Scientists dig into DNA to unlock secrets of early Parkinson's
NCT ID NCT02511015
First seen Jun 27, 2026 · Last updated Sep 18, 2026 · Updated 3 times
Summary
This completed study looked at 31 people with early-onset Parkinson's disease (starting before age 50) and their family members to find genetic causes. Researchers collected blood and skin samples to study DNA and create cell lines. The goal was to better understand which gene mutations lead to the disease, not to test a new treatment.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this research could help identify specific genetic defects linked to early-onset Parkinson's, paving the way for future targeted therapies.
- What could go wrong
- This is an observational study with only 31 participants, so findings may not apply to all cases. It does not test any treatment, so direct benefits are unlikely.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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31 people
The number who actually took part.
- Started
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Jul 2015
- Finished
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Aug 2017
- Lead sponsor
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A government research agency
The lead sponsor is the US National Institutes of Health.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Subjects that develop symptoms of Parkinson Disease within the first 5 decades of life would be enrolled onto this protocol. Additionally, subjects previously enrolled on protocol 12-H-0084 may also be enrolled on this protocol. Age (+/- 5 yrs) and gender matched healthy volunteers will be recruited as controls for this protocol. Controls will be recruited via web advertisements. An email advertisement will also be sent out via the NIH LISTSERV to aid in the recruitment of healthy volunteers. A list of healthy volunteers may also be requested from the NIH Office of Patient Recruitment. Family member controls without clinical evidence of Parkinsonism may be recruited as controls for index research subjects.
- Ages
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18 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
* INCLUSION CRITERIA Parkinson's Subjects \- Age 18 years to 80 years old with a history of early onset Parkinson's disease or Parkinsonism (Presentation within the first five decades of life). Healthy Control Subjects \- Age 18 years to 80 years old with no history or family history of Parkinson's disease or Parkinsonism. Family Member Control Subjects -Family members, of enrolled EOPD subjects, who themselves do not have Parkinson's disease or Parkinsonism can be enrolled as controls on this study. All Subjects * Willingness and legal ability to give and sign informed study consent * Willingness to have blood or tissue samples studied, and potentially stored for future research EXCLUSION CRITERIA All Subjects * Subjects who are unable or unwilling to sign an informed consent * Subjects with genetic defects associated with diseases including other neurologic syndromes. * Pregnancy
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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National Institutes of Health Clinical Center
Bethesda, Maryland, 20892, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.