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Could a common supplement protect eyesight after retinal detachment?

NCT ID NCT06587945

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether taking nicotinamide riboside (a vitamin B3-like supplement) can help preserve vision in people with a detached retina affecting the macula (central vision). Participants take the supplement or a placebo daily for 20 weeks, starting at diagnosis. The goal is to see if it helps retinal cells survive and recover after standard surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
nicotinamide riboside (a dietary supplement)
What this could lead to
If it works, this could offer a simple, safe supplement to help preserve vision after retinal detachment surgery.
What could go wrong
This is a small, early-phase trial. The supplement may not improve vision outcomes, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 144 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2025

Expected to finish

Mar 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 years old * Able to give informed consent and comply with all study visits and procedures. * Present within 10 days of macula-off retinal detachment (based on patient-reported history of loss of central vision) * Present to the hospital with a visual acuity of hand motion or better in the study eye * Have had previous cataract surgery in the study eye * Have clinical indication for standard retinal reattachment surgery by means of a pars plana vitrectomy and gas tamponade * In the opinion of the investigator, be able to safely undergo all study procedures. Key exclusion Criteria: * Any known significant ocular disease in the study eye (e.g., cornea opacity) which, in the opinion of the investigator, would preclude a visual acuity of at least 6/7.5 (20/25) following successful vitrectomy or limit adequate visibility of the retina. * Any other ocular pathology in the study eye requiring treatment with topical ophthalmic drops or intravitreal injection. * History of previous ocular surgery in the study eye other than uncomplicated cataract surgery with posterior chamber intraocular lens and intact posterior capsule or a refractive surgery (surgery must have occurred at least 3 months prior to the baseline visit). * Participation in other clinical trials or use of any other investigational drugs or devices within 3 months prior to study participation. * Females who are pregnant or lactating and women of childbearing potential. * Known retinopathy, known hepatic disease (or history of significant chronic liver disease), or known renal disease. Patients Participants with diabetes and no known retinopathy may be enrolled. * History of uncontrolled hypertension. * History of stroke, transient ischemic attack, or major cardiac surgery within 3 months prior to study, or current treatment for systemic infection. * Any ocular or systemic condition that in the opinion of the investigator could compromise the safety of the patientparticipant, or may interfere with the safety and tolerability assessments or study procedures of the trial.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    5 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Centre for Eye Research Australia

    RECRUITING

    East Melbourne, Victoria, 3002, Australia

  • Cerulea

    RECRUITING

    East Melbourne, Victoria, 3002, Australia

  • Dr David Fabinyi

    RECRUITING

    Geelong, Victoria, 3220, Australia

  • Dr David Sousa

    RECRUITING

    Geelong, Victoria, 3220, Australia

  • The Royal Victorian Eye and Ear Hospital

    RECRUITING

    East Melbourne, Victoria, 3002, Australia

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