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Awake but asleep: brain waves may explain crushing daytime sleepiness

NCT ID NCT06153615

Knowledge-focused Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 11, 2026 · Last updated Sep 11, 2026

Summary

Idiopathic hypersomnia causes severe daytime sleepiness that differs from narcolepsy, yet researchers do not know what drives it. This study uses 64-electrode EEG to look for local slow waves, a sign of sleep-like activity in parts of an otherwise awake brain, while participants rest and perform a attention task. The team compares people with idiopathic hypersomnia, people with narcolepsy type 1, and healthy volunteers to see whether local sleep tracks with sleepiness and mental lapses.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If local sleep explains the sleepiness of idiopathic hypersomnia, it could give doctors a measurable brain signal to diagnose the condition and a target for future treatments.
What could go wrong
This is an observational study with 63 participants, so it can only show a link, not prove cause. The findings may not apply to all people with idiopathic hypersomnia, and EEG slow waves may turn out to be a side effect rather than the reason for sleepiness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

63 people

The number who actually took part.

Started

Feb 2024

Finished

Apr 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Inclusion Criteria : * Healthy subjects and people with IH and NT1: -\>18 years old, of both sexes, without legal protection. * Affiliated to the French social security system * Signature of free and informed consent * Fluency in spoken and written French * Specific to people with IH: -Diagnosis of IH according to the ICSD-3, already made in the sleep pathology department of the Pitié after a specialized medical interview and a standardized 48h assessment (Night 1+TILE+Night 2+two naps): Sleep time \> 660 min or TILE latency \<8 min, \<2 SOREMPs. * Specific to people with NT1: * Diagnosis of narcolepsy type 1 according to the ICSD-3, already made in the sleep pathology department of the Pitié after a specialized medical interview and a standardized 48h workup (Night 1+TILE+Night 2+two naps) and sometimes a lumbar puncture: hypocretin \<110 pmol/L in CSF or cataplexy and TILE latency \<8 min, \>1 SOREMP. Exclusion Criteria: * Shift or night work * Sleep debt on the day of the recording (questioning and sleep diary one week before the recording) * Other sleep pathology causing daytime sleepiness (sleep apnea, insomnia, parasomnia for example) * Cerebral neurological pathology * Depressive episode * Any psychotropic treatment modifying the EEG structure * Failure to wean from arousing treatment on the day of the test. * Inability to travel by transport or to be transported by a relative on the day of the recording.

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Conditions

The condition(s) this trial relates to.

idiopathic hypersomnia narcolepsy-cataplexy syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Idiopathic hypersomnia

Contacts and locations

Locations

  • Pitié Salpêtrière

    Paris, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.