Trigeminal nerve disorder

This study tests an implanted device that stimulates nerves at the back of the head to prevent chronic cluster headaches. Ten adults with difficult-to-treat cluster headaches will receive the implant and use it daily for 48 weeks. Researchers will track side effects and whether t…

This small study tests an implanted device that sends mild electrical pulses to nerves in the head and neck to prevent chronic cluster headaches. Ten adults who did not get better with the drug verapamil will receive the stimulator. Researchers will check how safe it is and wheth…

This study tests whether repeated injections of a steroid around a nerve in the back of the head can prevent cluster headache attacks in people with chronic cluster headache. Fifty adults with at least four attacks per week will receive either the steroid or a placebo injection e…

Trigeminal neuralgia causes sudden, severe facial pain that can send people to the emergency department. This observational study at a Spanish hospital follows 20 adults who receive intravenous lacosamide, an anti-seizure drug, as a rescue treatment for a pain flare. Researchers …

This trial investigates whether an experimental, unapproved medical device can help relieve symptoms in people with a specific condition. Researchers are enrolling participants to test the device's effects and safety. The goal is to see if this new approach could offer a drug-fre…

This trial asks whether an intravenous dose of magnesium sulfate can relieve acute non-traumatic headaches—such as migraines, tension-type, or cluster headaches—more effectively than the standard painkiller paracetamol. Adults arriving at the emergency department with moderate to…

This study tests whether doing yoga-based exercises once a week for 8-12 weeks can reduce headache frequency and improve sleep and quality of life in people with chronic migraine or cluster headache. Participants can join online or in person. The goal is to see if yoga can be a h…

This early-stage study tests whether an injection of RP-008 followed by a daily varenicline pill is safe and can reduce pain for people with trigeminal neuralgia, a condition causing severe facial pain attacks. About 24 adults aged 18-80 with classic or idiopathic trigeminal neur…

This study tests a new type of deep brain stimulation called 'Burst-DBS' for people with long-term facial pain or pain after a stroke. Twenty adults will have electrodes placed in the thalamus (a pain-related brain area) and try both standard and burst stimulation patterns. The g…

This study tests whether injecting a long-lasting numbing medication (Exparel) into the side of the nose can reduce severe face and headache pain. About 15 adults with conditions like migraine or cluster headache will receive either the drug or a placebo, then switch groups. The …

This study tests whether giving Gamma Knife radiation early—within 2 years of diagnosis—can provide better pain relief for trigeminal neuralgia than waiting. About 80 adults with classic or idiopathic TN will be assigned to early treatment or standard care. Researchers will track…

This study tests whether Botox injections into the skin can reduce the number of painful attacks in people with trigeminal neuralgia, a severe facial pain condition. It includes 20 adults who have not gotten enough relief from medications or are not candidates for surgery. Partic…

Researchers at six Italian headache centers are following about 800 adults with trigeminal autonomic cephalalgias, a group of rare headaches that includes cluster headache, paroxysmal hemicrania, SUNCT, SUNA, and hemicrania continua. The study observes routine care rather than as…

This study is collecting information from 10,000 people aged 12 and older with common headache disorders like migraine and tension-type headaches. Researchers will track their symptoms, brain scans, genetics, and thinking abilities over time. The goal is to better understand thes…

This study is gathering information from 4500 people who have or will have brain surgery for conditions like aneurysms, tumors, epilepsy, and Parkinson's disease. The goal is to find patterns that help doctors predict how well someone will recover. By standardizing how outcomes a…

This study is gathering information from 1,500 people with cluster headache or trigeminal neuralgia to learn more about these painful conditions. Researchers will collect surveys, genetic samples, and other health data. The goal is to better understand what causes these headaches…

This study looks at whether measuring nerve signals during a procedure called rhizotomy can help treat trigeminal neuralgia, a condition that causes sudden, shock-like facial pain. Researchers will test a monitoring technique in 30 adults already scheduled for the surgery. The ma…

This study is testing whether measuring nerve signals during a standard procedure for trigeminal neuralgia (a type of severe facial pain) can help doctors target the treatment more precisely. About 30 adults scheduled for the procedure will have their nerve responses recorded fro…