Nonsyndromic genetic hearing loss
MONDO:0019497A disease characterized by hearing loss that is not part of a larger syndrome.
Also known as: nonsyndromic deafness, nonsyndromic hearing loss, nonsyndromic genetic hearing loss, familial deafness, isolated genetic deafness, non-syndromic genetic deafness, nonsyndromic genetic deafness
67 clinical trials for this condition and its sub-types, 4 tagged with Nonsyndromic genetic hearing loss itself.
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Sub-types of Nonsyndromic genetic hearing loss
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Prelingual non-syndromic genetic hearing loss 5 trials · 37 incl. sub-types
1 sub-type
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X-linked nonsyndromic hearing loss 0 trials · 32 incl. sub-types
6 sub-types
- X-linked mixed hearing loss with perilymphatic gusher 32 trials
- X-linked hereditary sensory and autonomic neuropathy with hearing loss 0 trials
- Hearing loss, X-linked 1 0 trials
- Hearing loss, X-linked 3 0 trials
- Hearing loss, X-linked 4 0 trials
- Hearing loss, X-linked 6 0 trials
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Hearing loss, autosomal recessive 1 trial · 17 incl. sub-types
102 sub-types
- Autosomal recessive nonsyndromic hearing loss 9 9 trials
- Autosomal recessive nonsyndromic hearing loss 39 3 trials
- Autosomal recessive nonsyndromic hearing loss 1A 2 trials
- Autosomal recessive nonsyndromic hearing loss 23 1 trial
- Autosomal recessive nonsyndromic hearing loss 5 1 trial
- Autosomal recessive nonsyndromic hearing loss 93 1 trial
- Hearing loss, autosomal recessive 118, with cochlear aplasia 1 trial
- Autosomal recessive nonsyndromic hearing loss 101 0 trials
- Autosomal recessive nonsyndromic hearing loss 102 0 trials
- Autosomal recessive nonsyndromic hearing loss 103 0 trials
- Autosomal recessive nonsyndromic hearing loss 104 0 trials
- Autosomal recessive nonsyndromic hearing loss 12 0 trials
- Autosomal recessive nonsyndromic hearing loss 124 0 trials
- Autosomal recessive nonsyndromic hearing loss 13 0 trials
- Autosomal recessive nonsyndromic hearing loss 14 0 trials
- Autosomal recessive nonsyndromic hearing loss 15 0 trials
- Autosomal recessive nonsyndromic hearing loss 16 0 trials
- Autosomal recessive nonsyndromic hearing loss 17 0 trials
- Autosomal recessive nonsyndromic hearing loss 18A 0 trials
- Autosomal recessive nonsyndromic hearing loss 18B 0 trials
- Autosomal recessive nonsyndromic hearing loss 1B 0 trials
- Autosomal recessive nonsyndromic hearing loss 2 0 trials
- Autosomal recessive nonsyndromic hearing loss 20 0 trials
- Autosomal recessive nonsyndromic hearing loss 21 0 trials
- Autosomal recessive nonsyndromic hearing loss 22 0 trials
- Autosomal recessive nonsyndromic hearing loss 24 0 trials
- Autosomal recessive nonsyndromic hearing loss 25 0 trials
- Autosomal recessive nonsyndromic hearing loss 26 0 trials
- Autosomal recessive nonsyndromic hearing loss 27 0 trials
- Autosomal recessive nonsyndromic hearing loss 28 0 trials
- Autosomal recessive nonsyndromic hearing loss 29 0 trials
- Autosomal recessive nonsyndromic hearing loss 3 0 trials
- Autosomal recessive nonsyndromic hearing loss 30 0 trials
- Autosomal recessive nonsyndromic hearing loss 31 0 trials
- Autosomal recessive nonsyndromic hearing loss 32 0 trials
- Autosomal recessive nonsyndromic hearing loss 33 0 trials
- Autosomal recessive nonsyndromic hearing loss 35 0 trials
- Autosomal recessive nonsyndromic hearing loss 36 0 trials
- Autosomal recessive nonsyndromic hearing loss 37 0 trials
- Autosomal recessive nonsyndromic hearing loss 38 0 trials
- Autosomal recessive nonsyndromic hearing loss 4 0 trials
- Autosomal recessive nonsyndromic hearing loss 40 0 trials
- Autosomal recessive nonsyndromic hearing loss 42 0 trials
- Autosomal recessive nonsyndromic hearing loss 44 0 trials
- Autosomal recessive nonsyndromic hearing loss 45 0 trials
- Autosomal recessive nonsyndromic hearing loss 46 0 trials
- Autosomal recessive nonsyndromic hearing loss 47 0 trials
- Autosomal recessive nonsyndromic hearing loss 48 0 trials
- Autosomal recessive nonsyndromic hearing loss 49 0 trials
- Autosomal recessive nonsyndromic hearing loss 51 0 trials
- Autosomal recessive nonsyndromic hearing loss 53 0 trials
- Autosomal recessive nonsyndromic hearing loss 55 0 trials
- Autosomal recessive nonsyndromic hearing loss 59 0 trials
- Autosomal recessive nonsyndromic hearing loss 6 0 trials
- Autosomal recessive nonsyndromic hearing loss 61 0 trials
- Autosomal recessive nonsyndromic hearing loss 62 0 trials
- Autosomal recessive nonsyndromic hearing loss 63 0 trials
- Autosomal recessive nonsyndromic hearing loss 65 0 trials
- Autosomal recessive nonsyndromic hearing loss 66 0 trials
- Autosomal recessive nonsyndromic hearing loss 67 0 trials
- Autosomal recessive nonsyndromic hearing loss 68 0 trials
- Autosomal recessive nonsyndromic hearing loss 7 0 trials
- Autosomal recessive nonsyndromic hearing loss 70 0 trials
- Autosomal recessive nonsyndromic hearing loss 71 0 trials
- Autosomal recessive nonsyndromic hearing loss 74 0 trials
- Autosomal recessive nonsyndromic hearing loss 76 0 trials
- Autosomal recessive nonsyndromic hearing loss 77 0 trials
- Autosomal recessive nonsyndromic hearing loss 79 0 trials
- Autosomal recessive nonsyndromic hearing loss 8 0 trials
- Autosomal recessive nonsyndromic hearing loss 83 0 trials
- Autosomal recessive nonsyndromic hearing loss 84A 0 trials
- Autosomal recessive nonsyndromic hearing loss 84B 0 trials
- Autosomal recessive nonsyndromic hearing loss 85 0 trials
- Autosomal recessive nonsyndromic hearing loss 86 0 trials
- Autosomal recessive nonsyndromic hearing loss 88 0 trials
- Autosomal recessive nonsyndromic hearing loss 89 0 trials
- Autosomal recessive nonsyndromic hearing loss 91 0 trials
- Autosomal recessive nonsyndromic hearing loss 96 0 trials
- Autosomal recessive nonsyndromic hearing loss 97 0 trials
- Autosomal recessive nonsyndromic hearing loss 98 0 trials
- Hearing loss, autosomal recessive 100 0 trials
- Hearing loss, autosomal recessive 106 0 trials
- Hearing loss, autosomal recessive 107 0 trials
- Hearing loss, autosomal recessive 108 0 trials
- Hearing loss, autosomal recessive 109 0 trials
- Hearing loss, autosomal recessive 110 0 trials
- Hearing loss, autosomal recessive 111 0 trials
- Hearing loss, autosomal recessive 112 0 trials
- Hearing loss, autosomal recessive 113 0 trials
- Hearing loss, autosomal recessive 114 0 trials
- Hearing loss, autosomal recessive 115 0 trials
- Hearing loss, autosomal recessive 116 0 trials
- Hearing loss, autosomal recessive 117 0 trials
- Hearing loss, autosomal recessive 119 0 trials
- Hearing loss, autosomal recessive 120 0 trials
- Hearing loss, autosomal recessive 121 0 trials
- Hearing loss, autosomal recessive 122 0 trials
- Hearing loss, autosomal recessive 123 0 trials
- Hearing loss, autosomal recessive 125 0 trials
- Hearing loss, autosomal recessive 57 0 trials
- Hearing loss, autosomal recessive 94 0 trials
- Hearing loss, autosomal recessive 99 0 trials
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Postlingual non-syndromic genetic hearing loss 6 trials · 10 incl. sub-types
1 sub-type
- Deafness, aminoglycoside-induced 4 trials
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Autosomal dominant nonsyndromic hearing loss 1 trial · 2 incl. sub-types
75 sub-types
- Autosomal dominant nonsyndromic hearing loss 9 1 trial
- Autosomal dominant auditory neuropathy 1 0 trials
- Autosomal dominant nonsyndromic hearing loss 1 0 trials
- Autosomal dominant nonsyndromic hearing loss 10 0 trials
- Autosomal dominant nonsyndromic hearing loss 11 0 trials
- Autosomal dominant nonsyndromic hearing loss 12 0 trials
- Autosomal dominant nonsyndromic hearing loss 13 0 trials
- Autosomal dominant nonsyndromic hearing loss 15 0 trials
- Autosomal dominant nonsyndromic hearing loss 16 0 trials
- Autosomal dominant nonsyndromic hearing loss 17 0 trials
- Autosomal dominant nonsyndromic hearing loss 18 0 trials
- Autosomal dominant nonsyndromic hearing loss 20 0 trials
- Autosomal dominant nonsyndromic hearing loss 21 0 trials
- Autosomal dominant nonsyndromic hearing loss 22 0 trials
- Autosomal dominant nonsyndromic hearing loss 23 0 trials
- Autosomal dominant nonsyndromic hearing loss 24 0 trials
- Autosomal dominant nonsyndromic hearing loss 25 0 trials
- Autosomal dominant nonsyndromic hearing loss 27 0 trials
- Autosomal dominant nonsyndromic hearing loss 28 0 trials
- Autosomal dominant nonsyndromic hearing loss 2A 0 trials
- Autosomal dominant nonsyndromic hearing loss 2B 0 trials
- Autosomal dominant nonsyndromic hearing loss 30 0 trials
- Autosomal dominant nonsyndromic hearing loss 31 0 trials
- Autosomal dominant nonsyndromic hearing loss 33 0 trials
- Autosomal dominant nonsyndromic hearing loss 36 0 trials
- Autosomal dominant nonsyndromic hearing loss 3A 0 trials
- Autosomal dominant nonsyndromic hearing loss 3B 0 trials
- Autosomal dominant nonsyndromic hearing loss 40 0 trials
- Autosomal dominant nonsyndromic hearing loss 41 0 trials
- Autosomal dominant nonsyndromic hearing loss 43 0 trials
- Autosomal dominant nonsyndromic hearing loss 44 0 trials
- Autosomal dominant nonsyndromic hearing loss 47 0 trials
- Autosomal dominant nonsyndromic hearing loss 48 0 trials
- Autosomal dominant nonsyndromic hearing loss 49 0 trials
- Autosomal dominant nonsyndromic hearing loss 4A 0 trials
- Autosomal dominant nonsyndromic hearing loss 4B 0 trials
- Autosomal dominant nonsyndromic hearing loss 5 0 trials
- Autosomal dominant nonsyndromic hearing loss 50 0 trials
- Autosomal dominant nonsyndromic hearing loss 51 0 trials
- Autosomal dominant nonsyndromic hearing loss 53 0 trials
- Autosomal dominant nonsyndromic hearing loss 54 0 trials
- Autosomal dominant nonsyndromic hearing loss 56 0 trials
- Autosomal dominant nonsyndromic hearing loss 58 0 trials
- Autosomal dominant nonsyndromic hearing loss 59 0 trials
- Autosomal dominant nonsyndromic hearing loss 6 0 trials
- Autosomal dominant nonsyndromic hearing loss 64 0 trials
- Autosomal dominant nonsyndromic hearing loss 65 0 trials
- Autosomal dominant nonsyndromic hearing loss 66 0 trials
- Autosomal dominant nonsyndromic hearing loss 67 0 trials
- Autosomal dominant nonsyndromic hearing loss 68 0 trials
- Autosomal dominant nonsyndromic hearing loss 69 0 trials
- Autosomal dominant nonsyndromic hearing loss 7 0 trials
- Autosomal dominant nonsyndromic hearing loss 70 0 trials
- Hearing loss, autosomal dominant 34, with or without inflammation 0 trials
- Hearing loss, autosomal dominant 37 0 trials
- Hearing loss, autosomal dominant 71 0 trials
- Hearing loss, autosomal dominant 72 0 trials
- Hearing loss, autosomal dominant 73 0 trials
- Hearing loss, autosomal dominant 74 0 trials
- Hearing loss, autosomal dominant 75 0 trials
- Hearing loss, autosomal dominant 76 0 trials
- Hearing loss, autosomal dominant 77 0 trials
- Hearing loss, autosomal dominant 78 0 trials
- Hearing loss, autosomal dominant 79 0 trials
- Hearing loss, autosomal dominant 80 0 trials
- Hearing loss, autosomal dominant 81 0 trials
- Hearing loss, autosomal dominant 82 0 trials
- Hearing loss, autosomal dominant 83 0 trials
- Hearing loss, autosomal dominant 84 0 trials
- Hearing loss, autosomal dominant 85 0 trials
- Hearing loss, autosomal dominant 86 0 trials
- Hearing loss, autosomal dominant 87 0 trials
- Hearing loss, autosomal dominant 88 0 trials
- Hearing loss, autosomal dominant 89 0 trials
- Hearing loss, autosomal dominant 90 0 trials
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Nonsyndromic deafness, Y-linked 0 trials
2 sub-types
- Deafness, Y-linked 2 0 trials
- Hearing loss, Y-linked 1 0 trials
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Gene therapy aims to restore hearing in children born deaf
Cure Recruiting nowThis study tests a new gene therapy called DB-OTO for children with hearing loss caused by changes in the otoferlin gene. The treatment is injected into the inner ear to help restore hearing. Up to 30 children and infants will take part to check safety and how well it works.
Phase 1/2 • Sponsor: Regeneron Pharmaceuticals • Aim: Cure
Last updated Aug 07, 2026 00:00 UTC
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One-time gene therapy aims to restore hearing in kids with genetic deafness
Disease control Recruiting nowThis early-stage trial tests a new gene therapy called SKY-GJB2 for children aged 9 months to 7 years with hearing loss caused by changes in the GJB2 gene. The therapy is given as a single injection into the inner ear using a special delivery device. The study will enroll 10 chil…
Phase 1/2 • Sponsor: Skylark Bio Inc. • Aim: Disease control
Last updated Aug 29, 2026 00:00 UTC
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Custom cochlear implant tuning based on ear shape may boost hearing
Disease control Recruiting nowThis study tests whether programming a cochlear implant based on each person's unique inner ear structure improves hearing compared to the standard one-size-fits-all approach. Adults with severe to profound hearing loss who already have a MED-EL cochlear implant will receive both…
Sponsor: Universitair Ziekenhuis Brussel • Aim: Disease control
Last updated Jul 04, 2026 00:00 UTC
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Gene therapy aims to restore hearing in deaf children
Disease control Recruiting nowThis trial tests a gene therapy called EHT102 for children with congenital hearing loss caused by mutations in the OTOF gene. Up to 30 children will receive a single injection in one ear to see if it safely improves hearing. The study is early-stage, focusing on safety and whethe…
Phase 1/2 • Sponsor: Shanghai Euhearing Therapeutics Co., Ltd • Aim: Disease control
Last updated Jun 27, 2026 12:07 UTC
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Can a herbal formula restore hearing? new trial investigates
Disease control Recruiting nowThis study tests whether Yiyuancong, a traditional Chinese medicine made from food-like ingredients, can help people with sudden hearing loss. About 128 adults aged 18-60 will take the formula for 1-2 months, and their hearing will be measured with standard tests. The goal is to …
Sponsor: Guangdong Provincial People's Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:01 UTC
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Balance-Restoring implant shows promise for dizziness sufferers
Disease control Recruiting nowThis study follows 15 adults (ages 22–90) with severe, long-term balance disorders caused by inner ear damage. Participants have already received a vestibular implant, a device that electrically stimulates the balance nerve to help restore steadiness and clear vision during movem…
Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Jun 27, 2026 11:00 UTC
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Gene therapy aims to restore hearing in children with rare genetic deafness
Disease control Recruiting nowThis trial tests a gene therapy called AAVAnc80-hOTOF for people with severe hearing loss caused by mutations in the otoferlin gene. The therapy is given as a single injection into the inner ear during surgery. The study will check if the treatment is safe and if it can improve h…
Phase 1/2 • Sponsor: Akouos, Inc. • Aim: Disease control
Last updated Jun 27, 2026 09:10 UTC
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Inner ear implant aims to steady older adults with chronic dizziness
Disease control Recruiting nowThis study tests a vestibular implant in 15 older adults (ages 65-90) with chronic balance issues due to bilateral vestibular hypofunction. The implant electrically stimulates the inner ear to improve balance and vision. Researchers will measure changes in gait and eye reflexes o…
Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Jun 27, 2026 08:10 UTC
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Inner ear implant aims to restore balance in dizzy patients
Disease control Recruiting nowThis study tests a vestibular implant, a device surgically placed in the inner ear to electrically stimulate balance nerves. It aims to improve balance, posture, and vision in up to 8 adults with bilateral vestibular hypofunction, a condition causing chronic dizziness and instabi…
Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Jun 27, 2026 08:10 UTC
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Hearing loss in children may hide a balance problem, and doctors are testing for it
Diagnosis Recruiting nowResearchers are studying how often children with sensorineural hearing loss also have problems with their balance system. The study enrolls 48 children aged 3 to 10 with hearing loss in one or both ears. Children complete questionnaires and a series of balance and inner-ear tests…
Sponsor: Gødstrup Hospital • Aim: Diagnosis
Last updated Sep 13, 2026 00:00 UTC
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Hope for cancer patients: drug may shield ears from chemo damage
Prevention Recruiting nowThis study tests whether acetylcysteine, a drug often used for other purposes, can prevent hearing loss caused by cisplatin chemotherapy. About 40 adults receiving high-dose cisplatin will get either acetylcysteine or a placebo after each chemo session. Researchers will measure h…
Phase 2 • Sponsor: Siriraj Hospital • Aim: Prevention
Last updated Jun 27, 2026 08:13 UTC
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Custom cochlear implant tuning based on ear anatomy may sharpen hearing in noise and music for the single-sided deaf
Symptom relief Recruiting nowThis trial tests whether programming a cochlear implant based on the individual's inner ear anatomy (anatomy-based fitting) improves speech understanding in noisy environments and music perception compared to standard programming. The study enrolls adults with single-sided deafne…
Sponsor: University Hospital, Antwerp • Aim: Symptom relief
Last updated Jul 23, 2026 00:00 UTC
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Cochlear implants tailored to ear anatomy could sharpen hearing
Symptom relief Recruiting nowThis study tests whether programming a cochlear implant based on a person's inner ear anatomy improves hearing compared to the standard approach. Participants are adults with severe hearing loss who use a cochlear implant in one ear and a hearing aid in the other. Researchers wil…
Sponsor: Universitair Ziekenhuis Brussel • Aim: Symptom relief
Last updated Jul 11, 2026 00:00 UTC
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Can tweaking cochlear implant settings help people hear better in noise?
Symptom relief Recruiting nowThis study is testing whether changing the low-frequency settings on a cochlear implant can improve hearing for people who are deaf in one ear but have normal hearing in the other. Twenty-two adults will try four different sound maps during their first month after implant activat…
Sponsor: NYU Langone Health • Aim: Symptom relief
Last updated Jul 09, 2026 00:00 UTC
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Could your DNA hold the key to preventing hearing loss?
Knowledge-focused Recruiting nowThis study aims to understand why people with Turner syndrome often lose their hearing. Researchers will look at genetic and epigenetic markers in 150 adults aged 18-60. Participants will have hearing, balance, blood, and imaging tests. The goal is to find new ways to treat or de…
Sponsor: Gødstrup Hospital • Aim: Knowledge-focused
Last updated Sep 13, 2026 00:00 UTC
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Could gene editing one day restore hearing? scientists begin by studying families with inherited hearing loss.
Knowledge-focused Recruiting nowThis study looks at people with a type of inherited hearing loss (called DFNA) and their family members to learn which genes cause it. Researchers will collect hearing tests, balance tests, blood samples, and skin biopsies over up to 20 years. The goal is to gather information th…
Sponsor: National Institute on Deafness and Other Communication Disorders (NIDCD) • Aim: Knowledge-focused
Last updated Jul 25, 2026 00:00 UTC
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Cochlear implant study tracks Long-Term performance in hearing loss patients
Knowledge-focused Recruiting nowThis study follows 19 adults with hearing loss who already received a cochlear implant that releases a steroid to reduce inflammation. Researchers will check how well the implant works over 5 years by measuring electrical signals and tracking any side effects. The goal is to see …
Sponsor: Cochlear • Aim: Knowledge-focused
Last updated Jul 09, 2026 00:00 UTC
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Mapping the brain's adaptation to cochlear implants in the first year
Knowledge-focused Recruiting nowThis study follows adults who have recently received a cochlear implant to track how their ability to distinguish sounds and understand speech changes over time. Participants complete at-home sound tests frequently during the first three months, then return for lab tests up to on…
Sponsor: NYU Langone Health • Aim: Knowledge-focused
Last updated Jul 03, 2026 00:00 UTC
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Newborn blood spots may reveal hidden risks from common virus
Knowledge-focused Recruiting nowThis study analyzes dried blood spots from 630 newborns to find protein and RNA markers that could predict which babies with congenital CMV will develop hearing loss or other problems. Researchers will compare samples from infected babies who had complications, those who did not,…
Sponsor: Rigshospitalet, Denmark • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:04 UTC
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Scientists track hearing loss in kids to unlock future treatments
Knowledge-focused Recruiting nowThis study follows 180 children up to age 16 who have hearing loss caused by mutations in the GJB2 or OTOF genes. Researchers will regularly measure their hearing using standard tests and questionnaires to see how it changes over time. The goal is to better understand the natural…
Sponsor: Sensorion • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:00 UTC
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Study seeks best speech therapy for children with cochlear implants
Knowledge-focused Recruiting nowThis study observes 60 children with severe hearing loss who received cochlear implants before age 2. Researchers will track their speech therapy sessions and language skills over time to see which therapy approaches and how much therapy lead to better language development. The g…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:39 UTC
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Scientists track rare genetic hearing loss over time
Knowledge-focused Recruiting nowThis study follows up to 150 people with hearing loss caused by changes in the otoferlin gene. Researchers will measure hearing function using tests like auditory brainstem response (ABR) and otoacoustic emissions (OAE). The goal is to learn how this type of hearing loss changes …
Sponsor: Akouos, Inc. • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:10 UTC
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New registry aims to unlock secrets of rare genetic hearing loss
Knowledge-focused Recruiting nowThis study is building a registry of 100 people with hearing loss caused by changes in the CABP2 gene. Researchers will collect hearing test results and genetic information to learn how the condition progresses over time. The goal is to better understand the disease, not to test …
Sponsor: University Medical Center Goettingen • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC
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Brain wave test could revolutionize hearing aid fitting
Knowledge-focused Recruiting nowThis study explores whether a test that measures brain waves in response to visual images can be used in a new way for people with hearing loss. Researchers will compare these brain responses to standard hearing tests and thinking skills tests. The goal is to see if this test can…
Sponsor: Dartmouth-Hitchcock Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:56 UTC
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Hearing loss linked to brain fog in middle age?
Knowledge-focused Recruiting nowThis study compares cognitive function in 180 adults aged 45-64 with severe hearing loss to those with normal hearing. Participants take memory, attention, and thinking tests. The goal is to see if hearing loss is linked to mild cognitive impairment earlier in life.
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 26, 2026 16:57 UTC
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Tiny recorder may boost talking in deaf children with cochlear implants
Knowledge-focused Recruiting nowThis study tests whether a small recording device called LENA can help speech therapists guide parents to improve their child's language environment. Thirty children with profound congenital deafness who received a cochlear implant before 18 months old will wear the recorder at h…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 26, 2026 16:34 UTC