Healthy volunteers help compare pill strengths for future ADHD drug
NCT ID NCT07486895
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at whether taking two smaller capsules of centanafadine (a potential ADHD medication) works the same as taking one larger capsule. 44 healthy adults took both versions at different times to compare how the drug enters the blood. The goal was to confirm the doses are equivalent, not to treat any condition.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 1
The first testing in people. Mainly checks safety and dose, usually in a small group.
- Participants
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44 people
The number who actually took part.
- Started
-
Mar 2023
- Finished
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May 2023
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 55 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria 1. Body mass index (BMI) between 19.0 to 32.0 kilograms per square meter (kg/m\^2) (inclusive). 2. In good health as determined by: 1. Medical history 2. Physical examination 3. Electrocardiogram (ECG) 4. Serum/urine chemistry, hematology, and serology tests. 3. Ability to provide written, informed consent prior to initiation of any trial-related procedures, and ability, in the opinion of the principal investigator, to comply with all the requirements of the trial. Exclusion Criteria 1. Clinically significant abnormality in past medical history, or at the screening physical examination, that in the investigators or sponsor's opinion may place the participant at risk or interfere with outcome variables including absorption, distribution, metabolism, and excretion of drug. 2. History of drug and/or alcohol abuse within 2 years prior to screening. 3. History of or current hepatitis or acquired immunodeficiency syndrome (AIDS) or carriers of hepatitis B surface antigen (HBsAg) and/or hepatitis C antibodies (anti-HCV), or human immunodeficiency virus (HIV) antibodies. 4. History of any significant drug allergy or known or suspected hypersensitivity. 5. Participants having taken an investigational drug within 30 days prior to screening. 6. Previous exposure to centanafadine. 7. Any history of significant bleeding or hemorrhagic tendencies. 8. A history of difficulty in donating blood. 9. The donation of blood or plasma within 30 days prior to the first dose of investigational medical product (IMP). 10. Use of prescription, over-the-counter, herbal medication or vitamin supplements within 14 days prior to the first dose of IMP and antibiotics within 30 days prior to the first dose of IMP. 11. Any participant who, in the opinion of the investigator, should not participate in the trial. Note: Other protocol-specified inclusion/exclusion criteria may apply.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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ICON plc
Lenexa, Kansas, 66219, United States
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