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Eye surgery silicone may change cornea cells, study finds

NCT ID NCT07418606

Knowledge-focused Sponsor: Minia University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 01, 2026 · Updated 2 times

Summary

This study looks at how silicone oil, used to repair detached retinas, affects the cells on the inner surface of the cornea. Researchers will measure cell density and shape changes in 40 patients at 1 and 3 months after surgery. They also want to see if any changes go away after the silicone oil is removed.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
silicone oil
What this could lead to
If successful, this could help doctors understand how silicone oil affects the cornea and guide better choices during retinal detachment surgery.
What could go wrong
This is a small, observational study with only 40 participants. It measures cell changes but does not test a new treatment, so direct patient benefits are limited.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

40 people

The number who actually took part.

Started

Jun 2025

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

All patients with Rhegmatodenous retinal detachment which need PPV will be included in this study.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: \- All patients with Rhegmatodenous retinal detachment which need PPV will be included in this study. Exclusion Criteria: * Patients with corneal dystrophies or degeneration. * Patients with a history of refractive surgery, either corneal or phakic lOL implantation. * Patients with a history of keratoplasty. * Patients with history of retinal detachment surgery in the same eye. * Recurrent cases during the follow-up period will be removed from the study. 6. patients with gas tamponade 7. patients with silicon oil 1000 cs 8. patients with Retinal pathologies such as macular hole , diabetic changes 9. patients undergo phacovitrectomy

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Conditions

The condition(s) this trial relates to.

rhegmatogenous retinal detachment

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Corneal endothelial cell changes in silicone filled eye Rhegmatogenous macula-off retinal detachment

Contacts and locations

Locations

  • Minia University

    Minya, 61111, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.