Tropical spastic paraparesis
MONDO:0008039Tropical spastic paraparesis is a chronic systemic immune-mediated inflammatory myeloneuropathy, more frequently reported in women than in men, that usually presents in adulthood with slowly progressive spastic paraparesis of the lower limbs, bladder and bowel dysfunction, and sensory disturbances in the lower extremities (e.g. paresthesia and dysesthesia) and that is associated with a human T-cell lymphotropic virus type 1 (HTLV-1) infection.
Also known as: HAM/TSP, HTLV-1-associated myelopathy/tropical spastic paraparesis, Human T-lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis, Human T-lymphotropic virus type-1-associated myelopathy/tropical spastic paraparesis, TSP, ham/TSP, tropical spastic paraplegia, HTLV-1 associated myelopathy/tropical spastic paraparesis
6 clinical trials for this condition and its sub-types, 3 tagged with Tropical spastic paraparesis itself.
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Supercharged donor cells take on viruses after transplant
Disease control Recruiting nowThis study tests whether specially grown donor immune cells (viral-specific T-cells) can safely treat viral infections that often occur after a stem cell transplant. These infections can be serious and sometimes don't respond to standard antiviral drugs. The approach aims to boos…
Phase 1/2 • Sponsor: Children's Hospital Medical Center, Cincinnati • Aim: Disease control
Last updated Sep 06, 2026 00:00 UTC
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Can donor cells stop viruses after transplant?
Disease control Recruiting nowThis study tests whether giving patients donor-derived immune cells (VSTs) on a regular schedule can prevent dangerous viral infections after a stem cell transplant. 180 participants will be randomly assigned to receive VSTs either on a fixed schedule or only when a virus is dete…
Phase 2 • Sponsor: Children's Hospital Medical Center, Cincinnati • Aim: Disease control
Last updated Sep 06, 2026 00:00 UTC
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Could an MS drug tame a rare Virus-Caused paralysis?
Disease control Recruiting nowThis study tests whether teriflunomide, a drug already used for multiple sclerosis, can help people with a rare spinal cord disease called HAM/TSP caused by the HTLV-1 virus. About 24 adults will take the drug daily for 9 months to see if it reduces harmful immune activity and im…
Phase 1/2 • Sponsor: National Institute of Neurological Disorders and Stroke (NINDS) • Aim: Disease control
Last updated Jun 27, 2026 14:01 UTC
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Can a two-drug combo beat the HTLV-1 virus?
Disease control Recruiting nowThis Phase 2 trial compares the drug dolutegravir alone versus dolutegravir combined with tenofovir in 146 adults with HTLV-1 infection and related symptoms. The main goal is to see if the combination lowers the virus level more effectively and improves pain, spasticity, and musc…
Phase 2 • Sponsor: Carlos Brites • Aim: Disease control
Last updated Jun 27, 2026 13:00 UTC
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Scientists launch Long-Term study to unravel rare spinal disease caused by a virus
Knowledge-focused Recruiting nowThis study follows people infected with HTLV-I virus, some of whom develop a rare spinal cord condition called HAM/TSP. Researchers will track changes in symptoms, immune system markers, and virus levels over time. The goal is to better understand why only a few infected people g…
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS) • Aim: Knowledge-focused
Last updated Sep 18, 2026 00:00 UTC