Could a common supplement protect eyesight after retinal detachment?
NCT ID NCT06587945
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether taking nicotinamide riboside (a vitamin B3-like supplement) can help preserve vision in people with a detached retina affecting the macula (central vision). Participants take the supplement or a placebo daily for 20 weeks, starting at diagnosis. The goal is to see if it helps retinal cells survive and recover after standard surgery.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- nicotinamide riboside (a dietary supplement)
- What this could lead to
- If it works, this could offer a simple, safe supplement to help preserve vision after retinal detachment surgery.
- What could go wrong
- This is a small, early-phase trial. The supplement may not improve vision outcomes, and results may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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About 144 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Sep 2025
- Expected to finish
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Mar 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age ≥ 18 years old * Able to give informed consent and comply with all study visits and procedures. * Present within 10 days of macula-off retinal detachment (based on patient-reported history of loss of central vision) * Present to the hospital with a visual acuity of hand motion or better in the study eye * Have had previous cataract surgery in the study eye * Have clinical indication for standard retinal reattachment surgery by means of a pars plana vitrectomy and gas tamponade * In the opinion of the investigator, be able to safely undergo all study procedures. Key exclusion Criteria: * Any known significant ocular disease in the study eye (e.g., cornea opacity) which, in the opinion of the investigator, would preclude a visual acuity of at least 6/7.5 (20/25) following successful vitrectomy or limit adequate visibility of the retina. * Any other ocular pathology in the study eye requiring treatment with topical ophthalmic drops or intravitreal injection. * History of previous ocular surgery in the study eye other than uncomplicated cataract surgery with posterior chamber intraocular lens and intact posterior capsule or a refractive surgery (surgery must have occurred at least 3 months prior to the baseline visit). * Participation in other clinical trials or use of any other investigational drugs or devices within 3 months prior to study participation. * Females who are pregnant or lactating and women of childbearing potential. * Known retinopathy, known hepatic disease (or history of significant chronic liver disease), or known renal disease. Patients Participants with diabetes and no known retinopathy may be enrolled. * History of uncontrolled hypertension. * History of stroke, transient ischemic attack, or major cardiac surgery within 3 months prior to study, or current treatment for systemic infection. * Any ocular or systemic condition that in the opinion of the investigator could compromise the safety of the patientparticipant, or may interfere with the safety and tolerability assessments or study procedures of the trial.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
5 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Centre for Eye Research Australia
RECRUITINGEast Melbourne, Victoria, 3002, Australia
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Cerulea
RECRUITINGEast Melbourne, Victoria, 3002, Australia
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Dr David Fabinyi
RECRUITINGGeelong, Victoria, 3220, Australia
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Dr David Sousa
RECRUITINGGeelong, Victoria, 3220, Australia
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The Royal Victorian Eye and Ear Hospital
RECRUITINGEast Melbourne, Victoria, 3002, Australia
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- A simple blood draw might reveal hidden eye lymphoma
- Gas bubble procedure may offer Surgery-Free fix for retinal detachment
- Silicone-Filled eyes put Eye-Measuring tools to the test
- Built-In eye scanner could give surgeons a live 3D view during operations
- AI eye scans aim to predict Sight-Threatening complication after retinal surgery
- AI eye scanner could speed up emergency referrals for vision loss