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Eye surgery liquid may reduce post-op vision distortion

NCT ID NCT07027098

Knowledge-focused Sponsor: Norfolk and Norwich University Hospitals NHS Foundation Trust Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether using a liquid called perfluorocarbon (PFCL) during retinal detachment surgery changes how the retina shifts after reattachment. About 292 adults with a detached retina that affects central vision will be randomly assigned to surgery with or without PFCL. The goal is to see if PFCL reduces visual distortions like wavy lines or blind spots after the eye heals.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Perfluorocarbon liquid (PFCL)
What this could lead to
If this trial succeeds, it could help surgeons decide whether to use PFCL during retinal detachment surgery to reduce visual distortions after the retina reattaches.
What could go wrong
This is an early-stage study focused on understanding a surgical technique, not testing a new treatment. The results may not lead to immediate changes in practice, and individual outcomes vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 292 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2025

Expected to finish

Oct 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 18 years of age, or older. * Diagnosis of primary MIRD with posterior vitreous detachment, and fovea off (confirmed with OCT) * Surgeons' decision that the patient is eligible for using gas as postoperative tamponade. * The surgeon is confident to proceed with surgery with or without the use of intraoperative PFCL Exclusion Criteria: * Previous RRD and/or RRD surgery in the study eye * Decision to use adjunct scleral buckle * Decision to use silicone oil as tamponade * Retinal detachment with macula on * Patients with other retinal pathologies causing permanent structural changes to the retina in the study eye, such as diabetic retinopathy (assessed above background, or any diabetic maculopathy), previous vascular occlusion (artery or vein occlusion), macula dystrophy, among others * Previous vitreoretinal surgery in the study eye * Inability to come for follow ups up to 3 months * Inability to take FAF and OCT imaging due to neck stiffness or other medical issue * Mental incapacity * Patient is unwilling or unable to follow or comply with all study related procedures or to sign informed consent form. * Contraindications for PFCL * Previous enrollment in a clinical trial involving retinal diseases and/or treatments * Media opacity leading to poor quality retinal images (not including post operative significant cataract. See section 7.11) * Patient inability to posture following surgery

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Conditions

The condition(s) this trial relates to.

retinal detachment rhegmatogenous retinal detachment

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Retinal displacement after retinal detachment surgery

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    1 site. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Norwich University Hospitals NHS Foundation Trust

    RECRUITING

    Norwich, Norfolk, NR4 7UY, United Kingdom

    Contact Email: •••••@•••••