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Which eye drop wins the dry eye battle? a Head-to-Head test

NCT ID NCT07745062

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 04, 2026 · Last updated Aug 05, 2026 · Updated 1 time

Summary

This study tests whether Systane PRO Preservative Free eye drops are as effective as Blink Triple Care Preservative Free in relieving dry eye symptoms. Adults with mild to moderate dry eye will use one of the two drops four times a day for 30 days. Researchers will measure changes in symptom scores and daily functioning to see if the two treatments perform similarly.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Systane PRO Preservative Free eye drops
What this could lead to
If Systane PRO proves as effective as Blink Triple Care, it could offer another reliable option for people with dry eye to find symptom relief and improve daily comfort.
What could go wrong
This is a small, short-term trial, so results may not apply to everyone. Individual responses to eye drops vary, and neither product may work for all users.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2026

Expected to finish

Apr 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age: Adults ≥ 18 years. * Diagnosis: Clinical diagnosis of mild to moderate dry eye disease in at least one eye with OSDI ≥ 13 to ≤ 32 at screening. * OSDI ≥ 13 to ≤ 32 at screening. * Objective evidence: NITBUT ≤ 10 seconds in the study eye(s) at screening. * Ocular surface status: CFS ≤ grade 3 (Oxford or NEI scale) in the study eye(s). * Stable medications: Systemic medications that may affect tear film must be stable ≥ 30 days prior to screening and expected to remain stable during the study. * Ability to participate: Able and willing to comply with procedures, attend visits, and provide written informed consent. * Contraception: Women of childbearing potential must agree to use an acceptable method of contraception for the study duration and have a negative pregnancy test at screening. Exclusion Criteria: * Active ocular infection or inflammation unrelated to DED (e.g., bacterial/viral conjunctivitis, active uveitis). * Severe ocular surface disease beyond typical DED (e.g., severe keratitis, Stevens-Johnson syndrome, ocular cicatricial pemphigoid). * Excessive corneal staining: CFS \> grade 3 in the study eye(s). * Recent ocular surgery or procedure: ocular surgery, laser, or punctal occlusion within 6 months prior to screening. * Current or prior use within 6 months before screening of either study drop (Systane PRO PF or Blink Triple Care PF) * Contact lens wear: soft or rigid contact lens use within 7 days prior to baseline, or unwillingness to discontinue lenses for the study; consider extending to 14 days if desired. * Use of topical ophthalmic medications that cannot be discontinued (e.g., topical antibiotics, corticosteroids). * Recent investigational product use: participation in another interventional trial or investigational product use within 30 days prior to screening. * Known hypersensitivity: allergy to any component of Systane PRO PF or Blink Triple Care PF. * Confounding systemic conditions: systemic diseases or medications that, in the investigator's judgment, could significantly affect tear production or ocular surface health (e.g., uncontrolled autoimmune disease, recent initiation/change of systemic medications known to affect tear production within 30 days). * Severe visual impairment in the study eye(s) not attributable to DED that would interfere with assessments. * Pregnancy or breastfeeding. * Investigator discretion: any medical, psychiatric, or social condition that would preclude safe participation or reliable completion of study procedures.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Gordon Schanzlin New Vision Institute

    RECRUITING

    La Jolla, California, 92037, United States

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