Double-Dose eye injections tested for two leading causes of blindness
NCT ID NCT06591598
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This completed Phase 4 study tested how much of the drug aflibercept gets into the bloodstream when a high dose (8 mg) is injected into both eyes of adults with diabetic macular edema or wet age-related macular degeneration. Fifty-one participants received the injections and had blood samples taken to measure drug levels. The goal was to gather more safety and exposure data, not to directly measure vision improvement.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- aflibercept (Eylea HD)
- What this could lead to
- If successful, this study could confirm that high-dose aflibercept is safe and effective when given to both eyes at once, potentially simplifying treatment for people with DME or wet AMD.
- What could go wrong
- This is a small, completed pharmacokinetic study (51 people) focused on drug levels, not on long-term safety or vision outcomes. Results may not apply to all patients or guarantee better vision.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Axon Clinical, s.r.o.
Prague, 150 00, Czechia
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Budapest Retina Associates
Budapest, 1133, Hungary
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Debreceni Egyetem Klinikai Kozpont
Debrecen, 4032, Hungary
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Fakultna nemocnica s poliklinikou Zilina
Žilina, 012 07, Slovakia
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Fakultní nemocnice Královské Vinohrady - Urologická klinikay
Prague, 10034, Czechia
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Univerzitna nemocnica Bratislava, Nem. Sv. Cyrila a Metoda
Bratislava, 851 07, Slovakia
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Longer-Lasting eye injection could cut treatment visits for macular disease
- Can a new eye injection preserve vision in south asians with diabetes?
- Could a biosimilar eye injection offer a new way to treat diabetic macular edema?
- Can a new eye injection save vision in wet AMD?
- Can a steroid implant boost the effect of standard eye injections for hard-to-treat diabetic macular edema?
- Eye injection aims to tame leading causes of blindness