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Wrist zap may tame tics: electrical pulses tested as Drug-Free option

NCT ID NCT05269953

Symptom relief Sponsor: Nottingham University Hospitals NHS Trust Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 30, 2026 · Last updated Jul 01, 2026 · Updated 1 time

Summary

This trial tests whether rhythmic electrical pulses delivered to the wrist (median nerve stimulation) can reduce tics and the urge to tic in people with Tourette syndrome or chronic tic disorder. Participants wear a portable device for 15 minutes at a time over four weeks. The study compares active stimulation to a sham (placebo) condition and to no stimulation, using questionnaires, interviews, and video recordings to measure changes in tic severity.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
median nerve stimulation (MNS) device
What this could lead to
If it works, this could offer a safe, portable, drug-free option to reduce tics and urges in people with Tourette syndrome or chronic tic disorder.
What could go wrong
This is a relatively small, early-stage trial comparing active stimulation to a sham (placebo) condition. The effect may be modest or not last beyond the stimulation period.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

135 people

The number who actually took part.

Started

Mar 2022

Finished

Mar 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

12 to 90 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged 12 years or older. Must also be able to give informed consent (along with parents/guardians). * Confirmed or suspected diagnosis of Tourette Syndrome or Chronic Tic Disorder with a moderate amount of tics (to be assessed during an initial screening interview). * Stable treatment regime/no treatment for the past 2 months (i.e. if taking medication same drug \& dosage). * Internet access \& access to electronic device to complete online questionnaires and video calls. * Participants must be able to travel to Nottingham for one visit and have reliable access to the internet. * Participant is willing and able to give informed consent for participation in the clinical investigation. * Able (in the Investigators opinion) and willing to comply with all clinical investigation requirements * Resident in the UK Exclusion Criteria: * Current diagnosis of epilepsy. * Participant or participants guardian (if under 16) unable to read/write in English. * Participants will be excluded from the trial if they find the stimulation too uncomfortable during a practice session at the in person baseline visit. * Individuals with implanted electronic devices (e.g. pacemakers, insulin pump, implantable cardioverter defibrillator, neurostimulators). * Individuals sharing the household with an individual with implanted electronic devices (e.g. pacemakers, insulin pump, implantable cardioverter defibrillator, neurostimulators). * Individuals with current/ recent diagnosis or symptoms of SARS-CoV-2 will not be invited to visit the university until it is safe for them to do so (2 weeks following positive test). * Individuals with a diagnosis of non-verbal autism or similar condition which would affect ability to give informed consent to take part in the study will not be recruited. * Pregnant women will not be recruited for this study. * Participants who have participated in previous research studies involving median nerve stimulation * Participants aged over 90 years old

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Conditions

The condition(s) this trial relates to.

chronic tic disorder tic disorder Tourette syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic tic disorder Tourette syndrome

Contacts and locations

Locations

  • Sir Colin Campbell Building

    Nottingham, Nottinghamshire, NG7 2TU, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.