Can a special light boost brain health in glaucoma patients?
NCT ID NCT07364929
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study looks at how glaucoma affects sleep, mood, alertness, and thinking by changing how the eye responds to light. Researchers will compare 120 adults with glaucoma to healthy volunteers aged 45-75. Participants will wear a sleep tracker and visit a lab to test their thinking after exposure to standard indoor light and a full-spectrum light that mimics daylight. The goal is to see if light-based treatments can improve quality of life for people with glaucoma.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Full-spectrum light exposure
- What this could lead to
- If successful, this could lead to simple light-based interventions to improve sleep, mood, and alertness in people with glaucoma.
- What could go wrong
- This is an early-stage observational and interventional study with a small sample size. The light exposure is short-term, so any benefits may not last or apply to daily life.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 120 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Sep 2025
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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45 to 75 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients with glaucoma must meet all of the inclusion criteria to participate in this study. * Patients diagnosed with primary open-angle glaucoma (POAG), as indicated by Humphrey Visual Field (HVF) mean deviation (VFMD) scores better than -12 dB in at least one eye during their most recent clinic visit. * Patients having spared central vision. * Patients aged 45 to 75 years old. * Patients with a best-corrected visual acuity better than 6/12 * English-speaking patients Healthy controls must meet all of the inclusion criteria to participate in this study: * Participants aged 50 to 70 years old. * Participants with a best-corrected visual acuity better than 6/12 * Normal ophthalmic examination * English-speaking participants Exclusion Criteria: * All subjects (patients and controls) meeting any of the exclusion criteria at baseline will be excluded from participation: * Participants with myopia exhibiting a refractive error exceeding -8.00 diopters (D) * Participants with a history of complicated previous intraocular surgery * Participants taking alpha-adrenergic agonist eye drops or other systemic medications or drugs that could affect the pupillary response * Participants with any past or current ocular condition (i.e., age-related retinal diseases (e.g., age-related macular degeneration), retinal pigment epithelium diseases (e.g., Best's disease), diabetic retinopathy, or other optic or generalized neuropathies, significant ocular trauma, or any eye condition affecting fixation (eg. Nystagmus)). * Participants diagnosed with cataracts at NS3+ (Nuclear Sclerosis) and above, as well as those with Posterior Subcapsular (PSC) cataracts * Participants with clinically diagnosed psychiatric or neurologic disorders, including cognitive impairment or dementia * Participants with diagnosed mood disorders * Participants engaged in night shift work within the past three months, are currently using sleeping pills, or have recently travelled across timezones within a month prior to the study * Participants with obstructive sleep apnea * Participants with abnormal auditory function * Participants with impaired color vision * Pre-menopausal women (last menstrual period \< 1 year) (If applicable) * Patients having unilateral glaucoma, congenital glaucoma, non-glaucomatous optic neuropathy, abnormal central vision * Diabetics on treatment
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
2 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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National University Hospital
NOT_YET_RECRUITINGSingapore, Singapore
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Singapore National Eye Center
RECRUITINGSingapore, Singapore
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can better Follow-Up schedules save sight in glaucoma?
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- Eye drops may shield the cornea after cataract surgery
- Can a puff of air replace the eye pressure probe?