Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

Eye transplant showdown: which corneal procedure gives better vision?

NCT ID NCT06818747

Disease control Sponsor: Centre Hospitalier Régional Metz-Thionville Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two types of corneal transplants—PKP and DSAEK—in 334 adults aged 50+ with advanced bullous pseudophakic keratopathy, a condition where the cornea swells and blurs vision. Participants are randomly assigned to one procedure and followed for 2 years to see which provides better visual acuity. The goal is to identify the more effective surgical option for restoring sight.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Corneal transplant procedure (either PKP or DSAEK)
What this could lead to
If this trial succeeds, it could show which corneal transplant method gives better vision recovery for people with advanced bullous keratopathy.
What could go wrong
This is a comparative effectiveness trial, not a test of a new drug. Results may not apply to all patients, and both procedures carry risks like graft rejection or infection.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 334 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2025

Expected to finish

Aug 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * The patient: 1. Is ≥ 50 years old. 2. Has advanced PBK, with a best corrected visual acuity that lies between being able to see a hand move (i.e. 2 logMAR, included) and 2/10 excluded (i.e. 0.7 logMAR, excluded) and a central corneal thickness that exceeds 600 μm. 3. Is indicated for a corneal transplant. 4. Is pseudophakic. 5. Has provided free and informed written consent. 6. Is affiliated to a social security scheme. 7. Can be followed-up by the same investigating team during the study period. Exclusion Criteria: * The patient: 1. Has a history of corneal transplant on either eye (i.e. the study surgery will be the first corneal transplant for the patient). 2. Has an anterior chamber lens implant or is aphakic. 3. Has an ocular comorbidity that will impact visual acuity recovery: exudative or advanced atrophic AMD, advanced diabetic retinopathy (macular edema), advanced glaucoma (damage to the central visual field), important sequelae of central venous thrombosis of the retina or retinal detachment, previous amblyopia. 4. Has a contraindication to general anesthesia. 5. Is deprived of freedom, or under a legal protective measure. 6. Is included in another clinical study. 7. Has a severe general condition that might lead to premature discontinuation of the trial before the end of treatment period.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Bullous pseudophakic keratopathy are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

bullous keratopathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bullous pseudophakic keratopathy Penetrating keratoplasty

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    11 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • APHP - Hopital Cochin

    NOT_YET_RECRUITING

    Paris, 75014, France

  • CHR Metz-Thionville Hopital de Mercy

    RECRUITING

    Metz, 57085, France

  • CHRU Strasbourg - Nouvel Hôpital Civil

    RECRUITING

    Strasbourg, 67091, France

  • CHRU Tours

    RECRUITING

    Tours, 37044, France

  • CHU Besançon - Hôpital Jean Minjoz

    RECRUITING

    Besançon, 25030, France

  • CHU Bordeaux - Hopital Pellegrin

    RECRUITING

    Bordeaux, 33076, France

  • CHU Brest - Hopital Morvan

    RECRUITING

    Brest, 29609, France

  • CHU Nantes - Hôpital Hotel-Dieu

    NOT_YET_RECRUITING

    Nantes, 44000, France

  • CHU Saint-Etienne - Hôpital Nord

    RECRUITING

    Saint-Etienne, 42055, France

  • CHU Toulouse - Hopital Purpan

    RECRUITING

    Toulouse, 31059, France

  • Chno Xv Xx

    NOT_YET_RECRUITING

    Paris, 75571, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.