New hope for kids with retinoblastoma: tailored therapies aim to save lives and sight
NCT ID NCT00186888
First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study tested personalized treatments for children with retinoblastoma, a rare eye cancer. Researchers divided 107 participants into groups based on whether one or both eyes were affected and how advanced the cancer was. They used combinations of chemotherapy drugs like vincristine, carboplatin, and topotecan, along with surgery if needed, aiming to cure the cancer while preserving vision.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Vincristine, Carboplatin, Topotecan
What this could lead to
If successful, this study could improve how doctors personalize treatment for children with retinoblastoma, potentially increasing cure rates and saving more vision.
What could go wrong
This is an older completed study, so results may not reflect current best practices. Chemotherapy has side effects like infection risk and organ damage, and some children may still need eye removal.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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St. Jude Children's Research Hospital
Memphis, Tennessee, 38105, United States