Could a daily eye gel replace injections for wet AMD?

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 50 years or older. * Subfoveal or juxtafoveal choroidal neovascularisation (CNV) secondary to AMD in the study eye(s). * Stable disease having received three (3) or more previous intravitreal aflibercept 2mg as standard-of-care. * Total CNV lesion area no greater than 12-disc areas. * BCVA in the study eye between 24 and 78 ETDRS letters inclusive. * Suitable for intravitreal aflibercept rescue per its approved label. * Able to self-administer eye drops or has a trained caregiver able to administer drops at home. * Willing and able to comply with the protocol-defined visit schedule. * Signed informed consent. Exclusion Criteria: * Ocular Exclusion Criteria * Contraindication to intravitreal aflibercept per its approved label, including active ocular or peri-ocular infection or active intraocular inflammation. * Dense fibrosis or scarring within the study eye(s) lesion limiting OCT interpretation. * Severe atrophy involving the fovea. * Subretinal haemorrhage involving or obscuring the fovea. * Subretinal fibrosis involving more than 50% of the lesion area. * Pigment epithelial detachment involving more than 50% of the CNV lesion. * Confounding retinal disease, including diabetic retinopathy, retinal vein occlusion, or myopic degeneration. * Significant corneal disease that would complicate topical safety interpretation. * Prior subfoveal laser photocoagulation, photodynamic therapy, or ocular radiation in the study eye. * Uncontrolled glaucoma or IOP greater than 25 mmHg at screening. * Systemic Exclusion Criteria * Clinically meaningful ECG abnormality or QTcF concern at baseline (QTcF greater than 460 ms in men or greater than 480 ms in women). * Current use of QT-prolonging medications per a pre-specified list * Current use of medications with known MEK or MAPK pathway activity. * Clinically significant hepatic, renal, cardiovascular, or haematological disease. * Known hypersensitivity to any component of the BETA-TT8 formulation or to aflibercept. * Active malignancy or history of malignancy requiring treatment within the prior 5 years. Cancers considered to be cured (eg. prostatectomy or radiation for prostate cancer, adjuvant treatment for breast cancer) or treated non-metastatic skin or melanoma are excepted. * Pregnancy, breastfeeding, or inadequate contraception during the study and for 30 days after last dose of BETA-TT8. * Other Exclusion Criteria * Inability or unwillingness to comply with study procedures or dosing requirements. * Cognitive impairment or insufficient home support that may compromise proper administration of study treatment. * Participation in another investigational study within 30 days of screening.