Nervous system disorder

Researchers are testing an experimental therapy called SRN-101 in adults with recurrent high-grade glioma, an aggressive brain cancer that has returned after standard treatment. Participants receive SRN-101 directly into the tumor before planned surgery to remove it. The trial's …

Researchers are testing an experimental oral drug called PRO-1562 in healthy adults and in adults with relapsing multiple sclerosis who also have long-term vision damage from chronic optic neuropathy. The trial has two parts: a phase 1 safety and absorption study in healthy volun…

This trial tests a therapy called CTX112 in adults with severe neurologic autoimmune diseases, including progressive multiple sclerosis, neuromyelitis optica, and stiff-person syndrome. CTX112 uses donor T cells edited with CRISPR to target and deplete B cells, which are thought …

Researchers are testing whether an educational and implementation tool helps hospitals follow best-practice guidelines for preventing second strokes caused by heart conditions. The trial enrolls about 2,400 patients who have had an ischemic stroke or a transient ischemic attack. …

Researchers are observing how satisfied people with relapsing-remitting multiple sclerosis are when they receive ocrelizumab as an injection under the skin instead of an intravenous infusion. The study follows about 1,800 participants across multiple countries for 12 months, incl…

This trial is testing an experimental eye gel called BETA-TT8 for people with wet age-related macular degeneration (AMD), a condition that causes rapid vision loss. The gel is applied to the eye up to three times daily for 12 weeks, and standard injections remain available if nee…

This trial tests an experimental drug called SFL-0821 in adults with facioscapulohumeral muscular dystrophy (FSHD), a genetic condition that causes progressive muscle weakness. Researchers give the drug by intravenous infusion, either once or multiple times, and compare it agains…

This phase 2 trial is testing whether the drug ivonescimab can help control advanced or metastatic adrenal cancers, specifically adrenocortical carcinoma (ACC) and pheochromocytoma/paraganglioma (PPGL), that have not responded to prior treatment. About 20 adults with these rare c…

This trial tests whether a smartphone app can enhance parent management training (PMT) for children aged 8 to 13 with disruptive behavior disorders, such as conduct disorder or ADHD. Parents receive 12 weekly PMT sessions, and half also use a digital tool with videos, a resource …

Researchers are testing a new immunotherapy called Lm-LLO-TT in adults with advanced pancreatic ductal adenocarcinoma that has already been treated with chemotherapy. Lm-LLO-TT uses a weakened form of Listeria bacteria engineered to carry a tetanus toxoid antigen, aiming to spark…

This early study tests a new, noninvasive laser treatment called Nano-Pulsed Laser Therapy (NPLT) for people with moderate to severe traumatic brain injury (TBI). The goal is to see if the treatment is safe and can be given soon after injury. Researchers will also check if the la…

This trial tests whether efgartigimod, a drug that lowers harmful antibody levels, can improve recovery in people with Guillain-Barré syndrome (GBS), a rare nerve condition that can cause weakness and paralysis. Adults aged 18 to 70 with recent GBS onset will receive either efgar…

Researchers are testing an experimental oral drug called ONO-2808 in adults with the Parkinsonian subtype of multiple system atrophy (MSA-P), a rare and progressive brain disorder. The phase 3 trial enrolls about 486 people in the early stages of the disease, within five years of…

Researchers are testing a new way to deliver antibiotics to the brain in people with moderate to severe bacterial meningitis who are not improving on standard intravenous treatment. The approach combines standard IV antibiotics with a continuous infusion of three antibiotics (van…

This phase 2 trial is testing whether a lower dose of the immunotherapy drug nivolumab, given less often, can still control cancer in people with various advanced or metastatic cancers. The goal is to see if a cheaper, more accessible regimen works as well as the standard high-co…

Researchers are testing a one-time CAR-T cell therapy called C-CAR168 in adults with progressive multiple sclerosis that has not responded to standard treatments. The therapy uses a patient's own immune cells, engineered to target two proteins, and is given as a single intravenou…

This study will test whether living in a self-contained, AI-managed community (called a Microcity) can improve mental health and reduce addiction in adults with conditions like autism, ADHD, substance use disorders, and behavioral addictions. Up to 1 million participants will liv…

This pilot study tests a procedure called left atrial appendage occlusion (LAAO) using the Watchman Flx PRO device in 40 dialysis patients with atrial fibrillation. The goal is to see if it safely reduces stroke and major bleeding compared to standard care. Participants will be f…

Guillain-Barré syndrome (GBS) is a rare condition where the immune system attacks nerves, causing weakness that can progress to paralysis. Standard treatment is intravenous immunoglobulin (IVIg), but recovery is often slow. This phase 2 trial tests whether adding an experimental …

This Phase 3 trial is testing whether adding lurasidone—a medication typically used for other mental health conditions—can help adults with major depressive disorder who haven't improved enough on an antidepressant alone. Participants will keep taking their current antidepressant…

This study tests whether a special low-calorie, plant-based diet taken for 5 days each month can safely improve blood flow to the brain in middle-aged adults who carry the APOE4 gene, which raises Alzheimer's risk. Forty participants aged 45-65 will be randomly assigned to either…

This study tests a liquid form of the seizure drug zonisamide in children aged 1 month to 17 years who have partial-onset seizures. The goal is to find the right dose and check for side effects. About 40 children will take the medicine for up to 12 weeks, with a follow-up visit o…

Researchers are testing whether adding a PCSK9 inhibitor to standard statin therapy can stabilize vulnerable plaques in the carotid artery, the main blood vessel to the brain. The trial enrolls 120 adults with carotid narrowing and high-risk plaque features. Participants receive …

Researchers are testing daraxonrasib, an experimental pill that blocks RAS proteins, in children with solid tumors that have come back or stopped responding to treatment. The tumors include neuroblastoma and rhabdomyosarcoma, and all carry RAS mutations. The trial has two parts: …

Researchers are testing whether GammaTile, a collagen tile embedded with radioactive cesium-131 seeds, can be safely placed in the brain after surgery for malignant glioma. The trial enrolls elderly or frail patients with newly diagnosed or recurrent tumors. The main goals are to…

This early-phase trial tests an experimental drug called NST-628 in adults with recurrent grade 4 glioma, an aggressive brain cancer. The study aims to see how well the drug enters the tumor and affects cancer-related proteins, as well as its safety. Participants take the drug be…

This study tests a drug called ADI-PEG 20, which breaks down an amino acid that some brain tumors need to grow. It is given alongside standard radiation and chemotherapy to children, adolescents, and young adults with newly diagnosed high-grade glioma. The goal is to see if this …

This study tests giving radiation therapy (SBRT) to the spine soon after surgery, while patients are still in the hospital, instead of waiting 2-4 weeks. The goal is to see if this faster approach is safe and helps control cancer growth in the spine. About 50 adults with cancer t…

Researchers compare two approaches for adults with small unruptured brain aneurysms found by chance: regular imaging surveillance without initial treatment, or immediate endovascular or surgical repair. The trial enrolls 600 adults aged 35 to 75 with aneurysms measuring 2 to 7.9 …

This early-stage study will test a new way of using deep brain stimulation (DBS) for Parkinson's disease. Instead of the usual constant high-frequency pulses, this 'Coordinated Reset' approach uses lower-power, patterned stimulation. Researchers want to see if it's safe and can i…

This early-stage trial is testing an investigational injection called GT802 in people with relapsing or refractory multiple sclerosis (MS) — meaning their disease is active despite standard treatments. The study aims to check whether GT802 is safe and to get a first look at wheth…

Researchers are testing an experimental eye injection called GenSci148 in people with neovascular age-related macular degeneration (nAMD), diabetic macular edema (DME), and retinal vein occlusion (RVO). GenSci148 is a fusion protein designed to block four proteins involved in blo…

Researchers are testing an experimental antibody called EA5 in adults with generalized myasthenia gravis whose blood contains antibodies against the acetylcholine receptor and who have not tried complement inhibitor drugs. EA5 targets complement protein C5, part of the immune cas…

Researchers are testing whether adding tirofiban to standard antiplatelet therapy improves recovery for people whose ruptured brain aneurysm is repaired with a stent. The trial enrolls adults with acute subarachnoid hemorrhage who receive stent-assisted coiling within 72 hours of…

This pilot study tests whether giving semaglutide (Ozempic) to 100 stroke patients who had a clot-removal procedure can improve recovery. Patients are randomly assigned to receive weekly injections for 12 weeks or no drug. The main goal is to see if a larger, definitive trial is …

This study tests whether combining a gentle nerve stimulation device worn on the ear (taVNS) with intensive arm therapy (CIMT) can help infants and toddlers (8–24 months) with perinatal brain injury improve movement in their weaker arm and hand. The therapy involves placing a mit…

This early-stage study tests a genetically-modified pig liver used outside the body to temporarily take over liver functions for people with acute-on-chronic liver failure. About 20 adults who are not eligible for a transplant will receive this treatment for a short time. The goa…

Researchers are testing an experimental antibody called SZN-8141 in people with diabetic macular edema, a swelling of the retina that can blur vision. About nine participants will each receive a single injection of SZN-8141 into the eye, with small groups getting increasing doses…

This study looks at the best way to switch children with Dravet or Lennox-Gastaut syndrome from artisanal (non-pharmaceutical) cannabidiol to Epidiolex, an FDA-approved CBD medication. About 25 children aged 2 to 18 will gradually increase their Epidiolex dose while reducing thei…

This phase 2 trial tests the safety of belzutifan, a daily oral tablet, in adolescents with rare solid tumors that cannot be surgically removed or have spread. The study includes three tumor types: pheochromocytoma/paraganglioma (PPGL), wild-type gastrointestinal stromal tumors (…

Researchers are testing an experimental drug called OLN324 against ranibizumab, a standard treatment for wet age-related macular degeneration (nAMD). The trial enrolls about 400 adults aged 50 and older who have not yet received treatment for active wet AMD in the study eye. Part…

Researchers are testing an experimental drug called OLN324 against the standard treatment, aflibercept, in adults with wet age-related macular degeneration. About 500 people aged 50 and older who have not yet received treatment for this condition will take part. Both drugs are gi…

Researchers are testing whether low-dose colchicine, an anti-inflammatory drug, can slow the decline in function caused by ALS. The trial enrolls 87 adults with ALS who already take riluzole, the standard treatment. Participants receive colchicine or a placebo for 30 weeks, then …

Researchers are studying how stable the RayOne RAO800S intraocular lens is after cataract surgery. The lens replaces the eye's cloudy natural lens and has marks to help surgeons position it. Adults scheduled for cataract surgery in both eyes receive the lens as part of routine ca…

This study tests a new treatment called Cerebraca Wafer for people with recurrent glioblastoma, a serious brain cancer. The wafer is placed in the brain during surgery and is followed by standard chemotherapy. The goal is to see if it helps people live longer and controls the dis…

This trial tests an experimental drug called VIS-101, given as an injection into the eye, for people with wet age-related macular degeneration (AMD), a leading cause of vision loss. Researchers compare two doses of VIS-101 against aflibercept, a standard treatment, to see if VIS-…

This pilot study will test whether deep brain stimulation (DBS) can help people with schizophrenia who still hear voices and have delusions despite trying multiple medications. Fifteen adults will have electrodes placed in a brain region linked to schizophrenia symptoms. The goal…

This phase 2 trial explores whether fecal microbiota transplantation (FMT) is safe, tolerable, and practical for adolescents aged 13–17 with ADHD. Participants receive oral FMT capsules after bowel prep, alongside antibiotics, to see if changing gut bacteria can influence ADHD sy…

This trial tests whether dexmedetomidine or propofol, two sedatives used in intensive care, better controls pressure inside the skull after a traumatic brain injury. Researchers will measure pressure indirectly using ultrasound of the optic nerve sheath and check blood levels of …

Researchers are testing whether a higher dose of proton beam therapy can normalise hormone levels better than standard radiotherapy in people with functioning pituitary tumours, including acromegaly and Cushing's disease. Participants receive about six weeks of either standard-do…

This trial tests whether sitagliptin, a common diabetes drug, can delay motor progression in people with early-stage Parkinson's disease. Participants take sitagliptin or a placebo daily for 72 weeks. Researchers measure the time until a confirmed increase in Parkinson's motor sy…

Researchers are testing an investigational oral drug called catequentinib hydrochloride (AL3818) in adults with advanced or metastatic endometrial cancer, low grade serous ovarian cancer, soft tissue sarcoma, or glioblastoma. The trial has two parts: a phase 1b part to find safe …

This study tests whether the experimental drug tazbentetol can slow the progression of ALS, a disease that weakens muscles and affects movement. About 430 adults with ALS will receive either the drug or a placebo. The main goal is to see if tazbentetol helps maintain daily functi…

Researchers are testing an experimental treatment called AB126, made from neural exosomes, in adults who have had a moderate to severe acute ischemic stroke and who showed limited improvement after a procedure to clear the blocked blood vessel. The trial aims to find out whether …

This study tests a community-based exercise program for people aged 50 and older who have at least two chronic conditions, such as heart disease, diabetes, arthritis, or obesity. The program is designed to improve muscle strength, heart and lung fitness, and overall well-being. R…

This trial compares two anesthetics, ciprofol and propofol, given during surgery to remove brain tumors that raise pressure inside the skull. The goal is to see whether ciprofol reduces common post-surgery problems like confusion (delirium) and stroke. About 434 adults scheduled …

Researchers at Yale are studying whether a prescription app called Rejoyn, which provides cognitive behavioral therapy exercises, can be a useful addition to standard depression treatments like TMS or esketamine. The study will enroll 50 adults with major depressive disorder who …

Some newborns with HIE, a brain injury from lack of oxygen at birth, also develop heart problems. This pilot trial tests whether starting a heart medication called dobutamine early, before heart failure signs appear, is feasible and safe. Forty babies receiving cooling therapy wi…

This trial tests whether adding metformin, a common diabetes drug, to standard Parkinson's treatment improves motor symptoms and reduces levels of harmful proteins and oxidative stress markers in the blood. Researchers will compare Parkinson's patients aged 50 to 70 who receive m…

This early-phase study tests a new treatment for children and young adults with aggressive brain tumors called high-grade glioma and DIPG. The therapy uses the patient's own immune cells, modified in a lab to better recognize and attack tumor cells. The main goals are to see if t…

This early-phase trial tests a new type of immunotherapy for adults with brain metastases from various cancers. The treatment uses the patient's own immune cells, modified to better target and attack tumor cells. The main goals are to see if the approach is safe and feasible in 1…

Researchers are testing a treatment for melanoma that has spread to the liver. They collect tumor-infiltrating lymphocytes, a type of immune cell, from the patient's own tumor and grow them in the lab. Before returning the cells, they use a technique called percutaneous hepatic p…

This early-stage trial tests whether immune cells taken from a patient's own tumor (TIL) can be safely given directly into the liver or through a vein to fight metastatic melanoma. 18 adults with advanced uveal or cutaneous melanoma that has spread will receive TIL along with che…

This trial tests whether transcranial magnetic stimulation (TMS) aimed at a brain circuit linked to the subgenual anterior cingulate cortex can reduce depression symptoms. Adults with major depressive disorder or persistent depressive disorder will receive either active or sham T…

This study tests adding a new drug, iberdomide, to standard chemoimmunotherapy for children and young adults (ages 1-30) whose neuroblastoma has returned, not responded, or worsened after prior treatment. The goal is to see if the combination is safe and works better at controlli…

Researchers are testing low-dose interleukin-2 (IL-2), an immune signaling protein, in adults with neuromyelitis optica spectrum disorder (NMOSD), a condition where the immune system attacks the optic nerves and spinal cord. The trial enrolls about 60 people aged 18 to 74 who rec…

This study will test hyperbaric oxygen therapy (HBOT) — breathing pure oxygen in a pressurized chamber — for over 30 conditions, including long COVID, Crohn's disease, frostbite, and multiple sclerosis. Researchers will track 100 patients to see if HBOT improves their quality of …

This study is for adolescents and young adults (ages 12-39) newly diagnosed with aggressive brain tumors called high-grade glioma or DIPG. The goal is to see if a combination of two immunotherapy drugs (relatlimab and nivolumab, sold as Opdualag) is safe and tolerable when given …

This trial tests a brain stimulation technique called sequential dual-site accelerated theta burst stimulation (SD-aTBS) in adults with schizophrenia who have cognitive impairment. The treatment targets two brain networks involved in thinking and memory. Researchers will compare …

This pilot study tests whether a structured care program called CARIBOU can reduce depressive symptoms in adolescents aged 15 to 18 with major depression. The program combines cognitive behavioral therapy, caregiver support, and medication management when needed, all coordinated …

This study investigates whether Shugan Jieyu Capsules, a traditional Chinese herbal medicine, can effectively treat depression of varying severity in everyday clinical practice. Researchers will follow 400 patients aged 13-65 with depression, giving them the capsules alone or alo…

This study tests the long-term safety of vonaprument, an experimental drug given as an injection into the eye, for people with geographic atrophy, a severe form of dry age-related macular degeneration that causes blind spots. Researchers will monitor participants who completed an…

This pilot study tests whether electroconvulsive therapy (ECT) can improve thinking and memory in people with Alzheimer's disease. ECT is a procedure that uses electrical stimulation to trigger a controlled seizure under anesthesia, and it is already used for severe depression. R…

This trial tests whether two types of talk therapy, Acceptance and Commitment Therapy (ACT) and Cognitive Behavioral Therapy (CBT), can ease depression and related issues better than usual care in people who have major depression and are facing marital crisis. About 120 adults wi…

This study compares two types of walking exercise—nordic walking (using poles) and treadmill training—to see which better improves walking symmetry in children aged 6-10 with unilateral cerebral palsy (weakness on one side). Both groups also receive standard physical therapy. The…

This study tests whether combining non-invasive light therapy on the head, electrical stimulation cycling for the arms, and cognitive tasks can improve thinking and arm movement in adults who have had a stroke. Participants attend 10 sessions over 2 weeks, and researchers measure…

This early-stage trial tests whether a daily supplement called HMB (beta-hydroxy-beta-methylbutyrate) is safe and can lower certain blood markers linked to ALS. One hundred adults with ALS will take 3 grams of HMB daily. Researchers will track changes in blood markers and functio…

This trial tests an experimental oral drug called DES-1357 in adults with metastatic colorectal cancer that has specific genetic features (dMMR or MSI-H). The study runs in three parts: first, to find a safe dose; second, to check tolerability and early signs of tumor shrinkage; …

This phase 2 trial is testing whether an experimental drug called BMS-986511 can reduce symptoms of major depressive disorder in adults. Participants with moderate to severe depression will receive either the drug or a placebo, and researchers will track changes in depression sco…

Researchers at UC San Diego are testing whether a computer-based working memory training session, done right before a brief exposure exercise, can improve fear extinction learning in adults with social anxiety disorder. Participants will be randomly assigned to either the working…

This trial tests whether a type of brain stimulation called accelerated deep transcranial magnetic stimulation (dTMS) can help reduce weight gain caused by antipsychotic medications in people with schizophrenia. Participants receive either real or sham stimulation after being exp…

This trial tests whether a gentle electrical earpiece, worn twice daily for two weeks, can reduce brain swelling caused by radiation necrosis. The device stimulates a nerve in the ear to calm inflammation. Forty people with brain tumors who need a laser procedure will be randomly…

This study tests a non-invasive laser treatment called photobiomodulation for people with early age-related macular degeneration (AMD) who have a specific type of deposit in the eye called reticular pseudodrusen. The treatment uses low-energy light to stimulate cells and reduce i…

This study tests whether a 12-week program of supervised exercise, Mediterranean diet education, and stress management workshops can improve health in 120 overweight or obese adults. Participants will wear a smart bracelet to track activity and sleep. Researchers will measure cha…

This trial tests whether giving adolescent girls a daily multiple micronutrient supplement (with or without extra nutrients) improves their growth, brain function, bone health, and overall well-being compared to the standard weekly iron-folic acid pill. About 3,000 girls aged 10–…

This trial investigates whether adding early lumbar drainage to standard care (a drain in the head plus clot-dissolving medication) improves long-term outcomes for people with bleeding into the brain's fluid-filled spaces. The study includes adults aged 18 to 85 who have had a fi…

This trial tests a rehabilitation technique called blood flow restriction training (BFRT) in adults on ventilators who develop ICU-acquired weakness, a condition of severe muscle loss. BFRT uses an inflatable cuff on the upper leg to partially restrict blood flow during low-inten…

Researchers are testing whether MRI-guided high-intensity focused ultrasound can safely reduce seizures in adults with generalized epilepsy that does not respond to medication. The procedure uses sound waves to precisely target and ablate a small brain region involved in seizure …

This trial tests whether a brief counseling session followed by an 8-week smartphone program can help rural adults who drink heavily and live with chronic pain. Participants are recruited online and complete all study steps through videoconferencing. After a first assessment, the…

This study asks whether tapering and stopping certain psychotropic medications before intensive trauma-focused psychotherapy helps people with PTSD more than continuing those medications during therapy. Researchers will compare patients treated under a new medication-review polic…

This trial tests a computer-based training method designed to improve stereo vision, or depth perception, in adults with conditions like amblyopia (lazy eye) or strabismus (misaligned eyes). Participants aged 18 to 39 with impaired depth perception will be randomly assigned to ei…

This study tests a smoking cessation program designed for veterans who have chronic pain. Participants receive counseling over the phone plus nightly automated calls to report their smoking and pain levels. The goal is to see if this approach helps more veterans quit smoking comp…

This trial tests whether adding a procedure called expansile duraplasty — opening and expanding the tough membrane around the spinal cord — to standard spinal surgery can improve neurological recovery in adults with acute severe spinal cord injury. Participants are randomly assig…

This trial is testing whether a 10-week course of fluconazole works as well as the standard 24-week course for people with HIV who have a cryptococcal infection in their blood (antigenemia) but no symptoms. It also compares starting HIV medications right away versus waiting 14 da…

This trial tests whether a granule form of the Chinese herbal formula Huayu Jiedu (FTFY-919) works as well as the traditional decoction for people with acute hypertensive intracerebral hemorrhage, a type of stroke caused by bleeding in the brain. About 300 adults who have had a b…

This study follows 250 Chinese adults with schizophrenia who are prescribed KarXT, a combination of xanomeline and trospium chloride. Over 17 weeks, researchers observe how doctors use the drug, how well patients stick with it, and what side effects occur. The goal is to see if K…

This trial tests whether a procedure to reopen a blocked carotid artery in the neck can improve cognitive function in people who have had a stroke or mini-stroke and now have thinking or memory problems. Participants are randomly assigned to receive standard medical care alone, o…

This study tests a drug called ocrelizumab in children and teens aged 10 to 17 with relapsing-remitting multiple sclerosis (MS). The goal is to see how the drug moves through the body, if it is safe, and how it affects the immune system. Participants will receive the drug as a sh…

This early-stage trial is testing an investigational drug called RO7845860, given as an injection under the skin, in people with relapsing multiple sclerosis (MS). The main goals are to check the drug's safety, how the body handles it, and its effects on immune cells. The study w…

This trial tests whether treadmill training with a robotic cable that gently pulls walkers side-to-side can improve balance and daily walking in adults who had a stroke. Participants complete 20 high-intensity treadmill sessions, either with the robotic pulling forces or without …

Researchers are testing whether a personalized form of brain stimulation can ease symptoms in people with anxiety disorders that have not improved with standard treatments. The approach uses a device to deliver rapid magnetic pulses to specific brain circuits, guided by each pers…

This trial tests whether adding behavioral activation therapy to intravenous ketamine helps people with treatment-resistant depression more than ketamine alone. Adults aged 18 to 65 who have not improved with at least two antidepressants will receive ketamine infusions twice week…

This trial tests whether an 8-week upper-limb resistance training program can improve cardiovascular autonomic function in adults with chronic spinal cord injury. Participants are randomly assigned to either supervised arm exercises three times per week or a control group. Resear…

Researchers at the University of South Florida are testing whether a daily probiotic fermented milk drink can improve gut health and reduce inflammation in people with Alzheimer's disease and related dementias, as well as their caregivers. The study will give 40 participants eith…

This study tests whether adding stem cells to standard cooling therapy helps newborns with brain injury from lack of oxygen at birth. Forty infants will receive either stem cells from donated placentas or a placebo. Researchers will track death and developmental delays for up to …

This trial compares three common anesthetics, ciprofol, propofol, and sevoflurane, to see which one best prevents delirium, a sudden state of confusion and memory problems, in older adults after brain tumor surgery. About 381 people aged 65 to 90 will be randomly assigned to rece…

This study tests whether combining two drugs—ASTX727 (a pill) and retifanlimab (given through a vein)—can shrink tumors and control advanced Merkel cell cancer in people whose disease has worsened after standard immunotherapy. About 31 adults with stage III or IV Merkel cell canc…

This pilot trial tests two online parenting programs designed for parents who struggle with anger and conflicts with their children. One program teaches standard behavioral parenting strategies, while the other adds emotion regulation techniques to help parents manage their own r…

This pilot study tests whether stroke survivors can follow a self-managed exercise program at home to maintain their health. Participants first complete an 18-session guided program with respiratory, strengthening, and cardiovascular exercises, plus weekly virtual coaching sessio…

This trial tests whether NVG-291, an investigational peptide, can improve hand function and daily activities in adults with chronic cervical spinal cord injury. Participants receive either NVG-291 or a placebo by daily injection under the skin for 12 weeks. Researchers measure ch…

This study tests a new, simple procedure done right after doctors remove a blood clot from the brain in severe stroke patients. The procedure involves briefly inflating and deflating a tiny balloon to gently restore blood flow, which may prevent extra brain damage. About 288 to 4…

This study compares two methods to remove large blood clots from the brain during a stroke: using a super large suction catheter versus a stent retriever. About 708 adults with acute ischemic stroke will be randomly assigned to one of the two techniques. The goal is to see which …

This trial compares two models of doula support for pregnant people on Medicaid in North Central Florida. One group receives enhanced support that starts earlier in pregnancy, happens more often, and continues through the first year after birth. The other group receives standard …

This trial tests a personalized approach to maintaining improvement in people with treatment-resistant depression. Participants who previously responded to a type of brain stimulation called iTBS will receive maintenance stimulation scheduled by a symptom-based algorithm, along w…

This trial tests whether daily seated cycling, started within two days of spinal surgery, can improve recovery in people with a mild spinal cord injury. Researchers will compare 107 participants who cycle for 30 minutes each day during their hospital stay with a similar group who…

This trial tests whether an experimental drug called JZP926 can safely reduce the number of days people aged 10 and older experience myoclonic seizures—brief, shock-like jerks—due to juvenile myoclonic epilepsy. Participants are randomly assigned to receive either JZP926 or a pla…

Autistic children in the emergency department often miss full vital sign checks because standard equipment can be distressing. This pilot study randomizes 100 children aged 2 to 17 to have their heart rate, breathing, oxygen and temperature measured either with wireless wearable …

Many people with diabetes skip regular eye exams, even though early treatment can prevent vision loss. This pilot study tests whether offering retinal photography during routine occupational health visits makes screening easier to access. Workers with diabetes attend one visit wh…

Researchers are testing whether adding a brain-injury blood test to standard clinical guidelines can safely reduce the number of brain CT scans ordered for adults who come to the emergency department with a suspected head injury. The blood test measures two proteins, GFAP and UCH…

This trial tests a new AI device that helps surgeons see brain tumors on ultrasound images during surgery. The AI highlights tumor tissue in real time, which may help remove more of the tumor while protecting healthy brain. The study involves 100 adults scheduled for brain tumor …

Researchers are testing whether a minimally invasive electrode placed under the scalp, called subgaleal EEG, can detect seizures as well as the standard approach that places electrodes inside the brain. The study enrolls 15 adults with drug-resistant epilepsy who are already sche…

This study explores whether artificial intelligence can help emergency department doctors identify depression and anxiety in patients. Researchers will record 30 adult patients' facial expressions and voice tones as they read a story, and then use AI to analyze those recordings. …

Researchers at Al-Nahrain University are developing a new clinical score called fREMS to predict the risk of dying in the hospital for patients with traumatic brain injury. The score combines the FOUR score, which measures consciousness, with physiological and clinical factors fr…

Researchers are studying whether two bedside ultrasound techniques can help emergency doctors identify traumatic brain injury patients at risk of getting worse within 24 hours. The study enrolls 60 adults with acute traumatic brain injury and a low Glasgow Coma Scale score who ar…

This study tests a wearable insole and ankle device that measures walking patterns to detect early cognitive decline in older adults. Researchers will collect gait data from 150 participants—some healthy, some with mild cognitive impairment or dementia—first in a lab and then dur…

Researchers are checking whether an Indonesian version of the Oxford Cognitive Screen-Plus accurately measures thinking skills in people who have had a stroke. The study enrolls 75 adults who can read and speak Indonesian and are in the subacute or chronic phase after stroke. Par…

Researchers are checking whether a Turkish translation of the Parkinson Neuropsychometric Dementia Assessment (PANDA) gives consistent and accurate results in people with Parkinson's disease. About 100 Turkish-speaking patients will complete the questionnaire, which tests memory,…

Many cancer trials require patients to have specific molecular markers, so researchers test large numbers of people to find the few who qualify. This study evaluates FATHOM, an AI system that reads clinical trial records and routine tumor slides to predict which patients carry th…

Carotid endarterectomy removes plaque from the neck artery, and surgeons clamp the artery briefly during the operation. In awake patients, doctors check hand strength and speech to decide if a shunt is needed. This study tests whether a forehead sensor that measures brain oxygen …

Hydrocephalus is often treated with a shunt that drains excess fluid from the brain, but shunts can stop working and checking flow usually requires imaging or invasive tests. This study compares two noninvasive thermal sensors placed on the skin over the shunt: the investigationa…

Researchers at Assiut University are studying whether three different tests, a blood marker called GFAP, a brain MRI scan, and a brain wave recording (EEG), can together help doctors tell normal aging, mild cognitive impairment, and dementia apart. The study enrolls 75 adults age…

Researchers at the University of Wisconsin, Madison are testing a decision-support tool that helps primary care providers talk with patients about blood biomarker testing for Alzheimer's disease. The tool is a flowchart that gives clear information about the Phospho-Tau blood tes…

Gliomas are the most common primary brain tumors in adults, and knowing whether a tumor is low-grade or high-grade before surgery guides treatment and prognosis. Currently, doctors need a tissue sample from surgery or biopsy to grade a glioma, and standard MRI scans often cannot …

Researchers at University Hospital Olomouc are studying whether a standardized driving simulator can detect differences in driving performance among people with Parkinson's disease, people with multiple sclerosis, and healthy drivers. About 100 participants with a valid driver's …

This study tests whether a radioactive tracer called [18F]fluorodeprenyl-D2 can make chronic active lesions visible on PET scans in people with multiple sclerosis. These lesions are areas of ongoing brain inflammation that standard MRI often misses. Researchers will compare the P…

This study tests whether a special PET-CT scan using a drug called evuzamitide can detect signs of cardiac amyloidosis in people whose standard heart scans were unclear but who have high levels of a blood marker called TAD1. About 25 adults with heart failure or a genetic risk fo…

This observational study will enroll 440 Danish-speaking adults over 50 to see if an artificial intelligence model can detect dementia and mild cognitive impairment from speech recordings. Participants will complete standard cognitive tests and describe a picture while being reco…

This trial tests whether a bedside ultrasound of the eye can reliably detect raised pressure inside the skull, a condition that can damage the brain if not treated quickly. Researchers will measure the optic nerve sheath diameter in adults suspected of having high brain pressure …

This trial tests whether non-geneticist doctors in Ontario can order genome-wide sequencing for patients with suspected rare genetic diseases. The goal is to see if this approach speeds up diagnoses and reduces the burden on genetic specialists. Researchers will track how often t…

This trial compares two imaging strategies—CT with CT angiography versus MRI with MR angiography—as the first test for people with suspected severe ischemic stroke. The goal is to see which approach is more cost-effective while still leading to good patient outcomes. Six hundred …

Researchers are testing an experimental vaccine called AV-1959R in adults aged 55 to 80 who have amyloid buildup in the brain but no memory or thinking problems. The trial compares the vaccine with a placebo to see whether it is safe, triggers an immune response, and lowers brain…

Researchers are testing a behavioral program that sends supportive text messages and offers small rewards to pregnant women who test positive for alcohol, tobacco, or cannabis use in South Africa. The program aims to reduce substance use during pregnancy and breastfeeding, which …

Researchers are testing whether a digital program that combines a smart bracelet and a mobile app can help people who have had an ischemic stroke avoid another one. The study enrolls adults who recently had a stroke and also have high blood pressure and diabetes. Half receive usu…

Researchers at a state hospital in Turkey are testing whether training an entire maternity unit in trauma-informed care changes the experience of childbirth. The program teaches hospital leaders, midwives, nurses, doctors, and support staff to communicate respectfully, protect wo…

Researchers in South Savo, Finland, invite residents turning 45, 50 or 55 to take a blood test that measures many small molecules at once. The test estimates each person's 10-year risk of type 2 diabetes, heart attack, stroke, chronic kidney disease and fatty liver disease. Peopl…

Researchers at Karolinska Institutet are testing a digital self-help tool called Preventox for patients discharged from intensive care after an intoxication or overdose. The tool lets patients set goals, track substance use, identify high-risk situations, and make a crisis plan. …

This phase 3 trial tests whether a homeopathic remedy called Stibium metallicum praeparatum 6x can prevent or reduce nerve damage caused by the chemotherapy drug paclitaxel. The study will include 120 breast cancer patients who will receive either the remedy or a placebo injectio…

This trial tests whether ticagrelor, an antiplatelet drug, can prevent stroke and delayed brain ischemia in people who have had a low-grade aneurysmal subarachnoid hemorrhage. Participants receive either ticagrelor or a placebo for 14 days, starting just before endovascular treat…

People with multiple sclerosis or neuromyelitis optica spectrum disorder who take anti-CD20 drugs have a higher risk of shingles. The shingles vaccine is recommended for them, but the drug may weaken its effect. This trial compares two dosing schedules: one gives the second shot …

This trial tests whether a head-mounted device delivering 40 Hz flickering light and pulsed sound can reduce the risk of postpartum depression in women having elective cesarean sections. Participants receive three 30-minute sessions starting after delivery, with a placebo group r…

This phase 2 trial tests whether a low dose of the steroid dexamethasone, given before the first four infusions of tebentafusp, can prevent cytokine release syndrome in people with advanced uveal melanoma. Tebentafusp is a standard first-line treatment for this eye cancer, but it…

This study looks at how to make HIV prevention pills (PrEP) easier for young people to get and keep using. Researchers will follow 1000 current or eligible PrEP users in Alabama and Botswana for 2 years. They will also create and test a decision-support toolkit to help patients a…

This study tests whether a digital program that combines cognitive behavioral therapy for insomnia with circadian rhythm coaching can prevent depressive symptoms from worsening in college students aged 18-24 who have trouble falling asleep and tend to be night owls. Participants …

This trial tests whether an AI-driven health management program can reduce the chance of a first ischemic stroke in adults at high risk. Participants in Beijing communities will be randomly assigned to either AI-supported care or usual community health services. The AI program us…

This pilot trial tests a two-hour educational workshop called SCREEN, designed to raise awareness of prostate cancer, its symptoms, and the benefits of early screening. The study enrolls men aged 18 to 79 who are not up to date with their prostate cancer screening. Researchers wi…

Researchers are testing whether transcranial magnetic stimulation (TMS) can improve social perception in adolescents with autism spectrum disorder. The trial targets the right posterior superior temporal sulcus, a brain region involved in processing social information. Sixteen pa…

Researchers are studying whether a broad-spectrum oral tincture containing CBD, CBN, and CBG changes anxiety symptoms in adults with generalized anxiety disorder. About 60 participants will take the tincture under the tongue or by mouth roughly every 12 hours for 8 weeks, with fo…

This early-phase trial tests whether giving adults with autism a 6-week course of vancomycin followed by a fecal transplant from a close relative can improve social and language problems. Ten participants will be tracked for changes in autism symptoms, quality of life, and gut he…

Researchers are testing whether a structured educational program based on Kolcaba's Comfort Theory can improve quality of life for adults with epilepsy. The program addresses physical, emotional, social, and environmental comfort needs through planned sessions delivered alongside…

This study compares three types of therapy for children aged 8 to 16.5 with severe irritability. Participants will receive either exposure-based cognitive behavioral therapy, parent management training, or supportive psychoeducation over 12 sessions. The goal is to see which appr…

This trial tests whether a single, two-hour online class called Empowered Relief can help American Indian adults with cancer-related pain. Participants learn three pain relief skills, create a personal plan, and get access to a free audio app for daily practice. The study aims to…

Researchers compare two rehabilitation approaches for children with cerebral palsy and immature brain injury: virtual reality training and task-oriented circuit training. Both aim to improve upper limb sensorimotor function, pinch grip, and quality of life. Forty-four children ag…

This study tests whether using a person's brain scan (MRI) to guide TMS treatment for depression works better than the standard scalp-measurement method. 160 adults with major depression will receive accelerated TMS (10 sessions a day for 5 days) with either MRI or scalp targetin…

Adults with sickle cell disease often face severe pain crises that require hospital treatment with intravenous morphine. This trial compares standard morphine treatment with combinations that add paracetamol, ketamine, or nefopam. Researchers want to see if these combinations eas…

Researchers at the University of Bergen are testing whether a two-week, self-guided smartphone screen time reduction program can reduce depression symptoms in young adults. The trial enrolls 200 students in Oslo who have sought help at the student mental health service. Participa…

Researchers at Tongji Hospital are testing a non-invasive brain stimulation technique called transcranial temporal interference stimulation (tTIS) in 26 people with Parkinson's disease. The study uses MRI scans to customize electrode placement so the stimulation reaches deep brai…

Researchers are testing whether older adults with high blood pressure who report insomnia can improve their sleep by pressing six acupoints on themselves each night for 28 days. The trial compares this self-acupressure routine with sleep hygiene training in 94 participants aged 6…

Researchers compare two exercise-based therapies for children with spastic cerebral palsy: virtual reality therapy and plyometric exercise training. The trial enrolls 44 children aged 12 to 18 who can stand alone and have mild to moderate mobility limits. Children in the virtual …

Researchers compare how people with paraplegia perform and feel about four daily tasks when using a self-balancing exoskeleton versus a manual wheelchair. Five participants attend daily sessions where they do tasks like making coffee or brushing teeth with each device. The study …

This pilot trial tests whether adding virtual pain neuroscience education to standard spinal cord stimulation can help chronic pain patients better manage their condition. The education teaches how the brain processes pain, aiming to reduce fear, anxiety, and catastrophizing. Par…

Researchers at Dana-Farber Cancer Institute are testing Healing Gardens, a mobile game that delivers pain-focused cognitive behavioral therapy and cancer pain education. The study enrolls 46 adults with advanced solid tumors who have chronic pain related to cancer or its treatmen…

Doctors insert a chest tube to drain air or fluid from around the lungs, but the procedure often causes severe pain. This trial compares two ultrasound-guided nerve blocks, the serratus anterior plane block and the erector spinae plane block, to see which one better controls pain…

This Phase 3 trial will test a web-based program called IMPACT for 250 veterans who have both opioid use disorder and chronic pain. The program includes 9 online modules and weekly feedback from a coach, all done from home. The goal is to see if it reduces how much pain interfere…

This study tests an online self-help tool called e-couch for adults with social anxiety. Over 5 weeks, 200 participants will use the program, which is based on cognitive behavioral therapy. Researchers will use surveys and computer tasks to predict who improves the most.

This study tests whether prucalopride, a drug used for gut issues, can improve thinking and memory in people with schizophrenia. About 34 adults will take the drug for 4 weeks while staying on their usual medications. Researchers will measure changes in memory, attention, and pro…

Researchers are testing whether a one-time injection of an experimental drug called paliroden into the middle ear is safe and can help adults with chronic, constant tinnitus in both ears. Participants, ages 18 to 75, have normal hearing thresholds but struggle to understand speec…

Researchers test whether adding lumateperone to ongoing antidepressant treatment reduces emotional blunting in adults with major depressive disorder. Emotional blunting means feeling numb or unable to experience pleasure or sadness. Thirty participants who score high on the Oxfor…

Researchers are testing whether a dietary supplement called KA-EX helps young elite football players recover after training. Players on the Udine Primavera team receive either KA-EX or a placebo powder mixed in water right after training for two months. The team tracks heart rate…

Researchers at Emory University are studying a modified Argentine tango program called Adaptango for adults with Parkinson's disease, mild cognitive impairment, or dementia, alongside younger adults. Over three months, participants take part in biweekly choreographic sessions tha…

Many burn survivors live with persistent pain that disrupts daily life, and negative thoughts about pain can make it worse. Researchers are testing an 8-week cognitive behavioral therapy program delivered by video to see if it reduces pain interference and pain catastrophizing mo…

Researchers at the University of North Carolina at Chapel Hill are testing whether daily exposure to S-cone stimulating colored light can reduce pain severity and pain sensitivity in adults with fibromyalgia or chronic widespread pain and fatigue. Participants use programmed ligh…

Plantar fasciitis causes heel pain when the tissue supporting the foot arch degenerates. Standard treatments like physical therapy, anti-inflammatory drugs, and orthotics help most people, but some continue to have pain for months. Researchers are testing three ultrasound-guided …

Researchers test anrikefon injection to see if it eases pain after laparoscopic liver surgery. Adults aged 18 to 75 scheduled for this operation receive either anrikefon or flurbiprofen after surgery. The trial measures pain scores over 24 hours and checks for side effects.

This Phase 2 trial tests whether combining psilocybin—a compound from certain mushrooms—with daily cognitive training can enhance brain plasticity in adults aged 65 and older. Participants include healthy older adults and those with mild cognitive impairment or early-stage Alzhei…

Some brain tumors, including meningiomas, hemangioblastomas, and certain metastases, have a rich blood supply that makes surgical removal difficult and risky. This study tests whether blocking the tumor's feeding blood vessels with a catheter procedure before surgery reduces blee…

Researchers compare two rehabilitation methods for children with hemiplegic cerebral palsy, a condition that causes muscle tightness and limited arm movement on one side. The trial enrolls 40 children aged 8 to 12 who receive either electromyography biofeedback training, which us…

Researchers at the University of Miami are testing a non-invasive ear stimulation treatment to understand nerve pain in older adults living with HIV. The study enrolls 70 people with HIV-associated peripheral neuropathy, a condition that causes tingling, numbness, or pain in the …

Researchers are testing whether intravenous ferric carboxymaltose, an iron replacement, eases severe restless legs syndrome that has not responded to standard drugs. The trial enrolls 66 adults with drug-resistant RLS and assigns them to receive the infusion either right away or …

Researchers at the University of Michigan are studying whether a home device called Transcutaneous Electrical Acustimulation (TEA) can help adults with cirrhosis manage chronic pain. The trial enrolls 100 people who report ongoing pain on most days. Participants use either a real…

This trial tests whether a traditional Chinese music therapy, called Ziwu Liuzhu Five-Element Music Therapy, can reduce anxiety in people with pancreatic cancer who are undergoing chemotherapy. The study will enroll 320 patients with mild-to-moderate anxiety and randomly assign t…

This study tests whether a virtual reality program can improve vision in 120 children, teens, and young adults who have lost part of their visual field (hemianopsia) after a brain tumor. Participants will use a VR headset at home for 8 weeks to do visual exercises. The goal is to…

Many people with Parkinson's disease develop hand tremor that standard drugs cannot control. This Phase 3 trial tests whether botulinum toxin injections, guided by each patient's tremor pattern, can reduce that shaking. Participants receive either the toxin or a placebo injection…

This study tests whether regular breathing exercises can improve symptoms of Postural Tachycardia Syndrome (POTS), a condition that causes dizziness and rapid heartbeat when standing. Twelve adults with POTS will practice breathing exercises daily for four weeks while researchers…

This trial tests whether an experimental oral drug called BR005-036C can quickly relieve migraine attacks in adults. Researchers will compare two doses of the drug against a placebo in about 2,079 people who have migraines with or without aura. The main goals are to see if the dr…

Many preschoolers with neurodevelopmental disorders struggle with sleep, which can worsen behavior and stress at home. This Hong Kong trial compares two ways of teaching parents sleep strategies: group sessions in person and a self-help mobile app, both added to usual care, again…

This study tests whether an 8-week group program teaching dialectical behaviour therapy (DBT) skills is feasible and acceptable for people aged 14–35 who have experienced a first episode of psychosis. The program focuses on managing emotions, tolerating distress, and improving re…

This study tests whether a self-balancing exoskeleton called XoMotion-R can help people with spinal cord injury (SCI) walk hands-free during rehab. Researchers will recruit 16 participants (8 inpatients and 8 outpatients) with specific levels of SCI to try the device. The goal is…

This study looks at whether using a pillow placed behind the shoulder after rotator cuff repair surgery can lower pain and improve sleep. About 126 adults aged 40 to 70 will choose whether to use the pillow or not. Their pain, sleep quality, and shoulder function will be checked …

Researchers at Stanford University are studying whether suzetrigine, a non-opioid pain medicine, can reduce the amount of oxycodone adults need after tonsillectomy or similar throat surgery. The trial enrolls 58 adults scheduled for these procedures. Participants receive suzetrig…

This trial tests whether live music therapy, delivered by a board-certified music therapist, can help adults with intellectual and developmental disabilities stay calm and cooperative during dental procedures. About 50 participants will be randomly assigned to receive either live…

Researchers are testing a portable knee-training robot in children aged 6 to 12 with spinal muscular atrophy. Each child trains one leg with a flexible, individually tuned stiffness setting and the other leg with a rigid setting for up to 8 weeks. The trial compares how much knee…

This trial tests whether a brain-training method called decoded neurofeedback, done during MRI scans, can help people with schizophrenia or schizoaffective disorder reduce persistent auditory hallucinations—like hearing voices. Participants are randomly assigned to either the act…

Researchers at Lund University are testing a new way to deliver deep brain stimulation using a cluster of very thin, flexible microelectrodes. The study includes up to 12 adults with Parkinson's disease or essential tremor who are already scheduled for standard deep brain stimula…

Researchers are testing whether a cooling spray called Pain Ease reduces the pain of getting an intravenous (IV) line. The trial compares Pain Ease with a sterile water spray in 100 adults who need an IV. They also check whether the spray increases germs on the skin after it is c…

Researchers are testing whether a single online urotherapy education session can improve parents' knowledge and daily habits around bladder and bowel care for children with Duchenne muscular dystrophy. About 50 parents or caregivers will take part. The session covers urinary trac…

This study tests whether a self-paced online program called WeACT can help family caregivers of people with dementia feel better mentally and emotionally. About 40 adult caregivers with mild to moderate depression will use the program for six weeks. Researchers will check if care…

This study tests a mobile app called 'Heart Voice: Starry Journey' designed to help parents and caregivers of children with autism feel more flexible and less anxious or depressed. About 52 caregivers will use the app for 6 weeks, doing interactive stories and exercises based on …

This study looks at whether drawing different colors and shapes can help calm adults who are anxious while waiting for surgery. About 175 people scheduled for elective surgery will participate. Researchers will measure their anxiety levels before and after the drawing activity to…

Researchers are testing whether adding diaphragmatic breathing training to standard physiotherapy helps people with chronic stroke improve trunk control and postural stability. Forty adults who had a stroke at least six months earlier will be randomly assigned to either breathing…

This study tests whether artificial intelligence-supported digital games and exercise activities can improve motor skills, working memory, and brain activity in children aged 6 to 10, both with and without autism. Children in the intervention group will play movement-based digita…

Researchers are testing a culturally adapted physiotherapy program for Somali women in Norway who have chronic pelvic pain. The program combines guided exercise, home exercise three times a week, pelvic floor muscle training, and pain education. Thirty women aged 18 to 45 will ta…

This study looks at whether the type of education patients receive about a single propofol sedation session can change how well it works for depression. Twenty adults with moderate to severe major depressive disorder will get one propofol infusion and be randomly assigned to eith…

Researchers at the Medical University of South Carolina are testing a program that adds community health workers to standard trauma recovery services. The study enrolls 100 adult trauma patients who screen positive for PTSD or depression risk and report at least one unmet social …

Progressive supranuclear palsy (PSP) causes problems with movement, thinking, and behavior, including impulsivity that can lead to falls. Researchers are testing a non-invasive brain stimulation technique called transcranial direct current stimulation (tDCS) aimed at the right in…

People with spinal cord injuries often rely on a bowel program to manage neurogenic bowel, a condition that makes it hard to control bowel movements. This trial compares three tools used during those programs: a bisacodyl suppository, a mini enema called Enemeez, and a transanal …

This trial compares a specially designed needle tip, the Transcodent painless needle, with a standard dental needle to see if it causes less pain during injections in the upper front teeth area. Sixty adults needing dental work on both sides of their mouth will receive injections…

This early-stage trial will test whether higher-than-standard doses of memantine, a drug already approved for Alzheimer's, are safe and tolerable in 25 adolescents and young adults with Down syndrome. The study also looks for early signs that the drug might improve memory and thi…

This study tests a medicine called IGIV 10% (a type of antibody treatment) against a placebo in 38 adults aged 18-70 with Stiff Person Syndrome, a rare condition causing muscle stiffness and spasms. The main goal is to see if the drug helps people walk faster (measured by a 25-fo…

Complex regional pain syndrome (CRPS) causes severe, lasting pain and can distort how people perceive the affected body part. Researchers are testing whether graded motor imagery, a rehabilitation approach that uses mental exercises and mirror therapy, can improve body perception…

Researchers are testing whether a rehabilitation program that combines mental tasks with balance exercises helps stroke survivors who have hemispatial neglect, a condition where the brain ignores one side of the body or space. Participants are randomly assigned to receive either …

Researchers compare three fluoroscopy-guided epidural steroid injection techniques for adults with leg pain from a herniated disc. Ninety-nine participants receive either a high-volume interlaminar injection, a low-volume interlaminar injection, or a transforaminal injection. The…

This study tests whether a mobile app that combines digital cognitive behavioral therapy (CBT) with personal mental health coaching can reduce anxiety in adults with hearing or mobility disabilities. Participants use either the active program or a sham version for 8 weeks, with f…

Researchers at Cairo University are testing whether virtual reality training can improve neck movement, joint position sense, and hand grip strength in people with cervical radiculopathy, a condition where a pinched nerve in the neck causes pain and weakness. Forty adults aged 35…

Researchers at Istanbul University are testing whether a structured home exercise program paired with self-management education helps adults with Parkinson disease improve balance, walking, hand dexterity, and quality of life. The trial enrolls 55 people aged 45 to 80 who have ha…

This study tests whether a single session of low-intensity focused ultrasound (LIFU) can safely reduce chronic pain and anxiety symptoms. Ten adults with either generalized anxiety disorder or chronic pain will receive multiple ultrasound pulses in one visit and be followed for s…

Researchers test whether injecting the steroid triamcinolone acetonide through the round window membrane into the inner ear can improve hearing in people with profound or complete sudden sensorineural hearing loss. The trial enrolls 56 participants aged 12 to 75 who have severe h…

Anterior cervical discectomy and fusion is a common neck surgery that can leave people with swallowing trouble, weaker breathing muscles, neck pain, and reduced quality of life. This trial tests whether a structured rehabilitation program improves those problems. Sixty adults who…

Researchers are testing whether a group-based acceptance and commitment therapy (ACT) program can improve the psychological well-being and quality of life of parents of children with cerebral palsy. The trial enrolls 76 parents who attend eight weekly 90-minute group sessions led…

Researchers are testing HHK101, an experimental injectable drug, in adults with stable schizophrenia. The trial measures how the body absorbs the drug, tracks side effects, and looks for changes in symptom scores. Participants receive one or more intramuscular injections at diffe…

This Phase 2 trial will test whether taking a daily probiotic supplement for six months is safe and practical for people with early Alzheimer's or those at risk. Researchers will enroll 40 participants aged 60 and older. The study does not test whether the probiotic improves memo…

Researchers test whether combined traditional and paraspinal acupressure can reduce restless legs syndrome and itching in people undergoing hemodialysis. Seventy adults with at least moderate symptoms join the randomized trial. Half receive the acupressure intervention plus routi…

Researchers test whether infusing lidocaine into the middle meningeal artery reduces headache severity in adults who have had a bleeding brain aneurysm. Participants receive either lidocaine or a saline placebo during their endovascular aneurysm repair. The trial measures headach…

This trial tests whether a weekly board game session, held over 12 weeks, can improve thinking and daily living skills in older adults with schizophrenia who live in psychiatric nursing homes. Participants are randomly assigned by group to either the board game program or usual c…

Researchers at Massachusetts General Hospital are testing whether a wearable patch can help autistic teenagers manage anxiety. The patch senses heart rate and guides paced breathing through a phone app, offering practice sessions and prompts during stressful moments. The trial en…

This study looks at whether combining group cardiovascular exercise with group therapy can help reduce symptoms of anxiety and depression in adults living in rural areas. Twenty participants with generalized anxiety or depressive disorders will take part in a structured program. …

Researchers are testing whether a five-minute box breathing exercise can reduce pain, anxiety, and breathlessness when a chest tube is removed after open-heart surgery. The trial enrolls 86 adults who have just had heart surgery and still have a chest tube. Half perform 15 cycles…

This study tests whether using a ride-on toy for 6 weeks can help children with cerebral palsy use their weaker arm and hand more. Ten children will wear a mitten on their stronger hand to encourage using the other hand while driving and playing. Researchers will measure changes …

Researchers are testing an oral drug called elismetrep (K-304) to see if it can quickly relieve moderate or severe migraine attacks. The Phase III trial enrolls about 1,500 adults aged 18 to 75 who have had migraines for more than a year. Participants receive either elismetrep or…

This study looks at whether adding a non-invasive brain stimulation technique called rTMS to standard physical therapy can help people with chronic stroke-related weakness improve their movement, balance, and quality of life. Twenty adults who had a stroke at least six months ago…

Ankle-foot orthoses (AFOs) help children with cerebral palsy walk better, but how they are prescribed and fitted varies widely. Researchers are testing a standardized protocol that guides healthcare professionals on AFO selection, training, and evaluation. The trial compares usua…

This study tests two types of deep brain stimulation (DBS) in 30 people with Parkinson's disease who already have a DBS implant. One type uses fixed settings, while the other adapts in real time to brain signals. Each participant tries both settings at home for up to a week and t…

Researchers are testing whether adding a procedure called interfascial hydrodissection to a standard ultrasound-guided piriformis injection helps adults with piriformis syndrome. The trial enrolls 110 people aged 18 to 70 who have buttock pain and signs of piriformis syndrome. Ev…

This trial investigates whether a home-based self-management program called HOBSCOTCH can improve thinking, memory, and quality of life in young adults (ages 18–29) and youth (ages 13–17) with epilepsy. Participants attend nine weekly one-on-one coaching sessions by phone or comp…

Researchers are testing a new group-based cognitive rehabilitation program for people with early Parkinson's disease who have mild thinking complaints. The program, called LifeCOG-PD, runs for seven 90-minute sessions at a hospital, with 3 to 4 patients per group. Sessions cover …

Researchers at Assiut University are studying whether scar-like arachnoid tissue can tether the trigeminal nerve and cause facial pain in people whose MRI scans show no blood vessel pressing on the nerve. Adults with trigeminal neuralgia that has not responded to medication can j…

Researchers are testing a smartphone app called FobiApp that uses augmented reality to guide people through exposure therapy for cockroach phobia. Adults with a diagnosed cockroach phobia use the app at home, working through increasingly difficult levels that show virtual cockroa…

Researchers are testing two mobile app-based programs, CHAMPS and iCanChange, for young adults with first-episode psychosis who use cannabis. CHAMPS targets safer use for people not looking to quit, while iCanChange supports those who want to reduce or stop. The trial compares ea…

This clinical trial is testing a non-invasive brain stimulation method called temporal interference transcranial alternating current stimulation (TI-tACS) for people with major depressive disorder or generalized anxiety disorder. The device uses two high-frequency electrical curr…

This study tests a new type of transcranial magnetic stimulation (TMS) that targets three brain areas at once to help with negative symptoms of schizophrenia, like lack of motivation, emotion, or social interest. Researchers will enroll 64 people with first-episode schizophrenia …

This study tests whether a gamification program—using game-like rewards and challenges—can help veterans with Parkinson's disease become more physically active. About 110 veterans will either use the gamification program or continue their usual routine. The goal is to see if incr…

This study tests whether a procedure called sacroplasty can help older adults recover faster from sacral fractures. Sacroplasty involves injecting cement into the broken bone to stabilize it. The trial will compare this procedure to standard care like pain medication and physical…

This study looks at whether racism-related stress affects how well a digital cognitive behavioral therapy program (Sleepio) works for insomnia in Black adults. One hundred participants will use the app for 6-10 weeks while researchers track their sleep and stress levels. The goal…

This trial tests whether an AI-driven personalized exercise feedback program can help people with mild traumatic brain injury (TBI) stay consistent with a walking routine. Participants follow a 12-week walking plan, with intensity adjusted to their heart rate and effort, while we…

Researchers test whether transcutaneous electrical acupoint stimulation, a non-invasive way to stimulate acupuncture points, adds benefit to exposure and response prevention therapy for adults with obsessive-compulsive disorder. The trial enrolls 90 people aged 18 to 50 with mode…

After a stroke, many people need rehabilitation to regain movement, balance, and independence, but repetitive exercises can be hard to keep up. This small Swedish study tests a mixed-reality system called RehAtt XR, which uses special glasses to project digital holograms into the…

Researchers test whether spending 10 minutes with a trained Judicial Assistance Dog in the waiting room lowers anxiety in child victims of abuse before a forensic interview. The trial enrolls 46 children aged 7 and older who are visiting a child advocacy and pediatric assessment …

Researchers at Peking University are studying a 49-day digital mindfulness program for adults with emotional distress, depression, or anxiety. About 100 participants use a mobile app that delivers daily guided meditations, short lessons on emotions, and practical exercises. The t…

This study tests an experimental drug called SP-102 for people with moderate to severe sciatica (leg and back pain). About 755 adults will receive a single injection of SP-102, a placebo, or an active comparator. The goal is to see how well SP-102 reduces pain and improves daily …

Researchers are testing whether a computer-based model can choose the better add-on medication for older adults with depression that has not improved after at least two standard treatments. The trial enrolls 300 people aged 60 and older who still have moderate to severe symptoms.…

Researchers at Beijing Normal University are testing whether a guided nature photography program can ease mild depression and anxiety in young adults. Around 300 participants with mild emotional distress will be randomly assigned to take nature photos, take photos of human-made o…

This trial tests two sedatives—remimazolam and dexmedetomidine—to see which better relieves anxiety while keeping pregnant women comfortable and safe during spinal anesthesia placement for scheduled C-sections. The study includes 150 women at full term and measures success by pat…

Researchers are testing whether squeezing a stress ball during femoral arterial sheath removal after coronary angiography can reduce pain and anxiety and improve patient satisfaction. The trial enrolls 34 adults who had a stent or balloon angioplasty through the femoral artery. H…

This trial tests whether a remote group program called FACETS-TBI can help adults with traumatic brain injury (TBI) manage persistent fatigue. Participants are randomly assigned to either the FACETS-TBI program or an attention control group that discusses healthy lifestyle topics…

Researchers at Stanford University are testing whether a single 120-minute pain relief skills class, called Empowered Relief, can help women who have ongoing pain after a cesarean delivery. The class teaches pain education, relaxation techniques, and cognitive strategies to refra…

This trial tests whether progressive muscle relaxation, a technique where you tense and then relax different muscle groups, can lower anxiety in parents who are the primary caregivers of children with cancer. Researchers will randomly assign 112 parents to either join relaxation …

Researchers are testing whether a web-based game that teaches sleep hygiene can improve sleep quality and reduce fatigue in people receiving chemotherapy. The trial enrolls 56 adults undergoing chemotherapy who do not have a diagnosed sleep disorder. Half receive the gamified Sle…

This study tests a cannabis plant extract called NTI164, which has very low THC (the compound that causes a high), in 40 females aged 4-25 with Rett syndrome, a rare genetic condition causing severe physical and mental challenges. Participants will receive either NTI164 or a plac…

This study compares two drugs, lumateperone and cariprazine, when added to a mood stabilizer for people with bipolar I depression. Researchers will track changes in depression symptoms over 8 weeks using standard rating scales. The goal is to see which drug works better and has f…

This study tests whether a full-spectrum cannabis plant extract called NTI164 can help reduce core autism symptoms (like social challenges and repetitive behaviors) in children and young adults aged 6 to 25. About 98 participants will receive either NTI164 or a placebo for 16 wee…

This trial tests whether a single session of deep transcranial magnetic stimulation (dTMS) can reduce food cravings in people with schizophrenia who gained weight from antipsychotic medications. Researchers will compare active stimulation to a sham (placebo) procedure in a crosso…

This trial tests whether photobiomodulation, a low-intensity light therapy, can reduce pain and improve healing of the surgical incision after a cesarean section. Researchers will enroll 30 women undergoing cesarean delivery and randomly assign them to receive either active light…

This study tests a special anesthesia method that uses fewer opioids during spine surgery in people aged 65 and older. The goal is to see if it lowers pain and the need for strong painkillers after surgery. Half the participants will get this opioid-sparing anesthesia, and the ot…

This trial tests whether brief, video-guided jaw relaxation or breathing exercises can reduce anxiety and fear in children aged 4 to 10 who are having burn dressings changed. Children in a pediatric burn unit will be randomly assigned to one of three groups: jaw relaxation, breat…

This study tests whether taking vitamin D supplements can reduce nerve pain, improve sleep, and boost quality of life in people with type 2 diabetes who have nerve damage. Researchers will give vitamin D to 150 adults with low vitamin D levels and track their pain and sleep over …

This study tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can reduce PTSD symptoms in adults who have survived intimate partner violence. 76 participants will receive either a high or low dose and complete weekly th…

This trial tests whether a mobile-guided mindfulness breathing program can reduce symptom distress, fatigue, anxiety, and depression in adults with cancer receiving chemotherapy. Eighty participants will be randomly assigned to either practice 5 to 10 minutes of guided breathing …

Researchers are testing whether an 8-week program that combines virtual reality experiences with educational lessons can help teenagers with major depression. The study will measure changes in depression and anxiety scores using standard questionnaires. Ten adolescents will parti…

This study tests if using a cotton-tipped applicator to hold the eyelid open during eye injections is less painful and faster than the standard metal speculum. About 120 adults with certain eye conditions will take part. The goal is to improve comfort and satisfaction without com…

This trial tests whether six sessions of receptive music therapy, using a specific method called Kigonki, can reduce anxiety in people with advanced cancer who are hospitalized in palliative care units. Participants will be randomly assigned to receive the music therapy or to hav…

This study looks at two methods to control pain after hindfoot surgery: a single nerve block injection versus a small tube (catheter) that delivers numbing medicine continuously for days. The goal is to see which approach reduces pain, cuts down on opioid use, and helps people re…

This study tests whether a drug called allopregnanolone can reduce depression and pain in veterans who have had a mild traumatic brain injury (TBI). About 132 participants will receive either the drug or a placebo through an IV. Researchers will check symptoms during the infusion…

This trial tests whether an AI-powered support tool, accessed through a WeChat Mini Program, can reduce anxiety in men recently diagnosed with metastatic prostate cancer. Participants are randomly assigned to use the platform with the AI agent or without it for the first two week…

Small fiber neuropathy damages tiny nerve fibers, causing severe pain that often resists standard painkillers. This trial tests whether repetitive transcranial magnetic stimulation (rTMS), a non-invasive technique that sends magnetic pulses to specific brain regions, can reduce t…

This study tests whether adding short mindfulness sessions (5-10 minutes) before physical therapy can reduce anxiety, depression, and body image concerns in people with non-flaccid facial paralysis. Twenty-four adults with conditions like Bell's palsy or Ramsay Hunt syndrome will…

This trial tests whether a specialized form of physical therapy, called vestibular physical therapy, can improve balance in people with early multiple sclerosis (MS) who have mild disability but still feel unsteady. Participants will be randomly assigned to receive the therapy or…

This trial tests whether adding sensorimotor training to standard physical therapy helps people with sciatica from a herniated disc walk better and feel less pain. Researchers will compare two groups of 30 adults aged 30 to 55 with radiating leg pain lasting over three months. On…

This trial tests whether a structured, one-on-one educational session led by a nurse before an endoscopic retrograde cholangiopancreatography (ERCP) can reduce patient anxiety and improve knowledge about the procedure. Sixty adults scheduled for elective ERCP will be randomly ass…

This trial tests a four-week digital nursing program designed to improve sleep in adults living with a colostomy, ileostomy, or urostomy. The program includes modules on stoma care, sleep hygiene, relaxation, body image, and physical activity, supported by a chatbot. Researchers …

This trial tests whether wearing virtual reality glasses during double J stent removal can lower patient anxiety and pain. The procedure, common after kidney stone surgery, often causes distress. Researchers will compare patients who use VR distraction with those receiving standa…

This study looks at how people with Parkinson's disease experience OFF episodes, when medication wears off and symptoms return. Researchers will follow up to 120 adults who are prescribed Inbrija, an inhaled levodopa, as part of their usual care. Over three months, they will trac…

This study tests a mobile app called DockTales, designed for adults with chronic pain. The app lets users track pain and sleep through short diaries, body maps, and journaling, with an optional AI feature for reflection. Researchers want to see if the app is easy to use and engag…

This study tests whether a daily supplement made from salmon protein (ProGo®) can help menopausal women manage their weight and improve quality of life. About 100 healthy, overweight women aged 40-65 will take either a low or high dose of ProGo® or a placebo for 18 weeks. Researc…

This trial tests whether using a weighted blanket during a hospital stay can reduce pain and anxiety in adults recovering from traumatic injuries. Half of the 50 participants will receive a weighted blanket, while the other half gets a standard hospital blanket. Researchers will …

This trial tests whether an 8-week lifestyle program can reduce the burden of chronic migraine, a condition marked by headaches on at least 15 days per month. Adults aged 18 to 55 with chronic migraine will be randomly assigned to either the lifestyle program or a wait-list contr…

This trial tests a new device that lets patients give themselves liquid acetaminophen (a pain reliever) after total shoulder replacement surgery, instead of waiting for a nurse. The device only releases a dose when it is safe and allowed. The study will see if patients and nurses…

This study tests whether a combination of two sedatives, esketamine and dexmedetomidine, can better control agitation and shorten delirium in intensive care unit (ICU) patients who are on non-invasive breathing support. The trial will enroll 388 adults with hyperactive delirium a…

This trial tests whether XPhe Piccos, a slow-release protein substitute in tiny tablets without phenylalanine, is acceptable and well-tolerated in children aged 3 and older with phenylketonuria (PKU) or hyperphenylalaninemia. Participants replace some or all of their usual protei…

This trial tests whether combining two ultrasound-guided nerve blocks, one near the knee and one behind the knee, can reduce pain after leg surgery in children with cerebral palsy. Children aged 3 to 18 will be randomly assigned to receive either the nerve blocks plus general ane…

This study tests whether brief, 1-2 minute videos featuring personal stories from other parents can reduce stigma and improve help-seeking among parents of children aged 6-18 with depression, ADHD, or substance use problems. Researchers will recruit 1,600 parents online and rando…

This pilot study will test whether adding a digital app to group cognitive-behavioral therapy (CBT) helps teens aged 12-17 who have both depression and overweight. Sixty participants will be randomly assigned to either CBT plus the app or CBT alone. The main goal is to see if the…

This pilot trial tests whether a single session of personalized brain stimulation, called PandA-tACS, is safe and tolerable for pregnant women with depression. Researchers will compare it to a standard brain stimulation method and a sham (placebo) to see if it changes brain activ…

This trial tests whether a lidocaine gel applied to the feet can ease painful diabetic neuropathy as well as the oral drug duloxetine. Adults with type 2 diabetes and moderate-to-severe nerve pain will be randomly assigned to one of the two treatments for 8 weeks. Researchers wil…

This trial tests whether a telehealth program called Babble Boot Camp can improve early communication in babies born very preterm (before 32 weeks). Parents in the treatment group join weekly 15-minute coaching sessions with a speech pathologist for six months, learning activitie…

Researchers are testing two behavioral programs to help Hispanic cancer survivors with insomnia. One combines gentle movement, meditation, and breathing. The other uses cognitive behavioral therapy for insomnia. Both are being culturally adapted with input from survivors. The stu…

This study tests a personalized, non-invasive brain stimulation device for 10 people with mild cognitive impairment (MCI). The device uses AI to tailor electrical stimulation to each person's brain patterns while they do memory exercises. The goal is to see if this approach can i…