Cognitive disorder

This study tests whether taking a daily probiotic (Lab4P) for 12 weeks can improve memory, thinking speed, and blood sugar control in overweight adults aged 18-40 with prediabetes (mildly high blood sugar). Seventy participants will be randomly assigned to receive either the prob…

This study looks at whether giving free reading or distance glasses to older adults in rural areas can slow down memory and thinking problems. About 964 people aged 60-79 with poor eyesight but normal hearing and memory will take part. Half will get glasses, and the other half wi…

This phase 2 trial tests whether donanemab, an antibody given by IV, can slow worsening of thinking and daily function in people with early cognitive decline and Lewy body dementia. The study enrolls 350 participants who also have signs of two brain proteins (amyloid and alpha-sy…

This study looks at whether eating wild blueberries can improve heart health, thinking skills, and gut bacteria in Black and White adults aged 45-65 with high blood pressure. Participants will eat blueberries daily and have their blood pressure, artery stiffness, and cognitive fu…

This study tests whether eating peanuts and peanut products daily for six months can improve blood sugar, blood pressure, thinking skills, and gut health in people with prediabetes. Researchers will enroll 72 adults from diverse racial backgrounds. Participants will eat different…

This study tests whether a daily dose of freeze-dried wild blueberry powder can improve blood sugar, blood pressure, and brain function in women with prediabetes. Thirty overweight women aged 20-65 will take either the blueberry powder or a placebo for six weeks. Researchers will…

This early-stage study tests a new drug called LY3954068 in 48 people with mild Alzheimer's symptoms. The drug is given directly into the spinal fluid, either once or twice, to see if it is safe and how it affects Alzheimer's markers. The study lasts up to 100 weeks and includes …

This study tests whether listening to a specific 40 Hz sound for one hour a day, five days a week over 12 weeks, can improve memory, brain activity, sleep, and quality of life in older adults with mild cognitive impairment or mild dementia. Half of the participants will receive t…

This trial tests whether 16 weeks of high-intensity interval training (HIIT) can improve blood vessel function and thinking skills in adults aged 50 and older living with HIV. Participants are randomly assigned to either HIIT or continuous moderate exercise. The study also explor…

This study tests two approaches to improve thinking and reduce inflammation in people with HIV who drink alcohol. One approach uses a probiotic supplement to restore healthy gut bacteria. The other uses a mild electrical device worn on the ear to stimulate a nerve linked to infla…

This trial tests whether a natural compound from citrus fruits, hesperidin, can improve cognitive function in overweight and obese adults aged 55 to 75. Participants take either a placebo, a low dose, or a high dose of hesperidin daily for 10 weeks. The study measures changes in …

This study investigates whether combining intranasal insulin (delivered as a nose spray) with high-intensity exercise can improve brain blood flow, insulin sensitivity, and thinking skills in older adults with type 2 diabetes. Participants aged 55–80 will receive either insulin o…

This study tests whether breathing in a safe, inexpensive gas called argon during carotid artery surgery can prevent brain damage and confusion after the operation. About 100 adults having elective carotid surgery will be randomly assigned to receive either argon gas or a placebo…

This study tests whether a daily polyphenol supplement (like berry capsules) can slow cognitive decline in 300 older adults at risk for Alzheimer's. Participants take the supplement or a placebo for 12 months, providing blood, stool, and brain scans. The goal is to see if the sup…

This study compares a procedure to remove blood clots (endovascular therapy) with standard medical care for people who have had a mild stroke caused by a blockage in a large brain artery. About 264 adults with mild symptoms (NIHSS score 2-5) will be enrolled within 24 hours of st…

This study tests whether stem cells taken from a person's own fat can reduce brain inflammation and slow memory decline in adults aged 60–80 with early Alzheimer's. Participants receive four stem cell infusions over 12 weeks and are monitored for a year. The goal is to see if thi…

This study looks at whether drinking non-alcoholic red wine, which is rich in natural compounds called polyphenols, can help older adults keep their thinking sharp and muscles strong. Researchers will give 72 people aged 60-74 either non-alcoholic red wine or water, both as part …

This global study tests whether applying a sunlight-reflecting coating to roofs can lower indoor temperatures and improve health. Researchers will enroll 3,200 households in five hot cities across Africa, Asia, Latin America, and the Pacific. They will measure heart rate, blood s…

This study tests whether a daily dose of flaxseed oil (alpha-linolenic acid) can slow memory loss and protect brain blood vessels in older adults with mild cognitive impairment and the APOE4 gene, which raises Alzheimer's risk. Twenty participants will take either the oil or a pl…

This study works with 300 Native American elders aged 50 and older who have sleep apnea and a PAP machine. It tests if adding motivational interviews and text messages to usual care helps them use their machine more often. The goal is to improve sleep apnea control and possibly l…

This large trial tests whether the sedative dexmedetomidine can prevent long-term memory and thinking problems that often follow heart surgery. Researchers will give the drug to 2,400 adults aged 60 and older during and after their operation, then track their cognitive function f…

This study tests whether a specific set of anesthesia targets, called NeuroFirst, can reduce silent brain injury and thinking problems in older adults having heart surgery. About 900 patients aged 60 and older will be randomly assigned to either the NeuroFirst approach or standar…

This phase 2 trial is testing whether a butyrate supplement (Cal-Mag Butyrate) can improve physical function in 120 veterans with Gulf War Illness. The study also looks at effects on fatigue, memory, gut health, and inflammation. Participants take the supplement or a placebo for …

This study compares light versus deep general anesthesia in older adults (65+ or Indigenous 55+) having major surgery. The goal is to see if lighter anesthesia reduces delirium—sudden confusion—and long-term memory problems. About 2,766 participants will be randomly assigned to o…

Researchers are building AI models that score standard physical and cognitive screening tests from video and audio, and that predict results a person did not obtain. The study enrolls adults 18 and older and follows them for life, linking records to a long-term aging study to che…

This study is testing a new memory assessment tool called NEM (New evaluation of Episodic Memory) to see if it can better diagnose Alzheimer's disease in people with mild memory problems. Researchers will compare the NEM test with standard memory tests in 150 adults aged 50 and o…

This study is testing whether a simple voice recording can help detect Alzheimer's disease early. Researchers will analyze speech patterns from 100 volunteers aged 50 and older and compare them to standard Alzheimer's biomarkers. If successful, this could replace painful lumbar p…

This study is testing whether a blood test (Quest AD-Detect) can help doctors identify Alzheimer's disease earlier in patients aged 60-90 who are hospitalized with confusion or delirium. The test looks for a protein linked to Alzheimer's. Patients with positive results will get f…

This study compares two approaches to prevent delirium in older adults during a hospital stay. One is standard hospital care (HELP), and the other adds daily support from family members (FAM-HELP). Researchers will track 1,900 patients aged 70 and older to see if family involveme…

This trial tests whether taking golden oyster mushroom powder every day for two years can help preserve memory and thinking in middle-aged and older adults who are at higher risk for dementia. Around 600 community-living adults aged 45 to 80, who have a family history of dementia…

This study tests an online educational program called Brain Health PRO in 700 Canadians at risk for dementia. Participants are randomly assigned to start the 6-month program immediately or after a 6-month delay. The program covers lifestyle factors like diet, exercise, sleep, and…

This study tests whether a program of group nutrition classes, physical activities like walking and gardening, and at-home cognitive training can help prevent cognitive decline in older adults at higher risk for dementia. Researchers will enroll 120 people aged 55-85 and track ch…

After surgery, many older adults experience confusion or memory problems, known as delirium. This study tests a program that identifies patients at high risk before surgery and then uses simple steps—like better sleep and hydration—to prevent delirium. The program also educates f…

This study compares two ways of delivering a combined attention and strategy training program to veterans with mild traumatic brain injury and PTSD. One group receives the training in person, the other via telehealth. The goal is to see if remote delivery works just as well for i…

This study tests whether a dietary supplement called AP-Brain can improve cognitive function in healthy adults aged 18-39 who feel they have attention problems. Participants will take different doses of AP-Brain or a placebo for 56 days and complete memory and attention tests. Th…

This study is testing whether a dietary supplement called AP-Brain can improve memory and thinking in healthy adults aged 40 to 79 who feel their memory is slipping. Participants will take different doses (1g, 3g, or 5g) or a placebo for 56 days and complete computer-based memory…

This study explores whether a virtual reality mindfulness meditation program is practical and well-liked by older adults with mild to moderate cognitive impairment living in long-term care homes. About 36 participants will try up to 8 VR sessions over 4 weeks, and researchers wil…

This study looks at whether eating pecans every day for three months can improve memory, mood, and brain function in people aged 50 and older with mild cognitive impairment. Sixty participants will be randomly assigned to eat either pecans or pretzels as a snack. Researchers will…

This study tests whether an immersive virtual reality program using nature scenes can improve cognitive and emotional well-being in older adults with mild to moderate cognitive impairment. Participants will attend 10 group sessions that combine virtual nature environments with mi…

This Phase 2 study tests an experimental drug, ML-007C-MA, to see if it can safely reduce hallucinations and delusions in people with Alzheimer's disease. About 300 participants aged 55 to 90 will receive either the drug or a placebo. The main goal is to measure changes in psycho…

This study compares two brain-training programs for adults with ME/CFS who experience brain fog. Both programs include computer games and a mild nerve stimulation device, but one focuses on processing speed and daily tasks while the other emphasizes relaxation and healthy habits.…

This trial tests whether a non-invasive electrical stimulation applied to specific acupoints on the fingers can improve memory, attention, and decision-making in people who have had a stroke. Adults aged 35 to 80 with mild to moderate cognitive impairment after an ischemic stroke…

This randomized trial tests whether a structured, personalized music program (MUSIC CARE©) can reduce care refusal during daily hygiene care in nursing home residents with dementia. Care refusal—resisting bathing, dressing, or medication—is common and stressful for both residents…

This study tests a new, non-invasive brain stimulation method called time interference stimulation (TIS) to see if it can improve thinking and memory problems in people with schizophrenia. Fifty adults aged 18-50 with schizophrenia will receive either real TIS or a fake (sham) tr…

This study tests whether 6 months of daily, home-based transcranial direct current stimulation (tDCS) can improve cognitive and motor function in 128 older adults (ages 65-90) with motoric cognitive risk syndrome, a condition that raises dementia risk. Participants use a headset …

This study tests whether ginkgo biloba tablets can help improve memory and thinking in people aged 55 and older who recently had a mild stroke. 400 participants will either take ginkgo biloba plus standard care or standard care alone for 12 months. Researchers will measure change…

This study tests whether a week of morning bright light therapy improves sleep, alertness, mood, and thinking in healthy university students. Participants use a 10,000-lux light box for 30 minutes each morning for one week, and their results are compared to a week with usual ligh…

This trial tests whether shining a specific type of near-infrared light on the forehead—called transcranial photobiomodulation (tPBM)—can improve attention and reduce impulsivity in adults with and without ADHD. Participants receive either active tPBM or a sham (fake) treatment f…

This study tests whether a virtual reality game can help older adults with mild cognitive disorders improve their inhibitory control—the ability to stop and think before acting. 48 participants will play the game either on a VR headset or a tablet for 20 minutes, twice a week for…

This study tests a speech therapy program for bilingual Spanish-English or Spanish-Catalan speakers with primary progressive aphasia, a condition that slowly damages language abilities. Sixty participants will receive personalized script training via video sessions, while 30 othe…

This study tests whether vortioxetine, an antidepressant known to boost thinking skills, can reduce the mental fogginess caused by the lung cancer drug lorlatinib. About 24 adults with advanced ALK-positive lung cancer who are already taking lorlatinib will receive vortioxetine. …

This study tests whether combining a special walking exercise with mild electrical brain stimulation can improve thinking and walking in adults aged 65 and older who have memory or mobility problems. Participants will do walking tasks while receiving either real or fake brain sti…

This study tests whether combining a non-invasive brain stimulation technique called accelerated iTBS with computerized cognitive training can help people with mild cognitive impairment (MCI). Fifty adults aged 60-85 will receive the brain stimulation and be randomly assigned to …

This study tests a type of talk therapy called acceptance and commitment therapy (ACT) for people with mild dementia and their care partners. The goal is to see if it helps reduce depression, anxiety, and grief. About 100 pairs will take part, either in person or online.

This study tests whether combining the drug memantine with a structured exercise program can improve memory and thinking problems (often called 'chemo brain') in women with early-stage breast cancer undergoing chemotherapy. Ninety participants will be split into three groups: mem…

This study tests whether giving 3-5 year olds a daily prebiotic fiber powder for several weeks can improve their mood, sleep, emotional control, and thinking. Parents of 106 children with low fiber intake will report on their child's behavior and emotions. The study is double-bli…

This study is testing a virtual reality (VR) program called bWell to see if it is a practical and enjoyable way to help people with major depression who have trouble with thinking and memory. Forty adults aged 19-55 will either use the bWell cognitive training or experience VR sc…

This study looks at whether taking ETAS® daily for 12 weeks can improve memory, mood, and brain activity in healthy adults aged 60 to 80 who have mild memory complaints. Participants will be randomly assigned to receive either ETAS® or a placebo, and will undergo memory tests, br…

This study tests whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) can improve thinking, memory, and other symptoms in people with long COVID. About 91 adults who have had cognitive problems for at least 3 months after a COVID infection will be ra…

This study tests a device that combines magnetic brain stimulation with cognitive exercises to see if it can improve thinking and memory in people with mild Alzheimer's disease. About 180 participants aged 60-85 will receive either real or sham stimulation along with real cogniti…

This study compares two cognitive rehab programs for adults with long COVID who have mild to moderate brain fog. Both programs include computer games, in-lab training, and a mild nerve stimulation device worn on the ear. One group focuses on processing speed and work-related task…

This small pilot study tests whether repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique, can reduce apathy in people with dementia or mild cognitive impairment. Ten participants will receive rTMS, some also taking the medication methyl…

This study tests whether using a gentle nerve-stimulating device on the ear, combined with computer-based brain training, can improve thinking skills and mood in adults aged 45 to 80 who have noticed changes in their memory or attention. Participants will do 10 sessions at home a…

This study tests whether a virtual reality (VR) app used at home with remote therapist guidance can improve memory, attention, and social skills in people with early memory decline (Subjective Cognitive Decline and Mild Cognitive Impairment). 480 adults aged 40-80 will either use…

This study is testing whether adding breathing exercises to balance training can improve thinking skills in people aged 65 and older. Forty participants will do 30 minutes of balance exercises plus 15 minutes of breathing exercises twice a week for 8 weeks. Researchers will measu…

This study tests whether daily 10-15 minute personalized reminiscence sessions delivered by a digital app can improve symptoms like apathy and depression in older adults with mild neurocognitive disorders. Eighty participants over 60 will use the app for 25 days, with a caregiver…

This study tests whether a neuroscience-based computer program can improve memory and thinking in older adults who have had cognitive problems for at least 12 weeks after a COVID-19 infection. Researchers will compare the brain-training program to other computer activities in 75 …

This study tests if a gentle electrical pulse to the wrist nerve can safely help thinking and memory in people with recent traumatic brain injury. About 30 adults aged 18-64 with moderate injury will receive either real or sham stimulation. The goal is to see if this simple, non-…

This study tests a non-drug light treatment called photobiomodulation to see if it can improve memory and thinking problems (chemobrain) in women who had chemotherapy for breast cancer. About 200 women who finished chemo within the past year and have ongoing cognitive complaints …

This study tests whether adjusting the electrical amplitude of ECT (electroconvulsive therapy) to each person can better treat depression and reduce memory problems. Researchers will compare a personalized amplitude approach to the standard fixed 800 mA setting in 50 older adults…

This study tests whether taking L-arginine, a natural supplement, can improve memory and thinking in people over 60 with mild to moderate cognitive issues. For 4 weeks, participants take either L-arginine or a placebo, and their cognitive skills are checked with simple tests. The…

This study tests whether combining aerobic, strength, and balance exercises with cognitive training (dual-tasking) can improve gait, balance, and cognition in people with mild cognitive impairment due to Alzheimer's. Forty-five participants will be split into three groups: one do…

This study tests whether a special type of artificial light that changes throughout the day can improve sleep, body clock function, and overall well-being in frail older adults. Researchers will enroll 300 people over age 65 who are staying in hospital rooms equipped with this dy…

This study tests whether taking broccoli sprout extract daily for 12 weeks can improve memory and thinking in adults aged 55-85 with mild cognitive impairment. One hundred participants will receive either the extract or a placebo. Researchers will measure changes in cognitive tes…

This study tests whether a nutritional supplement called 'Think Tank' can improve thinking and memory in middle-aged women after they experience stress. Forty healthy women aged 40-60 will take either the supplement or a placebo and then complete cognitive tests. The goal is to s…

This study looks at whether eating nuts can help reduce symptoms of depression, anxiety, and stress, and improve memory and thinking skills in young adults. Researchers will enroll 135 university students aged 18 to 25 and measure changes in mood, cognitive function, and a brain-…

This study tests if a liquid medicine called midazolam can help elderly patients with moderate to severe memory problems who refuse care. About 30 hospitalized patients will receive the medicine before care to see if it reduces their resistance. The goal is to make necessary care…

This study tests whether immersive virtual reality (VR) exercise can reduce pain, improve shoulder function, sleep, and thinking in people with mild to moderate frozen shoulder (grade 1-2). About 36 adults aged 18-64 who are new to physiotherapy will use VR headsets to gamify the…

This study tests an 18-week program where people with mild dementia and their family caregivers do sport stacking (a fast cup-stacking game) together at home. The goal is to see if it improves thinking skills, mood, and quality of life for both the person with dementia and their …

This study tests a home-based program called HOBSCOTCH-CA for brain cancer survivors who struggle with memory and thinking. The program involves weekly virtual sessions with a coach, teaching problem-solving and relaxation techniques. Researchers will compare two groups: one that…

This study tests whether adding immersive virtual reality (VR) 360-degree videos to aerobic exercise can improve memory, attention, and thinking skills in older adults with mild cognitive impairment (MCI). About 34 people aged 60 and older with MCI will either do aerobic exercise…

This study tests two remote brain-training programs for Veterans who have had a traumatic brain injury (TBI) and struggle with focus, memory, or staying on track. About 120 Veterans will use either BrainStrong-GSR or BrainStrong-OPT via tele-rehabilitation and digital apps. The g…

This study tests a safe, non-invasive brain stimulation technique (tDCS) that people can use at home while doing computer-based attention exercises. The goal is to see if it can improve complex attention in 160 active-duty service members and veterans who had a mild traumatic bra…

This study tests a home-based program called HOBSCOTCH-MS for people with multiple sclerosis who have memory or thinking problems. Participants meet virtually with a coach for 8 weekly sessions to learn problem-solving and relaxation skills. The goal is to improve quality of life…

This study tests whether a daily dietary supplement can improve memory, thinking, and emotional well-being in healthy adults aged 55 and older. Sixteen participants will take the supplement for 45 days and complete memory and mood tests at the start and end. The goal is to see if…

This study tests whether a technique called high-definition transcranial direct current stimulation (HD-tDCS) can improve word-finding difficulties in people who had a traumatic brain injury at least a year ago. The device delivers a very low electrical current through electrodes…

This study compares two fun activities—video games and ball tossing—to see if they can improve eye-hand coordination in older adults (60+) with mild cognitive impairment. Over 6 weeks, 34 participants will practice either a tapping game or ball exercises. Researchers will measure…

This study tests whether online cognitive exercises, guided by a neuropsychologist, can reduce memory and thinking problems (chemo brain) in 300 breast cancer patients after chemotherapy. Participants will do 20-minute brain games three times a week for 12 weeks, with some gettin…

This study looks at facial features of males aged 2 to 40 with creatine transporter deficiency (CTD), a genetic disorder that causes intellectual disability, seizures, and behavioral issues. Researchers will examine photos of participants to see if they share common facial traits…

This study looks at how stopping cannabis use for 28 days changes brain activity and memory in people with psychosis and in cannabis users without psychosis. Participants are randomly assigned to either quit cannabis or continue using, and undergo brain scans before and after the…

This observational study will enroll up to one million adults to understand how health, environment, and lifestyle affect aging and disease. Researchers will link participants' clinical data with information from public records, such as pollution and social factors, to create a d…

This study will follow 1,000,000 adults aged 18 and older for the rest of their lives. Researchers will collect health measurements and track who develops diseases, becomes frail, or dies. The goal is to find which tests best predict how well people age, so doctors can one day of…

This study aims to find the best way to deliver preventive health screenings to people in underserved and rural areas. It will compare different methods, such as interactive health reports, mobile screening units, and even droid-assisted screenings, to see which improves health e…

This study looks at how neoadjuvant chemotherapy (given before surgery) affects thinking skills like memory and attention in people with advanced ovarian cancer. Researchers will test 18 participants using questionnaires and cognitive tests over about 10 months. The goal is to be…

This study records brain activity from electrodes placed in the brains of epilepsy patients while they perform memory tasks. Researchers aim to understand how brain cells work together to hold and use information in the short term. The goal is to find new ways to diagnose and tre…

This study looks at whether a drug called fampridine, which blocks potassium channels in the brain, can improve working memory in people with cocaine use disorder. Forty chronic cocaine users will receive either the drug or a placebo and then take memory tests. The goal is to und…

This study aims to collect cognitive performance data from 1,000 healthy adults aged 18 to 100 using a fully digital, voice-recognition-based testing platform. Participants complete a one-time, 30-45 minute online assessment covering memory, language, attention, and problem-solvi…

This study looks at how chemotherapy for colon or rectal cancer affects thinking and memory. Researchers will track changes in brain function and blood proteins in 60 patients during and after treatment. The goal is to find tests that could identify who is at risk for 'chemo brai…

This study from Stanford University is looking at how a 6-week math training program changes brain activity and thinking skills in children with math learning disabilities (dyscalculia). About 180 children aged 6-12 will do math problems on a tablet at home and get weekly one-on-…

This study looks at older adults hospitalized for heart, lung, or orthopedic issues to see how many also have undiagnosed mild cognitive impairment or dementia. Participants take a memory test at admission, and those with possible problems get a full brain evaluation and a follow…

This study will put 56 healthy adults aged 25-60 through 27 hours of sleep deprivation and alcohol consumption (to a 0.08% BAC) in a lab over 110 hours. Researchers will measure how these stressors affect thinking, movement, and brain scans. The goal is to better predict and mana…

This study will collect health data from 250 Taiwanese adults aged 40 and older to understand how aging affects the brain, sleep, and thinking skills. Participants will undergo brain scans and wear activity monitors, and answer sleep questionnaires. The goal is to build a compreh…

This study follows 5,000 people with mild cognitive impairment or mild-to-moderate dementia living at home in Bavaria, along with their family caregivers. Researchers collect detailed information on health, daily function, care needs, and quality of life over several years. The g…

This observational study asks whether older patients placed under isolation precautions in the hospital are more likely to develop delirium or experience cognitive decline. Researchers will compare isolated patients aged 70 and older with similar non-isolated patients, tracking d…

This study looks at whether a single dose of modafinil or D-serine can improve decision-making and thinking in people who have had psychosis for less than five years. Twenty-four participants will play computer brain games and have brain scans before and after taking the drugs. T…

This study is testing whether a risk score can predict which older adults will experience confusion or memory problems after a common urological procedure. Researchers will follow 150 patients aged 65 and older undergoing transurethral resection, using cognitive tests before and …

This study looks at how chemotherapy affects thinking and the brain in older adults (age 60+) with breast cancer. Researchers will track changes in memory and thinking skills, and use brain scans to see if certain proteins are linked to these changes. The goal is to better unders…

This study looks at whether giving chemotherapy before surgery helps older adults (over 55) with advanced ovarian or endometrial cancer become fitter for their operation. Researchers will measure changes in frailty using a special score from medical records. The goal is to see if…

This study follows older adults (ages 70-95) who have memory concerns but no dementia, tracking them for up to 5 years to see who develops Alzheimer's. Researchers use brain scans, EEG, eye movement tests, and memory assessments to spot early warning signs. The goal is to better …

This study looks at whether people aged 70 and older experience changes in thinking skills, like attention and processing speed, after same-day hip or knee replacement surgery. About 48 participants will take a short cognitive test before surgery and again on the first and sevent…

This study checks whether keeping indoor temperatures at 26°C is enough to protect young, habitually active adults from heat stress. Ten healthy volunteers aged 18-29 will spend 8 hours in a controlled warm room, either resting or doing light exercise while wearing extra clothing…

This study looks at brain activity in 100 adults with epilepsy who already have electrodes implanted for seizure monitoring. Researchers will record brain signals while participants answer questionnaires and perform memory and impulse-control tasks. The goal is to find links betw…

This study looks at whether changes in movement, like how fast you can tap your fingers, can help detect early signs of dementia. Researchers will study 200 people, some with mild cognitive impairment (MCI) and some healthy, using a special glove to measure finger movements. The …

This study follows 417 older adults (65+) with mild cognitive impairment (MCI) for one year to identify what factors predict falls. Participants will be monitored through diaries and monthly calls. The goal is to develop better fall prevention strategies for this vulnerable group…

This study looks at whether the 'stickiness' or viscosity of the carotid artery wall differs between people with vascular dementia and those with Alzheimer's disease. Researchers will measure artery wall viscosity in 140 older adults using ultrasound and pressure sensors. The goa…

This study is testing whether a 15-minute app called Brainlab Cognition can be used in busy brain tumor clinics to track memory, attention, and other thinking skills. Researchers will also collect quality-of-life reports electronically from patients. The goal is to see if this ap…

This study is for adults with depression who have recently attempted suicide. It tests a group program that teaches emotion regulation and values to improve daily functioning and prevent future suicide attempts. Researchers will also measure thinking skills, quality of life, and …

This study explores how the brain recognizes and remembers places, using virtual tours and brain recordings in people with epilepsy. Researchers aim to map the brain regions critical for spatial memory, so surgeons can avoid them during epilepsy surgery. Over 600 participants, in…

This study is testing a new memory test called MAI in 60 adults aged 70 and older. Half have memory disorders like Alzheimer's, and half do not. The goal is to see if the test can tell the difference between the two groups and help doctors detect memory problems earlier.

This study is testing a new, non-invasive ultrasound technique called Tissue Pulsatility Imaging (TPI) to measure tiny brain movements. Researchers will compare these measurements in 300 people with mild versus major cognitive disorders. The goal is to see if brain pulse patterns…

This study looks at how being in a hot room affects the body, thinking, and mood of people with schizophrenia. Ten adults with and without schizophrenia will sit in a warm or very hot room for six hours, doing light activity. The goal is to learn how heat impacts them so we can c…

This study looks at whether keeping indoor temperatures at 26°C can prevent dangerous heat strain and mental fog in children aged 10-15 during a simulated school day. Ten kids will be exposed to both a mild (26°C) and a hot (36°C) room while their body temperature and mood are me…

This study looks at whether low magnesium in the blood is linked to memory, attention, and other thinking problems after a stroke. Researchers will measure magnesium levels and give cognitive tests to 80 stroke patients over several weeks. The goal is to understand if magnesium d…

This study is creating a large database of blood tests, digital assessments (like smartphone tasks), and brain scans from 1,200 older adults. Participants may have normal memory, mild memory problems, or mild-to-moderate Alzheimer's. The goal is to see if simple, non-invasive tes…

This study explores how aging affects the ability to learn who to trust. Researchers will use real-time fMRI to give older adults feedback on their brain activity while they practice trust-related tasks. The goal is to see if this brain training can improve their decision-making …

This study looks at how the antipsychotic medication haloperidol may block insulin action in the brain, which could explain why these drugs often cause weight gain and diabetes. Researchers will give healthy volunteers either haloperidol or a placebo and use brain scans to measur…

This study follows 100 adults with treatment-resistant depression who are prescribed esketamine nasal spray in real-world clinics. Researchers will track how well the drug works, who responds best, and how it affects daily life and thinking. The goal is to improve personalized ca…

This study looks at how chronic marijuana use changes brain inflammation and thinking abilities in people with HIV. Researchers will use brain scans and blood tests to measure brain health in 220 adults. The goal is to understand the effects, not to test a new treatment.

This study follows 225 children whose mothers had type 1 diabetes during pregnancy and took part in the CONCEPTT trial. Researchers will assess the children's thinking, behavior, and emotional skills using parent questionnaires. The goal is to understand if maternal diabetes affe…

This study is testing whether a smartphone app can help firefighters improve their sleep, reduce stress, and boost thinking skills. About 50 firefighters will use the app and report how well it works. The goal is to see if the program is easy to use and helpful for real-life fire…

This study looks at whether taking L-serine (an amino acid) with or without strength training can improve memory, thinking, and physical fitness in healthy adults aged 65 to 85. Over 48 weeks, participants will take either a placebo, L-serine, or L-serine plus strength training. …

This study looks at whether a 6-month cardio-dance fitness program can improve brain health and lower Alzheimer's risk in 280 older African Americans (age 60+). Participants will do either dance fitness or strength/flexibility exercises three times a week. Researchers will measur…

This study is creating and testing a new questionnaire called LiCCoS for adults with liver cirrhosis. The goal is to help identify common thinking problems like forgetfulness or trouble focusing, which are often missed. About 230 participants will fill out the questionnaire and t…

This study is testing whether a single dose of modafinil, a drug that promotes wakefulness, can change how healthy people perform decision-making tasks and alter their brain activity. Researchers will use EEG caps to measure brain waves while participants play computer-based brai…

This study is testing whether a special nutrition shake given after surgery can help older adults (70+) regain physical and mental function faster. Half of the 100 participants will receive the shake daily for 30 days, while the other half will follow standard recovery advice. Th…

This study tests whether shining a special light on the head (transcranial photobiomodulation) can improve blood flow and thinking in older adults. 30 healthy volunteers aged 21-85 will receive either real or fake light therapy sessions every other day for 4 weeks. Researchers wi…

This study is creating a large, diverse group of 1,000 older adults in Tennessee to help researchers better understand Alzheimer's disease. Participants, who may be healthy, have mild memory problems, or have Alzheimer's, will be followed yearly with tests like brain scans and bl…

This study is observing how the medication trazodone helps older adults (55+) who have both major depression and mild memory or thinking problems. Researchers will track changes in depression symptoms and thinking skills during routine care in Italy, Poland, and Romania. The goal…

This study looks at why some people who have had a stem cell transplant feel very tired and have trouble thinking clearly. Researchers will use brain scans and spinal fluid tests to see if inflammation in the brain is the cause. The goal is to better understand these problems, no…

This study looks at how obstructive sleep apnea (OSA) affects thinking skills and empathy in children aged 3 to 12. Researchers will compare surgery versus medication for mild OSA and track changes over 12 months. They will also use EEG to find brain signals linked to sleep apnea…

This study from the University of Michigan is testing whether cognitive rehabilitation (brain training exercises) and transcranial electrical stimulation (mild electrical currents applied to the scalp) can improve thinking abilities like memory, attention, and problem-solving in …

This study looks at how healthy adults plan several moves ahead when playing a strategy game called Four-in-a-Row (like Connect Four). Researchers will record brain activity and eye movements to understand the thinking process. The goal is to learn more about how the brain simula…

This study follows 1,000 adults with primary aldosteronism—a condition where the adrenal glands make too much aldosterone—to see how it affects thinking and memory over up to 5 years. Participants will take regular cognitive tests and have medical check-ups. The goal is to learn …

This study looks at how depression and other mental health issues impact symptom severity and quality of life in people with graft-versus-host disease (GvHD). Researchers will follow 200 adults with GvHD, using questionnaires to measure psychiatric status and symptoms. The goal i…

This study looks at memory, thinking, and mood problems that can happen with certain targeted lung cancer drugs (ALK/ROS1 inhibitors). About 20 patients who have these side effects will undergo detailed brain and psychiatric tests. The goal is to better understand these issues an…

This study is testing different types of computer-based brain training in 780 teenagers, some with ADHD and some without. The goal is to find out which training methods—like adding game elements or varying the number of tasks—work best for improving memory and focus. Participants…

This study follows 874 children aged 3 to 5 over one year to understand how using interactive devices like tablets and smartphones affects their thinking, social skills, and physical health. Parents will install an app to track device use, and researchers will measure development…

This research study looks at how practicing certain visual tasks can improve cognitive abilities like attention and reading. Healthy adults aged 18-30 and 60-85 will complete computer-based training over several weeks. The goal is to understand how training changes the way we see…

This study tests whether cognitive remediation—brain exercises with coaching—can improve thinking skills and reduce aggression in 30 forensic inpatients with conditions like psychosis, ADHD, or substance use. Participants will do exercises and be compared to an active control gro…

This study tests a 12-week mobile app program for parents of 3-4 year olds who currently meet few movement guidelines. Children wear activity trackers, and parents get weekly tips and goals through the app. The goal is to see if the app helps kids get more physical activity, bett…

This study explores whether a new system using ultrasound and light sensors can remotely monitor brain blood flow in people who have had a stroke. Researchers will test the technology in 140 participants, including healthy older adults and those with stroke, dementia, depression,…

This study looks at how natural compounds in fruits and vegetables (called flavonoids) are broken down by gut bacteria and whether those breakdown products help protect the brain. Researchers will give 100 adults aged 50+ at risk for Alzheimer's a special diet and measure changes…

This study aims to find new biological markers for neurodegenerative diseases like Alzheimer's, Parkinson's, and ALS. Researchers will analyze genetic, protein, and metabolic data from 1,200 patients to improve diagnosis, predict disease course, and monitor treatment response. Th…

This study tests whether a radio-wave sensor placed in the home can measure sleep, movement, and walking speed in 40 people with mild cognitive impairment or mild Alzheimer's who are taking nicotinamide riboside (a form of vitamin B3). The goal is to find digital biomarkers that …

This study tests whether a 14-day mobile diary is a practical way to measure daily stress and thinking (cognitive) changes in breast cancer survivors. Researchers will enroll 30 racially diverse women aged 40 and older who are at least five years past diagnosis. Participants comp…

This study is observing 1,000 critically ill ICU patients to learn how their bodies respond to life-threatening infections and injuries. Researchers will collect blood and lung fluid samples to identify biological factors that could lead to earlier diagnosis and new treatments fo…

This study explores whether a non-invasive brain stimulation technique called deep transcranial magnetic stimulation (dTMS) is safe and tolerable for older adults with mild memory or thinking problems. Thirty participants aged 60-90 will receive one of three types of dTMS coils. …

This early-phase study investigates how scopolamine, a drug known to affect memory, changes brain activity in people with epilepsy who are already undergoing brain monitoring for seizures. Sixty participants will receive either scopolamine or a placebo and perform memory tasks wh…

This study aims to find out how often sexual dysfunction occurs in women with relapsing-remitting multiple sclerosis and how it connects to fatigue, depression, anxiety, overactive bladder, and thinking problems. Researchers will use questionnaires and tests to measure these fact…

This study looks at how age-related changes in thinking skills, like memory and planning, affect movement and increase fall risk. Researchers will test arm and balance tasks in 684 adults aged 55 and older, including those with mild cognitive issues. The goal is to better underst…

This study looks at whether teens aged 15-18 who stop using cannabis for 8 weeks show improvements in thinking skills like memory, attention, and planning. Researchers will test 29 teens with cannabis dependence using brain games and urine tests. The goal is to see if abstinence …

This study looks at how central sensitization—a heightened pain response common in fibromyalgia—might be linked to cognitive problems like memory and concentration issues. Researchers will assess 100 adults with fibromyalgia using questionnaires and cognitive tests. The goal is t…

This study follows 65 adults with obstructive sleep apnea to see how three weeks of CPAP therapy changes their thinking skills, blood markers of brain health, and emotional well-being. Participants complete memory and attention tests, give blood samples, and fill out questionnair…