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Can a simple eye drop stop dry eye after LASIK?

NCT ID NCT07650708

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether Miebo eye drops, used for one month before and 1.5 months after LASIK surgery, can reduce dry eye symptoms in people who already have dry eye disease. One hundred adults will use the drops four times daily. The goal is to see if eye dryness after surgery is better than before treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Miebo eye drops
What this could lead to
If successful, this could show that using Miebo before and after LASIK helps prevent or reduce dry eye symptoms after surgery.
What could go wrong
This is a small, open-label Phase 4 trial with no placebo group, so results may be biased. It may not prove Miebo is better than standard care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2026

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Be at least 18 years of age at the time of consent, able to provide written voluntary informed consent, willing to follow instructions and participate in all trial assessments and visits 2. Be a candidate for routine, uncomplicated bilateral LASIK surgery (for spherical equivalent \[≤-8.00D\] myopia or myopic astigmatism correction, not combined with any other procedure; monovision myopic targets are allowed, however the myopic target eye will be the non-study \[fellow\] eye) 3. No history of refractive surgery including implantable Collamer lens (ICL) or cataract surgery 4. Total CFS score ≥1 and ≤6 using the National Eye Institute scale at Visit 1 (in at least one eye) 5. Ocular Surface Disease Index (OSDI) ≥13 and ≤22 at Visit 1 Exclusion Criteria: 1. Have any clinically significant ocular surface slit-lamp findings in the study eye that, in the opinion of the Investigator, could interfere with outcomes of a routine, uncomplicated LASIK surgery, including but not limited to: 1. History of eye trauma/surgery within the last 6 months that resulted in corneal scarring 2. DED secondary to scarring, irradiation, alkali burns, cicatricial pemphigoid, or destruction of conjunctival goblet cells, Stevens-Johnson syndrome, active blepharitis, or lid margin inflammation 3. Abnormal cornea (e.g., keratoconus or corneal epithelial defect, pterygium, or history of herpetic keratitis) 2. Use of any of the following ocular therapies in the study eye within 30 days prior to Visit 1: topical ocular steroid treatments, prescription dry eye therapy (including nasal spray), or topical intraocular pressure-lowering medications 3. Use of any eye drops (prescription or over the counter) in the study eye within 24 hours prior to Visit 1 4. Use of any oral medications known to cause ocular drying (e.g., antihistamines, antidepressants, etc.) on a non-stable regimen within 1 month prior to Visit 1 or is expected to be unstable during the trial 5. Had a LipiFlow®, intense pulsed light (IPL) therapy, etc. in the study eye within 3 months prior to Visit 1 6. Had received or removed a permanent punctum plug in the study eye within 1 month (3 months for dissolvable punctum plugs) prior to Visit 1 7. Have worn soft contact lenses within either 3 days prior to the study or rigid gas-permeable contact lenses for 1 month prior to Visit 1 or any planned wear during the study 8. Have undergone intraocular surgery or ocular laser surgery in the study eye within 3 months prior to Visit 1 9. Have ocular allergies that are/expected to be active during the trial period 10. Have active ocular or systemic infection (bacterial, viral, or fungal), including fever 11. Have any ocular findings or uncontrolled systemic disease that, in the opinion of the Investigator, will interfere with the trial 12. Female subjects who are pregnant, nursing, or planning a pregnancy 13. Female subjects of childbearing potential who are not using an acceptable means of birth control; acceptable methods of contraception include hormonal (oral, implantable, injectable, or transdermal) contraception; mechanical (spermicide in conjunction with a barrier such as a diaphragm or condom) contraception; intrauterine device; or surgical sterilization of partner. For non-sexually active female subjects, abstinence may be regarded as an adequate method of birth control; however, if the subject becomes sexually active during the trial, she must agree to use adequate birth control as defined above for the remainder of the trial. 14. Have a known allergy and/or sensitivity or lack of desired efficacy in response to the investigational drug 15. Are currently enrolled in an investigational drug or device study or had used an investigational drug or device within 30 days prior to Visit 1 -

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    4 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Vance Thompson Vision- Bozeman

    RECRUITING

    Bozeman, Montana, 59718, United States

  • Vance Thompson Vision- Fargo

    RECRUITING

    Fargo, North Dakota, 58078, United States

  • Vance Thompson Vision- Omaha

    NOT_YET_RECRUITING

    Omaha, Nebraska, 68137, United States

  • Vance Thompson Vision- Sioux Falls

    RECRUITING

    Sioux Falls, South Dakota, 57108, United States

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