

This study is looking at 60 people with a genetic eye surface disease called limbal stem cell deficiency. Researchers want to find out if certain gene changes are linked to more severe disease. They will compare patients' genes with their eye health to look for patterns. This is …

This study aims to find a way to predict which cancer patients will experience side effects from immunotherapy. These side effects happen when the immune system attacks healthy tissues, similar to autoimmune diseases. Researchers will collect blood samples from 300 cancer patient…

This study gathers standard eye movement and pupil data from 200 healthy volunteers, children, and people with eye or brain conditions using a VR headset called neos™. The headset shows images and tracks where participants look, how their pupils react, and how their eyes move. Th…

This study is observing how blood flow at the back of the eye changes after a type of retinal detachment surgery called scleral buckling. Researchers hope these observations will help them better understand other eye diseases, such as age-related macular degeneration. The study w…