Which eye drop wins the dry eye battle? a Head-to-Head test
NCT ID NCT07745062
First seen Aug 04, 2026 · Last updated Aug 05, 2026 · Updated 1 time
Summary
This study tests whether Systane PRO Preservative Free eye drops are as effective as Blink Triple Care Preservative Free in relieving dry eye symptoms. Adults with mild to moderate dry eye will use one of the two drops four times a day for 30 days. Researchers will measure changes in symptom scores and daily functioning to see if the two treatments perform similarly.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Systane PRO Preservative Free eye drops
- What this could lead to
- If Systane PRO proves as effective as Blink Triple Care, it could offer another reliable option for people with dry eye to find symptom relief and improve daily comfort.
- What could go wrong
- This is a small, short-term trial, so results may not apply to everyone. Individual responses to eye drops vary, and neither product may work for all users.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
-
About 30 people
The number the study aims to enrol. It can still change while the study runs.
- Started
-
Jul 2026
- Expected to finish
-
Apr 2027
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age: Adults ≥ 18 years. * Diagnosis: Clinical diagnosis of mild to moderate dry eye disease in at least one eye with OSDI ≥ 13 to ≤ 32 at screening. * OSDI ≥ 13 to ≤ 32 at screening. * Objective evidence: NITBUT ≤ 10 seconds in the study eye(s) at screening. * Ocular surface status: CFS ≤ grade 3 (Oxford or NEI scale) in the study eye(s). * Stable medications: Systemic medications that may affect tear film must be stable ≥ 30 days prior to screening and expected to remain stable during the study. * Ability to participate: Able and willing to comply with procedures, attend visits, and provide written informed consent. * Contraception: Women of childbearing potential must agree to use an acceptable method of contraception for the study duration and have a negative pregnancy test at screening. Exclusion Criteria: * Active ocular infection or inflammation unrelated to DED (e.g., bacterial/viral conjunctivitis, active uveitis). * Severe ocular surface disease beyond typical DED (e.g., severe keratitis, Stevens-Johnson syndrome, ocular cicatricial pemphigoid). * Excessive corneal staining: CFS \> grade 3 in the study eye(s). * Recent ocular surgery or procedure: ocular surgery, laser, or punctal occlusion within 6 months prior to screening. * Current or prior use within 6 months before screening of either study drop (Systane PRO PF or Blink Triple Care PF) * Contact lens wear: soft or rigid contact lens use within 7 days prior to baseline, or unwillingness to discontinue lenses for the study; consider extending to 14 days if desired. * Use of topical ophthalmic medications that cannot be discontinued (e.g., topical antibiotics, corticosteroids). * Recent investigational product use: participation in another interventional trial or investigational product use within 30 days prior to screening. * Known hypersensitivity: allergy to any component of Systane PRO PF or Blink Triple Care PF. * Confounding systemic conditions: systemic diseases or medications that, in the investigator's judgment, could significantly affect tear production or ocular surface health (e.g., uncontrolled autoimmune disease, recent initiation/change of systemic medications known to affect tear production within 30 days). * Severe visual impairment in the study eye(s) not attributable to DED that would interfere with assessments. * Pregnancy or breastfeeding. * Investigator discretion: any medical, psychiatric, or social condition that would preclude safe participation or reliable completion of study procedures.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Dry eye disease (DED) are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
-
The places running it
1 site. The list below names each one and where it is.
-
The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
-
A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
-
Gordon Schanzlin New Vision Institute
RECRUITINGLa Jolla, California, 92037, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Gel plug in tear duct tested to keep eyes moist after cataract surgery
- Can a dissolvable eye plug deliver targeted relief for dry eye?
- Can a Light-Based scan reveal the health of your eyes?
- Can acne drug harm the eyes? new study investigates
- Can a new eye drop soothe dry eye? a trial puts TRYPTYR to the test
- New eye drop aims to soothe dryness after cataract surgery