Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

New eye drop aims to ease dry eye symptoms and boost work productivity

NCT ID NCT07266948

Symptom relief Sponsor: Southern College of Optometry Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a drug called TRYPTYR (Acoltremon) can improve quality of life and work ability in adults with chronic dry eye disease. About 40 participants who are unhappy with their current treatment will use the eye drops for one month. Researchers will measure changes in quality-of-life scores and symptom relief.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Acoltremon (TRYPTYR)
What this could lead to
If it works, this could offer a new option for people with dry eye disease whose current treatment isn't helping enough, potentially improving daily comfort and work performance.
What could go wrong
This is a small, short-term study (40 people, 1 month) with no placebo group, so results may not be reliable or apply to everyone. The drug may not work better than existing treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2025

Expected to finish

Mar 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults ≥18 years of age. * Have a history of DED for at least the past 6 months. * Are currently using Restasis as directed by their eye care provider for ≥1 month. * Participant intends to stop Restasis in the near future because and expressed dissatisfaction with effectiveness of Restasis in reducing dry eye symptoms.. * Are symptomatic as determined with the Eye Dryness visual analog scale (VAS) (Score ≥50), SPEED (≥7), and have an abnormal Schirmer test score \[≥2 to \<10 mm/5 min\]) at Screening/Baseline. * Have corrected distance visual acuity of 20/100 or better. * Willing to discontinue contact lens wear throughout the study. Exclusion Criteria: * Have a systemic health condition that is known to alter tear film physiology (e.g., primary and secondary Sjögren's syndrome). * Have a history of ocular surgery within the past 12 months. * Have a history of severe ocular trauma, active ocular infection or inflammation that is not dry eye related. * Punctal plugs in place for \< 3 months and/or Lacrifill in place for \> 5 months. * Have ever used Accutane or are currently using ocular medications (must washout from all dry eye medications/treatments at least 1 week before entry, except for Restasis). * Use of artificial tears within 2 hours prior to the baseline visit or during the study. * Are pregnant or breast feeding. * Have had a physical meibomian gland treatment withing 1 month of enrollment. * Have a condition or be in a situation, which in the investigator's opinion, may put the participant at significant risk, may confound the results, or may significantly interfere with their study participation.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Dry eye are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

dry eye syndrome eye disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dry eye Eye diseases Eyes dry chronic

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    3 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Complete Eye Care of Medina

    RECRUITING

    Medina, Minnesota, 55340, United States

  • Kannar Eye Care

    RECRUITING

    Pittsburg, Kansas, 66762, United States

  • The Southern College of Optometry

    RECRUITING

    Memphis, Tennessee, 38104, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.