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Gut health breakthrough? probiotic PS128 shows promise for Tourette's in kids

NCT ID NCT04805385

Symptom relief Sponsor: China Medical University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a probiotic supplement called Lactobacillus plantarum PS128 can improve tic symptoms and quality of life in children with Tourette's syndrome. 121 children aged 4-18 took part. The main goal was to see if PS128 reduces tic severity and related emotional or behavioral issues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

121 people

The number who actually took part.

Started

Nov 2021

Finished

Dec 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

4 to 18 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 4-18 years old * Tourette's disease is diagnosed * Make sure it is not caused by medication or other diseases * Cause major interference in social interaction, study or work * The healthy control group is not diagnosed with Tourette's disease, and is judged by PI Exclusion Criteria: * Have taken antibiotics within a month or are receiving antibiotic treatment * Used probiotic products in powder, capsule or tablet form within two weeks (except yogurt, yogurt, Yakult and other related foods) * Patients who have undergone hepatobiliary gastrointestinal surgery (except for colorectal polypectomy and appendectomy) * Inflammatory bowel disease, such as Crohn's disease or ulcerative colitis * Those with a history of cancer * Those who are allergic to lactic acid bacteria products * Those who are not suitable to participate judged by PI

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Conditions

The condition(s) this trial relates to.

Tourette syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Tourette's syndrome

Contacts and locations

Locations

  • China Medical University Hospital

    Taichung, 404332, Taiwan

More trials for these conditions

Other studies related to the condition(s) this trial covers.