Clot-Buster shows promise for eye stroke in landmark trial
NCT ID NCT04526951
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This Phase 3 trial tested whether the clot-busting drug tenecteplase could improve vision in people with a central retinal artery occlusion (eye stroke). 81 participants received either tenecteplase or aspirin within 4.5 hours of symptoms. The main goal was to see if more patients in the tenecteplase group had significant vision improvement at 30 days.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Tenecteplase (a clot-busting drug)
- What this could lead to
- If it works, this could provide a proven treatment to restore vision in people who have an 'eye stroke' (blocked artery in the eye).
- What could go wrong
- This is a small, completed Phase 3 trial (81 people). The drug carries a risk of bleeding, and results may not apply to all patients or be confirmed in larger studies.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Aarhus University Hospital
Aarhus, Denmark
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Bispebjerg University Hospital
Copenhagen, Denmark
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Haukeland University Hospital
Bergen, Norway
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Helse Nord Trøndelag Trust
Namsos, Norway
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Helsinki University Hospital
Helsinki, Finland
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Karolinska University Hospital
Stockholm, Sweden
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Kauno Klinikos Kaunas
Kaunas, Lithuania
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Oslo University Hospital
Oslo, 0424, Norway
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Rigshospitalet University Hospital
Copenhagen, Denmark
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St Olav University Hospital
Trondheim, Norway
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Telemark Hospital Trust
Skien, Norway
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Turku University Hospital
Turku, Finland
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University Hospital Antwerp
Antwerp, Belgium
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University Hospital Leuven
Leuven, 3000, Belgium
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Vestfold Hospital Trust
Tønsberg, Norway
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Vestre Viken Hospital Trust Drammen
Drammen, Norway
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Vilnius University Hospital
Vilnius, Lithuania
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Østfold Hospital Trust Kalnes, Dept of Ophthalmology
Grålum, Norway
More trials for these conditions
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