Nervous system disorder

Researchers are testing a gene therapy called rAAV2/4.hRPE65 in people with Leber congenital amaurosis or severe early-onset retinal degeneration caused by mutations in the RPE65 gene. The treatment delivers a working copy of the gene directly into one eye through a single inject…

Researchers are testing a single injection of SKG0106, an experimental gene therapy, in Chinese adults aged 50 and older with wet age-related macular degeneration. The trial aims to find out whether the treatment is safe and how the body responds to it. Participants receive one i…

This study tests two new mRNA vaccines (GBP560) against Japanese encephalitis, a virus that can cause brain swelling. About 402 healthy adults will receive different doses of the vaccine or a comparison vaccine. Researchers will monitor safety and measure immune responses to find…

This study tests whether a steroid injection given during retinal detachment surgery can replace the usual course of antibiotic and steroid eye drops afterward. About 168 adults with a first-time retinal detachment will receive either the injection or standard drops. The goal is …

Researchers compare two versions of a mesh stent used to treat unruptured brain aneurysms. One version has a special coating and is paired with a single blood-thinning drug; the other is the standard device paired with two blood-thinning drugs. The trial measures tiny brain lesio…

Researchers test whether fecal microbiota transplantation delivered by oral capsules can help cirrhosis patients whose hepatic encephalopathy no longer responds to standard lactulose and rifaximin. The trial enrolls 33 adults with cirrhosis and persistent or recurrent hepatic enc…

This phase 3 trial tests whether adding a clot-busting drug (alteplase) directly into the brain artery during mechanical clot removal improves recovery for people with severe stroke. About 440 participants with large vessel blockages will be randomly assigned to receive the drug …

This Phase 3 study tests whether a gel containing patidegib can lower the number of new basal cell carcinomas (a type of skin cancer) on the face of adults with Gorlin syndrome. Participants apply the gel or a placebo to their face twice daily for a year. The study will compare h…

This trial is testing whether regular, short periods of sunlight exposure can increase vitamin D levels in children aged 1-5 with cerebral palsy. Half the children will get 10 minutes of sun three times a week for 8 weeks, while the other half continues their usual routine. The s…

This study compares video-based nurse consultations to standard in-person visits for people who recently had a stroke. About 196 participants will be randomly assigned to either telecare or face-to-face follow-up. The goal is to see if remote care can maintain or improve disabili…

Researchers are testing a combination of rituximab, acalabrutinib, and durvalumab in adults with primary central nervous system lymphoma, a rare cancer that starts in the brain or spinal cord. The trial enrolls people whose disease has returned or worsened after earlier treatment…

This study tests whether drinking a protein beverage after leg-strengthening exercises helps stroke survivors rebuild muscle better than exercise alone. About 93 people who had a stroke more than 3 months ago will take part. Researchers will measure changes in thigh muscle size, …

This trial investigates how a new experimental drug called KL0011034 interacts with alfentanil, a strong opioid painkiller, in adults with moderate-to-severe chronic pain. The study measures how the drugs affect each other's levels in the body and monitors safety. Participants re…

This phase 3 trial is testing the safety and tolerability of fenfluramine (Fintepla) in 25 infants aged 1 to 2 years with Dravet syndrome, a severe form of epilepsy. The drug is given as an oral solution twice daily alongside other seizure medications. Researchers will monitor he…

This study tests a short mindfulness and lifestyle program for people caring for loved ones with neurodegenerative diseases like Alzheimer's or Parkinson's. Caregivers often neglect their own health, raising their risk for heart disease and early death. The program combines in-pe…

Researchers are studying aflibercept (Eylea), an anti-VEGF drug given as an injection into the eye, in adults aged 50 and older with wet age-related macular degeneration. Everyone in the trial receives three monthly loading doses over 12 weeks. The team uses detailed retinal scan…

This study tested whether daily nicotine patches could improve memory and daily function in 348 people with mild cognitive impairment (MCI). Participants wore either a nicotine patch (up to 21 mg) or a placebo patch for two years. The goal was to see if nicotine, known to affect …

This study tests a combination of laser heat therapy (LITT) and the immunotherapy drug pembrolizumab in 32 adults with recurrent glioblastoma, an aggressive brain cancer. The laser heats and destroys hard-to-reach tumors, while pembrolizumab helps the immune system fight cancer c…

This study tests whether a combination of stereotactic (computer-guided) surgery and a clot-dissolving drug can help people recover from a deep brain hemorrhage. The trial enrolls 380 adults with small-to-moderate bleeds in the basal ganglia who have significant disability. The g…

This study tests an experimental drug called AVD-104, given as an eye injection, for people with geographic atrophy, a late stage of dry age-related macular degeneration that causes blind spots. The trial involves 300 participants and aims to see if the drug is safe and can slow …

Researchers at Tanta University are testing whether a high-dose version of the eye injection aflibercept (8 mg) can improve vision in people with diabetic macular edema or retinal vein occlusion that has not responded well to earlier anti-VEGF treatments. The study enrolls 60 adu…

Researchers compare two ways of managing blood flow during carotid endarterectomy, a surgery that clears plaque from the neck artery to prevent stroke. One group receives a shunt routinely, while the other gets a shunt only when a pressure measurement suggests it is needed. The t…

Researchers are testing whether adding AGuIX, a gadolinium-based nanoparticle, to whole brain radiation therapy improves how well brain metastases shrink in adults whose cancer has spread to the brain. Participants receive standard whole brain radiation, and some also receive thr…

This phase 2 trial tested vamorolone, a drug similar to steroids, against a placebo in 46 males with Becker muscular dystrophy. The goal was to check safety and tolerability over 24 weeks, while also looking for early signs of benefit. The study is complete, but results are not y…

Researchers compare two approaches for proliferative diabetic retinopathy, a condition where abnormal blood vessels grow in the retina and can cause vision loss. One group receives standard pan-retinal laser photocoagulation alone. The other receives the same laser treatment plus…

This study tests different ways to bring mental health treatment into methadone clinics in Ukraine. 1,350 patients from 12 clinics are taking part. Some clinics get extra training and financial rewards to help screen and treat depression. The goal is to see if these strategies im…

This study tests two different medicines given before a procedure to remove a blood clot from the brain in people having a major stroke. The goal is to see which medicine helps more people recover with little or no disability. About 800 adults who arrive at the hospital within 24…

Researchers are testing an experimental drug called TAK-935 in children aged 2 to 17 with Dravet syndrome or Lennox-Gastaut syndrome, two severe forms of epilepsy that often resist treatment. The trial compares TAK-935 added to standard anti-seizure medications against a placebo …

Progressive supranuclear palsy (PSP) is a rare brain disease that steadily damages movement, balance, and thinking. Researchers are testing valproic acid, a drug already used for epilepsy and mood disorders, to see if it can protect brain cells by blocking an enzyme involved in t…

Researchers are testing whether adding a stent retriever device to a suction-based clot removal technique works better than suction alone for people with a specific type of stroke clot. The trial enrolls adults who have a large blood vessel blockage in the brain and a clot that s…

Researchers compare two corticosteroid treatments for inflammatory macular edema, a condition where swelling in the center of the retina blurs vision. Adults with the condition receive either a subconjunctival injection of triamcinolone or an intravitreal implant of dexamethasone…

Researchers are testing whether adding brain radiotherapy to PD-1/PD-L1 inhibitors and chemotherapy helps people with untreated stage IV non-small cell lung cancer that has spread to the brain. The trial enrolls about 40 adults whose tumors lack common driver mutations and whose …

This study tests a new drug called zifibancimig for people with wet age-related macular degeneration (AMD), a leading cause of vision loss. The drug is given either as an eye injection or through a small implant placed in the eye that releases the drug over time. The trial involv…

This Phase 2 trial tests two experimental drug combinations in 63 women with a specific type of ovarian cancer (BRCA-mutant or HRD-positive) that has worsened after prior PARP inhibitor treatment. Participants receive either tuvusertib plus niraparib or tuvusertib plus larteserti…

This study tests a new drug, Tuvusertib, combined with an immunotherapy called Cemiplimab in people with a specific type of advanced lung cancer (non-squamous non-small cell) that has worsened after prior treatments. The trial aims to see if the combination can shrink tumors and …

Acromegaly is a rare condition where the pituitary gland makes too much growth hormone, causing bones and tissues to enlarge. Researchers are testing a long-acting octreotide injection called SYHX2008 in 78 adults with active acromegaly. Participants receive either the new inject…

This phase 2 trial tests whether glycerol phenylbutyrate (GPB) can slow corticobasal syndrome (CBS), a rare and fast-progressing brain disease. 32 adults with CBS will receive either GPB or a placebo for 26 weeks. The main goal is to see if GPB lowers levels of a nerve damage mar…

Researchers are studying a once-weekly tablet form of brexpiprazole, an antipsychotic drug, in adults with schizophrenia. The trial follows about 247 participants for 52 weeks to see how well they tolerate the medicine and whether it remains safe over the long term. Everyone in t…

This study is a follow-up to an earlier trial, testing the long-term safety and effects of a drug called AOC 1001 in adults with myotonic dystrophy type 1 (DM1), a genetic muscle disease. 37 participants who completed the first study received multiple doses of AOC 1001 by IV infu…

This trial tests a treatment called Melphalan/HDS for people whose eye melanoma has spread to the liver. The approach delivers high-dose melphalan, a chemotherapy drug, straight into the liver through a device system while limiting exposure to the rest of the body. Researchers wa…

This study tested whether giving the cholesterol-lowering drug evolocumab within 24 hours after clot-busting treatment (thrombolysis) can prevent early neurological decline in people with acute ischemic stroke. 132 participants were randomly assigned to receive evolocumab plus st…

This early-stage trial tests whether exosomes from stem cells can help people recover from a recent stroke. 29 participants will receive either the exosome treatment or a placebo, and researchers will check for safety and any signs of improved function. The study is small and exp…

This study tested a noninvasive brain stimulation technique (transcranial random noise stimulation) to see if it could reduce cravings in 225 adults with substance use disorder plus another psychiatric condition like ADHD, bipolar disorder, or schizophrenia. The approach targeted…

Researchers are testing whether fecal microbiota transplantation, which transfers stool from a healthy donor into the gut, can change the immune system in people with amyotrophic lateral sclerosis (ALS). The trial enrolls 42 adults aged 18 to 70 who were diagnosed within the past…

This phase 2 study tests a new treatment plan for diabetic macular edema, a condition that causes vision loss. Instead of waiting for severe swelling, patients receive two dexamethasone implants 12 weeks apart, then additional injections only as needed. The goal is to improve vis…

This study tests a drug called apatinib combined with two chemotherapy drugs (irinotecan and temozolomide) in children aged 5 to 18 with neuroblastoma that has returned or not improved after standard treatment. The goal is to see if the combination can shrink tumors and help chil…

This study tests a single booster dose of a combined vaccine against diphtheria, tetanus, and whooping cough (dTpa) in 85 healthy Japanese adolescents aged 11 to 13. Researchers will check if the shot triggers a strong immune response and monitor for side effects one month after …

Researchers are reviewing records from 200 adults who received CyberKnife stereotactic radiosurgery for vestibular schwannomas, benign tumors on the nerve that controls hearing and balance. The study compares MRI scans before and after treatment to see if the tumors shrink or sto…

This study tests whether gabapentin, an FDA-approved medication, can help restore the balance of key brain chemicals (GABA and glutamate) in people with bipolar disorder who also use cannabis. Participants are randomly assigned to receive either gabapentin or a placebo for 17 day…

Researchers are testing whether hydralazine, a drug already approved for high blood pressure, can slow cognitive decline in people with early Alzheimer's disease. The trial will give 228 participants either hydralazine or a placebo for one year, alongside their usual Alzheimer's …

Researchers are testing whether combining bevacizumab, a drug that blocks new blood vessel growth, with Optune, a device that delivers electric fields to the brain, can help people with recurrent high-grade meningioma. Participants wear the Optune device for at least 18 hours a d…

This study tested a special program to help people with both bipolar disorder and substance use problems stick to their treatment after leaving the hospital. 178 adults were split into two groups: one received extra counseling and support, while the other got enhanced safety moni…

This study tests a device that delivers specific light and sound patterns to the brain, aiming to slow the progression of mild-to-moderate Alzheimer's disease. About 670 participants will use the device at home for an hour daily over a year, with half receiving a sham (inactive) …

This trial tests whether a modified soft contact lens placed on the cornea during vitrectomy, a surgery for retinal disease, keeps the surgical view clearer than the standard method of intermittent saline irrigation. Researchers randomly assign 46 participants to receive either t…

This early-stage trial tested a combination of two oral drugs, tipifarnib and alpelisib, in 45 adults with recurrent or metastatic head and neck squamous cell carcinoma that has specific genetic changes (HRAS overexpression or PIK3CA mutations). The goal was to find a safe dose a…

This study follows adults in the United States who were prescribed zuranolone for postpartum depression (PPD) after giving birth. Researchers will track symptom changes using a standard questionnaire called the Edinburgh Postnatal Depression Scale (EPDS) at several time points, i…

This trial tests whether combining an online form of Acceptance and Commitment Therapy with a noninvasive brain stimulation technique can improve sleep quality in adolescents with depression and sleep problems. About 160 teens aged 11 to 19 are randomly assigned to receive the co…

This phase 2 trial tests an oral drug called ARD-101 in adults with Prader-Willi syndrome, a genetic condition that causes an unrelenting feeling of hunger. Researchers give the drug twice daily for 28 days to see if it safely reduces hyperphagia, the intense drive to eat, using …

This completed Phase 4 trial tested whether adding a second drug (B55R2) to standard treatment (B55R1) works better for people with non-proliferative diabetic retinopathy, an early stage of diabetic eye disease. 52 adults with mild to severe disease took either the combination or…

Researchers are testing a new face mask, the Smart Mask V1 System, that uses built-in light sensors to measure blood oxygen (SpO2) and pulse rate. The study enrolls healthy adults aged 18 to 65 who wear the mask while breathing air with gradually lower oxygen levels in a special …

This Phase 3 trial tests a radioactive imaging agent called 18F-mFBG to see if it can accurately detect neuroblastoma, a type of childhood cancer. The study involves 43 participants who either have or are suspected of having neuroblastoma. Researchers will compare the new PET sca…

This study is testing whether a mobile app can help detect postpartum depression early in pregnant women. Researchers will follow 120 women for 6 months, using daily mood questions and monthly surveys through the app. The goal is to understand how symptoms change over time and to…

Researchers are studying how measurements from two different optical coherence tomography (OCT) machines compare when scanning the back of the eye. The trial includes 338 adults with diabetes and diabetic macular oedema. Participants receive OCT scans on both a Heidelberg Spectra…

Researchers are testing whether a tablet-based, game-like version of the Motor Function Measure (MFM) gives consistent results compared with the standard paper-based scale. The study includes 70 people aged 2 to 60 with a confirmed neuromuscular disease. Participants complete the…

Researchers are testing whether a bedside ultrasound of the eye can help emergency doctors tell ischemic stroke (caused by a clot) from hemorrhagic stroke (caused by bleeding). The team measures the optic nerve sheath diameter, a marker linked to pressure inside the skull, in adu…

Researchers want to know how many people with neuropathy of unknown cause carry a mutation in the TTR gene, which leads to a rare and potentially fatal inherited disease called familial amyloid neuropathy. The study enrolls up to 400 adults under 90 who have neuropathy confirmed …

Researchers are checking whether a short 3-question depression survey can identify moderate-to-severe depressive symptoms in older adults having surgery as accurately as the standard 9-question version. The study analyzes existing records from more than 10,000 patients aged 65 an…

Researchers are testing whether tissue samples taken during a routine colon exam can help tell apart Parkinson's disease from two similar conditions: multiple system atrophy and progressive supranuclear palsy. The study includes 34 people aged 50 to 80, some with these conditions…

Young children who arrive at the emergency department with a fever and no obvious cause often get blood tests and antibiotics just in case. Researchers are testing whether a rapid finger-prick procalcitonin test, combined with a set of clinical rules, can help doctors identify wh…

This study aims to develop computer models that can help diagnose and monitor Parkinson's disease by analyzing eye movements and walking patterns. Researchers will collect data from 100 people with Parkinson's or similar conditions using special devices. The goal is to make diagn…

Researchers are studying whether ultrasound images of carotid artery plaques can reveal which plaques are unstable and more likely to cause a stroke. They compare scan features with the actual tissue composition of plaques removed during surgery, and they track plaque growth, str…

Visual problems after a mild traumatic brain injury often go unnoticed. Researchers at Bispebjerg Hospital are developing and testing a 42-item questionnaire and eye-tracking based screening tools to detect these issues. The study compares 100 adults with persistent symptoms afte…

Researchers are testing whether a special type of MRI, called diffusion tensor imaging, can detect subtle damage to the brain's white matter after a sports concussion. Standard brain scans often look normal after a concussion, even when athletes have lingering symptoms. This stud…

Researchers compare one French middle school that used the e-Bug educational programme with other schools in the region to see whether classroom lessons about vaccination relate to higher HPV and meningococcal ACWY vaccine coverage. The study uses only aggregated, anonymised vacc…

This study involves 60 young people at high risk for psychosis. They receive a stepped series of psychological treatments, starting with the least intensive options like group support, and moving to more intensive therapy if needed. The goal is to prevent the development of psych…

Researchers at Yale University are testing whether adding cognitive behavioral therapy (CBT) after esketamine treatment helps prevent relapse in people with major depression and suicidal thoughts. All participants receive esketamine, then half are randomly assigned to also get co…

This study tests whether giving probiotics (LactoLevure) to ICU patients on ventilators can prevent ventilator-associated pneumonia. The trial will enroll 186 adults with head injury, stroke, or brain hemorrhage. Patients receive probiotic or placebo capsules twice daily for 30 d…

This early-stage trial tests a vaccine called AV-1959R, designed to prevent Alzheimer's disease by targeting a protein linked to the condition. Sixteen healthy adults aged 40-60 will receive three shots of the vaccine or a placebo over 14 weeks. Researchers will monitor for side …

This trial tests whether a group prenatal care model that includes social services can improve maternal mental health and reduce preterm birth compared to standard individual care with added services. Pregnant women eligible for Medi-Cal in central California are randomly assigne…

Heavy drinkers who need a breathing machine in intensive care often become agitated, which can lead to pulling out tubes, falling, or harming themselves or staff. This Phase 3 trial tests whether baclofen, a drug that calms the nervous system, can prevent these dangerous events b…

Researchers are testing a school-based program that screens adolescents for anxiety, depression, and other mental health concerns, then offers stepped support. Students at eight schools in Spain complete regular mental health questionnaires. Based on their results, they receive d…

Patients on a breathing machine need the cuff around their endotracheal tube kept at about 25 cmH2O to seal the airway. Nurses usually check and adjust this pressure by hand every few hours, which can let the pressure drop too low between checks. This trial tests whether a mechan…

Researchers are testing whether 24 weeks of Tai Chi training can prevent episodic migraines in Chinese women as effectively as standard preventive medication. The trial enrolls 220 women aged 18 to 65 who have two to six migraines a month. Participants in the Tai Chi group attend…

Researchers are testing whether stopping proton pump inhibitors (PPIs) after a transjugular intrahepatic portosystemic shunt (TIPS) procedure can lower the risk of hepatic encephalopathy, a brain condition linked to liver disease. Adults already taking PPIs and scheduled for TIPS…

This pilot study is testing a smartphone app called Mindful Journey that teaches mindfulness skills. The goal is to see if it is practical and acceptable for adults who are in treatment for opioid use disorder and also have chronic pain. Ten participants will use the app for 8 we…

Researchers are testing whether a combined exercise program can improve muscle thickness, balance, and fall risk in people with multiple sclerosis who also have sarcopenia, a condition involving loss of muscle mass and strength. Participants in the exercise group attend 60-minute…

Researchers at the University of Tulsa are testing a five-session psychological treatment called Exposure, Relaxation, and Rescripting Therapy for adults who have bipolar disorder and chronic trauma nightmares. The therapy asks participants to revisit and rewrite their nightmares…

Researchers are testing whether lavender aromatherapy or calming music can improve sleep and brain oxygen levels in children with epilepsy. The trial enrolls 90 children who have generalized tonic-clonic seizures and take at least one anti-seizure drug. Children are assigned to r…

This study tests if adding dance therapy to standard physical therapy helps people with chronic stroke (at least 6 months after) improve their balance and walking. Sixteen participants will be split into two groups: one gets standard therapy plus dance, the other only standard th…

This study tests a dual-task training program for children aged 6-8 with unilateral cerebral palsy. About 70 participants will be split into two groups: one doing balance exercises while also performing fine motor tasks, and the other doing single-task exercises. The goal is to s…

Researchers at Karolinska Institutet are testing a parent training program for parents of children aged 8 to 16 who show angry, defiant, or aggressive behavior. The program teaches cognitive behavioral therapy skills and adds virtual reality role-plays so parents can practice res…

Researchers at Karolinska Institutet are testing a program called YourSkills for children aged 10 to 16 who have elevated anger or disruptive behaviors. The program combines cognitive behavioral therapy with virtual reality role-plays to practice social skills. Children attend te…

Researchers at the University of Washington are testing whether combining non-invasive spinal stimulation with an ankle exoskeleton can improve walking in people with neurologic conditions such as cerebral palsy, stroke, and premature birth. The study includes up to 10 participan…

This study tested an oral soft capsule of nalbuphine, a painkiller, for people recovering from hemorrhoid surgery. 106 adults took either the drug or a placebo for up to 2 days. Researchers measured pain levels and how much extra pain relief was needed. The goal was to see if the…

Researchers compare two six-week stress-management programs for female hospital nurses and midwives: heart rate variability biofeedback and eurythmy therapy. Participants are assigned at random to one program. Before and after, questionnaires and heart rate measurements track cha…

Researchers compare two spinal anesthesia mixtures for pain relief after lower limb surgery. One group receives bupivacaine alone, and the other receives bupivacaine plus tramadol. The trial measures pain scores and how long it takes before patients need additional pain medicine.…

This trial tests whether drinking lavender herbal tea twice daily for nine days around each menstrual cycle can reduce the emotional and physical symptoms of premenstrual syndrome (PMS), such as anxiety, depression, stress, and pain. Sixty women with PMS will be randomly assigned…

Researchers in Finland are testing a web-based neuropsychological rehabilitation program for adults who have recently had an acquired brain injury from causes such as stroke, encephalitis, or trauma. The program, called the iRENE Digital Pathway, uses online sessions and question…

Researchers test whether an 8-session dance workshop improves balance in adults with hemiparesis, a weakness on one side of the body. Participants are randomly assigned to either the dance program or an upper-limb rehabilitation program. The study measures changes in walking and …

This trial examines whether pelvic floor muscle exercises can improve vaginal and sexual health in postmenopausal women. Twenty women who are sexually active and have gone through menopause join the study. One group receives training from a physiotherapist and does home exercises…

Researchers are testing whether giving children a popit toy or a stress ball during inhaled medication can reduce anxiety, fear, and distress. The trial includes children aged 4 to 6 who come to a pediatric emergency unit with a respiratory condition needing nebulizer or inhaler …

Researchers are testing whether the 4-7-8 breathing technique can reduce anxiety, ease symptom burden, and improve sleep quality in people receiving chemotherapy. The trial enrolls 64 adults undergoing their third treatment cycle, splitting them into a group that practices the br…

Researchers at the University of Tulsa are studying Exposure, Relaxation, and Rescripting Therapy (ERRT), a brief treatment for frequent trauma-related nightmares. The trial enrolls about 90 adults who have experienced trauma and have roughly one nightmare per week. Participants …

Researchers are comparing two diets to see whether either one reduces fatigue in people with relapsing-remitting multiple sclerosis. Participants follow their usual diet for 12 weeks, then are randomly assigned to the Swank low-saturated-fat diet or the Wahls Elimination modified…

Researchers are testing a stepped mental health program for adolescents in Pakistani public schools. The program starts with teacher-led support for emotional distress. Students who do not improve move to a CBT-based guided self-help app. The study checks whether this approach is…

This study tests an experimental drug called GM-2505 in people with major depressive disorder. Participants receive two doses of the drug two weeks apart. The study has three parts: one for people not on antidepressants, one for those partially responding to current treatment, an…

Researchers are testing whether a horticultural therapy program can reduce anxiety and improve quality of life in older adults. The trial enrolls 56 volunteers who take part in gardening activities. Participants complete standard questionnaires about anxiety and well-being before…

Researchers are testing whether a 10-week mindful yoga program eases depression, anxiety, and stress in women who have recently given birth. The trial enrolls 198 postpartum women with depressive symptoms and assigns them to either weekly mindful yoga sessions or a psychoeducatio…

People with Parkinson's disease often struggle with walking, and their brains have trouble learning new movement skills. Researchers want to know if adding aerobic exercise or resistance exercise after gait training helps them learn and remember walking tasks better than gait tra…

Parents of children with complex medical conditions often feel unsure about managing their child's symptoms at home. This trial tests whether a mobile app with nurse support can help. Ninety-six parents receive either the app, which offers health checks, monitoring, education, an…

This study tests whether a special light therapy device can improve quality of life and movement for people with Parkinson's disease. About 350 participants who are already on standard Parkinson's medication will use the light at home. The goal is to see if adding this light ther…

Researchers are testing an accelerated form of brain stimulation called iTBS for depression. A single participant with major depressive disorder receives 50 iTBS sessions over 5 days while researchers monitor blood flow in the brain using fNIRS. The study measures changes in oxyg…

Researchers are testing a home-based program called action observation and motor imagery (AOMI) training for adults with spinal cord injury. Participants watch exercise videos and imagine themselves doing the movements without actually moving. The trial aims to see if this traini…

This study tested whether watching calming VR videos or squeezing a stress ball could reduce pain, anxiety, and improve satisfaction during insulin injections in older adults (65+) with type 2 diabetes. 90 participants were split into three groups: VR, stress ball, or usual care.…

This study looked at whether mandala art therapy (a structured coloring activity) can lower anxiety and increase comfort in people who received a kidney transplant. Eighty adult first-time kidney transplant recipients took part. The goal was to see if this simple, non-drug approa…

Researchers are testing whether certain ingredients in toothpaste can trigger migraines. Adults with migraine who do not take preventive medicines join one of two groups: one swaps toothpaste for saline solution when brushing, the other keeps using toothpaste. Both groups follow …

Tonsillectomy causes significant pain in children. Researchers are testing whether injecting ropivacaine, a local anesthetic, around the tonsils during surgery reduces postoperative pain. The trial enrolls 60 children aged 3 to 6 who are having their tonsils removed. Doctors comp…

Electromyography (EMG) and nerve conduction studies (NCS) check how nerves and muscles work, and many patients find them painful or stressful. Researchers are testing whether letting adults choose and listen to their own music during these tests lowers anxiety and pain compared w…

Researchers are testing a 12-week home-based programme that combines aerobic exercise, strength training, stretching, and self-management education for people who had a stroke more than six months earlier. The trial enrolls 30 community-dwelling survivors aged 20 to 59 who can wa…

Researchers are testing whether a dual-task exercise program helps stroke survivors walk while doing a mental task. The study compares dual-task training, which combines walking with cognitive activities, to single-task training, where walking and thinking are practiced separatel…

Researchers are testing a four-week acceptance and commitment therapy program for parents of children with complex medical conditions. The trial enrolls 24 parents who attend two-hour weekly sessions covering stress, values, mindfulness, and goal-setting. The study measures chang…

Researchers at Cairo University are studying whether a specific exercise program that targets the posterior oblique sling, a network of muscles in the lower back and pelvis, can improve muscle coordination and function in people with lumbosacral radiculopathy. This condition caus…

This study compared two types of nerve blocks (supra-inguinal fascia iliaca block and lumbar erector spinae plane block) for pain relief in 84 adults undergoing hip fracture surgery. The goal was to see which block works better for positioning the patient for spinal anesthesia an…

Researchers at Oregon State University are testing whether a brief, Spanish-language group program can reduce anxiety in Latino/a adults. The program teaches neuroscience-informed cognitive behavioral therapy over three weekly 90-minute sessions and asks participants to track the…

Researchers are testing whether giving mothers with ADHD a stimulant medication along with behavioral parent training works better than parent training alone for reducing ADHD-related problems in their young children. The study enrolls mothers aged 21 and older who meet criteria …

Researchers at Baylor College of Medicine are studying whether weekly art therapy can ease symptoms and improve quality of life for people with progressive supranuclear palsy (PSP), a rare brain disorder that affects movement, balance, and eye control. About 20 participants with …

This study tested whether a 12-week physical activity program could improve memory and attention in children who had radiation for brain tumors. Thirty-six kids aged 8–17 who finished radiation at least a year ago took part. Half started the program right away, while the other ha…

This study tests whether playing specially designed, AI-powered games can improve thinking skills and arm/hand function in people who have had a stroke. Forty adults aged 45-60 with mild memory or thinking problems after a stroke will use a smartphone app and motion-sensing games…

This study looked at whether a 12-week treadmill exercise program can improve cardiorespiratory fitness, reduce fatigue, and boost mood in people with traumatic brain injury (TBI). Thirteen physically inactive adults with TBI walked on a treadmill three times a week for 30 minute…

Researchers at the University of Manitoba are testing whether a single 90-minute virtual coaching session can help parents of 2 to 5 year olds who are on waitlists for developmental services. The session teaches coping skills like emotion regulation and communication, tailored to…

This study tests whether combining progressive muscle relaxation and guided imagery can lower stress, anxiety, and depression in people with stable coronary artery disease. Forty adults will be split into two groups: one gets eight sessions of these mind-body techniques over four…

Many people who move to a new country face depression, anxiety, stress, and trouble adjusting. This pilot study tests whether EMDR, a psychotherapy that uses guided eye movements to process distressing memories, can help when adapted for migration-related experiences. First-gener…

Pregnancy can worsen fibromyalgia symptoms like pain, fatigue, and poor sleep, affecting both mother and baby. This trial tests a community-based nursing program that combines weekly education sessions with twice-weekly exercise, including prenatal yoga and stretching, for pregna…

Researchers are testing whether a home-based program led by community health workers can reduce depression in older adults living in a low-resource district of Lima, Peru. The program, called VIDACTIVA, combines problem-solving exercises and physical activation over eight home se…

This study tested a new type of leg brace designed to help children with cerebral palsy and other movement disorders walk more easily. The brace was custom-made for each child and could be adjusted to provide different kinds of support. Researchers measured how well children walk…

Researchers are studying whether adding a Chinese herbal capsule called Shuganjieyu to the antidepressant fluoxetine helps ease depression symptoms more than fluoxetine alone. The trial enrolls 160 adults with depression, ages 18 to 65, who score at least 18 on a standard depress…

This study tested whether a 3-month home exercise program on an elliptical machine and 3 months of bright light therapy could improve movement, balance, and mood in adults with traumatic brain injury. Thirty-four participants (including healthy volunteers) were enrolled. The goal…

Intravitreal injections deliver medicine directly into the eye and are usually quick, but many patients feel anxious before and during the procedure. Researchers are testing whether playing classical music during the injection lowers anxiety and pain compared with no music. The t…

Researchers at the University of Oxford are studying an optimized rehabilitation program for children with spinal muscular atrophy (SMA) who are already on a stable disease-modifying treatment. The program adds goal-oriented rehabilitation, hands-on physiotherapy sessions, and a …

This study tests whether a type of brain stimulation called cTBS can improve thinking and memory in people with schizophrenia. Forty participants will receive targeted stimulation to a brain network linked to daydreaming and self-focus. The goal is to see if this changes brain ac…

Ataxia-telangiectasia is a rare, inherited disease that damages the nervous system, skin, and immune system, and it has no cure. Researchers are testing sirolimus, an immune-suppressing drug, in children under 17 with the condition. The six participants take sirolimus by mouth fo…

Researchers are comparing two ways of delivering exercise therapy to people with multiple sclerosis: supervised sessions with a physiotherapist and a program followed over the internet. The study enrolls 34 adults with moderate to severe disability, measured by an EDSS score of 5…

This study will test whether watching a liquid-gel or sand hourglass during blood collection can reduce pain, fear, and anxiety in children aged 5 to 10. About 120 children will be randomly assigned to use one type of hourglass or no hourglass. The goal is to find a simple, non-d…

Researchers are testing whether propionic acid, a short-chain fatty acid, can slow nerve damage and ease fatigue in people with multiple sclerosis. The trial enrolls 101 adults aged 18 to 60 who have stable MS and signs of immune activity in their spinal fluid. Participants recei…

Researchers are testing whether balance training on a moving platform can change reflex activity and improve reactive balance and walking in children with spastic cerebral palsy. The study includes 24 children aged 5 to 17 with spastic cerebral palsy, plus typically developing ch…

Researchers are studying whether TENS, a device that sends mild electrical pulses through the skin, can lower pain and reduce the need for painkillers after total hip replacement. The trial enrolls 60 adults who have had hip replacement surgery and do not have a pacemaker, heart …

This completed Phase 1 study tested whether olanzapine, an antipsychotic drug, can reduce the discomfort of tinnitus (ringing in the ears). Fifty adults with stable tinnitus for at least 6 months received either olanzapine or a placebo in a crossover design. The main goal was to …

This study tests whether using a virtual reality headset showing nature scenes with relaxing music can reduce pain and anxiety during dressing changes for pressure sores. Sixty-two adults with pressure sores will be randomly assigned to either receive VR during dressing or standa…

This pilot study tests whether a short, 5-session writing therapy called Written Exposure Therapy (WET) is practical and helpful for pregnant or postpartum adolescents and young adults (ages 15-24) with PTSD. The therapy involves writing about traumatic experiences with minimal t…

This study tested two non-drug methods—reflexology (foot massage) and sleep hygiene education—to improve sleep and comfort in 60 adults on hemodialysis. Both approaches helped, but reflexology was more effective. The results suggest a simple, drug-free option for better rest in d…

This study looked at whether structured play activities could reduce anxiety in children aged 4-10 receiving chemotherapy and their parents. 62 children and their parents took part in play sessions during chemo. Anxiety levels were measured before and after play. The goal is to s…

This study tests whether adding a gentle, non-invasive nerve stimulation on the ear (taVNS) to standard physical therapy can reduce muscle stiffness, improve movement, and boost quality of life in children with spastic cerebral palsy. Eighteen children aged 8-18 will be split int…

Researchers in Chile are testing whether pediatricians trained to detect and respond to social withdrawal can help late and moderately late preterm infants engage more with their parents. The study enrolls 110 preterm infants born between 32 and 36 weeks and their Spanish-speakin…

Researchers compare two surgical techniques for rebuilding the tongue after cancer removal: the submental island pedicled flap, taken from under the chin, and the radial forearm free flap, taken from the arm. Twenty-eight adults with tongue cancer that requires partial or total r…

This study tests whether an 8-week forest therapy program—combining walking, resistance band exercises, and sensory activities like aromatherapy—can improve muscle strength and well-being in older women with sarcopenia. Thirty-six women aged 55 and older will participate in 16 se…

This study tested whether a web-based exercise program could reduce nerve pain and improve quality of life in breast cancer patients receiving chemotherapy. 90 patients with stage II-III breast cancer and neuropathy symptoms took part. The program was guided by a physiotherapist …

Researchers are testing whether the experimental drug LY2140023 (pomaglumetad methionil) reduces schizophrenia symptoms better than a placebo. The trial enrolls adults diagnosed with schizophrenia who stay in a hospital or clinic during the four-week study. Participants take the …

Researchers are testing whether an experimental drug, LY2140023, eases schizophrenia symptoms better than placebo in people who are acutely ill. The trial also compares it to risperidone, an approved antipsychotic. About 1,100 patients with schizophrenia join this phase 2 study. …

Researchers are testing whether short, repeated sessions of mild low oxygen (mild intermittent hypoxia) can strengthen upper airway muscles and improve sleep apnea treatment. Adults with newly diagnosed obstructive sleep apnea and prehypertension or stage 1 hypertension, includin…

Researchers in Pakistan are comparing two psychological treatments, Eye Movement Desensitization and Reprocessing (EMDR) and Cognitive Behavioral Therapy (CBT), for people with post-traumatic stress disorder (PTSD) and major depression. The trial enrolls 100 adults aged 18 to 60 …

Researchers are testing whether a two-week course of functional magnetic stimulation applied to the sole of the foot can improve feeling, foot strength, balance, and walking in adults with type 2 diabetes and diabetic peripheral neuropathy. Participants are randomly assigned to r…

This study tested a probiotic (BB-12 with LGG) in 123 children with autism and stomach problems. The goal was to see if different doses are safe and can improve behavior and gut health. Researchers tracked side effects, behavior changes, and gut bacteria over 56 days of treatment…

Researchers test whether an 8-session mindfulness-based stress reduction program can lower anxiety and work-related burnout and improve job satisfaction among midwives. Midwives at a Turkish hospital join either the program or a control group. The program runs online twice a week…

Researchers are testing whether Iberogast, a herbal blend used for digestive complaints, can relieve constipation in people with Parkinson's disease. The trial enrolls 45 adults aged 30 to 80 who have Parkinson's disease and functional constipation. Participants take Iberogast fo…

This study tests whether dry needling (inserting thin needles into tight muscles) can reduce spasticity—stiffness that makes movement hard—in people who have had a stroke. About 28 adults who can walk independently will receive either real or sham (fake) needling once a week for …

This trial compares three common anesthetic blocks used during knee replacement surgery to see which one controls pain best right after the operation. It also looks at how well patients can move their knee in the first few days, and whether pain and recovery differ by age or sex.…

Researchers are testing whether a structured Enhanced Recovery After Surgery (ERAS) program improves recovery for people having their first coronary artery bypass graft. The program bundles 31 care steps before, during, and after surgery, including patient education, nutrition su…

Researchers are testing whether a combination of water-based exercise and cognitive training can improve memory in veterans with amnestic mild cognitive impairment, a condition that often precedes dementia. Participants first complete six months of pool exercise three times a wee…

Researchers test whether an eight-week mindfulness group program can improve family resilience and mindfulness in mothers of children with intellectual disabilities. The program combines mindfulness practices with a family resilience framework. Mothers attend weekly 90-minute ses…

Researchers at UC Davis are comparing two pain-control plans for women having weight-loss surgery. One group receives standard opioid-based care, while the other gets a mix of non-narcotic medicines with opioids available only if needed. The trial measures pain scores and how muc…

Researchers are testing three non-drug approaches for nerve pain caused by paclitaxel, a common chemotherapy for breast cancer. The trial enrolls 140 women receiving weekly paclitaxel who develop mild nerve symptoms. Participants are assigned to TENS, compression, cryotherapy, or…

Researchers are testing an experimental drug called TAK-935 in adults with developmental and/or epileptic encephalopathies, severe brain conditions that cause frequent seizures and developmental problems. The trial enrolls a small number of participants who continue their regular…

This study is testing a mobile health app designed to help cancer survivors manage pain and other symptoms after treatment. Twenty-five survivors who have finished cancer treatment but still have pain will use the app for one week, receiving helpful messages and completing daily …

Researchers are testing whether memantine, a drug already used for Alzheimer's disease, can ease symptoms or slow decline in people with frontotemporal dementia. The trial enrolls adults aged 45 to 75 with mild to moderate FTD and compares memantine against a placebo over one yea…

Pudendal neuralgia is a painful condition caused by a trapped nerve in the pelvis. Researchers at Nantes University Hospital are comparing three injection mixtures placed near the pudendal nerve: lidocaine alone, lidocaine plus a steroid, and lidocaine plus steroid plus a large v…

Researchers are testing whether soticlestat, an experimental tablet, can reduce pain in adults with chronic complex regional pain syndrome (CRPS) that has lasted at least six months. About 24 participants will take either soticlestat or a placebo alongside their usual pain treatm…

Researchers are testing whether virtual reality glasses that show nature scenes with nature sounds can reduce pain and anxiety in women after a cesarean section. The trial enrolls 80 women who had spinal anesthesia and a healthy pregnancy, assigning half to use the VR glasses for…

Researchers are testing whether a vibrating dolphin-shaped massage device or tablet-based digital storytelling reduces pain and fear in children aged 3 to 6 during blood collection. The trial assigns children to one of these two distraction methods or to a control group. Parents,…

This completed study tested a sound-based therapy for tinnitus (ringing in the ears) in 108 Veterans. Participants used hearing aids that played either notched noise (sound with the tinnitus frequency removed) or broadband white noise. The goal was to see if notched noise could r…

Researchers at Atlas University are comparing three daily breathing practices, mindfulness breathing, box breathing, and Nadi Shodhana pranayama, in 48 healthy adults aged 18 to 40. Participants practice one technique at home for six weeks after learning it in person. The trial m…

Children with spinal cord injury often struggle to sit upright because their trunk muscles are paralyzed. Researchers are testing a device that sends electrical pulses through the skin to the spinal cord, called transcutaneous spinal stimulation, to see if it can improve sitting …

Researchers at the University of Louisville are testing whether combining activity-based locomotor training with non-invasive spinal stimulation can improve sitting posture and trunk control in children with chronic spinal cord injuries. The trial enrolls 14 children, ages 3 to 1…

This phase 2 trial tests whether fasudil, a drug already used in Japan for blood vessel spasms, is safe and can help symptoms in people with early Parkinson's disease. 75 participants will take either fasudil or a placebo for 3 weeks. The study focuses on safety and tolerability,…

This study tested whether providing overnight infant care and parenting support helps new mothers with substance use disorder living in residential treatment programs. 41 mothers participated, and researchers measured how many enrolled, completed the program, and gave feedback. T…

Many people on long-term hemodialysis struggle with persistent pain at night and poor sleep, which lowers their quality of life. Researchers are testing a nurse-led Benson's relaxation program to see whether it reduces night pain intensity and improves sleep quality. The study en…

This study tests whether atogepant, a drug already used to prevent migraines, can also treat migraine attacks quickly. About 1300 adults with a history of migraines will take either atogepant or a placebo when they have a migraine, and then report pain levels and symptoms after 2…

This study tests whether pairing meditation with a brain stimulation technique called rTMS can better treat depression. rTMS is already FDA-approved but only works for about 15-30% of patients. The researchers hope that adding a focus on internal attention (like breathing) during…

Researchers are testing MDMA-assisted therapy in military veterans who have both alcohol use disorder and post-traumatic stress disorder. The treatment combines two monthly therapy sessions with the drug MDMA, along with preparation and follow-up counseling. The study measures ch…

Researchers are comparing two 9-week group classes for veterans who have a history of mild traumatic brain injury and post-traumatic stress disorder. One class teaches mindfulness, meditation, and yoga; the other teaches how the brain works and recovers after injury. The study me…

This study tests a laser treatment for people with bothersome eye floaters that make vision blurry or distracting. Researchers will measure how vision, eye structure, and quality of life change after the procedure. The study involves 50 adults with floaters caused by certain eye …

Researchers are testing whether cognitive behavioral therapy for insomnia (CBT-I) can improve blood sugar control in older Chinese adults with type 2 diabetes and insomnia. The trial compares CBT-I to usual care in 214 participants aged 60 and older. They will measure changes in …

This study tests whether osteopathic manipulative treatment (OMT) — a gentle, hands-on therapy — can reduce muscle stiffness, improve jaw motion, and ease pain in people with chronic neck pain and headaches. Thirty adults aged 19 to 65 will receive OMT and undergo various measure…

This study tested two types of magnetic brain stimulation (iTBS and rTMS) combined with robotic walking therapy in 30 people with chronic spinal cord injury. The goal was to see if these treatments could improve leg strength, walking ability, and daily independence. All participa…

York University researchers are testing two ways to train teachers to help children with dyslexia who have not improved with standard classroom reading instruction. One program adds morphology, which teaches shared word meanings like sign, design, and signal. The other adds set-f…

This study will test whether watching a short educational video or having a standard talk with a doctor is better at reducing anxiety and stress in women scheduled for a planned cesarean delivery. 140 women will be randomly assigned to one of the two groups. Their anxiety levels …

This study will test whether foot reflexology—a type of foot massage—can help women aged 18-45 with migraines feel less pain, anxiety, and fear of movement. Twenty women will either receive 10 foot massage sessions over 5 weeks or no massage. Researchers will measure changes in h…

Researchers are testing a rehabilitation platform called PRoBio that pairs a robotic arm with virtual reality and wearable sensors. The study enrolls 10 adults with mild Parkinson's disease and mild cognitive impairment. Participants take part in a four-week program with three we…

Researchers at Tanta University are testing whether fractional CO2 laser can reduce skin amyloid deposits and itching in people with primary cutaneous amyloidosis. The trial enrolls 22 adults with confirmed disease who have not used other treatments for at least six months. Parti…

Researchers are testing whether cognitive behavioral therapy for insomnia (CBT-I) can help returning veterans who drink heavily. The trial enrolls veterans deployed after September 11, 2001, who have insomnia and at least one heavy drinking episode in the past month. Participants…

This study tests whether a nerve block called the serratus posterior superior intercostal plane block can reduce pain and the need for strong painkillers after minimally invasive heart surgery. Sixty adults will be randomly assigned to receive either the nerve block plus standard…

This study tests two types of exercises to help people who get dizzy, nauseous, or have blurry vision from using computers for long hours. 46 computer users will do either head-movement or eye-movement exercises for 4 weeks. The goal is to see which exercise better reduces sympto…

Researchers at the University of Guadalajara are testing whether a short acceptance and commitment therapy (ACT) program can reduce anxiety in medical students. The program runs four in-person group sessions that teach students to accept difficult thoughts and feelings, step back…

This completed trial tested a virtual program for people with Alzheimer's or related dementias and their caregivers. Nearly 1,000 participants received monthly video or phone visits from nurses or social workers over a year. The program focused on managing symptoms, reducing care…

Researchers are testing an experimental drug called soticlestat in people with two rare genetic conditions: Dup15q syndrome and CDKL5 deficiency disorder. Both conditions cause frequent motor seizures that are hard to control. The trial enrolls about 20 participants who take one …

Whole-brain radiotherapy is a common treatment for cancer that has spread to the brain, but it often harms memory and thinking. This phase III trial tests whether adding the drug memantine and using a radiation technique that avoids the hippocampus, a brain area key to memory, ca…

This completed trial tested whether electroacupuncture (acupuncture with a mild electric current) can reduce pain in people with postherpetic neuralgia, a lingering nerve pain after shingles. 448 adults aged 45-75 with moderate-to-severe pain were randomly assigned to real or sha…

This study tests an experimental drug called KDT-3594 in 150 people with advanced Parkinson's disease who already take levodopa. The goal is to see if the drug can improve movement and daily living skills during their 'on' times (when medication is working). Participants take esc…

This study tests whether 80 sessions of a gentle brain stimulation technique called tDCS, given over 12 months, can improve attention, social skills, and language in 180 children aged 6 to 11 who have autism along with rare diseases, genetic problems, or PANDAS. The treatment is …

This trial tests a support package called CaknaStrok for people caring for a family member who just had a stroke. The package includes a mobile app with videos and tools, plus a guidebook, all tailored for Malaysian caregivers. Researchers compare caregivers who get the package w…

Researchers at the University of Sfax are testing whether the timing of exercise changes its benefits for sleep and well-being. They enroll 102 sedentary university students aged 18 to 25 and assign them to three weekly 50-minute sessions, two weekend 75-minute sessions, or a con…

Fatigue is one of the most common problems in multiple sclerosis, and it can make walking, balance, and thinking harder. Researchers want to measure how fatigue changes these functions during a long walking test using wearable sensors. They are also testing whether a high-intensi…

Researchers are testing whether a 10-session mechanical massage program can improve sleep quality, lower stress hormones, and affect immune function in people who report high stress and poor sleep. The study enrolls 32 adults who score high on stress and insomnia questionnaires a…

Researchers are testing a smartphone app called Pai.ACT that uses acceptance and commitment therapy to help parents of children with special needs manage stress and improve well-being. The study enrolls 60 Cantonese-speaking parents in Hong Kong who care for children aged 2 to 8 …

This study tests whether special knee strengthening exercises can improve balance and body awareness (proprioception) in people who had a stroke. About 34 participants who had a stroke 3 months to 1 year ago will do either isokinetic knee exercises or standard rehab. The goal is …

This trial tests whether acupressure, a traditional therapy that presses on specific body points, can reduce pain and anxiety in women who have just had a cesarean delivery. Sixty postpartum women will receive either acupressure or a sham version, along with standard medical care…

This study tests two different exercise programs in 40 people with diabetic peripheral neuropathy, a condition that causes numbness and balance problems. One program uses Feldenkrais exercises, which focus on movement awareness, and the other uses task-oriented gait training, whi…

This study tested whether adding transcranial magnetic stimulation (TMS) to standard exercise can reduce fatigue, pain, and improve walking in people with postpolio syndrome. 26 adults who had polio earlier in life and now have new symptoms took part. Half got TMS plus exercise, …

Researchers are testing whether soticlestat, an experimental drug, can reduce major drop seizures when added to standard antiseizure therapy in children, teenagers, and adults with Lennox-Gastaut syndrome. About 270 participants will take either soticlestat or a placebo for 16 we…

Researchers are testing a full-spectrum medicinal cannabis extract with very low THC to see if it can reduce the severity of autism spectrum disorder in young people aged 8 to 17. The study compares the extract to a control and then allows some participants to receive it openly. …

Researchers at Saveetha University studied a structured play-based program called the B.A.S.I.C.S. framework for children with autism spectrum disorder. The program combines balance, social, thinking, and self-reliance activities into 45-minute sessions three times a week for six…

Researchers at Ataturk University are testing whether watching nature videos through virtual reality glasses can improve sleep quality and mental well-being in people with multiple sclerosis. The trial enrolls 42 adults aged 18 to 80 who have MS and are not in an attack. One grou…

Researchers are testing whether a stretching exercise program supervised over video call can improve pain, depression, sleep, and daily function in women with fibromyalgia. The trial enrolls 28 women aged 30 to 60 in southern Brazil. Half join live stretching sessions twice a wee…

This study tests whether adding a specific leg-rotation technique to standard physical therapy can better relieve sciatica caused by disc problems in the lower back. Researchers will measure pain, flexibility, and daily function in 70 adults aged 18 to 50. The goal is to see if t…

People with type 2 diabetes often face higher rates of anxiety and depression than the general public. Researchers at Dasman Diabetes Institute are testing whether six weeks of guided breath awareness, practiced inside a pyramid-shaped structure, can reduce those symptoms. The pi…

Researchers are studying whether adding myofascial release, a hands-on technique that stretches tight tissue, to standard physiotherapy helps children with cerebral palsy recover better after Achilles tendon surgery. The trial enrolls 40 children aged 2 to 5 in the Gaza Strip who…

This study tests whether a new medicine called CagriSema can reduce nerve pain in people with type 2 diabetes. About 142 adults with painful diabetic neuropathy will receive either CagriSema or a placebo for around 10 months. The main goal is to see if the drug lowers weekly pain…

Researchers test whether adding cognitive training to a 10-week exercise program helps children with developmental coordination disorder improve balance, motor skills, and fitness more than exercise alone. Twenty children aged 7 to 11 join the study and are randomly assigned to e…

Researchers are testing a non-invasive brain stimulation technique called transcranial direct current stimulation (tDCS) in adults with chronic neuropathic pain. The trial compares three approaches: stimulating two brain targets alternately, stimulating one target, or a sham (pla…

This study tests a remote program called teleABLE that helps people who had a stroke within the past year reduce their sitting time. Participants either get 12 behavioral coaching sessions or 6 health education sessions. The goal is to see if the program improves quality of life …

This study tested whether a special type of heated yoga (hyperthermic yoga) could help adults with mild to moderate depression. 80 people were randomly assigned to either take yoga classes twice a week or join a waitlist. The main goals were to see if people would stick with the …

This study tests a group cognitive-behavioral therapy (CBT) program designed to help young adults who struggle with uncertainty. The program includes techniques like cognitive restructuring and exposure to uncertain situations, and it considers how a person's social environment a…

Researchers are testing transcranial direct current stimulation (tDCS), a non-invasive technique that applies a weak electrical current to the scalp, in adults with severe obsessive-compulsive disorder that has not improved with at least two antidepressants. The study compares ac…

This study tests two simple, non-drug methods to reduce pain and fear in children aged 6-9 during blood draws. One group watches a cartoon, the other squeezes a stress ball. Researchers will measure pain and fear levels during the procedure to see which works better.

Researchers at the University of Utah are testing a new non-invasive brain stimulation method for people with moderate-to-severe depression. The study uses a device called the Diadem prototype to deliver personalized low-intensity focused ultrasound to specific brain areas. Parti…

Researchers are testing whether an electromyography-controlled functional electrical stimulator (FitFES) helps stroke survivors regain arm and hand function. The device reads muscle signals and delivers electrical stimulation during task-oriented exercises. Fifty adults who had a…

This study tests whether adding motor imagery—mentally practicing movements without actually moving—to standard physical therapy can improve balance and reduce fear of movement in people with Parkinson's disease. Forty-two participants will be randomly assigned to receive either …

This study tested three non-drug treatments—cognitive behavioral therapy, a breathing exercise, and psychoeducation—to see which best reduces the distress caused by tinnitus (ringing in the ears). Seventy adults with tinnitus were randomly assigned to one of the three approaches.…

This small pilot study tested a mindfulness-based therapy designed for older Black adults (age 50+) who have both chronic pain and early memory decline. The goal was to see if the program could improve quality of life and reduce how much pain interferes with daily activities. Nin…

This study tests whether eptinezumab can reduce migraine days and improve quality of life in 164 adults who previously did not get enough relief from other CGRP-targeting migraine drugs. Participants receive the drug and report changes in migraine frequency and severity over time…

This trial tests whether an 8-week Clinical Pilates program can improve balance and physical function in adults with multiple sclerosis. Participants are randomly assigned to Clinical Pilates, standard physiotherapy, or a control group with no structured exercise. Researchers mea…

This study tested whether electrostimulation and compression can reduce nerve pain and improve quality of life in people with gastrointestinal cancer who developed peripheral neuropathy from oxaliplatin chemotherapy. 140 patients were split into four groups: control, electrostimu…

This pilot study tested whether a non-invasive vagus nerve stimulator can help people with post-COVID syndrome who suffer from fatigue and headaches. Eighteen participants used the device, and researchers measured changes in their functional status and fatigue levels. The goal is…

Researchers at MIT are testing whether a smartwatch that vibrates in time with your heartbeat can improve interoceptive awareness, the ability to sense what is happening inside your body. The study enrolls 29 people with high alexithymia scores, a trait linked to difficulty ident…

Researchers test whether a home-based myofascial self-stretching program can ease symptoms of restless legs syndrome, also called Willis-Ekbom disease, in adults with chronic RLS. Participants do a 10- to 20-minute stretching routine each evening for two weeks and record their sy…

Researchers want to know if a wireless peripheral nerve stimulator, already implanted in some patients for chronic arm pain, can also make paralyzed muscles contract. The trial enrolls adults with stroke or spinal cord injury who have the device on nerves in the arm. Participants…

Researchers are testing a full-spectrum medicinal cannabis extract called NTI164 in girls and young women with Rett syndrome, a rare genetic disorder that affects movement, speech, and behavior. The study includes 14 participants aged 5 to 20 who take the extract daily for 16 wee…

This study tests a mindfulness program (called GEM) delivered through an app and weekly group video calls. It aims to see if young adults (ages 18-24) who have faced early life hardships find the program helpful and easy to use. The study also checks if the program reduces sympto…

This study tests whether balance training guided by artificial intelligence can improve pelvic alignment and reduce fall risk in people who have had a stroke. Thirty-eight stroke survivors will wear sensors and perform static and dynamic balance exercises. The AI adjusts the exer…

Researchers are testing an AI-integrated proactive thought control program for young adults with social anxiety disorder. The program uses two computer tasks: one where participants type the first word that comes to mind after seeing a social threat word, and another where they c…

Researchers are testing an experimental oral drug called XY03-EA in adults who have just had an acute ischemic stroke. The trial compares several doses of the drug with a placebo to see whether it improves recovery and reduces disability. About 360 participants receive treatment …

Researchers are testing whether transcranial direct current stimulation (tDCS) can reduce symptoms in people with severe obsessive-compulsive disorder that has not improved with standard medications. The study enrolls 20 adults aged 18 to 70 who have chronic OCD and have tried at…

This study tests a smartphone app called CT-155 designed to help people with schizophrenia manage negative symptoms like low motivation and reduced pleasure. About 262 adults with schizophrenia will use the app for 16 weeks, with an optional extension. Researchers will track symp…

Stroke often damages trunk control, balance and walking ability. Researchers are testing whether combining transcranial direct current stimulation, a mild electrical current applied to the scalp, with pelvic proprioceptive neuromuscular facilitation, a hands-on stretching and mov…

This study tested a nerve block called a stellate ganglion block for people with chronic migraine that didn't get better with other treatments. 42 patients received the injection under ultrasound guidance. Researchers tracked changes in monthly headache days and pain scores over …

This study tests a nasal spray containing (R)-Ketamine, a fast-acting drug, in 98 adults with major depression who are currently having suicidal thoughts. Participants receive either the spray or a placebo twice a week for 4 weeks. The goal is to see if the spray can quickly redu…

Researchers are testing whether propranolol, a common blood pressure drug, can help people with fibromyalgia who also have post-traumatic stress disorder. Participants take propranolol and then read their own traumatic story about 75 minutes later, once a week for six weeks. The …

Researchers are testing whether a non-invasive brain stimulation technique called temporal interference stimulation can improve motor symptoms in people with early-to-mid-stage Parkinson's disease. The study compares stimulation while participants are on and off their usual Parki…

Researchers are testing a full-spectrum medicinal cannabis extract called NTI164, which contains 0.08% THC, in children with pediatric acute-onset neuropsychiatric syndrome (PANS). PANS causes sudden, severe obsessive-compulsive symptoms, restricted eating, and other psychiatric …

This study tests whether physical therapy, combined with motivational support and planning, can help older adults with chronic hip, knee, or back pain become more physically active. Participants work with physical therapists to set personal goals and adapt activities to their con…

This trial tests whether meclizine, a drug often used for motion sickness, works as well as dimenhydrinate for controlling acute vertigo symptoms that come from inner-ear problems. Adults aged 18 to 64 with moderate to severe vertigo take one of the two drugs three times a day fo…

Diabetic polyneuropathy damages nerves in the feet, dulling the sense of touch and raising the risk of unnoticed injuries. This trial tests whether transcutaneous electrical nerve stimulation (TENS) can restore that sensation. Researchers compare high-frequency TENS, low-frequenc…

This study looked at whether two specific diets—the ketogenic diet and the Therapeutic Lifestyles Changes diet—could improve thinking and memory in people with Alzheimer's disease. Researchers measured changes in cognitive test scores over three months in 84 adults aged 50 to 90 …

This trial tests a telephone-based coaching program called MOTIVATE for older veterans who live with chronic musculoskeletal pain and depression. Participants receive eight individual phone sessions with a health coach over up to five months, focusing on managing pain and mood. R…

This study compares a 6-month physiotherapy program focused on pelvic floor relaxation to no structured exercise in women with pudendal neuralgia, a chronic pelvic pain condition. Researchers will measure muscle stiffness using ultrasound and track symptoms like pain and sexual d…

This trial tests whether real acupuncture can reduce the numbness, tingling, and pain that chemotherapy often leaves behind. Cancer survivors with persistent nerve symptoms will receive either genuine acupuncture or a sham version with superficial needling at non-acupoints. The g…

This trial tests whether S(+) ibuprofen, a purified form of the common painkiller, can reduce pain in people with knee or hip osteoarthritis better than a standard ibuprofen product. Researchers will compare the two treatments in about 176 adults aged 18 to 75. Participants will …

This study is testing a robotic lower-limb exoskeleton combined with functional electrical stimulation (FES) to help people with conditions like spinal cord injury, brain injury, or multiple sclerosis improve their walking. The device provides robotic support and electrical stimu…

This early-stage study tested a new drug called 4ET1103 in 40 healthy volunteers to see if it is safe and how the body processes it. Each person received a single dose of either the drug or a placebo. The goal was to check for side effects and measure drug levels, not to treat pa…

This phase II trial tests whether S(+) ibuprofen, a modified form of the common painkiller, provides better pain relief than a standard treatment for people with sudden, at least moderate low back pain. Researchers will compare the two approaches in 177 adults whose pain started …

This study tested a combination of platelet-rich plasma (PRP) from the patient's own blood and hyaluronic acid injected into the jaw joint. Twenty-two adults with painful clicking and limited mouth opening received the treatment. Researchers used a jaw tracking device to measure …

This study tests whether wearing cooling gloves and socks can reduce nerve pain and numbness in children aged 7 to 18 who are receiving vincristine chemotherapy for cancers like leukemia and Wilms tumor. The therapy uses adjustable gel packs that wrap around the hands and feet wi…

This trial tests whether a daily oral oil made from a full-spectrum cannabis plant extract with very low THC (FEN164) can safely help children with autism. The study will include 18 children aged 8 to 17 with moderate to severe autism (Level 2 or 3). Over 20 weeks, researchers wi…

This trial tests whether teaching mothers how to perform aspiration care for their children in the intensive care unit can lower their anxiety and hopelessness. Researchers will compare two teaching methods: a video and a picture booklet. The study includes mothers whose children…

This study tests a rehabilitation method called modified constraint-induced movement therapy (mCIMT) for people recovering from a stroke. Participants wear a mitten on their unaffected arm for several hours a day while practicing tasks with the affected arm. The goal is to see if…

This trial tests whether a sensory rehabilitation program, guided by physiotherapists, can reduce nerve pain and improve balance in people with chemotherapy-induced peripheral neuropathy (CIPN). Participants are adults who finished chemotherapy more than three months ago and repo…

This study tests whether a non-invasive electrical stimulation device placed on the skin over the spine can help veterans with spinal cord injury improve blood pressure, exercise capacity, and body temperature regulation. Twenty veterans with injuries between the neck and upper b…

Researchers at the University of Reading are testing an online guided-writing program for people who care for a loved one with Parkinson's disease. The program asks caregivers to complete four writing exercises that encourage them to respond to their own struggles with the same k…

This study used brain imaging to understand how Parkinson's disease changes the brain over time. Researchers compared people with definite or possible Parkinson's to healthy volunteers. Participants had up to six visits over nine years, including MRI scans and symptom checks. The…

This completed study looked at 31 people with early-onset Parkinson's disease (starting before age 50) and their family members to find genetic causes. Researchers collected blood and skin samples to study DNA and create cell lines. The goal was to better understand which gene mu…

This completed study looked at insurance claims data from 70,000 people with type 2 diabetes and established heart disease to compare the heart-related risks of three diabetes drugs: tirzepatide, dulaglutide, and semaglutide. The goal was to see if any of these drugs was linked t…

This study looked at 132 teenagers with Tourette syndrome to understand how their brains and thinking skills change during adolescence. Researchers used brain scans (MRI), magnetic pulses (TMS), and computer tests to measure brain connections, control, and decision-making. The go…

This study looked at 85 people with tremor conditions like Parkinson's disease, essential tremor, and dystonia, plus healthy volunteers. Researchers used tests like brain scans, electrical recordings, and movement tasks to learn how the brain controls movement and what goes wrong…

This study uses advanced brain imaging and non-invasive stimulation to understand how the brain changes in the early stages of Parkinson's disease. Researchers will compare people with early Parkinson's (not yet on medication) to healthy volunteers of similar age and sex. The goa…

This study follows 61 people who previously used the REVISYON SDS 100 device for mild-to-moderate cataract. Researchers will check for side effects and measure vision changes over about 20 months. No new treatment is given; the goal is to see if the device stays safe and works we…

Some people develop an irregular heartbeat called atrial fibrillation after a stroke or mini-stroke. Researchers want to understand what causes this by comparing nerve function, inflammation, and heart rate patterns in three groups: patients with this post-stroke irregular heartb…

This study looks at whether falls and mobility problems can signal very early, preclinical Alzheimer's disease in older adults who are still cognitively normal. Researchers will follow 355 volunteers aged 65 and older, some with and some without biological signs of Alzheimer's, t…

This study looks at how common sleep breathing problems are in children with cerebral palsy across the UK, and how often they use breathing support like CPAP machines. Researchers will track new cases over a year and explore what helps or hinders access to care. The goal is to im…

This early-phase study tested whether ferumoxytol, an iron-based contrast agent, can help MRI scans better detect inflammation in the brains of people with multiple sclerosis (MS). Fourteen participants (some with MS, some healthy) received a single IV dose of ferumoxytol and had…

Researchers are studying whether daily step counts and other smartwatch measurements can predict which cancer patients will be readmitted to the hospital after discharge. Adults who have just left an oncology ward wear a Huawei smartwatch for 30 days to track steps, heart rate, a…

This completed study followed 26 adults aged 55 and older with early age-related macular degeneration (AMD) or healthy eyes for up to 5 years. Researchers used eye exams, imaging, and vision tests to track changes in the retina and visual function. The goal was to better understa…

This completed study from the National Institute of Neurological Disorders and Stroke aimed to better understand how the brain controls movement and what goes wrong in movement disorders like Parkinson's disease, Tourette's syndrome, and dystonia. Over 1,200 adults—both patients …

Researchers are analyzing records from about 180,000 people who received cochlear implants in China between 1995 and 2026. The study aims to map how severe hearing loss and implant use have changed over time, how age and gender patterns look, and how patients move between provinc…

This study looks at whether a parent coaching and family navigation program (Project AFECT) can help families right after a child is diagnosed with autism. About 200 parents of children aged 1 to 5, who are Hispanic/Latino, Black/African-American, or have Medi-Cal insurance, will…

This study explores whether artificial intelligence can simplify the language used in informed consent forms for clinical trials. Researchers will test AI tools like ChatGPT and NotebookLM to rewrite these forms and see if people understand them better. The study involves 230 par…

This completed study looked at how well different eye tests can track changes in retinitis pigmentosa (RP), a group of blinding eye diseases. Researchers tested 49 people with RP and healthy volunteers using exams like vision tests, retinal imaging, and electrical signal recordin…

This study looked at whether high-intensity interval training (HIIT) or weight-loss surgery can reduce the risk of nerve damage (peripheral neuropathy) in people with obesity. About 140 adults who were candidates for bariatric surgery took part. Researchers measured nerve health …

This study followed 76 children with brain tumors to learn how radiation therapy affects their quality of life, thinking, and body functions over time. Researchers collected blood, urine, and MRI scans before and after treatment, along with tests of memory, behavior, vision, and …

Researchers are studying blood and tumor tissue from people with squamous cell cancer of the larynx, pharynx, or oral cavity who have no history of smoking, heavy drinking, or workplace exposure to substances like asbestos or wood dust. The goal is to learn how DNA changes and bi…

Researchers at Hacettepe University are studying people who had surgery for a massive rotator cuff tear. They want to see how the brain's signals to shoulder muscles, shoulder function, and psychological resilience relate to each other. Participants complete shoulder and mood que…

Researchers are observing how two osmotic therapies, 20% mannitol and 10% hypertonic saline, affect outcomes in adults with severe subarachnoid hemorrhage, a type of bleeding around the brain. The study follows patients at multiple hospitals who receive standard care chosen by th…

This study tests whether wearable sensors and caregiver questionnaires can capture the behavioral signs of apathy in people with dementia during daily life. Patients with Alzheimer's or frontotemporal dementia and their caregivers wear a sensor bracelet for 28 days, while caregiv…

This completed study looked at how the social networks of caregivers affect their stress and health when caring for someone with an inherited disease. Researchers surveyed over 680 participants, including family members and formal caregivers, to understand caregiving burden and s…

This completed study enrolled 377 individuals and families with a high risk of breast or ovarian cancer due to known or suspected genetic factors. Researchers collected medical records, questionnaires, and biological samples to better understand the disease's natural history and …

This study aimed to understand the brain and genetics behind autism spectrum disorders (ASD). Researchers compared brain scans, thinking tests, and DNA from 678 people with ASD, healthy volunteers, and their parents. The goal was to find links between brain activity, behavior, an…

This study used PET scans to look at dopamine and blood flow in the brains of 502 people, including healthy volunteers and those with Parkinson's disease or schizophrenia. The goal was to understand how these conditions affect brain function and to compare inherited versus non-in…

This study looked at whether standard radiation treatment for cancer that has spread to the brain causes changes in thinking skills like memory and attention. 35 adults with brain metastases received radiation and took tests and surveys before and after treatment. The goal was to…