Eye surgery showdown: one step or two for retinal detachment?
NCT ID NCT06997874
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at the best way to fix a detached retina, a serious eye problem that can cause vision loss. It compares doing one surgery (vitrectomy) alone versus doing it together with cataract surgery at the same time. The goal is to see which approach gives better vision, fewer complications, and is more cost-effective for adults aged 50 and older.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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About 276 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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May 2025
- Expected to finish
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May 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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50 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adults ≥50 years of age * Non-highly myopic (\< -6 diopters; ≤26.5 mm axial length) phakic RRD * Naive to previous vitreoretinal surgery * Pars plana vitrectomy is planned to repair their RRD Exclusion Criteria: * Presence of a "formed/established cataract." A "formed/established cataract" is defined as a cataract that, based on the Age-Related Eye Disease Study (AREDS) Research Group, is graded as nuclear sclerosis of \>3 and/or if there is an anterior cortical cataract and/or a subcapsular posterior cataract involving the visual axis. * Pseudophakia or aphakia * High myopia (≥ -6 diopters; \>26.5 mm axial length) * Giant retinal tear (i.e. presence of one or more retinal tears of \>3 clock hours in size) * Retinal dialysis * Inclusion in an investigational drug study * Declined consent for participation
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
31 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Barts Health NHS Trust
RECRUITINGLondon, United Kingdom
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Belfast Health and Social Care Trust
RECRUITINGBelfast, United Kingdom
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Bradford Teaching Hospitals NHS Foundation Trust
RECRUITINGBradford, United Kingdom
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Buckinghamshire Healthcare NHS Trust
RECRUITINGAylesbury, United Kingdom
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County Durham and Darlington NHS Foundation Trust
RECRUITINGDarlington, United Kingdom
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Guys & St Thomas NHS Foundation Trust
RECRUITINGLondon, United Kingdom
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Hull University Teaching Hospitals NHS Trust
RECRUITINGHull, United Kingdom
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Imperial College NHS Trust
NOT_YET_RECRUITINGLondon, United Kingdom
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King's College Hospital NHS Foundation Trust
RECRUITINGLondon, United Kingdom
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Liverpool University Hospitals NHS Foundation Trust
RECRUITINGLiverpool, United Kingdom
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Manchester University NHS Foundation Trust
RECRUITINGManchester, United Kingdom
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Mid & South Essex NHS Foundation Trust
RECRUITINGWestcliff-on-Sea, United Kingdom
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Moorfields Eye Hospital NHS Foundation Trust
RECRUITINGLondon, United Kingdom
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NHS Greater Glasgow & Clyde
RECRUITINGGlasgow, United Kingdom
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NHS Lothian
NOT_YET_RECRUITINGEdinburgh, United Kingdom
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Newcastle Upon Tyne Hospitals NHS Foundation Trust
RECRUITINGNewcastle upon Tyne, United Kingdom
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Norfolk and Norwich University Hospital NHS Foundation Trust
NOT_YET_RECRUITINGNorwich, United Kingdom
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Nottingham University Hospital NHS Trust
NOT_YET_RECRUITINGNottingham, United Kingdom
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Oxford University Hospitals NHS Foundation Trust
RECRUITINGOxford, United Kingdom
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Royal Berkshire NHS Foundation Trust
RECRUITINGReading, United Kingdom
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Sandwell and West Birmingham Hospitals NHS Trust
RECRUITINGBirmingham, United Kingdom
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Sheffield Teaching Hospitals NHS Foundation Trust
RECRUITINGSheffield, United Kingdom
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South Tees Hospitals NHS Foundation Trust
RECRUITINGMiddlesbrough, United Kingdom
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South Tyneside and Sunderland NHS Trust
RECRUITINGSunderland, United Kingdom
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The Leeds Teaching Hospitals NHS Trust
NOT_YET_RECRUITINGLeeds, United Kingdom
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The Royal Wolverhampton NHS Trust
NOT_YET_RECRUITINGWolverhampton, United Kingdom
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University Hospital Southampton NHS Foundation Trust
RECRUITINGSouthampton, United Kingdom
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University Hospitals Bristol NHS Foundation Trust
RECRUITINGBristol, United Kingdom
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University Hospitals Leicester NHS Trust
RECRUITINGLeicester, United Kingdom
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Wirral University Teaching Hospital NHS Foundation Trust
RECRUITINGMetropolitan Borough of Wirral, United Kingdom
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York and Scarborough Teaching Hospitals NHS Foundation Trust
RECRUITINGYork, United Kingdom
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Gas bubble procedure may offer Surgery-Free fix for retinal detachment
- Can a steroid injection tame the inflammation behind retinal detachment?
- Could a single injection replace weeks of eye drops after retinal surgery?
- Silicone Oil's hidden impact on retinal signals revealed in new study
- Eye surgery silicone may change cornea cells, study finds
- Eye surgery showdown: UNITY VCS vs CONSTELLATION trial pulled