Eye drops could replace needles for Diabetes-Related vision loss

NCT ID NCT06172257

Completed Disease control Sponsor: Oculis Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a steroid eye drop called OCS 01 can improve vision in people with diabetic macular edema, a common cause of vision loss in diabetes. Over 400 participants used the drops several times daily for a year. The goal was to see if this non-invasive treatment could match or beat current injection therapies.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Dexamethasone eye drops (OCS 01)
What this could lead to: If it works, this could offer a simple eye drop alternative to eye injections for controlling diabetic macular edema and improving vision.
What could go wrong: This is a completed Phase 3 trial, but results are not yet public. Eye drops may be less effective than injections, and side effects like increased eye pressure or cataracts are possible with steroids.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

diabetic macular edema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETIC MACULAR EDEMA

Contacts and locations

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Locations

Advanced Research

Coral Springs, Florida, 33067, United States
Agrawal Hospital

Jaipur, Rajasthan, 302004, India
Associated Retina Consultants

Gilbert, Arizona, 85297, United States
Associated Retina Consultants

Phoenix, Arizona, 85020, United States
Austin Retina Associates

Round Rock, Texas, 78681, United States
Blue Ocean Clinical Research

Clearwater, Florida, 33761, United States
Buenos Aires Macula (BAM) Clinical Research

CABA, Buenos Aires, C1061AAE, Argentina
California Retina Consultants

Bakersfield, California, 93309, United States
California Retina Consultants

Santa Barbara, California, 93103, United States
Centro De Ojos Loria Srl

CABA, Buenos Aires, 1663, Argentina
Centro Privado de Ojos

CABA, Buenos Aires, 1663, Argentina
Centro Privado de Ojos Romagosa

Córdoba, Córdoba Province, 5000, Argentina
Centro de la Vision Dr. Kolton

Salta, Salta Province, A4400, Argentina
Charles Centro Oftalmológico

Ciudad Autónoma de Buenos Aires, Buenos Aires, C1008, Argentina
Charles Retina Institute

Germantown, Tennessee, 38138, United States
Cumberland Valley Retina Consultants

Hagerstown, Maryland, 21740, United States
East Coast Institute for Research

Jacksonville, Florida, 32256, United States
Emanuelli Research & Development Center

Arecibo, 00612, Puerto Rico
Erie Retina Research

Erie, Pennsylvania, 16507, United States
Eye Care Center of Northern Colorado

Longmont, Colorado, 80503, United States
Fundacion Zambrano

Buenos Aires, Buenos Aires, 1023, Argentina
GSVM Medical College

Kanpur, Uttar Pradesh, 208005, India
Georgia Retina

Peachtree City, Georgia, 30269, United States
Grupo Laser Vision

Rosario, Santa Fe Province, S2000 PRB, Argentina
Houston Eye Associates, North Loop

Houston, Texas, 77025, United States
Illinois Retina Associates

Oak Park, Illinois, 60304, United States
Instituto de Microcirugía Ocular Córdoba (IMOC)

Córdoba, Córdoba Province, X5016KEH, Argentina
Island Retina

Shirley, New York, 11967, United States
Lotus Eye Hospital and Institute

Coimbatore, Tamil Nadu, 641014, India
Macula Retina Vitreous Center

Torrance, California, 90503, United States
Marietta Eye Clinic

Marietta, Georgia, 30060, United States
Medical Center Ophthalmology Associates

San Antonio, Texas, 78240, United States
Mid Atlantic Retina Specialists

Hagerstown, Maryland, 21740, United States
Mississippi Retina Associates

Jackson, Mississippi, 90033, United States
Narayana Nethralaya

Bangalore, Karnataka, 560010, India
Oftalmologìa Global

Rosario, Santa Fe Province, S2000, Argentina
Oftalmos - Instituto Oftalmológico de Alta Complejidad

Buenos Aires, Buenos Aires, C1120 AAN, Argentina
Oftar Mendoza - Centro Privado de Oftalmología en Mendoza Capital

Mendoza, Mendoza Province, M5500, Argentina
Ophthalmic Consultants of Boston

Boston, Massachusetts, 02114, United States
Organizacion Medica De Investigacion

CABA, Buenos Aires, C1015, Argentina
Palmetto Retina Center

West Columbia, South Carolina, 29169, United States
Piedmont Eye Center

Lynchburg, Virginia, 24502, United States
Retina Associates of Southern California

Huntington Beach, California, 92647, United States
Retina Consultants of Southwest Florida

Naples, Florida, 33912, United States
Retina Consultants of Texas

Bellaire, Texas, 77401, United States
Retina Group of Florida

Fort Lauderdale, Florida, 33308, United States
Retina Specialists of Colorado

Denver, Colorado, 80210, United States
Retinal Consultants Medical Group

Sacramento, California, 95841, United States
Retinal Consultants Medical Group, Inc

Sacramento, California, 95825, United States
Retinal Consultants of Arizona - Phoenix North

Phoenix, Arizona, 85053, United States
Rising Retina Clinic

Ahmedabad, Gujarat, 380015, India
San Antonio Eye Center - Downtown Clinic

San Antonio, Texas, 78215, United States
Sibia Eye Institute

Boynton Beach, Florida, 11195, United States
Sierra Eye Associates

Reno, Nevada, 89502, United States
St. Theresa's Hospital

Hyderabad, Telangana, 500038, India
Stanford Byers Eye Institute

Palo Alto, California, 94303, United States
Star Retina

Burleson, Texas, 76028, United States
Tennessee Retina

Nashville, Tennessee, 37203, United States
Tyler Retina Consultants

Tyler, Texas, 75703, United States
Vision Research Solutions in Philadelphia

Philadelphia, Pennsylvania, 19141, United States
VitreoRetinal Consultants of NY

Hauppauge, New York, 11788, United States
Vitreoretinal Consultants of NY

Westbury, New York, 11590, United States

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