Developmental disorder of mental health

This study tested a noninvasive brain stimulation technique (transcranial random noise stimulation) to see if it could reduce cravings in 225 adults with substance use disorder plus another psychiatric condition like ADHD, bipolar disorder, or schizophrenia. The approach targeted…

This trial tests whether children with autism improve balance and coordination more when they exercise in a group or on their own. Researchers will randomly assign 16 children aged 3 to 12 to either individual or group exercise sessions, held three times a week for six weeks. The…

This trial tests whether Masgutova Neurosensorimotor Reflex Integration (MNRI) therapy can improve fine motor skills in children aged 2-6 with developmental delays. Participants receive either MNRI sessions or standard care for four weeks. The study measures changes in hand funct…

This study tests whether adding DIR/Floortime—a child-led, relationship-based therapy—to standard care helps children aged 4-12 with mild-to-moderate autism improve emotional, social, communication, and daily living skills. Half the children receive the 10-week Floortime program …

This trial tests an 8-week online coaching program that teaches parents of preschool autistic children how to use everyday interactions to boost their child's social communication. Families are randomly assigned to either the coaching program or a waitlist, and the study measures…

This trial tests whether a non-invasive technique called transcranial electrical stimulation (tES) can help reduce ADHD symptoms and improve thinking skills in children and teenagers aged 7 to 18. The approach uses low-intensity electrical currents applied to the scalp to gently …

This study tests whether aripiprazole, a medication already used for behavioral symptoms, remains safe and tolerable for children and adolescents with autistic disorder when taken daily for up to a year. Most participants will have already completed a short-term trial of the drug…

This trial tests whether a 12-week exercise program can improve motor skills, aerobic capacity, and quality of life in children aged 5–13 with autism spectrum disorder. Participants do activities like walking, balancing, and ball games. Researchers compare them to a non-exercisin…

Autistic children drown at 160 times the rate of their peers, yet standard swim lessons often fail them. This study tests a new approach that adapts instruction based on a child's sensory profile—whether they seek, avoid, or have mixed reactions to sensory input. Researchers will…

This study tests whether a group-based behavioral program, where caregivers are actively involved, can help autistic preschoolers improve social communication, play skills, and daily adaptation. The program is compared to one-on-one therapy. Researchers will measure changes in au…

This study tests whether a behavior therapy program called Partnering to Achieve School Success (PASS) can improve outcomes for children aged 5-11 with ADHD from low-income families. Children are randomly assigned to receive PASS integrated into their primary care visits or to re…

This study tests a computer-based practice method to help people with aphasia—a language disorder often caused by stroke—retrieve words they know but struggle to say or understand. Participants practice naming pictures with or without cues, repeating items until they reach a set …

This study tests whether structured physical games can improve memory, attention, gross motor skills, and social adaptability in children aged 4 to 6. Over 8 weeks, preschoolers play specially designed games like 'Eagle Catching Chicks' and 'Puppy Seeking Bones' during class. Res…

This phase 3 trial tests whether a new formulation of dexmethylphenidate (CTx-1301) can improve attention and reduce ADHD symptoms in adults for up to 16 hours. Participants take an optimized dose (25, 37.5, or 50 mg) and complete math tests in a simulated classroom. The study co…

This study tests whether a small social robot named Tessa can help people with disabilities who have trouble planning and remembering daily tasks. Participants use the robot in their home, and researchers track how much professional caregiver support they need. The goal is to see…

This study tests whether a wide-spectrum nutritional supplement can improve mitochondrial function in children with autism spectrum disorder (ASD). Mitochondria are the energy factories in cells, and some children with ASD have abnormal mitochondrial activity. The trial enrolls c…

This study tests an oral capsule called AK0901 (AZSTARYS) in children aged 6 to 12 with attention deficit hyperactivity disorder (ADHD). The trial compares the drug against a placebo to see if it reduces ADHD symptoms like inattention and hyperactivity. Researchers measure sympto…

This Phase 3 study tested whether ecopipam can safely maintain tic control in 216 people with Tourette's disorder, ages 6 and up. Participants first received open-label ecopipam, then those who responded were randomly switched to placebo or continued ecopipam to see if benefits l…

This study tested whether N-acetylcysteine (NAC), an antioxidant drug, can improve motor skills and learning in children with neurofibromatosis type 1 (NF1). Twenty-five children aged 8 to 16 took NAC or a placebo for 8 weeks. The goal was to see if NAC is safe and helps with mov…

This study tested the long-term safety of a daily medication called centanafadine in 680 children and teens (ages 4-17) with ADHD. The drug is a non-stimulant capsule taken once a day. Researchers tracked side effects over time to see if it is safe for extended use. The trial is …

This study tested three ways to help children aged 7-11 with ADHD: a computer-based cognitive training program using a virtual classroom, the medication methylphenidate, and supportive talk therapy. Fifty-one children took part to see which approach best improves attention and re…

This study tested a Norwegian intensive habilitation program for children aged 2-6 with severe cerebral palsy or similar brain damage. The program aimed to improve the child's daily living skills and empower parents. 93 children and their families took part in a randomized trial …

This study tested whether tolcapone, a drug used for Parkinson's disease, could change how people with both alcohol use disorder and ADHD respond to alcohol and make decisions. 23 adults completed the trial, which involved taking tolcapone or a placebo and then undergoing alcohol…

This completed study in Damietta, Egypt, involved 300 children aged 3 to 5 years to find out how common developmental delays are and whether early physical therapy can help. Kids with delays received twice-weekly therapy for six months, focusing on motor, language, and social ski…

This study tested whether a 16-week lifestyle program delivered through WeChat could help children with autism (ages 8-12) manage their weight. 276 families were split into three groups: usual care, the WeChat program alone, or the program plus weekly group coaching. The main goa…

This study compared two FDA-approved medications, risperidone and aripiprazole, used to treat irritability in children with autism. The goal was to see which one causes more weight gain. Thirty children under 18 who had never taken these drugs before were followed during routine …

This study tested the drug Qelbree (viloxazine) in 161 adults with ADHD who also had mood symptoms. Participants took the medication for several weeks, and researchers tracked changes in ADHD symptoms using a standard rating scale. The goal was to see if Qelbree is both safe and …

This study tested two teaching methods—watching a peer brush teeth in a video or using a 3D jaw model—to improve toothbrushing in 120 children with autism aged 6-12. Children who watched the peer video had less plaque and better brushing skills over six months compared to those u…

This study tested the drug allopurinol in 8 children and adults with adenylosuccinate lyase deficiency (ADSL), a rare genetic disorder that can cause autism, seizures, and developmental delays. Researchers measured changes in thinking, daily skills, and seizure control over 12 mo…

This study tested a summer program called Summer Academy for 124 young children with behavior problems who were about to start kindergarten. The program aimed to improve their school readiness and behavior. Researchers measured progress right after the program and again six month…

This study tested whether repeated low doses of LSD (called MM120) can safely help adults with ADHD. Fifty-three adults took either the drug or a placebo, and researchers measured changes in ADHD symptoms using a standard rating scale. The goal was to see if this approach could b…

This study tested two online versions of parent management training for children diagnosed with conduct disorder or oppositional defiant disorder. Researchers wanted to see if online delivery could help families who cannot access in-person therapy. The study involved 86 children …

This study tested whether an in-vehicle device that gives real-time feedback on driving, plus optional parent communication training, can reduce risky driving and traffic violations among teens who recently got a moving violation. 240 teens aged 16-17 with a valid Ohio license an…

This study tested whether a personalized treatment plan—based on each person's test results—works better than standard care for people with mild cognitive impairment or early-stage dementia. 73 adults aged 45-76 took part, receiving either the tailored plan or usual care for 9 mo…

This completed study tested a digital app called Poppins Clinical in 306 children with dyslexia or other reading/writing learning disabilities. The app combines musical and cognitive exercises with reading training. One group used the app plus bi-monthly speech therapy, while the…

This pilot trial tested whether taking oral zinc every day for 6 months is safe and doable for people with GNAO1 disorders, a rare genetic condition that causes movement problems, seizures, and developmental delays. 13 participants aged 6 months to 30 years took zinc acetate. The…

This study tested whether a child's own bone marrow stem cells, combined with educational therapy, can safely reduce autism symptoms. 54 children aged 3-7 with moderate to severe autism took part. Researchers measured changes in behavior, social skills, and quality of life. The g…

This study looked at whether a brain-computer interface (BCI)-based attention training program, used alone or with medications like methylphenidate or citicoline, can improve attention and executive function in school-age children with ADHD. 174 children participated in this real…

This study looked at the long-term safety of cariprazine, a medication, in 310 children and teens with schizophrenia, bipolar I disorder, or autism spectrum disorder. Over 52 weeks, researchers monitored side effects, vital signs, lab results, and movement disorders. The goal was…

This study tested a phone-based program called MommyCheckup to see if it helps pregnant women who drink alcohol cut back or stop. The program includes a short motivational video and tailored text messages. Researchers enrolled 384 pregnant women across three states to see if the …

This early-stage study tested a drug called NFC-1 in 30 adolescents aged 12-17 with ADHD who also have specific genetic changes affecting brain receptors. The goal was to check the drug's safety and how the body processes it, while also looking for signs it might reduce ADHD symp…

This study tested whether stem cells taken from a child's own bone marrow could improve autism symptoms. Thirty children aged 5 to 15 received an injection of their own stem cells into the spinal fluid. Researchers measured changes in behavior and social skills over six months us…

This study tested a combination therapy—including antibiotics, a bowel cleanse, stomach acid suppressants, and beneficial bacteria from human feces—to treat gastrointestinal problems in 18 children with autism. The goal was to see if the treatment could reduce gut symptoms like p…

This completed study tested whether a special diet plus a nutritional supplement called T-2 could improve thinking skills, sleep, and overall health in 76 people with Down syndrome, autism, or ADHD, aged 2 to 35. Participants followed either the diet alone, the diet plus suppleme…

This study tested whether a special MRI technique called ASL-MRI can measure blood flow in the brains of children with autism. The goal was to see if this could be used as a non-invasive diagnostic tool, similar to PET scans but without radiation. Researchers studied 115 children…

This study tests a telemedicine tool called the TAP, designed to assess autism symptoms in toddlers aged 18-42 months. Researchers will compare diagnoses made via video call with traditional in-person evaluations to see how accurate the tool is. The goal is to make autism diagnos…

This study tested whether a portable eye-tracking device can help diagnose autism in young children in Kenya. 27 children aged 14-72 months watched pictures and videos while the device measured their eye movements. The goal was to see if these eye-tracking patterns match a clinic…

This study tested whether a blood test called exome sequencing can find genetic causes of autism better than standard care. Researchers studied 300 people with autism to see if the test could identify risk genes. The goal is to improve diagnosis and help families understand the b…

This study tested a virtual reality application to help diagnose Attention Deficit Hyperactivity Disorder (ADHD) in children aged 8 to 12. The goal was to see if a 3D immersive environment could better measure attention and behavior compared to standard tests. Thirty children wit…

This study tested whether an iPad game (Play.Care) could help diagnose autism spectrum disorder (ASD) in children aged 2.5 to 5 years. The game measures how children move while playing, since movement differences may be early signs of autism. Researchers compared the game's resul…

This study tested a device called EarliPoint that tracks where children look while watching short videos. The goal was to see if it could help diagnose autism spectrum disorder (ASD) in children ages 2.5 to 7. Nearly 1,000 children participated, and the device's results were comp…

This study tests a 12-session program called Forging Hopeful Futures, designed to reduce violence among teens ages 13-19. The program uses group discussions and activities to help youth understand how racism, gender inequality, and economic injustice can lead to violence, and tea…

This study is developing and testing a smartphone app designed for Native American women to help them avoid pregnancy affected by alcohol. Researchers will gather feedback and pilot test new features with 407 women who are at risk. The goal is to reduce risky drinking and improve…

This study tested a web-based simulation to help college students with ADHD prescriptions avoid giving away or misusing their medication. About 250 students from three universities used the program, which taught them how to say no to requests for their pills and how to talk to th…

This study tested a training program called SAFE for people with intellectual or developmental disabilities who are working or looking for work. The program taught them about COVID-19, how to use protective gear, social distancing, and self-advocacy. 67 young adults took part, an…

This study tested a culturally adapted mobile health program called Mobile CHOICES to help urban American Indian and Alaska Native young women (ages 16-20) avoid drinking alcohol during pregnancy. The goal was to reduce the risk of Fetal Alcohol Spectrum Disorders, which cause li…

Many adults with ADHD still struggle with inattention, planning and impulsivity even after medication. Researchers are testing whether group cognitive behavioural therapy helps more than a structured activity group. About 226 adults with ADHD join weekly two-hour sessions for 12 …

Researchers are testing a cognitive behavioral therapy program designed for autistic teens who have anxiety, depression, or both. The therapy focuses on exposure and behavioral activation, with adjustments for autism. Teens and their caregivers take part together. The trial compa…

Researchers at Karolinska Institutet are testing a parent training program for parents of children aged 8 to 16 who show angry, defiant, or aggressive behavior. The program teaches cognitive behavioral therapy skills and adds virtual reality role-plays so parents can practice res…

Researchers at Karolinska Institutet are testing a program called YourSkills for children aged 10 to 16 who have elevated anger or disruptive behaviors. The program combines cognitive behavioral therapy with virtual reality role-plays to practice social skills. Children attend te…

Researchers are testing whether giving mothers with ADHD a stimulant medication along with behavioral parent training works better than parent training alone for reducing ADHD-related problems in their young children. The study enrolls mothers aged 21 and older who meet criteria …

This study tested a probiotic (BB-12 with LGG) in 123 children with autism and stomach problems. The goal was to see if different doses are safe and can improve behavior and gut health. Researchers tracked side effects, behavior changes, and gut bacteria over 56 days of treatment…

York University researchers are testing two ways to train teachers to help children with dyslexia who have not improved with standard classroom reading instruction. One program adds morphology, which teaches shared word meanings like sign, design, and signal. The other adds set-f…

Researchers are testing an experimental drug called soticlestat in people with two rare genetic conditions: Dup15q syndrome and CDKL5 deficiency disorder. Both conditions cause frequent motor seizures that are hard to control. The trial enrolls about 20 participants who take one …

This study tests whether 80 sessions of a gentle brain stimulation technique called tDCS, given over 12 months, can improve attention, social skills, and language in 180 children aged 6 to 11 who have autism along with rare diseases, genetic problems, or PANDAS. The treatment is …

Researchers are testing a smartphone app called Pai.ACT that uses acceptance and commitment therapy to help parents of children with special needs manage stress and improve well-being. The study enrolls 60 Cantonese-speaking parents in Hong Kong who care for children aged 2 to 8 …

Researchers are testing a full-spectrum medicinal cannabis extract with very low THC to see if it can reduce the severity of autism spectrum disorder in young people aged 8 to 17. The study compares the extract to a control and then allows some participants to receive it openly. …

Researchers at Saveetha University studied a structured play-based program called the B.A.S.I.C.S. framework for children with autism spectrum disorder. The program combines balance, social, thinking, and self-reliance activities into 45-minute sessions three times a week for six…

Researchers test whether adding cognitive training to a 10-week exercise program helps children with developmental coordination disorder improve balance, motor skills, and fitness more than exercise alone. Twenty children aged 7 to 11 join the study and are randomly assigned to e…

Researchers are testing a full-spectrum medicinal cannabis extract called NTI164 in girls and young women with Rett syndrome, a rare genetic disorder that affects movement, speech, and behavior. The study includes 14 participants aged 5 to 20 who take the extract daily for 16 wee…

This trial tests whether a daily oral oil made from a full-spectrum cannabis plant extract with very low THC (FEN164) can safely help children with autism. The study will include 18 children aged 8 to 17 with moderate to severe autism (Level 2 or 3). Over 20 weeks, researchers wi…

This study tested a new anxiety program designed for autistic youth ages 7 to 17. The program was delivered in community care centers to make it more accessible. Researchers wanted to see if it was practical and helpful for reducing anxiety symptoms. The study involved 32 partici…

Many children with autism are picky eaters, often refusing fruits, vegetables, and proteins, which can lead to poor nutrition and obesity. This trial tests whether nutritional counseling focused on the Mediterranean diet can help these children become less selective and adopt hea…

This study tests whether a common probiotic (Lactobacillus rhamnosus GG) can reduce stomach issues like constipation and diarrhea in children with autism spectrum disorder. About 50 children aged 4 to 12 with both autism and ongoing stomach problems will receive the probiotic or …

Researchers are testing whether a virtual reality job interview training tool, called VR-JIT, is safe and practical for teenagers with autism. The study includes teens aged 13 to 18 with autism or typical development. Participants practice job interviews with a virtual interviewe…

This study tested whether an 8-week mindfulness-based stress reduction program could lower depression, anxiety, stress, and hopelessness in parents of children with autism. 96 parents took part in weekly 60-minute group sessions. The goal is to see if this simple, non-drug approa…

This pilot trial explores whether social virtual reality (VR) training can help children with ADHD improve their social interaction skills. About 90 children aged 6 to 12 will be randomly assigned to either VR training, traditional social skills training, or a waitlist control gr…

This pilot trial tests whether an eight-week online coaching program for parents of children with autism in Palestine is practical and acceptable. Parents receive one-on-one video sessions to help them set goals and find strategies to support their child's daily activities. The s…

This pilot study tests whether a combination of two natural compounds, L-theanine and paraxanthine, can temporarily improve attention and self-control in adults with ADHD or autism. About 24 participants will complete thinking tests and brain scans after taking the supplement or …

This study tests whether playing movement-based digital games can improve motor skills in children aged 6-10 with mild or moderate autism. Half the participants will play these games twice a week for 10 weeks, while the other half continues their usual education and rehabilitatio…

This study tests whether pediatric massage can improve behavior and social skills in children aged 3 to 10 with autism spectrum disorder (ASD). Children receive massage twice a week for 12 weeks from a professional, plus at-home massage from trained parents. Researchers also use …

This study explores whether sleep problems in children with ADHD are linked to being overly sensitive to everyday sensations, like touch or sound. It tests a bedtime routine called 'Power Down' that uses gentle massage and calming cues to help children relax before sleep. The stu…

This study tests a program called I2-ART, where trained family navigators support caregivers of minority children with ADHD. The goal is to help families follow through with recommended treatments like medication or behavior therapy. The study involves about 108 participants and …

This study tests whether adding a sensor-based exergame to regular table tennis practice can help adolescent boys with mild autism react faster and move more quickly during play. Half of the 24 participants will do 20 minutes of light-based reaction training twice a week for 8 we…

This study tests an 8-week online group program that teaches parents of young autistic children (ages 2-6) strategies to support their child's social communication and development. Parents attend weekly sessions and practice techniques at home. Researchers will measure changes in…

This trial tests whether playing with a rainbow parachute can improve upper arm strength and social-emotional skills in children aged 5 to 8 with developmental delays. Half the children will do parachute games for 8 weeks, while the other half does rhyming activities. Researchers…

This trial tests a 12-week guided self-help program for parents of young children (ages 2-6) with neurodevelopmental disorders like autism or ADHD. The program combines a workbook, online modules, and group sessions to teach acceptance and mindfulness skills. The goal is to see i…

This study tests an online psychological support program based on Acceptance and Commitment Therapy (ACT) for mothers of children with autism. The program aims to reduce parenting stress and improve mothers' mental health, which may also benefit their children's behavior. Mothers…

This trial tests a 12-week smartphone-based program called PACT, which combines acceptance and commitment training with positive parenting advice, for parents of children with special health care needs. The goal is to see if it can improve parents' mental well-being, psychologica…

This trial tests whether low-frequency whole body vibration—standing on a gently vibrating platform—can improve motor skills and sensory integration in children aged 5 to 9 with mild to moderate autism. Participants receive vibration sessions alongside routine physical therapy, a…

This study tests a new type of brain training for children with ADHD. It uses a device that measures brain activity and gives feedback, sometimes with virtual reality goggles. The goal is to see if this training can improve attention and reduce hyperactivity. About 110 children a…

This study compares online parent coaching to in-person coaching for improving social communication in toddlers with autism or social communication delays. About 188 children aged 18-33 months will take part. Parents learn techniques to engage their child during play, aiming to i…

This study looks at whether adding active video game training to standard occupational therapy can improve how children with developmental coordination disorder (DCD) see and plan movements. About 70 children aged 5 to 8 will be split into two groups: one gets video games plus th…

This study tests whether combining two types of exercises—sensory motor training and special stretches—can reduce toe walking and improve foot posture in children with mild autism. Researchers will measure changes in foot position and sensory responses in 36 children. The goal is…

This trial tests whether daily omega-3 fish oil supplements can improve sleep, mood, and behavior in children who have sleep problems and symptoms of ADHD, autism, or both. The study takes a symptom-focused approach, aiming to identify which specific difficulties—like emotional u…

This study tested a special light helmet (called tPBM) on 6 autistic children aged 4–12 who also had abnormal brain activity or epilepsy. The helmet delivered near-infrared light to specific brain areas twice a week for 10 weeks. The goal was to see if it could safely improve foc…

This study tests a new therapy for young children (ages 2-5) with autism who use few or no words. The therapy involves parents or therapists responding to the child's sounds and gently encouraging more vocalizations. Researchers will see if this approach helps children make more …

This small study tested whether Epidiolex (a prescription CBD oil) can safely reduce symptoms of obsessive-compulsive disorder, hair-pulling, Tourette syndrome, and hoarding. Four adults took the drug for two weeks. The goal was to see if symptoms improved and if the drug was wel…

This trial tests whether a structured, therapist-led dance program can improve cognitive-motor skills, balance, self-esteem, and sensory processing in children aged 6 to 12 with ADHD. Over five weeks, participants attend ten dance sessions designed to combine rhythm and movement …

This study tested a 16-week sensory-friendly physical activity program for autistic children aged 7-12 in special education schools. The program included predictable routines and calming cool-downs to help with sleep. Researchers measured sleep quality using wrist monitors and pa…

This early-stage trial is testing an experimental drug called lumateperone in children aged 5 to 12 who have autism spectrum disorder and symptoms of irritability. The study aims to see how the body processes the drug and whether it is safe and tolerable at different doses. It is…

This pilot trial explores whether Nintendo Switch exergaming—active video games like RingFit Adventure and Switch Sports—can improve motor skills in autistic youth aged 5 to 30. Participants are randomly assigned to an exergaming group or a no-intervention control group. The stud…

This study is testing a behavioral therapy called 'Being Brave' to help reduce anxiety in autistic children aged 3 to 6. The therapy involves 16 weekly sessions with parents and children, using visual aids and practice exercises. Researchers will also look at biological markers t…

This study tests a program called START that helps families of children with ADHD learn about the condition, reduce stigma, and overcome obstacles to getting care. About 106 children aged 6-12 with a new or recent ADHD diagnosis will take part. Some families get the START program…

This pilot study tests whether a single session of repetitive transcranial magnetic stimulation (rTMS) can improve the brain activity behind working memory — the ability to hold information in mind. The trial includes teenagers with ADHD and working memory deficits, as well as he…

This study tests a 12-week online program for mothers of infants (12-36 months old) with SMA Type 1. The program aims to teach mothers how to support their baby's development and improve their own knowledge. Thirteen mothers will take part, with 10 receiving the program and 3 rec…

This study tests a program called Autism Parent Navigators, which offers six in-home sessions to support parents of young children (ages 2-6) recently diagnosed with autism. The goal is to help parents adjust, find services, and improve family well-being. About 360 parents are ta…

This trial tests whether a device called Cognilum, which shines light on the head (transcranial photobiomodulation), can reduce autism symptoms in children aged 2 to 6 with moderate to severe autism. Children wear the device for up to 15 minutes twice a week for 8 weeks. Research…

This trial tests whether a device called Cognilum, which shines light on the head (transcranial photobiomodulation), can reduce autism symptoms in children aged 2 to 7 with moderate to severe autism. Children wear the device for up to 15 minutes twice a week for 10 weeks. Researc…

This study tests whether a brief, telehealth-delivered therapy called Written Exposure Therapy (WET) can help autistic adults who have experienced trauma. Participants complete five weekly writing sessions and wear a Fitbit to track sleep, activity, and heart rate. The goal is to…

This pilot study in Pakistan tests a culturally adapted psychological therapy (Y-CMAP) for autistic young people aged 14-24 who have a history of self-harm. The therapy is based on cognitive behavioral therapy and includes 8-10 sessions over three months. The study will check if …

This trial tests whether a program called MyRAKAN Autism, which combines video modeling with virtual reality, can help autistic young adults improve their social communication skills. Participants attend eight sessions over five weeks, practicing skills like eye contact, conversa…

This study tests a non-invasive brain stimulation technique called tACS in 50 children and teens aged 6-18 with ADHD. The goal is to see if a mild electrical current applied to the scalp can improve attention and executive function. Participants will receive both real and sham st…

This trial tests whether rhythmic electrical pulses delivered to the wrist (median nerve stimulation) can reduce tics and the urge to tic in people with Tourette syndrome or chronic tic disorder. Participants wear a portable device for 15 minutes at a time over four weeks. The st…

This study tested whether a single infusion of stem cells from donated umbilical cord tissue could improve social communication in children with autism. 137 children aged 4 to 12 took part. The main goal was to see if their socialization and communication scores improved after si…

This study tested whether adding group music therapy to standard speech therapy helps autistic children aged 3-5 improve their language and social skills. Forty children were split into two groups: one got music therapy plus usual speech therapy, the other only speech therapy. Af…

This study tested whether an intensive, center-based version of Pivotal Response Treatment (PRT) can improve social communication in preschoolers with autism. 75 children aged 2 to 4 years participated. The therapy combined weekly parent training with center-based sessions for a …

This study tested a swimming and water safety program designed for children with autism spectrum disorder. The program uses individualized teaching methods and sensory modifications to help kids learn to swim and stay safe around water. Over 350 children with autism took part, an…

This study tests whether cognitive behavioural therapy for insomnia (CBT-I) can improve sleep and ADHD symptoms in adolescents aged 12 to 18 who have both ADHD and insomnia. Participants receive either CBT-I plus usual care or usual care alone. The goal is to see if addressing in…

This study tested a virtual reality program called Impact VR to help youth aged 10-17 with conduct disorder learn to recognize and regulate emotions. The program involved four weekly sessions in a private setting. Researchers measured changes in callous-unemotional traits, conduc…

This study tested whether Collaborative Problem Solving (CPS), a behavioral approach that teaches caregivers to address children's underlying thinking skill deficits, can improve executive function and reduce behavioral symptoms in 54 youth receiving home-based mental health care…

This study tested two ways to improve dental care for children with autism. One group received a dental toolkit with tips and resources. The other group got the toolkit plus special parent training to help with brushing and dentist visits. The goal was to see if the extra trainin…

This study looked at whether a recreational ballet program called Ballet for all Kids can help children with autism spectrum disorder (ASD) improve their motor skills. 32 children aged 6-12 with ASD participated in the program for 12 weeks. Researchers measured changes in coordin…

This study tested a structured online program for parents of children with autism or ADHD. 90 families took part to see if the program could lower parental stress, improve coping skills, and boost social support. Researchers compared parents who received the program to those who …

This study tests a 10-week visual rehabilitation program for children with autism spectrum disorder who also have vision problems. The program uses games and activities to improve how children use their eyes and process visual information. Researchers want to see if better vision…

This study tested a new behavior therapy for teens with autism who struggle with irritability and aggression. The therapy teaches emotion regulation and coping skills for the challenges of growing up. 65 adolescents participated, and researchers measured changes in aggressive beh…

This study tested a program called ASPEN, which coaches parents of young children with autism in low-resource communities. The program includes 12 sessions teaching parents strategies to improve their child's social communication and play skills, while also reducing parenting str…

This study tested whether a natural supplement called ultramicronized palmitoylethanolamide (umPEA) can improve smell, taste, and other sensory issues in children with autism. Eighty children took either umPEA or a standard treatment (probiotics plus omega-3) for six months. Rese…

This study tested a program called the Westmead Feelings Program 2 for Chinese children with autism in Hong Kong primary schools. The goal was to help them better understand and manage emotions. 85 children took part, and researchers measured changes in emotional skills and behav…

This study tested whether playing virtual reality games (like Nintendo Switch Sports) could improve balance and walking in young people with autism, compared to standard physical therapy exercises. Thirteen participants aged 7-22 did six sessions over two weeks at home via Zoom. …

This study tested a personalized brain-training method called neurofeedback for children with ADHD. 51 children participated, and the training was tailored to each child's unique brain patterns. The goal was to see if this approach could improve attention and reduce ADHD symptoms…

This study tested an online training program called CHATO for nursing home staff who care for people with Alzheimer's or other dementias. The training aimed to improve how staff communicate, which may reduce behavioral symptoms like agitation or rejection of care. Over 5,000 staf…

This study tested a drug called ecopipam in 40 children aged 7 to 17 with Tourette's syndrome. The goal was to see if it could reduce the frequency and severity of their motor and vocal tics. The drug works by blocking certain dopamine receptors in the brain. The main measure was…

This study tested a psycho-educational program designed to help family caregivers of children with autism become more aware of their own needs and better at seeking support. Fifty caregivers of children aged 6 to 12 took part. The program involved teaching coping strategies and w…

This pilot study tested whether adding cognitive behavioral therapy (CBT) to usual care helps reduce irritability and suicidal thoughts in children aged 8 to 12 with anger and aggression issues. 46 children were assigned to either CBT plus usual care or usual care alone. The ther…

This Phase 2 trial tested a new drug called EB-1020 SR (centanafadine) in 45 adult men with ADHD. The goal was to see if it could reduce symptoms like inattention and hyperactivity. Participants took the drug or a placebo for a few weeks, and researchers measured changes using a …

This study tested a 6-week program called BUILT for families with children aged 6 to 12 who have ADHD. The program teaches healthy habits around sleep, nutrition, and exercise to help improve focus and behavior. Researchers measured changes in physical activity, sleep, diet, and …

This study tested whether a virtual reality (VR) social skills program works as well as an in-person group program for preschool children with autism. Thirty-two children aged 4 to 6 were randomly assigned to either VR or in-person sessions over 8 weeks. Researchers measured soci…

This study tested whether adding a virtual reality (VR) module that helps children imagine future events could improve standard brain-training exercises for kids with ADHD. Eighty children aged 5 to 12 took part, with half doing only the standard training and half also using VR h…

This study tested a home-based brain-training program in 12 autistic adults who also had insomnia. Participants played cognitive games for 18 hours over 6 weeks while wearing a sleep tracker and filling out sleep diaries. The goal was to see if the training was usable and could i…

This study tested whether aripiprazole (Abilify) can reduce serious behavioral problems in children and teens aged 6 to 17 with autistic disorder. 98 participants received either the drug or a placebo for 8 weeks. Researchers measured changes in irritability and overall improveme…

This early study tested esketamine, a form of ketamine, in 3 girls with Rett syndrome. The goal was to see if weekly infusions over five weeks could improve symptoms and be safe. The trial is complete, but with only 3 participants, it's too small to draw firm conclusions.

This study tested a new system called FamilyNet that uses a smart speaker and a mobile app to help parents of children aged 10-17 with challenging behaviors like oppositional defiant disorder or conduct disorder. The system helps parents create a positive behavior plan and sends …

This study tested whether smelling lemon essential oil for 5 minutes could improve attention in 52 children aged 9-16 with ADHD who were not on medication. The children were randomly assigned to inhale either lemon oil or a placebo before taking attention and memory tests. Result…

This study tested whether Acceptance and Commitment Therapy (ACT) can improve the well-being of parents caring for children with autism. Thirty parents in Saudi Arabia took part in online ACT sessions over five weeks. Researchers measured changes in stigma, mindfulness, and stres…

This study tested a program called 'My DEER Compassion' that teaches self-compassion skills to children with ADHD. 96 children in Hong Kong, along with their parents, took part in sessions to learn how to be kinder to themselves. The goal was to see if this could improve their em…

This pilot study tested whether a nurse-led community sailing program could improve resilience, quality of life, and mood in 36 school-aged children with autism. Children in the sailing group took part in 24 hours of sailing over six days, while a control group did simple crafts.…

This study tested a non-invasive device that gently stimulates a nerve on the forehead (trigeminal nerve) during sleep to see if it can reduce ADHD symptoms in children ages 7 to 12. Over 200 children used either the active device or a sham (inactive) device nightly for 4 weeks. …

This study tested whether aripiprazole (Abilify) can reduce serious behavioral problems in children and adolescents with autistic disorder. 218 participants aged 6 to 17 received either a fixed dose of aripiprazole or a placebo daily for 8 weeks. The main goal was to see if the d…

This study tested two non-drug therapies—graded motor imagery (mental rehearsal) and mirror therapy (using a mirror to trick the brain)—in 44 chronic stroke patients aged 45 to 65. The goal was to see which better reduces muscle spasticity and improves independence. Both therapie…

This study looked at the safety and tolerability of the drug Azstarys in 123 children aged 4 to 5 with ADHD over 12 months. Researchers monitored sleep, weight, and height changes, as well as how well the drug controlled ADHD symptoms. The goal was to see if this medication could…

This study tested whether adding a gentle brain stimulation technique called tDCS to a reading therapy (PMT) could help stroke survivors with aphasia read better. Six people with chronic aphasia took part. The goal was to see if the combination improved reading accuracy more than…

This study adapted a behavioral activation treatment called BeatIt-MV to help improve mood in minimally verbal autistic adults with depression. Nine adults took part, along with a caregiver. The therapy focused on increasing meaningful activities like recreation and social time. …

This study tested a 12-session outdoor group training program where children interacted with animals to build resilience. It included 107 children aged 2-4 or 8-12 who had either autism or a history of stressful life events. The goal was to see if this approach could help them be…

This Phase II trial tested PDC-1421, a capsule made from a plant extract, in 99 adults with ADHD. Participants were randomly assigned to receive the capsule or a placebo for up to 8 weeks. The goal was to see if the treatment could reduce ADHD symptoms and to check its safety.

This study tested a Spanish-language program called Unstuck and On Target with 20 families in Ecuador. Children aged 8-11 with autism or ADHD took part in an 8-week program to improve flexibility and problem-solving. The goal was to see if the program was practical and helpful fo…

This study tested a gentle, non-invasive brain stimulation technique called tDCS in 14 people who had a stroke at least a year ago and still have trouble finding words (aphasia). The goal was to see if stimulating a key language area could improve their ability to name pictures a…

This study tested a non-invasive brain stimulation technique called TMS in 20 young adults with autism. The goal was to see if stimulating a specific brain area could improve how they look at faces and interact socially. Participants received 10 daily sessions, and researchers me…

This study tested a program called PRISM, which teaches skills like stress management and goal setting, to see if it helps racial minority patients with serious illnesses feel more resilient and communicate better with their healthcare providers. The study enrolled 28 seriously i…

This study tested whether 3 weeks of intensive language therapy (at least 2 hours daily, 5 days a week) helps people with long-term aphasia after a stroke communicate better in everyday situations. 156 participants with aphasia for at least 6 months were assigned to either immedi…

This study tested whether bumetanide, a diuretic, can improve social skills in children with autism. Researchers used a blood test and machine learning to pick children likely to respond. 66 children aged 3-6 took bumetanide or standard behavioral therapy for three months. The go…

This pilot study tested whether electromagnetic therapy (EMT) can help improve autism symptoms in children. Thirty children aged 3-12 with mild to moderate autism were randomly assigned to receive either their usual care plus EMT or usual care alone. The treatment involved 30 ses…

This study tested whether an adapted form of Narrative Exposure Therapy (NET) is acceptable and helpful for adults with mild learning disabilities who have experienced trauma. Thirteen participants completed the therapy, which involved talking through their life events in a struc…

This study looked at whether teaching parents to use Reciprocal Imitation Training (RIT) at home helps young children with autism improve their imitation and social skills more than therapist-only sessions. Eighteen children aged 2 to 5 years participated. The goal was to see if …

This study tested whether wrapping children with autism in sheets (wet or dry) can reduce severe injurious behaviors like self-harm or aggression. 48 children took part, and researchers compared wet wraps to dry wraps. The goal was to see if this gentle, drug-free approach could …

This study tested whether a mix of vitamins and supplements could ease autism symptoms in 88 children aged 2.5 to 6 years. Half received the supplements plus behavioral therapy, the other half only behavioral therapy. After three months, researchers measured changes in social ski…

This study looked at whether a structured yoga program can help children aged 7–11 with Developmental Coordination Disorder (DCD) — a condition that makes everyday tasks like tying shoes or catching a ball hard. Forty children took part to see if yoga could improve their movement…

This completed study tested whether Vita 6 (a vitamin supplement) or zinc, each given alongside behavioral therapy, could reduce autism severity in children aged 3-12. Sixty-four newly diagnosed children who were not on any other treatment took part. The goal was to see if either…

This study tested a new psychological treatment for autistic young people who struggle with overwhelming sensory experiences, like sounds or lights. Twenty-five participants completed a group therapy program and did tasks before and after to see if their brain responses and anxie…

This study tested whether a once-daily capsule called centanafadine helps reduce ADHD symptoms in children aged 4 to 12. Over 500 children took either the drug or a placebo for 6 weeks. Researchers measured changes in ADHD rating scales to see if the drug works better than a suga…

This study tested whether phosphatidylserine supplements with or without DHA (an omega-3 fat) could improve thinking skills in children with ADHD. 45 children aged 10-14 who had never taken ADHD medication took either a placebo or one of three supplement formulas daily for 8 week…

This small pilot study tested a structured plate with separate compartments to help children aged 5 to 7 with autism and feeding difficulties eat more easily. Six children used the plate during school lunch three times a week for two months, guided by an occupational therapist. R…

This study tested a therapy called Sentido's Model in 24 children aged 3 to 7 with autism or other neurodevelopmental challenges. The therapy combines behavior analysis, sensory integration, and stress science to help children improve adaptive behaviors like communication and dai…

This study tested the PACE technique, a therapy that encourages people with aphasia to use any form of communication—like gestures, drawing, or writing—to get their message across. Sixteen adults aged 45 to 65 with mild to moderate aphasia took part. Half received PACE plus stand…

This study tested a custom probiotic blend in 296 children and adults with autism spectrum disorder. The goal was to see if the supplement could improve autism symptoms and gastrointestinal issues. Participants took a personalized mix of probiotics, prebiotics, and botanicals, an…

This study tested whether a pet therapy program, based on the Human Caring Theory, could reduce stress and improve social and communication skills in children aged 7-11 with speech and language disorders. Thirty-six children participated, with some receiving six sessions of anima…

This study tested whether a brain-training technique called neurofeedback, combined with virtual reality (VR), could improve attention and self-control in children with ADHD. 138 children aged 7-12 took part in 16 training sessions over 8 weeks. The goal was to see if this approa…

This study tested whether a virtual reality (VR) product called Floreo can help autistic children improve their social skills. 117 children aged 5 to 18 used the VR program twice a week for 12 weeks. Researchers compared the Floreo VR group to a control VR group to see if there w…

This small pilot study tested whether a non-invasive brain stimulation technique called TMS, guided by each person's unique brain map, could help improve language and social skills in 22 children and young adults with autism and language delay. The treatment targeted a specific b…

This small pilot study tested whether a gentle electrical current applied to the brain (tACS) could improve naming ability in 11 people with chronic aphasia after a stroke. Participants received either real or sham stimulation during language training over two weeks. The goal was…

This study tested a six-week summer camp program to help children aged 4-6 with developmental language disorder improve their grammar. 24 children received language therapy during the camp and were tested again six weeks later to see if they kept their new skills. The goal was to…

This pilot study tested whether a 12-week course of a synbiotic supplement (probiotics plus prebiotics) could help reduce anxiety in 30 children with autism spectrum disorder. The main goals were to see if the treatment was safe and tolerable, and to measure any changes in anxiet…

This study looked at whether adding Ayres Sensory Integration therapy to usual education helps preschool children with autism. 63 children aged 4 to 5 years took part. The therapy focused on improving daily skills and sensory processing over 12 weeks.

This study tested a new type of therapy called reminder-focused positive psychiatry (RFPP) for teenagers who have both ADHD and PTSD. The goal was to see if the therapy is acceptable and helpful for reducing symptoms. Eleven teens took part, and the study measured how well they l…

This study tested a 6-week mobile app designed to support Chinese parents of children with autism. The app provided knowledge, skills, and mindfulness training. 852 parents took part to see if the app could reduce anxiety, depression, and stress while boosting parenting confidenc…

This pilot study tested a wearable device that gently stimulates a nerve in the ear to help manage anxiety in teenagers with autism. Ten participants used the device at home twice daily for four weeks. The goal was to see if it was safe and easy to use, not yet to prove it works.…

This pilot study tested a 4-week laughter yoga program (8 sessions, 15 minutes each) in 45 adolescents with intellectual or physical disabilities at a special school in Hong Kong. Half did laughter yoga, half got routine care. The goal was to see if laughter yoga could improve mo…

This completed trial tested whether LEGO therapy can improve social skills in 50 adolescents aged 10–14 with high-functioning autism. Participants attended 12 weekly 90-minute group LEGO sessions over 3 months. Researchers compared their social skills to a control group who conti…

This study tested an in-person mindfulness program for adolescents with autism and their caregivers. The goal was to help reduce stress, anxiety, and depression. 28 teens and their caregivers took part in group sessions. The program aimed to improve mental health and well-being.

This study looked at whether creating personalized profiles for children with disruptive behavior disorders (like ADHD or oppositional defiant disorder) and their parents could help predict which therapy works best. Researchers tested two common treatments—child cognitive behavio…

This study tested whether playing a specially designed multitask game for 25 minutes a day, at least 5 days a week, could improve attention in children aged 8-12 with ADHD. Forty children participated, and researchers measured changes in attention using a computer test called TOV…

This study tested a school program for children aged 7 to 11 with Developmental Coordination Disorder (DCD), which affects movement and coordination. The program combined motor exercises with cognitive tasks like imagining actions and watching movements. Over 10 weeks, 20 childre…

This study tested whether a gentle, non-invasive brain stimulation technique could safely improve social symptoms in children with autism. 36 children aged 4-10 received either real stimulation or routine rehabilitation for 5 days. The goal was to see if the treatment is safe and…

This study tested whether extra tutoring in reading and math can improve skills for first-graders who are behind. 385 students from Nashville public schools were randomly assigned to reading tutoring, math tutoring, combined tutoring, or their usual school program. Tutoring laste…

This study tested a special video game controlled by muscle signals (EMG) to help people who had a stroke at least 6 months ago improve hand movement. Twenty participants with moderate hand weakness played the game using either one hand or both. The goal was to see if this fun tr…

This study tested whether a mild electrical current applied to the scalp for 5 days in a row could help adults who stutter speak more fluently. 36 participants received either real or sham stimulation while doing fluency exercises. Researchers measured changes in stuttering durin…

This study tested whether taking part in art activities like theatre, dance, visual arts, music, or cinema can improve mental health. 541 adults with psychiatric diagnoses were randomly assigned to either an art program or a waitlist. Researchers measured changes in depression an…

This study looked at whether a 16-week swimming and water exercise program could improve behavior and physical skills in 35 boys aged 6 to 12 with mild autism. Half the boys did the water exercises twice a week, while the other half continued their usual school routine. The resul…

This study tested a new parenting program called ADAPT for depressed parents of children aged 6 to 10 with emotional and behavioral difficulties. The program combines emotion regulation skills with parenting techniques. The goal was to see if the program is feasible and acceptabl…

This study tested a structured movement program (Sherborne Developmental Movement) in 30 children aged 8-12 with autism. The program aimed to improve how they process sensory information, move their bodies, and perform everyday tasks. Results were measured using motor skill tests…

This study tested whether having a therapy dog present during dental visits could reduce anxiety and improve cooperation in autistic children aged 6 to 17. Fifty children received two sessions with a dog and one without. The goal was to see if the dog's presence made later visits…

This study tested a group program to help parents of children with learning or attention difficulties manage stress. About 28 parents took part in either a mind-body resiliency group or a health education group, both held online. The goal was to see if the program was practical a…

This study tested a structured program to help children and teens with autism, developmental delays, or intellectual disabilities cooperate during eye exams. Twenty participants attended six training sessions that used practice in a mock clinic, rewards like snacks or toys, and o…

This study tested an app called iTalkBetter for people who have trouble finding words after a stroke. 31 participants used the app to practice naming specific items. The goal was to see if the app could improve word retrieval for those practiced items. This small trial helps unde…

This study tested a summer program called STRIPES, where trained peers helped ninth graders with ADHD get ready for high school. 72 students were randomly assigned to the program or to regular school services. Researchers tracked grades, attendance, and ADHD symptoms to see if th…

This study tested a video-based therapy called Focused Acceptance and Commitment Therapy (FACT) for parents of children with special health needs, like ADHD or autism. The goal was to see if it could reduce stress, anxiety, and depression. 104 parents took part, and the therapy w…

This study tested whether adapted judo training plus nutritional counseling could improve physical fitness, body composition, and stability in children and adolescents with autism spectrum disorder (ASD). One hundred participants aged 7–14, with and without ASD, took part in 10 m…

This study tested whether a physical activity program delivered via telehealth could improve sleep in children with autism spectrum disorder (ASD) and reduce stress for their parents. 160 children aged 8-12 and their caregivers took part from home, using activity trackers and que…

This study tested whether ongoing Tai Chi and mindful movement classes could help children with ADHD improve motor control, attention, and reduce symptoms. Fifteen children took part in one-hour classes twice a week for a year. Researchers measured changes in cognitive control, m…

This study looked at whether circuit aerobic training (like walking and stepping) or circuit resistance training (like hand grip exercises) can improve heart and lung fitness in children with autism aged 7 to 17. Thirty-two children took part, and researchers measured their breat…

This study tested a 40-week music program using bone conduction headphones in 8 children with autism who are overly sensitive to sound. The goal was to see if the program could reduce their discomfort with noise and improve their daily living skills. Researchers measured changes …

This study tested a dynamic blended learning module for 49 people with pulmonary hypertension, a chronic disease causing symptoms like shortness of breath and fatigue. The program included face-to-face education, regular phone follow-ups, and a video from a patient who successful…

This study tested a drug called NOE-105 in 75 adult men who have stuttered since childhood. The goal was to see if it could improve speech fluency without the side effects of older treatments. Participants took the drug or a placebo for 10 weeks, and researchers measured changes …

This study looked at how 10 months of judo training affects physical fitness and anxiety in children with autism. Ninety kids aged 7 to 14, with and without autism, trained together. Researchers measured fitness with standard tests and anxiety with questionnaires. The goal was to…

This study tested whether special tinted glasses can reduce visual stress symptoms (like eye strain and reading difficulties) in university students. 72 students with visual stress symptoms wore the glasses and reported their reading speed and symptoms. The goal was to see if the…

This study looked at whether taking Lion's Mane mushroom extract daily for two months can improve memory and attention in healthy, working women aged around 40-60. Participants took either the extract or a placebo pill and completed thinking and memory tests at several points. Th…

This study tested a special sleep program for teenagers with ADHD who also have sleep problems. The program combines cognitive behavioral therapy with sleep tips and planning skills. Researchers wanted to see if better sleep could also improve ADHD symptoms and daily life. The st…

This study tested whether virtual reality glasses or white noise headphones could reduce pain and anxiety in 48 children with ADHD during dental procedures. The children were distracted with cartoons or white noise while dentists worked. Researchers measured pain through behavior…

This study tested a school-based program called Unstuck & On Target: High School for autistic teens. The program teaches skills like flexibility, planning, and self-advocacy through 25 lessons led by school staff. Researchers measured changes in classroom behavior and daily livin…

This Phase 3 trial tested whether solriamfetol, a drug already approved for sleep disorders, can reduce ADHD symptoms in adults. Over 500 participants took either a daily dose of solriamfetol or a placebo for six weeks. The study measured changes in attention and hyperactivity us…

This study tested whether a therapy called dialectical behavior therapy (DBT) is helpful and acceptable for teens aged 14–17 with fetal alcohol spectrum disorders (FASD). Nine teens and their caregivers took part in a program that included individual therapy, group skills trainin…

This study tested two high-tech teaching methods—AI-assisted learning and virtual reality classrooms—in 90 children aged 8-15 with ADHD. Over 12 weeks, researchers measured changes in ADHD symptoms and thinking skills. The goal was to see if these digital tools can help without m…

This study tested a telehealth program that teaches caregivers skills to manage ADHD-related behaviors and sleep problems in preschoolers aged 3-5 at risk for ADHD. 46 families participated, and researchers measured changes in ADHD symptoms and sleep habits. The goal is to provid…

This study looked at whether a 12-week structured movement program could help young children (ages 4-6) with autism improve their motor skills and daily functioning. Twenty-eight children participated; some did the movement program twice a week plus their usual education, while o…

This phase 3 trial tested an experimental drug called AST-001 in 169 children with autism spectrum disorder. The goal was to see if it improves core symptoms like social communication and repetitive behaviors better than a placebo. The study is already completed, and results will…

This small study tested whether a gentle electric current applied to the scalp (tDCS) could improve word-finding in 5 civilians who had a traumatic brain injury more than a year ago. Participants received both real and sham stimulation to see if the real treatment boosted verbal …

This study tested whether a gentle, non-invasive brain stimulation called tDCS could make speech therapy work better for people with aphasia (trouble speaking or understanding language) after a stroke. 23 adults who were at least 6 months past their stroke received speech therapy…

This study tested a device called transcranial photobiomodulation (tPBM), which shines invisible light on the front of the brain through a headband. Researchers wanted to see if it is safe and can improve social and behavioral symptoms in adults with autism. Forty-one adults took…

This study looked at whether two types of structured exercise—Gince Zumba (rhythm-based aerobic dance) and Square Stepping (patterned steps on a mat)—could improve thinking, movement, and behavior in 51 children with ADHD. Kids were randomly assigned to one of the exercise groups…

This study tested whether a probiotic supplement called Lactobacillus plantarum PS128 can improve tic symptoms and quality of life in children with Tourette's syndrome. 121 children aged 4-18 took part. The main goal was to see if PS128 reduces tic severity and related emotional …

This study tested a 10-week program of biofeedback and breathing exercises in children and teens aged 6-18 with ADHD. The goal was to see if these techniques could reduce ADHD symptoms and improve heart rate variability. The small, completed trial involved 12 participants and use…

This study tested a theatre-based program called SENSE Theatre for adults with autism. 72 participants took part in 10 sessions of role-play and peer interaction, ending with a public performance. The goal was to see if this approach could improve social skills like reading faces…

This study tested the Triple P parenting program for mothers of children aged 6-13 with ADHD. The program teaches strategies to reduce behavior problems and boost mothers' confidence. 67 mothers took part, with some receiving the program and others not. Researchers measured chang…

This study tested whether adding art therapy to standard speech rehab could help people who recently had a stroke and now have trouble speaking (aphasia). Fifteen participants received 12 art therapy sessions alongside their usual therapy. Researchers used brain scans to see if a…

This study tested a web-based app called Gotcha! designed to help people with mild-to-moderate dementia remember names of people they know. 48 participants practiced daily for 6 weeks using a tablet at home. The goal was to see if the therapy improves name recall and whether it c…

This study tested a new medication called CTx-1301 (dexmethylphenidate) for children and teens aged 6 to 17 with ADHD. The goal was to see if it reduces ADHD symptoms better than a placebo. 103 participants took either the drug or a placebo, and researchers measured changes in AD…

This study tested whether a 5-month program of dialectical behavior therapy (DBT) can help adults with autism who struggle with self-harm or suicidal thoughts. Researchers enrolled 92 adults with autism and no intellectual disability. The goal was to see if DBT reduces emotional …

This study looked at whether high-dose omega-3 fatty acids can reduce ADHD symptoms in children aged 6-12 who have high inflammation levels. Fifteen children took omega-3 supplements for 12 weeks. Researchers measured changes in ADHD symptoms and inflammatory markers to see if om…

This study tested a safe, noninvasive treatment for memory and word-finding problems in Gulf War veterans. 93 veterans received either real or fake (sham) brain stimulation over 10 sessions. The goal was to see if the stimulation improved their ability to recall words and speak m…

This study tested a therapist-guided online program called AMOR for pregnant women and new mothers with ADHD. 31 participants listened to podcasts and attended online group sessions. The goal was to see if the program was easy to use and helpful for managing ADHD, stress, anxiety…

This study tested a flexible, play-based program to improve social communication and language in toddlers (ages 2-3) with autism. 199 children took part in community early-intervention settings. The program adjusted the type and amount of one-on-one play coaching based on each ch…

This study tested whether taking creatine supplements could improve brain health and reduce symptoms in people with autism spectrum disorder (ASD). Twenty participants aged 10 and older took creatine or a placebo for a period. Researchers measured changes in brain creatine levels…

This study tested a 22-week online parenting program (Incredible Years) for families of children aged 3-7 with genetic abnormalities and mental health or developmental problems. 53 families were randomly assigned to the program or usual care. The goal was to see if parents would …

This study tested a program called PRISM that teaches stress management, goal-setting, and coping skills to adolescents and young adults (ages 12-24) with advanced cancer. Researchers wanted to see if it could improve quality of life and reduce anxiety and depression. The program…

This study looked at whether adding music activities like playing harmonica and drums to occupational therapy can improve attention and thinking skills in children with ADHD. Thirty-nine children aged 6 to 17 took part. After six weeks, both standard and music-based therapy helpe…

This study tested whether adding in-home decluttering practice to a group workshop (Buried in Treasures) helps people with hoarding disorder. 41 adults aged 18-70 took part. The goal was to reduce clutter, difficulty discarding, and excessive acquiring. Results were measured usin…

This study tested whether adding homeopathic treatment to standard therapies (speech, occupational therapy) helps children with autism. 54 kids aged 3–12 were randomly given either individualized homeopathic medicines or a placebo. Researchers tracked changes in communication, be…

This study tested a time-limited version of Parent-Child Interaction Therapy (PCIT) delivered via telehealth for young children (ages 2-6) with autism and disruptive behavior problems. 80 families were randomly assigned to receive 10 sessions of Tele-PCIT or continue with their u…

This study tested speech entrainment therapy (SET) in 80 people with non-fluent aphasia after a stroke. Participants practiced speaking along with an audio-visual computer program for 3, 4.5, or 6 weeks, or received no therapy. The goal was to find the best duration for lasting i…

This study looked at whether a non-invasive brain training method called neurofeedback can help veterans who have had a mild traumatic brain injury and still suffer from chronic headaches, trouble sleeping, and attention problems. 87 veterans were randomly assigned to receive neu…

This study tested a program where adults with aphasia (a language disorder often from stroke) learn to train dogs using positive reinforcement. The goal was to see if this boosts quality of life, confidence, and social engagement. Seventeen participants completed the program, and…

This pilot study tested whether lithium can improve social communication in children with autism spectrum disorder who also have a SHANK3 gene mutation (Phelan-McDermid syndrome). 22 children took either lithium or a placebo for 12 weeks. Researchers measured changes in social re…

This study tested different doses of melatonin to see which one best improves sleep quality in autistic children aged 3 to 12 who have trouble sleeping. Researchers measured things like how long it takes to fall asleep, total sleep time, and number of night awakenings using sleep…

This study tested whether taking part in art activities (like painting, music, or dance) can improve mental well-being. 382 people with mental health issues such as anxiety, depression, or emotional disorders were randomly assigned to either an art program or a waitlist. The stud…

This pilot study tested whether a daily dose of EGCG, a natural compound found in green tea, could improve cognitive performance in 36 children aged 7 to 14 with fetal alcohol syndrome. The children took EGCG for one year and had their thinking skills measured at the start, at 6 …

This study tested a smartphone app called SRAVI that reads lip movements and turns them into words on a screen. It was used by 31 adult patients in acute or critical care who had a tracheostomy and could not speak. The goal was to see if the app could help them communicate better…

This study tested whether adding a therapy dog to standard social skills training could help children with ADHD. Thirty-nine children took part, some receiving dog-assisted sessions and others only social skills training. Researchers measured ADHD symptoms, self-esteem, and stres…

This study tested whether a self-hypnosis smartphone app called Hypnotidoo could improve attention and reduce anxiety in children aged 7 to 12 with ADHD who were already taking methylphenidate. The app offers short, screenless audio sessions with stories and breathing exercises. …

This study tested whether showing people a live ultrasound image of their tongue during speech therapy helps them improve faster. It included 18 adults and children with speech problems after surgery or brain injury. They compared therapy sessions with and without the ultrasound …

This pilot study tested a program called PRE-CARE for 54 low-income families of preschoolers with ADHD symptoms. The program helps families find and enroll in community resources like food assistance or housing support. Researchers wanted to see if this approach could reduce ADHD…

This study looked at 132 teenagers with Tourette syndrome to understand how their brains and thinking skills change during adolescence. Researchers used brain scans (MRI), magnetic pulses (TMS), and computer tests to measure brain connections, control, and decision-making. The go…

This completed study from the National Institute of Neurological Disorders and Stroke aimed to better understand how the brain controls movement and what goes wrong in movement disorders like Parkinson's disease, Tourette's syndrome, and dystonia. Over 1,200 adults—both patients …

This study looks at whether a parent coaching and family navigation program (Project AFECT) can help families right after a child is diagnosed with autism. About 200 parents of children aged 1 to 5, who are Hispanic/Latino, Black/African-American, or have Medi-Cal insurance, will…

This study explores whether artificial intelligence can simplify the language used in informed consent forms for clinical trials. Researchers will test AI tools like ChatGPT and NotebookLM to rewrite these forms and see if people understand them better. The study involves 230 par…

This study aimed to understand the brain and genetics behind autism spectrum disorders (ASD). Researchers compared brain scans, thinking tests, and DNA from 678 people with ASD, healthy volunteers, and their parents. The goal was to find links between brain activity, behavior, an…

This study looked at 128 physiotherapy students to see if taking an academic literacy class helped with their reading, writing, and thinking skills. Researchers compared students who took the class to those who did not using surveys. The goal was to understand if such education b…

This study tested whether a 6-session psychoeducation program could improve autism knowledge, sibling relationships, well-being, and resilience in 88 adult siblings of people with autism. Participants were all neurotypical adults living in Greece. The program was designed to prov…

This study follows nearly 600 people with Smith-Magenis syndrome (SMS), a rare genetic condition, to track how their health, behavior, and development change over time. Researchers will perform detailed medical exams, genetic tests, and surveys to better understand the syndrome's…

This study aims to help people from underserved communities talk about their wishes for end-of-life care and complete advance directives. Researchers will use trusted community networks to host events where two conversation tools are tested. About 1500 adults will participate to …

This study looks at whether children diagnosed with a specific learning disorder that affects written expression have different fingertip touch, hand grip strength, and pain sensitivity compared to healthy children. Researchers will measure these sensations using simple tools lik…

This study tested a set of questions to better identify suicide risk in young people aged 8–17 with autism or other neurodevelopmental disorders. Researchers asked 278 participants and their parents about thoughts of self-harm and understanding of death. The goal was to create a …

This study looked at whether asking children with developmental language disorder to repeatedly recall new words helps them learn better than just hearing the words. Twenty-seven 4- and 5-year-olds learned made-up words during storybook reading. The goal was to see if retrieval p…

This study looks at how autistic people who also have anorexia nervosa differ in brain structure and behavior from autistic people without anorexia. Researchers want to understand if 'masking' (acting non-autistic to fit in) is linked to eating disorder symptoms and brain changes…

This study tests whether a structured communication protocol called StOP? helps surgical teams talk more clearly during operations. Researchers will compare death rates and other outcomes in 400 patients whose surgeons use the tool versus those who don't. The goal is to see if be…

This study follows children born moderately or late preterm (32-36 weeks) to age 9, measuring their thinking, movement, language, behavior, and growth. Researchers compare these kids to full-term peers to understand long-term effects. The goal is to learn how early development pr…

This completed study at the NIH enrolled 96 children with known or suspected genetic disorders, including autism and Fragile X syndrome. The main goal was to give clinic staff hands-on experience and explore new research ideas. Participants received medical exams, lab tests, and …

This study tested a new parent questionnaire called ORALQUEST to assess feeding and eating disorders in children aged 9 months to 6 years. Researchers included 338 children with chronic conditions like heart defects or autism, as well as those with picky eating. The goal was to s…

This study investigates how emotional stress impacts sleep and learning in children aged 7 to 12 with autism spectrum disorder (ASD) or attention deficit hyperactivity disorder (ADHD). Researchers will use a social stress task to trigger emotional responses, then monitor sleep pa…

This study follows children with specific reading disorders (like dyslexia) who previously took part in a training program using the Poppins Clinical app, which combines musical, cognitive, and written language exercises. The goal is to see if the benefits of that training on rea…

This study investigates how the brain learns to recognize patterns across experiences and how sleep helps solidify those memories. Healthy adults aged 18-35 will perform learning tasks while their brain activity is monitored using MRI and EEG. The researchers will also use sound …

This study is testing whether epigenetic changes in newborn blood can serve as a biomarker for fetal alcohol spectrum disorder (FASD). Researchers will collect umbilical cord blood at birth and heel stick blood at 48 hours from 600 newborns, and compare these with blood alcohol l…

This pilot trial is testing whether a program called CRUSH, designed to teach sexual health and relationship skills, is practical and well-received by autistic adults aged 18 to 30. Participants will attend 15-20 group sessions with one-on-one coaching and complete assessments be…

This study uses brain scans to compare how a single dose of two ADHD medications—guanfacine (a non-stimulant) and lisdexamfetamine (a stimulant)—affect brain function in children and teens with ADHD, relative to a placebo. Participants perform tasks of attention, working memory, …

This study looks at how the gut microbiome and its chemical byproducts relate to gastrointestinal and behavioral symptoms in children with autism. By tracking 23 participants over time, researchers hope to identify biological markers that could one day help manage these symptoms.…

This study tests whether a special technology tool can help deaf or hard-of-hearing children ages 3-10 improve their language skills. About 114 children will be randomly assigned to use the tool or continue their usual therapy. Researchers will measure changes in vocabulary, sent…

This trial tests whether adding role-play video demonstrations to an online course helps fifth-year medical students at Ain Shams University learn doctor-team communication skills. One group receives the standard online course, while the other also watches recorded videos showing…

This observational study looks at whether the types of bacteria living in the gut, along with diet and lifestyle, are linked to a person's risk of catching SARS-CoV-2. It follows over 900 children, their family members, and teachers in Spain for 17 months. Researchers collect sto…

This study explored why some children with autism respond better to parent-led therapies than others. Researchers tested different sequences of parent education and child coaching in 81 toddlers (12-36 months) to see which approach worked best for which families. The goal was to …

This study explores how adults who stutter process and produce speech compared to those who do not. Participants complete computer-based listening and speaking tasks over one or two visits. The goal is to better understand the underlying differences in speech processing that may …

This study tests whether a script-guided conversation before surgery helps patients and their families better understand general anesthesia, the anesthesiologist's role, and the risks they are consenting to. Adults having elective surgery under general anesthesia will receive the…

This study tested a program that uses technology and trained family navigators to help children with autism and their families get connected to mental health services more quickly. The program was used in primary care clinics. Researchers measured how acceptable, feasible, and he…

This study investigates how different language treatments affect both language skills and brain function in people with aphasia, a condition that impairs the ability to speak, understand, read, or write after a stroke. Participants will receive therapy targeting naming, spelling,…

This study adapts an existing advocacy program, called ASSIST, for Latinx families of autistic youth aged 12 and older. The program teaches parents how to advocate for adult disability services, aiming to improve access to care. Researchers will test the adapted program with 48 S…

This study looked at how adults with autism spectrum disorder (ASD) form emotional attachments to others. Researchers used questionnaires to measure social responsiveness and attachment styles in 32 adults with ASD. The goal was to better understand the link between autism and at…

This study looks at whether children with ADHD are more likely to have very flexible joints (benign joint hypermobility) and if a certain blood marker differs. Researchers will compare 171 children aged 6 to 12—some with ADHD and some without—using physical exams and blood tests.…

This study tested a two-day training program designed to help newly graduated nurses speak up about patient safety concerns. 76 nurses from a hospital in Ankara, Turkey, were split into two groups: one received the training, the other did not. Researchers measured changes in comm…

This study tests a tool called the Cultural Formulation Interview-Engagement Aid (CFI-EA), designed to help clinicians and patients from different cultural backgrounds communicate better. The goal is to see if using this tool improves patient satisfaction and keeps people in trea…

This study looked at how different ways of communicating (like talking in person vs. texting) change brain activity. Researchers used fMRI scans on 30 healthy young adults while they watched videos of different communication styles. The goal was to see if each style uses a differ…

This study tested a digital app called CICADAS, designed to improve thinking skills in teenagers with autism. Sixty-eight teens aged 11-18 used the app for up to 40 hours, doing exercises that adapt to their ability. The goal was to see if the app is acceptable and easy to use, n…

This study looked at how adults with autism spectrum disorder (ASD) and bipolar disorder (BD) experience and show emotions. Researchers measured things like heart rate, pupil size, and facial expressions in a lab, and also tracked emotions in daily life for a week. The goal was t…

This study tested whether a computer program could predict which older patients (over 75) would have unnecessary days in the hospital. Researchers analyzed electronic health records from 102 patients in an acute geriatric unit. The goal was to create an algorithm that flags when …

This completed study looked at how adults with autism spectrum disorder (ASD) process emotions in moral situations, compared to people without autism. Researchers used stories about harm and accidents, then asked participants to quickly identify faces or judge if facial expressio…

This study looked for hidden genetic changes in 10 children with developmental delays who had a balanced chromosomal translocation (a rearrangement of DNA that appears normal under a microscope). Researchers used high-resolution DNA microarrays to check for tiny missing or extra …

This study looked at how Doose syndrome, a rare form of epilepsy, affects children's ability to learn and develop. Researchers followed 9 children and asked their parents about the disease's impact on school and daily life. The goal was to better understand the link between seizu…

This study looked at two ways to assess ADHD in children aged 8-17: a brief protocol (medical history, interview, rating scales) and a comprehensive one that also includes neuropsychological testing. Researchers wanted to see if the shorter method is as reliable, valid, and cost-…

This study tested whether a 6-session online class called HEARTS helps autistic adults feel more satisfied with their friendships and dating relationships, compared to a 6-week online discussion group. Ninety-two autistic adults took part over three months, completing surveys abo…

This study tested a family navigator program and a smartphone app to help low-resourced families of young children (ages 3-5) with autism find and access services. 52 families took part. The program aimed to improve parents' knowledge, skills, and confidence in getting support fo…

This study looked at whether an adaptive e-learning course on urgent medical conditions could reduce anxiety and improve skills in junior doctors starting work in emergency departments. 233 new doctors were randomly assigned to either take the course in their first six weeks or r…

This study looked at whether a therapy called FAST (Forensic Outpatient Systemic Therapy) helps teens aged 12-21 with conduct disorder or aggressive behavior. The therapy involves weekly sessions with the teen and their caregivers for several months. Researchers measured changes …

This study looked at how children with autism (without intellectual disability) form and recall paired memories, like linking a face to a name. Researchers used EEG brain scans and memory tests to compare 74 right-handed children aged 10-18, half with autism and half without. The…

This study looked at how the brain uses 'noise'—random variations in brain cell activity—to help people learn. Researchers tested 47 healthy adults using brain scans and computer models to see if this noise makes learning faster or more efficient. The goal was to understand a bas…

This study compared how 59 children with and without autism look at videos of people interacting. Researchers measured where children focused their eyes—on faces, objects, or the background—to understand differences in social attention. The goal was to learn more about how autism…

This study used eye-tracking to see how emotional expressions (low, medium, or high intensity) influence how children with autism understand intentions. Researchers watched where 80 children looked during a puzzle task. The goal was to learn more about attention patterns, not to …

This completed study used eye-tracking technology to understand how children with autism spectrum disorder (ASD), intellectual disability (ID), and typically developing children process visual cues. Researchers showed 80 children videos of a model choosing objects and recorded th…

This study compared virtual reality (VR) training to standard classroom teaching for nursing students learning how to triage in a mass casualty incident. 100 nursing students took part. The goal was to see if VR helps them triage more accurately and quickly.

This study looked at brain activity in the frontal cortex of 14 people with Tourette syndrome using a 24-hour portable EEG. Participants pressed a button each time they had a tic, so researchers could compare brain signals with and without tics. The goal was to identify which bra…

This study looked at how children with autism pay attention to social threats compared to non-social threats. Using eye-tracking and brain imaging, researchers measured eye movements and brain activity in 56 children while they watched videos. The goal was to understand joint att…

This study used eye-tracking to see how children with autism spectrum disorder (ASD) and typically developing children look at faces during social interactions. Researchers measured where and how long children focused on faces versus objects. The goal was to understand when diffe…

This completed study looked at sleep problems in over 1,100 children and adults with specific learning disabilities (like dyslexia or dyspraxia), with or without ADHD. Participants filled out online questionnaires about their sleep habits. The goal was to find out how common diff…

This study looked at how healthy adults decide where to look in a busy scene, like finding Waldo in a crowded picture. Researchers tracked eye movements while people viewed images with different colors and motion to understand how the brain highlights important spots. The goal wa…

This study looked at two ways to help children with Developmental Language Disorder (DLD) improve their grammar: recast therapy (where a therapist corrects the child's speech) and reading specially designed stories. Researchers worked with 137 children aged 4-9 to see how well th…

This study looked at whether solving crossword puzzles helps nursing students learn how to give intramuscular injections. 140 students took part, with some solving puzzles about the skill before practicing. Researchers measured their motivation, mental effort, and skill performan…

This study looked at brain activity in adults with ADHD while they performed tasks that required stopping an action. Researchers used EEG to measure electrical signals in the brain. The goal was to understand the brain processes behind impulse control problems in ADHD. No treatme…

This study looks at 128 children who were part of an early intervention program in infancy and are now teenagers. Researchers measure brain activity, stress responses, and behaviors like risk-taking and mood to see if early help made a difference. No new treatment is given; this …

This study looked at 60 teens ages 12 to 18 to see if those with Avoidant and Restrictive Food Intake Disorder (ARFID) had more feeding problems before age 4 compared to healthy teens. Researchers used questionnaires to check early feeding history, growth, and sensory sensitiviti…

This pilot study tested whether personalized medication experiments could help teens with ADHD and their parents make better decisions about future medication use. Thirty-one parent-teen pairs (teens aged 11-15) completed a medication experiment chosen together. The goal was to s…

This study examined how the frequency of speech therapy sessions affects speech and language outcomes in children. Researchers followed 39 children with speech or language disorders who were receiving individual therapy. They measured changes in articulation, vocabulary, and over…

This study looked at how nicotine from dissolvable tablets affects attention in 40 adults who occasionally use nicotine pouches. Participants tried tablets with different nicotine amounts (0 to 2 mg) and took attention tests after 15 minutes and 2 hours. The goal was to understan…

This study looked at whether being socially excluded (ostracized) affects the memory of children with ADHD. Twenty-four kids played a computer ball-tossing game where they were eventually left out, and their memory was tested before and after. The goal was to see if emotional dys…

This study tested a smartphone app that gives parents of children with ADHD quick tips and feedback on their parenting. 34 families took part, and the app sent messages at random times to see if parents used more positive skills right after. The goal was to see if parents liked t…

This study looked at whether children with dyscalculia (a math learning disability) have trouble automating counting procedures rather than recalling math facts. Three children aged 8–11 solved simple addition problems over three years while researchers measured their response ti…

This study tested simple toolkits to encourage women living with HIV in Ghana to collect their own samples for HPV testing, which can help prevent cervical cancer. About 108 women took part, and the researchers checked if they completed and returned the self-sampling kit or got a…

This study tested whether an artificial intelligence tool could help therapists deliver better behavior therapy to minority adolescents with ADHD. Researchers worked with three community mental health agencies and 51 teens. Therapists received either AI-assisted supervision or st…

This study used brain scans like MEG, EEG, and MRI to learn how the brains of people with autism spectrum disorder process sensory information. 85 people between the ages of 14 and 32 took part. The goal was to better understand the condition, not to test a new treatment.

This study looked at how the brain tracks speech sounds in healthy young adults. Researchers measured brain waves in English and Mandarin speakers to see how language experience and attention affect sound processing. The goal was to better understand the brain's role in hearing, …

This study created a database of 40 people, including healthy volunteers and those with autism spectrum disorder, to make it easier to recruit for future research. Participants were between 14 and 32 years old. The goal was to build a pool of willing volunteers for upcoming studi…

This pilot study tested whether using artificial intelligence to personalize educational games can help nursing students learn better about pregnancy and childbirth. 38 second-year nursing students were split into two groups: one received a standard gamified lesson, and the other…

This study looked at how the brains of people with aphasia (a language disorder after stroke) and healthy people work together during gestures. Using EEG, researchers measured brain synchronization while participants watched and copied different types of gestures. The goal was to…

This study looked at the types of bacteria in the mouth and the levels of a protective antibody in the saliva of children with autism, aged 6 to 18. Researchers collected dental plaque and saliva samples to compare with dental health. The goal was to learn more about oral health …

This study looked at whether a blockchain-powered electronic portfolio helps nursing students track their skills and keep learning. 72 third-year nursing students used either a blockchain e-portfolio or a standard one during their clinical rotation. Researchers measured their cli…

This study looked at whether digital services like smartphone apps can help people with psychosomatic disorders continue their treatment during the COVID-19 pandemic, when social distancing and hygiene rules limit in-person therapy. About 2000 patients from clinics took part, usi…

This study followed 344 infants with a sibling diagnosed with autism from birth to age three. Researchers collected blood, stool, urine, and saliva samples to find early biological markers that might predict autism. The goal is to better understand how autism develops and eventua…

This study looked at whether a special reading program called Reach Out and Read (ROR) could help parents read more often to their babies in the Neonatal Intensive Care Unit (NICU). Researchers surveyed 101 parent-infant pairs before and after the program was introduced. The goal…

This study looked at whether the design of a common ADHD screening questionnaire (the ASRS) influences how people answer. Researchers wanted to see if shading and grouping certain answer choices made it easier for patients to guess which responses lead to a positive screen. 587 a…

This study looked at whether a new drug called EB-1020 has abuse potential in 80 healthy adults who use stimulants recreationally. Participants received single doses of EB-1020, d-amphetamine, or placebo, and rated how much they liked the drug. The goal was to see if EB-1020 prod…

This study looked at 15 people with a rare genetic condition called DDX3X syndrome, which can cause intellectual disability and sometimes autism. Researchers used interviews, play-based assessments, and genetic tests to better understand the condition. The goal was to describe th…

This study looked at why girls with Rett syndrome often develop weak bones (osteoporosis) at a very young age. Researchers checked bone density, looked at medical history, and measured certain proteins in the blood. The goal was to find risk factors and understand the biological …

This study looked at whether teenagers with autism spectrum disorder can comfortably wear different types of wearable devices—like wristbands, headbands, patches, or rings—for two weeks. Forty teens and their caregivers participated, answering questions and wearing the device as …

This completed study followed 509 children aged 3 to 18 who were taking risperidone or aripiprazole for conditions like schizophrenia or bipolar disorder. Researchers measured weight changes over up to 50 months to understand long-term risks. The goal was to provide better safety…

This study looked at whether children with autism spectrum disorder (ASD) can learn new words by overhearing conversations, compared to being directly taught. Researchers tested 342 children aged 18 to 71 months, both with and without ASD, using video sessions. They measured lear…

This study tested whether a flipped classroom model helps midwifery students learn pregnancy exams better than traditional lectures. 95 students were split into two groups: one used online materials before class, the other had standard teaching. Researchers measured knowledge, pr…

This completed study looked at how teenagers with autism or schizophrenia understand emotions, metaphors, and social situations compared to healthy teens. Researchers tested 60 participants using facial emotion recognition and other tasks. The goal was to find out if social diffi…

This study looked at whether taking two smaller capsules of centanafadine (a potential ADHD medication) works the same as taking one larger capsule. 44 healthy adults took both versions at different times to compare how the drug enters the blood. The goal was to confirm the doses…

This study used a non-invasive brain stimulation technique called TMS to temporarily quiet a part of the brain involved in language processing. Researchers then tested how well 42 older youth with dyslexia learned and remembered made-up spoken words. The goal was to understand th…

This study looked at whether using feedback and spacing out practice sessions can help children aged 5 to 9 who are deaf or hard of hearing learn new words more efficiently. Thirteen children took part in word-learning exercises to see which methods worked best. The goal was to f…

This study tested a modified behavioral parent training program for children with ADHD who also have peer problems. The program aimed to increase parent engagement, especially for parents with their own ADHD or depression symptoms. Thirty-three parents participated, and researche…

This study looked at whether a program called Movement Matters is practical and acceptable for children aged 7-11 with intellectual disabilities or autism. The program includes teacher training, school activities, family involvement, and role models. Researchers worked with 43 ch…

This study looked at new ways to help children with autism who also have severe destructive behaviors, like aggression or self-harm. The goal was to make communication therapy more flexible and prevent bad behaviors from coming back when therapy is interrupted. Nine children aged…

This completed study looked at whether giving doctors access to genetic tests called FirstStepDx PLUS and NextStepDx PLUS helps them diagnose intellectual disability and developmental delay more accurately and cost-effectively. The study involved 217 pediatric neurologists, devel…

This study looked at 105 babies born to mothers who smoked during pregnancy, comparing those whose mothers quit versus those who continued. Researchers checked health indicators like birth weight, Apgar scores, and developmental milestones up to 24 months. The goal is to understa…

This study tested a 10-week group education program for parents of autistic preschoolers in Türkiye. The program taught naturalistic teaching strategies to help parents support their child's development. Researchers measured changes in parents' confidence and tracked how many fam…

This study created and tested a program called Families FORWARD to help parents of autistic teens (ages 14-21) plan for their child's future. 27 families in Massachusetts took part. The program focused on improving family readiness for the teen's transition to adulthood. Research…

This study looked at whether a personalized training program could improve driving skills in 90 teens with ADHD (ages 15-18) who hadn't started driving lessons. Teens were split into three groups: one received the special training, one got educational materials, and one got no in…

This study looked at whether a single dose of methylphenidate (Ritalin) changes how people with both ADHD and alcohol use disorder respond to alcohol-related cues. Thirty-one adults aged 18-25 completed brain scans, EEG, and behavioral tests after taking either the drug or a plac…

This study looked at gut bacteria in children with autism and their neurotypical siblings who live together. Researchers collected stool samples from 20 children aged 3 to 10. The goal was to compare the types of bacteria and other substances in the gut. This was an observational…

This study tested a small-group program called 'Let's Know!' to see if it helps first graders with weak oral language skills. 22 children participated. The program focused on vocabulary, making inferences, and understanding stories. The goal was to see if the program could improv…

This study looked at how speech production helps reading in adults with and without dyslexia. 56 adults completed reading tasks while sucking a lollipop, holding a bite bar, or having their mouth numbed with lidocaine. The goal was to see if these motor tasks change reading speed…

This completed study looked at 500 children aged 5 to 18 to understand how factors around birth, thinking abilities, and social-emotional skills are linked to learning difficulties and developmental disorders like ADHD or autism. Researchers compared children with and without the…

This study explored whether a summer psychosocial program could improve emotional control, behavior, and school readiness in 323 children aged 4-7 with ADHD or disruptive behaviors. Researchers measured changes in emotion regulation, ADHD symptoms, social skills, and academic rea…

This study used brain scans to understand how speech therapy helps children with cleft palate who have trouble speaking clearly. Researchers looked at brain connections and structure before and after therapy in 164 children aged 4 to 16. The goal was to see if therapy changes abn…

This study looked at how emotions influence speech coordination in 68 preschool children, some who stutter and some who don't. Kids repeated a phrase after seeing emotional or neutral pictures. The goal was to understand how emotional reactions and speech control interact in earl…

This study tested JASPER, a play-based therapy for autism, in 84 toddlers aged 18 months to 5 years. Children were randomly assigned to receive JASPER from a clinician or their parent. The goal was to see if two new measurement tools (BOSCC and ELSA-T) could track changes in soci…

This study looked for early signs of epilepsy in children with autism and tested whether a structured exercise program could influence those signs. Fifty children aged 10-15 with autism, epilepsy, or both took part. Researchers analyzed blood, sleep, brain activity, and thinking …

This completed study looked at whether playing white noise during reading and writing tests helps children aged 8-13 with ADHD and specific learning disorders. Thirty children took the same tests twice—once with white noise and once without—to see if the sound improved their spee…

This study looked at 263 severely injured trauma patients to find out how often they develop early blood clotting problems (called trauma-induced coagulopathy) and excessive clot breakdown (hyperfibrinolysis) within the first hour of arriving at the emergency room. Researchers us…

This study tested a virtual educational program called FLAPS, designed to help members of organizations learn how to support suicide prevention for autistic people. Fifty-one participants completed surveys before, after, and three months after the program, and some gave interview…

This study looked at 188 children (ages 0-18) with Fetal Alcohol Spectrum Disorders (FASD) in Reunion Island to better describe the condition and find a unique "epigenetic signature" in their DNA. Researchers collected blood and cheek swabs from a small group of children with FAS…

This study used special PET and MRI scans to look at brain activity in 27 men with autism, Fragile X syndrome, or no condition. The goal was to measure a brain chemical called glutamate, which helps nerve cells communicate. Researchers hope this will reveal how brain signaling di…

This study looked at whether the ability to learn patterns (called statistical learning) can predict how well first-graders with autism and their non-autistic peers improve their language and reading skills over three months. Forty-one children completed language tests and comput…

This study looked at whether learning to ride a bike improves planning, memory, and self-control in children aged 8-10 with autism. Sixty-two children tried different cycling exercises for two weeks. Researchers measured changes in thinking skills and a brain chemical called BDNF…

This study looked at how the brain processes speech sounds in 25 people with language impairment or hearing loss. Researchers used e-learning games or hearing aids to see if these interventions change brain activity. The goal was to better understand the underlying problems and g…

This completed study looked at how people with Tourette syndrome perceive their own actions compared to external forces. Researchers measured a phenomenon called sensory attenuation, which reflects how the brain integrates sensory feedback with motor commands. The study involved …

This study looked at how autism affects personal identity in adults without intellectual disability. Researchers compared 102 autistic adults to healthy controls using memory tests and questionnaires about self-concept. The goal was to understand how autism influences the way peo…

This study looked at whether adults with ADHD are more likely to relapse into drinking after completing a detox program. Researchers followed 113 people for 12 weeks, using interviews and questionnaires to assess ADHD and other mental health conditions. The goal was to see if ADH…

This study tested a 15-week reading program called Sit Together and Read (STAR) for 20 children aged 4-5 who are being raised by relatives (kinship caregivers) because their parents used opioids. The program was designed to improve children's reading skills and help caregivers fe…

This study uses eye-tracking technology to see how children with language development disorders process and remember sounds compared to typically developing children. Researchers will track eye movements while children perform language tasks to understand how their brains handle …

This study looked at whether asking children with Specific Language Impairment (SLI) to talk about new words during storybook reading helps them learn and remember those words better. 48 kindergarteners aged 5-6 took part. Researchers compared three versions of book reading with …

This study measured how children with and without autism look at faces, body movements, and objects using eye-tracking technology. Researchers wanted to see if visual patterns could help understand social differences in autism. 150 children took part, including those with autism …

This completed study looked at how people with autism spectrum disorder (ASD) pay attention to emotional cues and changes in their environment, compared to people without ASD. Researchers used brain imaging (fMRI, DTI) and EEG to measure brain activity in 120 children and adults.…

This completed study looked at 224 adults who already had at least one psychiatric condition to see how many also had undiagnosed ADHD. Researchers measured how often ADHD was missed and tracked quality of life in those diagnosed. The goal is to highlight the need for better dete…

This completed study looked at how the body processes certain amino acids in people with autism compared to healthy volunteers. Researchers gave participants a special infusion of stable isotopes to track metabolism, and also tested their thinking and mood. The goal was to find l…

This study tested whether children with ADHD are more likely to produce false memories compared to children without ADHD. Researchers used a word-list task called the DRM paradigm, where children heard lists of related words and later recalled them. The study involved 28 children…

This completed study from Yale University enrolled 565 children aged 6-11, both with and without autism, to confirm whether certain brain wave and eye-tracking measures can serve as reliable biomarkers. The goal is to provide objective tools for future clinical trials to measure …

This completed study tested a device called EarliPoint that uses eye-tracking to monitor changes in children with autism spectrum disorder (ASD) or developmental delays. Researchers followed 325 children aged 15-84 months over 180 days to see if the device could detect improvemen…

This study aimed to create and test a new scale called TD-STIGMA to measure stigma and discrimination in children and young adults with chronic tic disorders, including Tourette syndrome. Researchers worked with 43 participants, including people with tics and their caregivers, to…

This study followed 50 children who received cochlear implants, measuring their brain's electrical responses to sounds and comparing them with speech and language test results over three years. The goal was to see if certain brain wave patterns could predict how well a child deve…

This completed study used a non-invasive brain stimulation technique called rTMS to investigate how a specific brain area (the superior temporal sulcus) influences social perception in people with autism and healthy controls. Researchers measured changes in eye-gaze patterns and …

This study looked at 558 people with congenital hypothyroidism, a rare thyroid condition found in newborns. Researchers examined their genes, medical images, and health records to find links between genetic changes and the type or severity of the disease. The goal is to improve e…

This study tested whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can reduce abnormal brain activity and improve language in children with benign epilepsy with centrotemporal spikes (BECTS). Twenty-two children receive…

This study used brain scans and behavioral tests to explore why people with Tourette syndrome often act impulsively. Researchers compared 80 patients (40 on medication, 40 not) with 40 healthy volunteers. The goal was to map brain connections linked to impulsivity, which could he…