Nonsyndromic genetic hearing loss

This study tests a new gene therapy called DB-OTO for children with hearing loss caused by changes in the otoferlin gene. The treatment is injected into the inner ear to help restore hearing. Up to 30 children and infants will take part to check safety and how well it works.

This study tests whether programming a cochlear implant based on each person's unique inner ear structure improves hearing compared to the standard one-size-fits-all approach. Adults with severe to profound hearing loss who already have a MED-EL cochlear implant will receive both…

This early-stage trial tests a new gene therapy called SKY-GJB2 for children aged 9 months to 7 years with hearing loss caused by changes in the GJB2 gene. The therapy is given as a single injection into the inner ear using a special delivery device. The study will enroll 10 chil…

This study tests an experimental drug called REGN5093 in people with advanced non-small cell lung cancer that has a specific change in the MET gene. The first part finds a safe dose, and the second part checks if the drug can shrink tumors. About 231 participants will take part.

This study tests whether placing a cochlear implant's ground electrode near the vagus nerve behind the ear works as well as the standard placement under a muscle. Twelve adults getting a cochlear implant will participate. The main goal is to see if speech understanding in noise i…

This trial tests a gene therapy called EHT102 for children with congenital hearing loss caused by mutations in the OTOF gene. Up to 30 children will receive a single injection in one ear to see if it safely improves hearing. The study is early-stage, focusing on safety and whethe…

This study tests whether Yiyuancong, a traditional Chinese medicine made from food-like ingredients, can help people with sudden hearing loss. About 128 adults aged 18-60 will take the formula for 1-2 months, and their hearing will be measured with standard tests. The goal is to …

This study follows 15 adults (ages 22–90) with severe, long-term balance disorders caused by inner ear damage. Participants have already received a vestibular implant, a device that electrically stimulates the balance nerve to help restore steadiness and clear vision during movem…

This trial tests a gene therapy called AAVAnc80-hOTOF for people with severe hearing loss caused by mutations in the otoferlin gene. The therapy is given as a single injection into the inner ear during surgery. The study will check if the treatment is safe and if it can improve h…

This study tests a vestibular implant in 15 older adults (ages 65-90) with chronic balance issues due to bilateral vestibular hypofunction. The implant electrically stimulates the inner ear to improve balance and vision. Researchers will measure changes in gait and eye reflexes o…

This study tests a vestibular implant, a device surgically placed in the inner ear to electrically stimulate balance nerves. It aims to improve balance, posture, and vision in up to 8 adults with bilateral vestibular hypofunction, a condition causing chronic dizziness and instabi…

This study tests an auditory brainstem implant in 20 children who are deaf because they are missing the inner ear or the nerve that carries sound to the brain. The device is surgically placed to stimulate the brainstem directly, bypassing the missing parts. Researchers will monit…

This study compares two common hearing screening methods—pure-tone audiometry and otoacoustic emissions—in over 13,000 preschool children. The goal is to determine which method is better at identifying hearing loss early, so children can get the help they need to avoid speech and…

This study tests whether acetylcysteine, a drug often used for other purposes, can prevent hearing loss caused by cisplatin chemotherapy. About 40 adults receiving high-dose cisplatin will get either acetylcysteine or a placebo after each chemo session. Researchers will measure h…

This study is testing whether changing the frequency settings on a cochlear implant can improve sound quality and speech understanding for people who use both a cochlear implant and a hearing aid. Thirteen experienced bimodal users will try an experimental frequency setting for o…

This study is testing whether changing the low-frequency settings on a cochlear implant can improve hearing for people who are deaf in one ear but have normal hearing in the other. Twenty-two adults will try four different sound maps during their first month after implant activat…

This study tests a new way for hearing aids to process soft sounds, aiming to make quiet speech clearer. Sixteen adults with hearing loss will try two different hearing aid settings in a lab and rate which one sounds more natural and understandable. The goal is to improve hearing…

This study tests whether automatic sound processing in cochlear implants helps children with hearing loss understand speech in noisy environments. Twenty children aged 6 to 16 who use cochlear implants will compare three different sound settings. The goal is to see which setting …

This study tests whether a new AI-based noise reduction feature in Phonak hearing aids helps people with hearing loss or cochlear implants hear speech more clearly in noisy settings. Researchers will measure how well 500 participants repeat words and sentences in quiet and noisy …

This study is testing a new software algorithm called SEDA that reduces background noise for cochlear implant users. Researchers will measure how well 60 participants (ages 12 and older) understand speech in quiet and noisy settings with and without the algorithm. The goal is to …

This study tests an injection called KP-100LI for people with vocal fold scars that cause voice problems. About 62 adults will receive either the study drug or a placebo to see if it improves voice function over 24 weeks. The goal is to confirm the treatment is safe and effective…

This study tests a new hearing aid, Audiocap, in 100 adults with mild-to-moderate hearing loss who have never used a hearing aid before. The goal is to see if it improves hearing better than a placebo device after one month of use. Participants will undergo standard hearing tests…

This study compares using virtual reality glasses versus the standard 'show-do' technique to reduce dental anxiety in 54 children with moderate to severe hearing impairment. The children will have their pulse and anxiety scores measured during a dental cleaning. The goal is to se…

This study tests whether community healthcare workers can effectively fit hearing aids using a smartphone app in low- and middle-income communities. 90 adults with mild to severe hearing loss will be randomly assigned to receive either a smartphone-based fitting, a pre-set fittin…

This study follows adults who have recently received a cochlear implant to track how their ability to distinguish sounds and understand speech changes over time. Participants complete at-home sound tests frequently during the first three months, then return for lab tests up to on…

This study analyzes dried blood spots from 630 newborns to find protein and RNA markers that could predict which babies with congenital CMV will develop hearing loss or other problems. Researchers will compare samples from infected babies who had complications, those who did not,…

This study will follow 5,000 children and teens with hearing loss and normal hearing over time. Researchers will measure changes in hearing, speech, language, and brain scans to see how different treatments—like hearing aids, cochlear implants, or gene therapy—affect development.…

This study follows 180 children up to age 16 who have hearing loss caused by mutations in the GJB2 or OTOF genes. Researchers will regularly measure their hearing using standard tests and questionnaires to see how it changes over time. The goal is to better understand the natural…

This study looks at how people with normal hearing, hearing loss, or cochlear implants use nearby sounds to recognize speech. Researchers will test participants' ability to identify words and sentences in quiet and noisy settings. The goal is to better understand how hearing aids…

This study observes 60 children with severe hearing loss who received cochlear implants before age 2. Researchers will track their speech therapy sessions and language skills over time to see which therapy approaches and how much therapy lead to better language development. The g…

This study looks at people with a type of inherited hearing loss (called DFNA) and their family members to learn which genes cause it. Researchers will collect hearing tests, balance tests, blood samples, and skin biopsies over up to 20 years. The goal is to gather information th…

This study tests a patient navigation program to help rural adults in Kentucky get hearing tests. 500 participants from primary care clinics will receive guidance every two weeks to overcome barriers like travel and cost. The goal is to see if more people complete diagnostic hear…

This study looks at how people with hearing aids perceive the timbre (quality) of sounds and understand complex sound scenes, like music or crowded rooms. Researchers will compare 75 adults aged 60-75 with and without hearing loss. Participants will listen to sounds and rate how …

This study follows up to 150 people with hearing loss caused by changes in the otoferlin gene. Researchers will measure hearing function using tests like auditory brainstem response (ABR) and otoacoustic emissions (OAE). The goal is to learn how this type of hearing loss changes …

This study aims to improve how children with cochlear implants perceive sound by testing new sound coding strategies. Researchers will compare hearing performance between children and adults, and between those with implants and those with normal hearing. The goal is to understand…

This nationwide study aims to understand how hearing loss affects thinking, language, reading, and emotional wellbeing in 256 deaf or hard-of-hearing adolescents. Researchers will use tests and questionnaires to measure speech perception, cognitive skills, and school burnout. No …

This study is gathering information from 100 children and adults who use MED-EL hearing devices, including implants and non-implantable devices. Researchers will collect data on hearing ability, speech understanding, and quality of life through tests and questionnaires. The goal …

This study aims to understand why people with Turner syndrome often lose their hearing. Researchers will look at genetic and epigenetic markers in 150 adults aged 18-60. Participants will have hearing, balance, blood, and imaging tests. The goal is to find new ways to treat or de…

This study is building a registry of 100 people with hearing loss caused by changes in the CABP2 gene. Researchers will collect hearing test results and genetic information to learn how the condition progresses over time. The goal is to better understand the disease, not to test …

This research study looks at how children and adults who use cochlear implants or auditory brainstem implants hear and understand sounds. Participants will listen to words, sentences, and tones to see how well they identify speech and tell differences in loudness or pitch. The go…

This study looks at whether inner-ear balance (vestibular) problems make reading harder for children with hearing loss. Researchers will test 90 children, some with normal hearing and some with severe hearing loss, measuring their ability to see clearly during head movements and …

This study follows 19 adults with hearing loss who already received a cochlear implant that releases a steroid to reduce inflammation. Researchers will check how well the implant works over 5 years by measuring electrical signals and tracking any side effects. The goal is to see …

This study looks at how people with cochlear implants understand speech in everyday situations, like conversations with background noise. Researchers will test 460 adults (both with and without hearing loss) using listening tasks that measure effort and comprehension. The goal is…

This study explores whether a test that measures brain waves in response to visual images can be used in a new way for people with hearing loss. Researchers will compare these brain responses to standard hearing tests and thinking skills tests. The goal is to see if this test can…

This study compares cognitive function in 180 adults aged 45-64 with severe hearing loss to those with normal hearing. Participants take memory, attention, and thinking tests. The goal is to see if hearing loss is linked to mild cognitive impairment earlier in life.

This study tests whether a small recording device called LENA can help speech therapists guide parents to improve their child's language environment. Thirty children with profound congenital deafness who received a cochlear implant before 18 months old will wear the recorder at h…