Retinal disorder

This early-stage trial tests an experimental drug called Kamuvudine-8 (K8) for people with geographic atrophy, a form of advanced age-related macular degeneration that causes vision loss. About 30 participants receive eye injections of K8 and are monitored for 26 weeks to check s…

This study tests whether NPI-001 tablets can safely slow or stop vision loss in people with Usher syndrome, a rare genetic condition that causes blindness and hearing loss. About 49 adults will take either the study drug or a placebo for 24 months. The main goal is to see if the …

This completed trial tested whether daily omega-3 fish oil supplements can help maintain healthy blood vessels in the eyes of adults with type 1 diabetes. 82 participants took either a 1000 mg omega-3 capsule or a placebo for the study, with regular eye exams to monitor retinal c…

This trial tests whether an experimental drug called ONS-5010 (a form of bevacizumab) works as well as an approved drug, Lucentis, for treating wet age-related macular degeneration (AMD). Wet AMD causes rapid vision loss due to abnormal blood vessels leaking fluid in the eye. Abo…

This study examines how well a biosimilar (a lower-cost copy) of the drug ranibizumab works for diabetic macular edema, a condition that causes vision loss in people with diabetes. Researchers will review medical records of 60 adults who received at least one injection of the bio…

This study tests an experimental drug called RO7446603, given alone or with existing medications (aflibercept or faricimab), for people with diabetic macular edema—a condition that causes vision loss due to diabetes. The trial has two parts: an early safety phase (Phase I) and a …

This study tested a higher dose (8 mg) of the drug aflibercept against the standard dose (2 mg) in 892 adults with macular edema from a blocked retinal vein. The goal was to see if the higher dose works as well or better while allowing fewer injections. Participants received inje…

This study tested the long-term safety and effectiveness of pegcetacoplan in 792 people with geographic atrophy, a form of advanced dry age-related macular degeneration that causes vision loss. Participants had previously been in earlier pegcetacoplan trials. The goal was to see …

This study tests a drug called faricimab (VABYSMO) in people with diabetic macular edema, a condition where diabetes causes fluid buildup in the center of the retina, leading to vision loss. Participants receive injections of faricimab into the eye every four weeks. The goal is t…

This early-phase study tested a new drug called ASKG712 in 56 people with wet age-related macular degeneration (AMD), a leading cause of vision loss. The drug is injected into the eye and works by blocking two proteins that fuel abnormal blood vessel growth. The main goals were t…

This early study tested a new eye injection called ASKG712 in 10 people with diabetic macular edema, a condition where fluid builds up in the retina and blurs vision. The drug targets two proteins that cause leakage and abnormal blood vessel growth. The main goal was to check saf…

This early-stage study tested a gene therapy called CPK850 in 12 adults with a rare inherited eye disease (RLBP1 retinitis pigmentosa) that causes progressive vision loss and night blindness. The treatment was injected under the retina to deliver a working copy of the faulty gene…

This study tested an oral medication called APX3330 in 103 adults with moderate to severe diabetic retinopathy, a leading cause of vision loss. The pill aims to reduce inflammation and low-oxygen stress in the eye. Researchers measured whether the drug could improve the severity …

This study tested a gene therapy called voretigene neparvovec in 4 Japanese patients with a rare inherited eye disease that causes vision loss. The treatment was given as an injection under the retina to replace the faulty gene. The goal was to see if it could safely improve ligh…

This study tested a new eye implant called PER-001 in 27 people with diabetic retinopathy, a diabetes complication that can damage vision. The implant is placed inside the eye and releases medication over time. The main goal was to check safety and how well people tolerate it, lo…

This early-stage study tested the safety of a new drug called VP-001, given as an injection into the eye, for people with a rare genetic eye disease (PRPF31 mutation) that causes vision loss. Six participants aged 12 and older received multiple doses. The main goal was to check f…

This early-stage study tested a new drug, VP-001, given as an injection into the eye to see if it is safe for people with a rare genetic eye disease caused by a PRPF31 mutation. Seventeen adults took part. The main goal was to check for side effects, not to measure vision improve…

This study tested a pre-filled syringe containing a high dose (8 mg) of the drug aflibercept for two eye conditions: diabetic macular edema and wet age-related macular degeneration. The main goal was to see if retina specialists could prepare and inject the drug easily and safely…

This study tested a new eye medication called PRO-169 against a standard drug (ranibizumab) for people with diabetic macular edema, a condition that causes vision loss in people with diabetes. About 509 adults with diabetes took part, receiving injections into the eye over one ye…

This early-phase trial tested NT-101 eye drops in 20 people with wet age-related macular degeneration (AMD), a leading cause of vision loss. The study aimed to check safety and see if the drops could reduce fluid buildup and improve vision. Participants received either a low or h…

This study checks the long-term safety of an eye injection called avacincaptad pegol for people with geographic atrophy, a form of advanced age-related macular degeneration that causes vision loss. About 278 adults who finished a previous study of this drug will receive the injec…

This study tested an eye injection called tarcocimab in 255 people with diabetic retinopathy, a diabetes complication that can damage vision. Participants received either the drug or a sham (fake) injection. The goal was to see if the drug improves the severity of the disease and…

This phase 2 trial tested a new drug called vamikibart, given as an eye injection, for people with diabetic macular edema—a condition where diabetes causes fluid buildup in the center of the retina, leading to vision loss. The study involved 394 participants and compared vamikiba…

This study tested an experimental drug called KIO-301, given as an injection into the eye, in 32 adults with retinitis pigmentosa or choroideremia—two inherited conditions that cause progressive vision loss. The main goal was to check safety and tolerability at increasing doses. …

This study tested an oral drug called ADX-629 in 8 people with Sjögren-Larsson syndrome, a rare inherited disorder that causes harmful fatty substances to build up in the skin, brain, and eyes. The main goals were to see if the drug is safe and can reduce these fatty aldehydes. P…

This study tested OCS-01, a steroid eye drop, in 552 people with diabetic macular edema (DME), a condition where fluid builds up in the eye and blurs vision. Participants used the drops several times daily for up to a year. The goal was to see if the drops improve vision and redu…

This study tested whether a steroid eye drop called OCS 01 can improve vision in people with diabetic macular edema, a common cause of vision loss in diabetes. Over 400 participants used the drops several times daily for a year. The goal was to see if this non-invasive treatment …

This study tested whether a form of vitamin B6 called pyridoxamine can improve the health of small blood vessels in people with type 2 diabetes. The researchers gave 40 participants either pyridoxamine or a placebo for a period, then switched treatments to compare effects. They m…

This study tested whether a pre-filled syringe of the medicine SB11 (a biosimilar to ranibizumab) is easy for eye doctors to use. Thirty adults with wet age-related macular degeneration, macular edema from retinal vein occlusion, or myopic choroidal neovascularization received on…

This phase II trial tested an experimental drug called ADX-2191 in 8 adults with retinitis pigmentosa caused by specific genetic mutations. Participants received monthly injections into one eye for up to six months. The main goal was to check safety, but researchers also looked a…

This phase 2 trial tested the drug crizanlizumab in 18 people with RVCL, a rare and fatal genetic condition that damages small blood vessels in the brain and eyes. There is currently no treatment for RVCL. The study measured changes in brain lesions on MRI scans to see if the dru…

This study tested an experimental drug called Zimura in 121 people with Stargardt disease, a genetic condition that causes vision loss. Participants received either Zimura injections or a sham procedure. The goal was to see if Zimura could safely slow damage to the retina over 18…

This study tested the safety and effectiveness of brolucizumab, a drug injected into the eye, for treating diabetic macular edema (DME) in 66 Indian patients. DME is a complication of diabetes that can cause vision loss. The study aimed to see how well the drug works in real-worl…

This study looked at whether faricimab injections can help people with diabetic retinopathy, a diabetes-related eye disease. Over 12 months, 60 patients received the treatment and doctors measured changes in the back of the eye. The goal was to see if the drug could reduce abnorm…

This study tested three different doses of SYL1801 eye drops in 99 people with wet age-related macular degeneration (AMD). The goal was to see if the drops are safe and can improve or maintain vision. Participants used the drops for a set period, and their vision was measured aft…

This early-stage trial tested a gene therapy called EXG102-031 in 12 people with wet age-related macular degeneration (nAMD), a condition where abnormal blood vessels damage central vision. The therapy was injected into the eye to block these vessels. The main goal was to check s…

This study tested a tiny implant called the PRIMA Bionic Vision System in 5 people with advanced dry age-related macular degeneration who had lost central vision. The implant is placed under the retina and uses electrical stimulation to replace damaged light-sensing cells. The go…

This phase 3 trial tested a small, refillable implant placed in the eye that continuously releases the drug ranibizumab to control diabetic retinopathy. The study enrolled 174 people with moderate-to-severe non-proliferative diabetic retinopathy but without swelling in the center…

This study tested whether a higher dose (8 mg) of the drug aflibercept, given every 16 weeks, works as well as the standard dose (2 mg) given every 8 weeks for Chinese people with diabetic macular edema (DME), a diabetes-related eye condition that causes vision problems. 333 part…

This early-phase trial tested a gene therapy called ZM-01 in 2 boys aged 3 to 18 with X-linked retinoschisis, a rare genetic eye condition that causes vision loss. Each boy received an injection of the therapy into one eye. The main goal was to check safety, but researchers also …

This study looked at 742 people newly diagnosed with wet age-related macular degeneration (nAMD) who received 3 monthly injections of faricimab (Vabysmo) instead of the usual 4. The goal was to see how long the effect lasted before another injection was needed. Researchers tracke…

This study tested a drug called faricimab in 179 people with non-proliferative diabetic retinopathy, a condition where diabetes damages blood vessels in the eye. The goal was to see if the drug could improve blood flow in the retina over 48 weeks. Participants received either mon…

This early-phase trial tested an investigational eye injection called OLN324 in 164 adults with either wet age-related macular degeneration (AMD) or diabetic macular edema (DME). The main goal was to check safety and how the drug moves in the body, with a preliminary look at whet…

This Phase 3 trial tests a gene therapy called botaretigene sparoparvovec for X-linked retinitis pigmentosa, a genetic condition that causes progressive vision loss. The study involves 105 participants who receive the therapy via injection under the retina. The main goal is to se…

This study tested a gene therapy called JNJ-81201887 in 305 people with geographic atrophy, a late stage of dry age-related macular degeneration that causes blind spots. The treatment is injected into the eye and aims to slow the growth of damaged areas. Researchers measured chan…

This study tested an experimental drug called ENV-101 (taladegib) in 20 adults with advanced solid tumors that have a specific genetic mutation (PTCH1 loss-of-function). The drug works by blocking a growth pathway in cancer cells. Researchers measured how many patients' tumors sh…

This study tested whether levodopa, a drug used for Parkinson's disease, can help people with diabetes who have early signs of eye damage (diabetic retinopathy). The goal was to find the best dose and understand how it works to improve the retina's electrical signals. 230 adults …

This completed phase 4 trial tested whether a rapid weight loss program using semaglutide (Ozempic/Wegovy) plus a very low calorie diet can help people with idiopathic intracranial hypertension (IIH), a condition where high pressure in the skull causes headaches and vision proble…

This study tested whether injecting a concentrated form of a patient's own blood, called platelet-rich plasma (PRP), into the eye could slow the progression of advanced dry age-related macular degeneration (AMD). Fourteen people with advanced dry AMD received three PRP injections…

This study looked at whether early surgery (vitrectomy) or waiting with ultrasound monitoring is better for people with sudden, dense bleeding inside the eye. The goal was to see if early surgery could lower the chance of the retina detaching. Only 8 adults with recent bleeding f…

This study tested an experimental drug called KUS121, given as an eye injection, for people who suddenly lost vision due to a blocked artery in the eye (central retinal artery occlusion). The goal was to see if the injection could improve vision better than a sham procedure. The …

This study looked at 83 people with diabetes and early-stage eye disease. It compared having laser treatment in one session versus four sessions to see which approach better controls the disease and reduces the risk of swelling in the center of the eye. The main goal was to measu…

This study looked at the long-term safety of faricimab, a medicine injected into the eye, for people with diabetic macular edema (DME). About 1,500 patients who had completed earlier studies received faricimab at personalized intervals. The main goal was to track side effects, no…

This study tested a new medicine called JL14002 against a standard treatment (ranibizumab) for wet age-related macular degeneration, a leading cause of vision loss. 443 adults aged 50-80 with active disease received injections into the eye. The main goal was to see if JL14002 imp…

This study tested a new medication, LUBT010, against the standard drug Lucentis for people with wet age-related macular degeneration (AMD), a leading cause of vision loss. Six hundred participants received monthly injections into the eye for one year. The goal was to see if LUBT0…

This small Phase 2 study tested INV-102 eye drops in 19 people with diabetic macular edema, a swelling in the back of the eye caused by diabetes. Participants used the drops daily for 8 to 12 weeks. The goal was to see if the drops could improve retinal health and reduce swelling…

This study followed 42 people who received a gene therapy for X-linked retinitis pigmentosa, an inherited eye disease that causes blindness. The goal was to check the treatment's safety over up to 5 years. Researchers also looked at whether patients' vision and ability to move ar…

This study tested whether eating one avocado and one cup of mango daily for 8 weeks could improve blood vessel health and thinking in 82 adults with pre-diabetes. Participants were randomly assigned to either a diet including these fruits or a matched control diet. Researchers me…

This completed Phase 1/2a trial tested a gene therapy called RST-001 (AGN-151597) in 14 people with advanced retinitis pigmentosa, a genetic eye disease that causes severe vision loss. All participants had very poor vision (hand motion or worse) at the start. The study aimed to c…

This early-stage trial tested a new drug called PMC-403 in 17 people with wet age-related macular degeneration (nAMD), a leading cause of vision loss. The drug is injected directly into the eye. The main goal was to check safety and find the best dose for future studies. The tria…

This study tested a new medicine called 601 against an existing drug, ranibizumab, for people with vision loss due to a blocked vein in the eye (branch retinal vein occlusion). 351 adults received injections into the eye to reduce swelling and improve sight. The goal was to see i…

This study tested a personalized treatment plan using the drug brolucizumab for people with a specific eye condition called polypoidal choroidal vasculopathy (PCV). The goal was to see if adjusting the treatment schedule based on each person's needs could maintain or improve visi…

This study tested a drug called pegcetacoplan, given as an eye injection using a prefilled syringe, in 44 people with geographic atrophy (a form of advanced age-related macular degeneration). The main goal was to see if the new syringe is safe and easy for doctors to use. The dru…

This study tested a herbal extract called Nuvastatic in 100 adults with type 2 diabetes who have early-stage diabetic retinopathy (eye damage). The goal was to see if it can safely slow the disease and improve vision. Participants received either the extract or a placebo, and res…

This early-stage study tested a new drug called OLX10212 in 21 people with wet age-related macular degeneration (AMD), a leading cause of vision loss. The main goal was to see if the eye injections are safe and tolerable. Researchers also looked for early signs that the drug migh…

This study tested a new medicine called BAT5906 against a standard treatment (Lucentis) for wet age-related macular degeneration, a condition that can cause rapid vision loss. 488 adults aged 50-85 with active disease received either BAT5906 or Lucentis injections into the eye. T…

This study looked at whether taking omega-3 supplements for 6 months can improve blood flow in the eyes of people with mild to moderate diabetic retinopathy, a common diabetes complication. Researchers measured tiny blood vessels in the retina using a special camera. The goal was…

This study tested whether aflibercept injections into the eye can improve areas of poor blood flow in the retina of people with diabetic retinopathy. 38 adults with nonproliferative diabetic retinopathy received the treatment. The goal was to see if the drug could reduce the risk…

This study tested whether adding a light-based treatment (photodynamic therapy) to the standard drug ranibizumab could reduce the number of eye injections needed for wet macular degeneration. Sixty adults over age 50 with the condition took part. The goal was to see if the combin…

This study tested a new drug called EYE103, given as an injection into the eye, for people with diabetic macular edema (DME) or wet age-related macular degeneration (NVAMD). The trial had two parts: first, checking safety at increasing doses in about 12 people, then comparing two…

This study tested whether the antibiotic minocycline, taken as a pill twice daily for at least 3 years, could safely slow the growth of geographic atrophy—an advanced form of age-related macular degeneration that causes blind spots. Thirty-seven adults aged 55 and older with geog…

This completed Phase 4 trial tested whether adding a second drug (B55R2) to standard treatment (B55R1) works better for people with non-proliferative diabetic retinopathy, an early stage of diabetic eye disease. 52 adults with mild to severe disease took either the combination or…

This study tested a new drug called FYB203, which is a biosimilar (a close copy) of the existing medication Eylea, for people with wet age-related macular degeneration (AMD), a leading cause of vision loss. The trial involved 434 participants and compared how well FYB203 worked v…

This completed Phase 4 study tested how much of the drug aflibercept gets into the bloodstream when a high dose (8 mg) is injected into both eyes of adults with diabetic macular edema or wet age-related macular degeneration. Fifty-one participants received the injections and had …

This study tests a daily pill called ALK-001, a modified form of vitamin A, to see if it can slow the growth of geographic atrophy—an advanced form of dry age-related macular degeneration that causes blind spots. About 300 people with the condition took either the drug or a place…

This study tested an experimental drug called tinlarebant in 104 teenagers with Stargardt disease, a genetic condition that causes progressive vision loss. The goal was to see if the drug could slow the growth of damage in the back of the eye. Participants took the drug or a plac…

This study looked at the long-term safety of faricimab, a drug injected into the eye, for people with wet age-related macular degeneration (AMD). Over 1,000 participants who had completed earlier studies received faricimab at personalized intervals. The main goal was to track sid…

This study tested an eye injection called Zimura (avacincaptad pegol) in 448 people with geographic atrophy, a late stage of dry age-related macular degeneration that causes permanent vision loss. The goal was to see if the drug could slow the growth of damaged areas in the retin…

This phase 2a trial tested a new biologic drug called AG-73305, given as an injection into the eye, in 25 adults with diabetic macular edema (DME), a common cause of vision loss in people with diabetes. The study aimed to check the drug's safety and how well it works over 6 month…

This phase 2 trial tested a new drug called EYP-1901, given as an eye injection, for people with wet age-related macular degeneration (AMD). The goal was to see if it works as well as the standard treatment, aflibercept (Eylea), but with fewer injections. 161 participants receive…

This Phase II trial tested whether adding vamikibart to the standard treatment ranibizumab improves vision more than ranibizumab alone in people with diabetic macular edema. 187 participants received injections into the eye over 76 weeks. The study is complete, and results will s…

This study tested whether an eye injection called brolucizumab works as well as laser treatment for people with proliferative diabetic retinopathy, a serious eye condition caused by diabetes. 689 participants received either the injection or laser, and researchers measured vision…

This study tested an experimental drug called RZ402 in 94 people with diabetic macular edema, a condition that causes vision loss in people with diabetes. The goal was to see if the drug is safe and can reduce swelling in the retina and improve eyesight compared to a placebo. Par…

This Phase 3 trial tested whether the clot-busting drug tenecteplase could improve vision in people with a central retinal artery occlusion (eye stroke). 81 participants received either tenecteplase or aspirin within 4.5 hours of symptoms. The main goal was to see if more patient…

This study looked at whether adding a dexamethasone implant (Ozurdex) to standard bevacizumab (Avastin) eye injections could reduce the number of injections needed for people with non-ischemic central retinal vein occlusion. Sixty-eight participants received either Avastin plus a…

This study compared two different dosing schedules of brolucizumab (Beovu) in 52 people with wet age-related macular degeneration (AMD) who had not responded well to previous treatment. Participants received the drug as an eye injection either on a fixed schedule or with adjustme…

This phase 2 trial tested carbidopa-levodopa (Sinemet), a drug usually used for Parkinson's disease, in 20 people with wet age-related macular degeneration (AMD). The goal was to see if the drug is safe and can improve vision or reduce retinal swelling. Participants took the pill…

This study tested whether a steroid implant (Ozurdex) or anti-VEGF injections (Avastin, Lucentis, or Eylea) work better to prevent worsening of diabetic macular edema after cataract surgery. Sixteen adults with diabetes and pre-existing eye swelling received one treatment before …

This phase 2 trial tested carbidopa-levodopa, a drug used for Parkinson's disease, in 35 people with wet age-related macular degeneration (AMD). The goal was to see if the drug could improve vision and reduce the need for standard anti-VEGF eye injections. Participants took the o…

This phase 3 trial tested whether a new drug called ABP 938 works as well as the standard treatment Eylea for wet age-related macular degeneration (AMD), a leading cause of vision loss. 576 adults aged 50 and older with wet AMD received injections of either ABP 938 or Eylea every…

This study tests a drug called carbidopa-levodopa (Sinemet), typically used for Parkinson's disease, in people with wet age-related macular degeneration (AMD). It is a 9-month extension for 35 participants who completed an earlier study. The goal is to see if the drug can help ma…

This study tested whether nepafenac 0.1% eye drops, given before surgery, can lower inflammation in people with retinal detachment. Sixty-one adults used the drops or a placebo for five days before surgery. Researchers measured inflammatory markers in the eye fluid. The goal is t…

This early-stage trial tested the safety of SCAI-005, an eye drop containing axitinib, in 48 healthy Korean adults. The goal was to see if the drug is safe and how it behaves in the body when given as single or multiple doses. It is a first step toward a potential needle-free tre…

This study tested personalized treatments for children with retinoblastoma, a rare eye cancer. Researchers divided 107 participants into groups based on whether one or both eyes were affected and how advanced the cancer was. They used combinations of chemotherapy drugs like vincr…

This study tested the safety of aflibercept, an already-approved eye injection, in 100 Indian adults with diabetic macular edema (DME). Participants received injections every 4 weeks for 5 months, then every 8 weeks for a total of 48 weeks. The main goal was to track any side eff…

This phase 2 trial tested a new way to deliver dexamethasone directly to the back of the eye using tiny microspheres (OXU-001) compared to the standard Ozurdex implant. The study enrolled only 3 adults with diabetic macular edema to check safety and how well the treatment is tole…

This study tested a robotic stabilizer to help surgeons inject a clot-busting drug (tPA) under the retina in 20 patients with bleeding from age-related macular degeneration. The robot held the needle steady for up to 3 minutes during standard surgery. The main goals were to see i…

This study tests whether a smartphone-based camera can accurately screen for eye diseases such as diabetic retinopathy, glaucoma, and age-related macular degeneration. About 550 patients will have photos taken with both the smartphone camera and standard equipment. Ophthalmologis…

This study tested whether an AI tool can help eye doctors diagnose four common retinal diseases (diabetic retinopathy, age-related macular degeneration, retinal vein occlusion, and glaucoma) more accurately and quickly. Ten doctors from five hospitals read fundus images both with…

This study looked at whether a special eye scan (SS-OCTA) can detect signs of cardiovascular disease. Researchers compared retinal blood vessel changes to results from a standard carotid ultrasound in 42 adults. The goal was to see if the eye scan could predict the presence or se…

This study tested an artificial intelligence (AI) system called Retina4IRD that helps doctors diagnose inherited retinal diseases, which are rare eye conditions that can cause vision loss. The AI looks at eye images and patient information to suggest which gene might be causing t…

This study tested an artificial intelligence tool called RetinAIcheck to see if it can accurately detect and grade hypertensive retinopathy—eye damage caused by high blood pressure. Researchers used 729 patients' eye photos and compared the AI's results to assessments by eye doct…

This study tested a software called OPTDR01 that automatically checks retinal images for signs of diabetic retinopathy, a leading cause of vision loss. Researchers enrolled 300 adults with diabetes to see if the tool is easy to use and practical in a clinic setting. The goal is t…

This study tested a new device called CRYSTALSIGHT that uses eye-tracking and artificial intelligence to monitor macular diseases like age-related macular degeneration and diabetic retinopathy. Twenty participants used the device at home to see if it could accurately track eye mo…

This study tested whether special MRI scans can better detect signs of central retinal artery occlusion (CRAO), also known as an eye stroke. Researchers enrolled 63 adults with CRAO and performed detailed brain and eye imaging. The goal was to find imaging clues that help diagnos…

This study looked at whether a new, high-resolution MRI can help doctors more accurately and confidently diagnose the cause of optic disc swelling (a sign of various eye or brain problems). Researchers used these detailed scans on 197 adults with optic disc swelling to see if the…

This study tested a computer system called i-ROP DL that automatically checks eye images from premature babies for a serious condition called retinopathy of prematurity (ROP), which can cause blindness. Researchers used over 1,200 babies' eye photos from multiple hospitals to see…

This study tested a device called RETeval that measures how the retina responds to light. Researchers collected data from 664 people, both with and without retinal disease, to create a reference for normal eye function. The goal is to improve diagnosis of retinal conditions.

This study tested an artificial intelligence (AI) algorithm to detect diabetic retinopathy and glaucoma from eye photos. Researchers compared the AI's accuracy to that of family doctors and retina specialists. The goal was to see if AI could be a reliable screening tool in primar…

This study tested a new imaging device called OCT angiography (OCTA) that takes 3D pictures of blood vessels in the back of the eye without needing dye injections. Researchers compared OCTA images to standard dye-based imaging in 88 people with retinal blood vessel problems or no…

This study tested whether a device called MAIA, which measures light sensitivity in the retina, can predict when intermediate age-related macular degeneration (AMD) progresses to the advanced stage. Researchers followed 182 people who already had advanced AMD in one eye and inter…

Researchers tested an artificial intelligence program that analyzes retinal images to diagnose several nerve and brain conditions, such as optic neuropathy and brain tumors. The study used data from 693 patients with confirmed diagnoses. The goal is to create a fast triage tool f…

This study tested whether injections of aflibercept (Eylea) into the eye could prevent the development of wet age-related macular degeneration (AMD) in people at high risk. 128 participants with early signs of AMD in one eye and wet AMD in the other eye received either Eylea or a…

This study compared two ways to control pain during laser treatment for diabetic retinopathy: a numbing injection around the eye versus standard numbing eye drops. Fifty adults with diabetes were split into two groups to receive either the injection or a sham injection with drops…

This study tested a nursing intervention designed to help patients relax and feel more comfortable during diabetic retinal laser surgery. 136 adults received either standard care or extra support including guided breathing, clear communication, and reassurance. The goal was to se…

This early study tested a tiny dexamethasone insert placed in the tear duct of 15 children after retinal surgery or laser treatment. The goal was to see if it could safely reduce pain and eye inflammation. Researchers measured pain using a standard scale and tracked any side effe…

This study tested whether a low-immunogenic oat variety called Saul is well-tolerated by adults with celiac disease who are in remission. Forty participants ate 50 grams of gluten-free Saul oat flakes daily for 14 days. Researchers tracked symptoms and blood markers to see if the…

This study tested a new antiseptic called IRX-101 against the standard povidone-iodine in 155 people receiving eye injections for retinal disease. The goal was to see if IRX-101 reduces pain and corneal damage after the injection. Researchers measured safety and corneal staining …

This study tested four different ways of giving dilating eye drops to 84 diabetic patients who needed eye exams for diabetic retinopathy. The goal was to find which method works best to get the pupil large enough for a good exam. Researchers measured pupil size and watched for si…

This study tested an eye drop (POS) in 200 adults who had poor night vision after LASIK or similar eye surgery. The goal was to see if the drops could help them see better in dim light, reducing problems like glare and halos. Participants used the drops for 15 days and had their …

This study tested whether a tiny eye insert called DEXTENZA, placed after cataract surgery, works better than standard eye drops alone for reducing pain and swelling. Fifty adults having cataract surgery took part. The insert slowly releases medicine over time, aiming to improve …

This study tested whether a dietary supplement could improve dry eye symptoms by changing the bacteria in the gut. Twenty adults with dry eye disease took the supplement for 8 weeks. Researchers measured tear production and eye surface health before and after treatment. The goal …

This study looked at whether a treatment called transscleral lutein iontophoresis (TSLI) is safe and helpful for people with a specific type of age-related macular degeneration (AMD) that includes reticular pseudodrusen. Thirty participants received the treatment, and their visio…

This early-phase study tested a single dexamethasone implant (Ozurdex) in 10 people with uveal melanoma who had fluid buildup under the retina after radiation treatment. The goal was to see if the implant is safe and can help reduce the fluid to prevent vision loss. The implant i…

This study tested whether Nyxol eye drops can help people who have trouble seeing in dim light, often after eye surgeries like LASIK or cataract surgery. 144 adults received either the eye drops or a placebo for 8 days. The main goal was to see if Nyxol could improve vision in lo…

This study tested whether playing slow tempo music before and during an eye injection (intravitreal injection) can reduce anxiety and pain. 144 adults took part, with half listening to music and the other half receiving standard care. Researchers measured anxiety using saliva tes…

This study tested whether a steroid eye drop (loteprednol) can reduce pain after intravitreal injections for age-related macular degeneration. 64 participants received either the steroid drop or artificial tears right after their injection. Pain was tracked by phone over a week. …

This study looks at how isotretinoin, a vitamin A-based acne medication, affects eye structures and tear production in people with severe cystic acne. Participants receive standard treatment and undergo eye exams, including dry eye tests and advanced imaging, before and during th…

This study followed 20 adults aged 55 and older with geographic atrophy, an advanced form of age-related macular degeneration that causes central vision loss. Researchers measured how the damaged area in the eye changed over nearly 4 years using eye exams and photos. The goal was…

This study looked at whether a simple test measuring how fast eyes recover in the dark can help track early to middle dry age-related macular degeneration (AMD). Researchers followed 217 adults aged 50 and older, with or without AMD, for up to 5 years. The goal was to see if chan…

This trial tests a new device called P200TxE that takes detailed images of the back of the eye. Researchers want to see how well it captures images in people with retinal diseases like glaucoma or macular degeneration. The study involves adults aged 22 and older who have been dia…

This study looks at what people with age-related macular degeneration (AMD) know about their disease and what they need to manage it better. Researchers will survey and interview 118 patients to understand their knowledge, daily challenges, and support needs. The goal is to use t…

This study tested whether artificial intelligence (AI) can help doctors detect retinal diseases from ultra-widefield eye images. 462 images were read by four eye doctors with different experience levels, both with and without AI assistance. The goal was to see if AI improves accu…

This study compared two different eye imaging machines (Clarus and Optos) to see how well they measure geographic atrophy, a form of vision loss from age-related macular degeneration. Researchers enrolled 62 patients and took images with each device, then compared the measurement…

This study followed 57 people with age-related macular degeneration (AMD) for up to 5 years to see how their eyes adjust to darkness. Participants had yearly eye exams and dark adaptation tests, where they sat in a dark room and pressed a button when they saw a light. The goal wa…

This study looks back at 20 years of medical records from 25 people who had a freezing treatment (cryotherapy) for retinal hemangioblastoma, a rare eye tumor often linked to von Hippel-Lindau disease. Researchers want to see how well the treatment controlled the tumors and affect…

This study tested whether doctors could safely and correctly use a new prefilled syringe (SCD411) for eye injections. It included 33 adults with wet age-related macular degeneration, retinal vein occlusion, diabetic macular edema, or diabetic retinopathy. The main goal was to see…

This study looked at whether monitoring moderate diabetic retinopathy (an eye condition caused by diabetes) through tele-expertise (remote specialist review) works as well as the usual in-person eye doctor visits. Researchers followed 97 patients with diabetes and moderate retino…

This pilot study looked at how weight loss affects bone density in overweight or obese men. 44 men either followed a reduced-calorie diet to lose weight or maintained their weight for 6 months. Researchers measured changes in bone density and quality to see if weight loss has any…

This study followed 516 older adults in France for 8 years to see how many develop age-related macular degeneration (AMD), a leading cause of blindness. Researchers used eye exams and imaging to track the disease and look for risk factors like genetics and lifestyle. The goal is …

This study examined how vision loss progresses in people with geographic atrophy, an advanced form of dry age-related macular degeneration. Researchers analyzed past medical records and eye images from 60 patients to see which retinal changes are linked to faster vision decline. …

This completed study collected eye images from 1,000 people with intermediate age-related macular degeneration (AMD) to create a detailed database. Researchers will analyze these images to find signs that predict whether the disease will worsen to advanced stages. The goal is to …

This study looked at 60 adults with type 2 diabetes and early diabetic eye disease. Researchers used a special eye scan (OCTA) to measure blood flow in the retina. The goal was to find which scan details best predict if the disease will get worse and threaten sight. No treatment …

This study tested four different approaches to find and treat eye diseases like cataracts, glaucoma, and diabetic retinopathy in communities in Nepal. Over 87,000 people aged 50 and older took part. The goal was to see which method—comprehensive screening, cataract camps, communi…

This study tested dexamethasone eye drops in 11 premature infants at risk of blindness from retinopathy of prematurity. Researchers measured how the drug enters the blood and saliva, and monitored for side effects. The goal was to gather safety and dosing information, not to prov…

This study looked at how much of a burden patients feel from repeated anti-VEGF eye injections for three different eye diseases: wet age-related macular degeneration, retinal vein occlusion, and diabetic macular edema. Researchers surveyed 393 patients about their treatment burde…

This study looked at 78 people in Pakistan who had surgery for a detached retina. Doctors compared two types of fillers used inside the eye after surgery—gas or silicone oil—to see if one caused more shifting of the retina afterward. The goal was to learn how the choice of filler…

This completed study followed 26 adults aged 55 and older with early age-related macular degeneration (AMD) or healthy eyes for up to 5 years. Researchers used eye exams, imaging, and vision tests to track changes in the retina and visual function. The goal was to better understa…

This study looked at proteins in the eye fluid of 100 people with wet age-related macular degeneration (AMD). The goal was to measure certain growth factors that might explain why about 37% of patients do not respond well to standard anti-VEGF injections. Researchers collected a …

This study tested whether using an indoor air purifier changes health measures like heart rate, sleep, and oxygen levels. 42 healthy adults wore Apple Watches while using a real or fake (sham) air purifier at home. The goal was to see if cleaner air makes a short-term difference …

This study followed 609 nearsighted adults who had lens surgery to see if a natural eye change called posterior vitreous detachment (PVD) affects their risk of retinal detachment. Participants were grouped by whether they had PVD before surgery or not, and were monitored for up t…

This pilot study tested whether a patient navigator—a person who helps coordinate medical care—could increase eye exam rates in 35 adults with diabetes who were at high risk for blindness. Participants met with a navigator quarterly to overcome barriers to care. The study measure…

This study tested a new type of camera that can see individual cells in the retina, which standard clinical cameras cannot do. Five people with retinal disease (inherited degeneration or toxicity) had their eyes scanned with the device. The goal was to compare image quality and o…

This study looked at 14 adults with melanoma who were taking a combination of BRAF and MEK inhibitor drugs. The goal was to understand how these drugs can affect the retina, the light-sensitive part of the eye. Researchers used eye exams and special imaging to track changes over …

This study measured the thickness of the conjunctiva and Tenon's capsule (outer eye layers) in 736 people with neovascular age-related macular degeneration (nAMD) or diabetic macular edema (DME), and in healthy volunteers of similar age. Researchers used a special eye scanner (SD…

This study measured three substances in the blood (endocan, alarin, and galanin-like peptide) in people with and without diabetic retinopathy, an eye complication of diabetes. Researchers compared these levels across different stages of the disease and looked at how they relate t…

This study looked at 91 people with a type of bleeding in the eye caused by age-related macular degeneration (AMD). It compared two treatments: surgery followed by anti-VEGF injections, or a gas injection followed by anti-VEGF injections. The goal was to see which approach helps …

This study looked at 360,000 French patients who received eye injections for conditions like age-related macular degeneration. The goal was to find out how often a serious eye infection called endophthalmitis happens within 28 days after the injection. Researchers analyzed data f…

This study looked at 202 people who had surgery for retinal detachment, a condition where the light-sensitive layer at the back of the eye pulls away. Researchers used high-resolution eye scans and vision tests to see how the eye heals over a year. The goal was to better understa…

This study explored whether the amount of omega-3 fatty acids in premature babies' bodies is linked to a serious eye condition called retinopathy of prematurity (ROP). Researchers measured omega-3 levels in 62 premature newborns born before 29 weeks. The goal was to see if lower …

This study looked at how the COVID-19 lockdown changed the health habits and medical care of 1,343 people with chronic conditions like heart disease, multiple sclerosis, and hemophilia. Researchers used phone surveys to track medication use, lifestyle changes, and access to healt…

This study tested whether people with diabetes can use a smartphone game to monitor their vision at home, instead of always going to the clinic. 55 participants at high risk for diabetic retinopathy played vision games on their phones for 6 months. The goal was to see if people w…

This completed French study followed 748 adults undergoing retina/vitreous surgery to see if taking blood thinners (anticoagulants or antiplatelets) raises the risk of bleeding complications. Researchers compared patients who continued or stopped their medication with those not o…

This study looked at 30 patients with a type of age-related macular degeneration (AMD) to see how treatment affects the barrier between blood and eye fluid. Researchers measured protein levels in the eye fluid before and during anti-angiogenic therapy. The goal was to better unde…

This completed study looked at fluid samples from the eyes of 137 people undergoing surgery for retinal detachment or other eye conditions. Researchers measured fats and proteins in these fluids to understand inflammation and cell death that can harm vision after surgery. The goa…

This study collected information from nearly 1,000 people in France with inherited retinal diseases (IRDs) to better understand the genetics behind these conditions. Researchers looked at genetic test results and disease types to help build a national registry. The goal is to imp…

This study examined whether certain genes are linked to a severe form of diabetic eye disease called proliferative diabetic retinopathy (PDR). Researchers analyzed DNA from 302 people with type 2 diabetes, some with PDR and some without. The goal was to find genetic markers that …

This study tested whether artificial intelligence (AI) can help doctors better predict how diabetic retinopathy (an eye disease from diabetes) will progress. Over 3,000 adults with diabetes were followed for about 2 years. The goal was to create a smarter system that uses eye ima…

This study looked at two ways of monitoring wet age-related macular degeneration (AMD) using eye scans: standard OCT B-scans and a newer technique called OCT angiography. The goal was to see if the newer scan could better detect when the disease is active, helping doctors decide …

This completed study looked at over 7,000 premature infants to understand which babies develop a serious eye condition called retinopathy of prematurity (ROP) and need treatment. Researchers used a cloud-based database to compare risk factors and outcomes. The goal was to improve…

This completed study used a special eye scan called OCTA to look at tiny blood vessels in the retina of 200 people with type 2 diabetes who had no signs of eye disease on a standard exam. The goal was to see if the duration of diabetes affects these vessels. The findings could he…

This study tested a device called RETeval that measures the retina's electrical activity in response to light flashes. Researchers wanted to see if changing the flash color or skipping pupil dilation still gives useful results. 18 healthy adults participated. The goal is to make …

This study looked at whether thinning of the retina (the back part of the eye) can be a sign of Alzheimer's disease. Researchers compared eye scans from 55 people with Alzheimer's, Lewy body disease, and healthy volunteers. The goal was to see if measuring retinal layers could he…

This study created a national DNA and blood repository for inherited eye diseases like retinitis pigmentosa. Over 6,600 participants provided blood samples and eye exam data to help researchers identify genetic causes. The stored samples are available to scientists without person…

This study looked at 202 adults with type 2 diabetes and early-stage diabetic eye disease (non-proliferative diabetic retinopathy). Researchers used non-invasive eye scans to find markers that could predict if the disease would get worse or lead to sight-threatening problems. The…

This completed study examined inflammation markers in the fluid from the eyes of 82 people with different stages of age-related macular degeneration (AMD) and a control group without AMD. Researchers collected samples during cataract surgery and tested for 27 inflammation-related…

This study looked at 10 people with rare genetic conditions that cause very low cholesterol and trouble absorbing vitamins. Researchers measured a protective pigment in the eye called macular pigment, which may be low in these patients and could explain why some still develop vis…

This completed study observed 572 patients with neovascular age-related macular degeneration or diabetic macular edema who were already receiving brolucizumab injections. Researchers collected routine medical data to see how well the drug resolved fluid in the eye and improved vi…

This study looked at 119 children who had platinum-based chemotherapy for certain cancers. Researchers wanted to find out if certain genes make some kids more likely to develop hearing loss from the treatment. By analyzing DNA from saliva samples, they hope to identify high-risk …

This study looked at 175 premature babies to see if high iron levels in their blood during the first month of life are linked to a serious eye condition called retinopathy of prematurity (ROP). Researchers measured iron-related markers and tracked which babies developed ROP. The …

This study looked at whether specific features on eye imaging scans can predict how well a person with diabetic macular edema will respond to treatment. Researchers analyzed images from 32 participants to find patterns linked to better or worse outcomes. The goal is to help docto…

This study looked at over 550,000 people who received Eylea® injections for eye conditions to find out how often retinal vasculitis (a rare eye inflammation) occurs. Researchers used a large US registry and medical records to confirm cases. The goal was to better understand the s…

This study looked at new ways to measure and train eye movements in 21 people with macular degeneration, a condition that causes central vision loss. The goal was to see if training could help them use their remaining side vision more effectively. The research focused on understa…

This study looked at 470 people with age-related macular degeneration (AMD) to see if special eye scans (SDOCT) can predict vision loss and disease worsening. Participants were already in the AREDS 2 trial and had moderate to high risk of progression. Researchers tracked changes …

This study followed about 100 babies who were treated for retinopathy of prematurity (ROP) with either Eylea injections or laser therapy in an earlier trial. Researchers checked their vision and eye health years later to see how well the treatments held up. The goal is to underst…

This completed study analyzed data from nearly 290,000 patients who received aflibercept (Eylea) injections for various retinal diseases. The goal was to estimate how often retinal vasculitis (inflammation of blood vessels in the eye) occurs in real-world clinical practice. Resea…

This study looked at the brain's lymphatic system in 40 women with idiopathic intracranial hypertension (IIH), a condition causing severe headaches and vision loss. Researchers used a special MRI technique to compare lymphatic vessels in patients and healthy controls. The goal wa…

This completed study looked at how well different eye tests can track changes in retinitis pigmentosa (RP), a group of blinding eye diseases. Researchers tested 49 people with RP and healthy volunteers using exams like vision tests, retinal imaging, and electrical signal recordin…

This study looked at 100 older adults (60+) to see if those with severe vision loss from age-related macular degeneration have more shoulder pain, stiffness, and movement problems compared to those with normal vision. Researchers measured pain, range of motion, and daily living a…

This study looked at whether telling healthy adults their genetic risk for age-related macular degeneration (AMD) encourages them to eat more carotenoid-rich foods, which are good for eye health. Eighty Caucasian participants aged 18 to 64 without AMD were given genetic risk info…

This completed study looked at 556 people to understand how night vision problems are connected to early age-related macular degeneration (AMD). Participants took vision tests and had detailed eye imaging. The goal was to find reliable markers that could help design future treatm…

This completed study tracked 87 patients who received Luxturna gene therapy for a rare inherited eye condition that causes blindness. Researchers monitored side effects and pregnancy outcomes for up to 5 years after treatment. The goal was to gather real-world safety data, not to…

This study looked back at the medical records of 400 people with neovascular glaucoma, a severe eye condition. Researchers wanted to see how it relates to other diseases, lifestyle factors, and inflammation. The goal is to better understand the condition and guide future treatmen…

This study tested a special eye imaging device that can take pictures of the retina while a person lies down. Researchers compared images from the new device to those from a standard upright device in 88 adults with healthy eyes or retinal disease. The goal was to see if the new …

This study tested whether personalized risk profiling (including genetic testing) and coaching can motivate people with age-related macular degeneration (AMD) to change their lifestyle. 150 participants received standard lifestyle advice plus supplements, and some also got person…

This study tested whether a computer technique called radiomics can help analyze eye scans from people with vitelliform lesions, which are yellow deposits under the retina that can change over time. Researchers looked at 50 participants' OCT images to see if radiomics could disti…

This study tested a new, non-invasive eye scan called OCT angiography to see if it can better detect changes in abnormal blood vessels in people with wet age-related macular degeneration (AMD) who are being treated with Eylea. Researchers followed 49 patients to compare the new s…