Eye drops could replace needles for diabetic eye swelling

NCT ID NCT05066997

Completed Disease control Sponsor: Oculis Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested OCS-01, a steroid eye drop, in 552 people with diabetic macular edema (DME), a condition where fluid builds up in the eye and blurs vision. Participants used the drops several times daily for up to a year. The goal was to see if the drops improve vision and reduce swelling compared to a placebo. If effective, this could offer a simpler alternative to current treatments that require eye injections.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Dexamethasone eye drops (OCS-01)
What this could lead to: If successful, this could provide a convenient, non-invasive eye drop treatment for diabetic macular edema, reducing the need for injections.
What could go wrong: This is a mid-stage trial; results may not confirm lasting benefit. Eye drops require frequent dosing, and side effects like increased eye pressure or cataracts are possible with steroids.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

diabetic macular edema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETIC MACULAR EDEMA

Contacts and locations

Locations

Amrita Institute of Medical Sciences & Research Centre

Kochi, Kerala, 682041, India
Arizona Retina and Vitreous Consultants

Phoenix, Arizona, 85016, United States
Black Hills Regional Eye Institute

Rapid City, South Dakota, 57701, United States
California Eye Specialists Medical Group

Pasadena, California, 91107, United States
California Eye Specialists Medical Group

Redlands, California, 92373, United States
California Retina Consultants

Santa Maria, California, 93454, United States
Chang Gung Memorial Hospital

Taoyuan, Taoyuan, 33305, Taiwan
Changhua Christian Hospital

Changhua, Changhua, 500, Taiwan
Charleston Neuroscience Institute

Ladson, South Carolina, 29456, United States
China Medical University Hospital

Taichung, Taichung, 40447, Taiwan
Chinese University of Hong Kong Eye Centre

Kowloon, Hong Kong
Cumberland Valley Retina Consultants

Hagerstown, Maryland, 21740, United States
East Florida Eye Institute

Stuart, Florida, 34994, United States
Florida Retina Institute

Jacksonville, Florida, 32216, United States
Florida Retina Institute

Orlando, Florida, 32806, United States
HKU Eye Centre

Hong Kong, Hong Kong
ICARE Eye Hospital & Post Graduate Institute

Noida, Uttar Pradesh, 201301, India
L V Prasad Eye Institute

Bhubaneswar, Odisha, 751024, India
MedEye Associates

Miami, Florida, 33143, United States
Midwest Eye Institute

Carmel, Indiana, 46290, United States
Nethra Eye Hospital

Bengaluru, Karnataka, 560094, India
North Carolina Retina Associates

Wake Forest, North Carolina, 27587, United States
Phoenix Retina Associates

Phoenix, Arizona, 85050, United States
Piedmont Eye Center

Lynchburg, Virginia, 24502, United States
Rand Eye Institute

Deerfield Beach, Florida, 33064, United States
Retina Associates

Elmhurst, Illinois, 60126, United States
Retina Care Specialists

Palm Beach Gardens, Florida, 33410, United States
Retina Center of Texas

Grapevine, Texas, 76051, United States
Retina Consultants of Austin/Austin Research Center for Retina

Austin, Texas, 78705, United States
Retina Consultants of Charleston

Beaufort, South Carolina, 29902, United States
Retina Consultants of Minnesota

Saint Louis Park, Minnesota, 55416, United States
Retina Consultants of Southern California

Redlands, California, 92374, United States
Retina Group Of New England

Waterford, Connecticut, 06385, United States
Retina Partners of Northwest Arkansas

Springdale, Arkansas, 72764, United States
Retina Research Institute of Texas

Abilene, Texas, 79606, United States
Retina-Vitreous Associates Medical Group

Beverly Hills, California, 90211, United States
Retina-Vitreous Surgeons of Central New York

Liverpool, New York, 13088, United States
Retinal Consultants Medical Group

Modesto, California, 95356, United States
Sarakshi Netralaya

Nagpur, Maharashtra, 440025, India
Shivam Retina Clinic and Eye Hospital

Surat, Gujarat, 395001, India
Southeast Retina Center

Augusta, Georgia, 30909, United States
Strategic Clinical Research Group

Willow Park, Texas, 76087, United States
Taipei Veterans General Hospital

Taipei, Taipei, 11217, Taiwan
Texas Retina Associates

Dallas, Texas, 75231, United States
The Retina Institute

St Louis, Missouri, 63128, United States
The Retina Partners

Encino, California, 91436, United States
Tyler Retina Consultants

Tyler, Texas, 75703, United States
University Retina

Lemont, Illinois, 60439, United States
Valley Retina Institute PA d.b.a. Gulf Coast Eye Institute

McAllen, Texas, 78503, United States
Velocity (Meridian) Clinical Research

Cincinnati, Ohio, 45202, United States
Verum Research LLC

Eugene, Oregon, 97401, United States
Vision Research Solutions in Philadelphia

Philadelphia, Pennsylvania, 19141, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.