GLAUCOMA

This study tests whether a tiny implant that releases medication inside the eye can control eye pressure as well as standard eye drops in people with glaucoma or high eye pressure who are also having cataract surgery. About 400 adults will receive either the implant plus a specia…

This study tests a modified trabeculectomy surgery in 20 glaucoma patients whose previous combined cataract and glaucoma surgery did not control eye pressure well. The modified approach avoids cutting a layer called Tenon's capsule. The main goal is to see if it can safely lower …

This study tests a small device called iStent that is placed in the eye during cataract surgery to help drain fluid and lower pressure in people with open-angle glaucoma. About 60 adults will take part to see if the implant safely reduces eye pressure. The goal is to better contr…

This study is testing the ELIOS laser, a new tool used during cataract surgery to also treat glaucoma. The laser creates tiny channels in the eye's drainage system to lower eye pressure. Researchers will measure how well it works and how it affects quality of life in 46 adults wi…

This Phase 3 trial tests a second-generation travoprost implant placed inside the eye to lower pressure in people with open-angle glaucoma or ocular hypertension. The implant slowly releases medication over time, potentially reducing the need for daily eye drops. About 510 adults…

This study looks at whether using pilocarpine eye drops after a combined cataract and glaucoma surgery (Kahook Dual Blade) helps lower eye pressure more than surgery alone. About 142 adults with glaucoma or high eye pressure will take part. The goal is to see if more patients ach…

This study tests a device called Eyetronic that sends a mild electrical current through the head to the eyes. The goal is to see if it can improve vision in people with open-angle glaucoma. About 30 adults with moderate vision loss will receive either real or fake (sham) treatmen…

This study looks at whether adding a combination of two eye drops (netarsudil and latanoprost) after laser treatment works better than adding just one drop (latanoprost) for lowering eye pressure in people with glaucoma. About 36 adults with mild to moderate glaucoma will take pa…

This study tests whether a tiny implant that releases eye-pressure-lowering medicine, placed during cataract surgery, works better than standard eye drops. About 400 adults with mild-to-moderate glaucoma or high eye pressure who need cataract surgery will take part. The goal is t…

This study tests whether metformin, a widely used diabetes medicine, can slow down vision loss in people with glaucoma. Researchers will give 125 adults with worsening glaucoma either metformin or a placebo for 24 months and measure changes in the optic nerve and visual field. Th…

This study tests a tiny implant placed inside the eye that slowly releases medication to lower eye pressure. It is for adults with open-angle glaucoma or high eye pressure. The goal is to see if the implant is safe and works better than standard eye drops.

This study tests a device that sends mild electrical pulses through the eye to treat vision loss in people with open-angle glaucoma. About 50 adults with worsening vision will receive either real or sham (fake) stimulation to see if it safely improves their visual field. The goal…

This study tests whether giving a laser treatment (transscleral cyclophotocoagulation) to lower eye pressure before a Boston keratoprosthesis (a plastic cornea implant) can prevent or slow glaucoma. Twenty adults who need the implant will receive one of two laser types 4-8 weeks …

This study follows about 200 glaucoma patients who received the Hydrus implant (often with cataract surgery) to see if it safely lowers eye pressure for 8 to 14 years. Researchers will check pressure, medication use, and quality of life. The goal is to understand how well the imp…

This study compares three types of glaucoma surgery (Hydrus Microstent, incisional goniotomy, and excisional goniotomy) done at the same time as cataract surgery. About 243 adults with mild to moderate open-angle glaucoma will take part. The goal is to see which surgery lowers ey…

This study tests whether a daily supplement called BrudyGlauco (containing DHA and citicoline) can help protect eyesight in people with glaucoma. Glaucoma damages the optic nerve and can lead to vision loss, and current treatments mainly focus on lowering eye pressure. The trial …

This study looks at whether a laser procedure called Direct Selective Laser Trabeculoplasty (DSLT) can reduce the natural ups and downs of eye pressure throughout the day in people with glaucoma. About 40 adults who already take 1 to 3 eye pressure-lowering drops will receive the…

This study tests whether using special cameras and eye pressure tests through telehealth can find glaucoma earlier in people at high risk (Black adults 50+, Hispanic adults 65+, and adults with diabetes 50+). About 2000 participants will either get the telehealth screening or jus…

This study tests a special contact lens that measures eye pressure continuously for 24 hours, compared to the standard method that only gives a quick reading. It involves 12 adults with open-angle glaucoma or high eye pressure. The goal is to see if the lens is accurate and comfo…

This study tests a new, non-invasive eye imaging technique called hyperspectral imaging. It takes pictures of the back of the eye using many different colors of light to find details that standard cameras miss. Researchers will compare this new method with current imaging in 1000…

This study checks how well a new device called TonoVera measures eye pressure compared to standard tools. It involves 300 adults with glaucoma. The goal is to see if the new device is accurate enough for routine use.

This study tests whether an artificial intelligence (AI) system can accurately screen for glaucoma, a leading cause of blindness, in people with diabetes. About 1040 participants will be randomly assigned to either the AI-assisted screening or the current standard method. The goa…

This study aims to develop new ways to measure eye pressure that are more objective, reliable, and portable than current methods. Researchers will compare two new devices to standard eye pressure tests in 200 adults. The goal is to improve glaucoma diagnosis and monitoring.

This study compares a technology-enhanced eye screening to a standard eye exam for detecting three leading causes of blindness: glaucoma, diabetic retinopathy, and cataracts. About 900 adults from a health center will participate. The goal is to see if the faster telemedicine app…

This study is testing whether a simple vision screening done in a regular doctor's office can help find vision problems early in people over 70 who have at least one chronic condition like diabetes or high blood pressure. About 460 participants will be invited to take vision test…

This study tests a new handheld device that automatically aligns to take detailed pictures of the back of the eye (retina) in adults and children. Researchers want to see if it can help detect eye diseases like glaucoma and retinal problems. About 50 volunteers and patients will …

This study is testing whether an AI-assisted eye screening program at community health centers can help detect glaucoma and other eye conditions early. About 1,800 adults at higher risk for eye disease will receive a quick screening using AI tools. Researchers will compare detect…

This study tests whether a community and faith-based program can encourage Black Americans at high risk for glaucoma to see an eye doctor. About 60 participants will receive education and extra resources to help them get eye exams. The goal is to prevent blindness by improving ac…

This study looks at whether Xiidra, an FDA-approved eye drop for dry eye, can help glaucoma patients who have eye discomfort from using multiple eye pressure-lowering medications. About 75 adults who already take glaucoma drops and have dry eye symptoms will receive Xiidra as par…

This early-stage trial tests the safety of insulin eye drops in 52 people with glaucoma or similar optic nerve conditions. Participants will use the drops for 1-2 months while doctors monitor for side effects and measure any changes in eye health. The goal is to see if this appro…

This study tests a special eye exercise program called biofeedback training for people with glaucoma, a disease that can damage eyesight. The training helps patients learn to use the healthy parts of their retina more effectively. Researchers will compare 70 participants who rece…

This study looks at whether Baduanjin, a gentle exercise, can help older adults with glaucoma. 60 participants will either do Baduanjin for 8 weeks or be on a waitlist. The main goal is to see if it lowers eye pressure and improves mood and quality of life.

This study tests whether adding brimonidine eye drops can reduce eye redness in adults with glaucoma who are already using a common combination drop (netarsudil/latanoprost). About 35 participants aged 18-65 will have their redness measured on a standard scale. The goal is to imp…

This study tests a gentle, non-invasive brain stimulation called rtACS in 188 adults with glaucoma. The goal is to see if it can wake up damaged cells in the eye and improve vision, measured by visual field tests. It's an early-stage trial focused on symptom relief, not a cure.

This study compares four new tonometer tips that don't require numbing eye drops to the standard tip used with anesthesia. Researchers want to see which tip is most comfortable and tolerable for patients. The goal is to develop a better tip for home use, making it easier for peop…

This study uses advanced, non-invasive eye scans (OCT and OCTA) to look at the retina and choroid—the layers at the back of the eye—in people with different types of glaucoma. Researchers will compare images from 132 participants, including healthy volunteers and those with prima…

This study follows 200 people with glaucoma for 3 years to see how their vision changes. Researchers will compare two different eye tests to find out which one detects vision loss earlier and more accurately. No new treatments are tested—the goal is to improve how doctors monitor…

This study uses a special camera (Brillouin microscopy) to measure how stiff the cornea is in people with glaucoma and healthy volunteers. The goal is to see if corneal stiffness can help predict glaucoma risk or track how well treatment is working. About 60 adults will participa…

This study looks at how glaucoma changes the way the eye responds to light and whether that affects sleep, mood, alertness, and thinking. Researchers will compare 120 adults with glaucoma to healthy adults aged 45-75. Participants will wear a wrist device to track sleep and light…

This study compares the inner lining of blood vessels (called the glycocalyx) in 100 people with and without primary open-angle glaucoma. Researchers want to see if damage to this lining is linked to the eye disease. Participants will have a non-invasive test to measure the linin…

This study tests two different eye-imaging machines (OCT) to see which one takes better pictures of the back of the eye in children. About 30 participants, including healthy adults and children with eye conditions, will be scanned. The goal is to find a device that gives doctors …

This study observes 300 glaucoma patients to see how eye tissues heal after minimally invasive surgery. Researchers will use special cameras to track changes in the eye's drainage angle over time. The goal is to learn how to make these surgeries safer and more effective.

This study looks at whether measuring blood flow in the back of the eye can help spot early glaucoma. Researchers will compare blood flow in people with early glaucoma and healthy volunteers. The goal is to find a new way to detect the disease sooner, before vision is damaged.

This study is for 150 adults having cataract or glaucoma surgery. Researchers will measure eye pressure and fluid drainage during the operation. The goal is to see if these measurements can help surgeons plan better care after surgery and reduce complications.

This study measures certain proteins in tears (called interleukins) that are linked to inflammation. Researchers want to see if changes in these proteins after glaucoma surgery or laser treatment relate to how much eye pressure drops. The study involves 24 adults with glaucoma wh…

This study is gathering detailed eye scans from 180 people, including those with healthy eyes and those with retinal disease, glaucoma, or corneal conditions. The goal is to collect data that may help researchers better understand these eye diseases. Participants will have their …

This study looks at whether the thickness of a layer in the eye (the choroid) can predict how well a laser treatment works for people with glaucoma. Researchers will measure eye pressure and choroid thickness before and after laser treatment in 20 adults. The goal is to find a si…

This study uses special high-resolution and high-speed cameras to take detailed pictures of the eye. The goal is to see tiny structures that regular eye exams miss, which could help doctors better understand eye diseases. About 1,200 people with various eye conditions or healthy …

This study looks at whether switching from daily glaucoma eye drops to a long-lasting injectable implant (Durysta) can reduce inflammation on the eye's surface. Researchers will measure a marker of inflammation called caspase-1 in 20 adults with open-angle glaucoma or ocular hype…

This study looks at different ways to help people with age-related macular degeneration, diabetic retinopathy, or glaucoma get to their eye hospital appointment after a screening. About 3,000 participants will be split into three groups: some get text reminders, some get calls fr…

This study aims to understand how glaucoma impacts quality of life by asking 5,000 adults with glaucoma to fill out questionnaires about their symptoms and daily functioning. Participants will complete surveys before starting or changing treatment, and again 3 to 6 months later. …