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Brain scans reveal how language therapy rewires Stroke-Damaged brains

NCT ID NCT01927302

Knowledge-focused Sponsor: Northwestern University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 01, 2026 · Last updated Jul 02, 2026 · Updated 1 time

Summary

This study investigates how different language treatments affect both language skills and brain function in people with aphasia, a condition that impairs the ability to speak, understand, read, or write after a stroke. Participants will receive therapy targeting naming, spelling, or sentence processing, and will undergo brain scans before and after treatment to track changes. The goal is to understand which therapies produce the best language recovery and how the brain adapts.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
language treatment (naming, spelling, or sentence processing therapy)
What this could lead to
If successful, this could reveal which language therapies best rewire the brain after stroke, guiding more effective rehabilitation.
What could go wrong
This is an early-stage observational study with only 90 participants, so results may not apply to all people with aphasia. The therapies may not produce lasting improvements.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

90 people

The number who actually took part.

Started

Apr 2013

Finished

Mar 2019

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

35 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aphasia following a stroke * Stoke was at least 1 year ago * Medically stable * Right-handed * Normal or 'corrected to normal' vision and hearing * English as primary language * At least a high school education Exclusion Criteria: * History of neurological disease, head trauma, psychiatric disorders, alcoholism, or developmental speech, language, or learning disabilities

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Conditions

The condition(s) this trial relates to.

agraphia aphasia Aphasia, Broca dysgraphia nominal aphasia progressive non-fluent aphasia stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Agrammatism ANOMIA Aphasia Dysgraphia Stroke

Contacts and locations

Locations

  • Boston University

    Boston, Massachusetts, 02215, United States

  • Harvard University

    Cambridge, Massachusetts, 02138, United States

  • Johns Hopkins University

    Baltimore, Maryland, 21218, United States

  • Northwestern University

    Chicago, Illinois, 60208, United States

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