Baby eye treatment checked years later: did it last?

NCT ID NCT04015180

Completed Knowledge-focused Sponsor: Bayer Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study followed about 100 babies who were treated for retinopathy of prematurity (ROP) with either Eylea injections or laser therapy in an earlier trial. Researchers checked their vision and eye health years later to see how well the treatments held up. The goal is to understand long-term safety and effectiveness.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Aflibercept (Eylea) injection or laser photocoagulation

What this could lead to

If successful, this study will show how well these treatments work over the long term for vision and eye health in premature babies.

What could go wrong

This is a follow-up study, not a new treatment test. Results may not apply to all babies, and some children may still have vision problems.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

retinopathy of prematurity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RETINOPATHY OF PREMATURITY (ROP)

Contacts and locations

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Locations

A.O. di Perugia_Hospital Santa Maria della Misericordia - S.C. Oculistica

Perugia, Umbria, 06129, Italy
AZ Sint Jan Brugge - Ophthalmology

Bruges, 8000, Belgium
Acibadem City Clinic Multiprofile Hospital for Active Treatm

Sofia, 1407, Bulgaria
Adana Sehir Egitim ve Arastirma Hastanesi

Yüreğir, 1370, Turkey (Türkiye)
Asan Medical Center - Oncology Department

Seoul, Seoul Teugbyeolsi, 05505, South Korea
Birmingham Womens Hospital

Birmingham, B15 2TG, United Kingdom
Children's Hospital of Athens P&A Kyriakou - Pediatric Nephrology Department

Athens, MISSING, Greece
City Children Hospital ?1

Saint Petersburg, 198205, Russia
Clinical Emergency County Hospital

Cluj-Napoca, Cluj, 400347, Romania
Eskisehir Osmangazi Universitesi Tip Fakultesi

Eskişehir, 26480, Turkey (Türkiye)
Eszak-Kozep-budai Centrum, Uj Szent Janos Korhaz és Szakrendelo

Budapest, H-1125, Hungary
FGBUZ "NPC of special children care n.a. Voino-Yaseneckogo"

Moscow, 119620, Russia
FSAI NMRC IRTC "Eye Microsurgery", Kaluga's Branch

Kaluga, 248007, Russia
Fakultní nemocnice Ostrava

Ostrava, 708 52, Czechia
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Oculistica

Milan, Lombardy, 20122, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - UOC Oculistica

Rome, Lazio, 00136, Italy
Fukuoka University Hospital

Fukuoka, 814-0180, Japan
Fukushima Medical University Hospital

Fukushima, 960-1295, Japan
Gazi Universitesi Tip Fakultesi

Ankara, 6560, Turkey (Türkiye)
General Hospital Of Thessaloniki Papageorgiou-2nd Ophthalmology Clinic

Efkarpia, 564 29, Greece
Hacettepe Universitesi Tip Fakultesi

Ankara, 6100, Turkey (Türkiye)
Hospital Kuala Lumpur

Kuala Lumpur, 50586, Malaysia
Hospital Prof. Dr. Fernando Fonseca

Amadora, Lisbon District, 2720-276, Portugal
Hospital Público Descentralizado "Dr. Guillermo Rawson"

San Juan, 5400, Argentina
Hospital Universitario 12 de Octubre

Madrid, 28041, Spain
Hospital Universitario Regional De Malaga - Oftalmologia

Málaga, 29011, Spain
Hospital das Clínicas de Botucatu - UNESP Botucatu

Botucatu, São Paulo, TBC, Brazil
Hospital la Paz - oftalmologia

Madrid, 28046, Spain
Hospital of the University of Occupational and Environmental Health, Japan

Kitakyushu, Fukuoka, 807-8556, Japan
Institute of Eye Diseases and Tissue Therapy named after V.I. Filatov, Consultative Polyclinic

Odesa, 65061, Ukraine
KK Women's and Children's Hospital

Singapore, 229899, Singapore
Kaohsiung Medical University Chung-Ho Memorial Hospital

Kaohsiung City, Kaohsiung, 807377, Taiwan
Kaplan Medical Center

Rehovot, 7610001, Israel
Kindai University Hospital

Osakasayama-shi, Osaka, 589-8511, Japan
Kurume University Hospital

Kurume, Fukuoka, 830-0011, Japan
Kyushu University Hospital

Fukuoka, 812-8582, Japan
Mackay Memorial Hospital

Taipei, 104, Taiwan
Maxima Medisch Centrum, locatie Veldhoven

Veldhoven, 5504 DB, Netherlands
Narodny ustav detskych chorob

Bratislava, 833 41, Slovakia
Okinawa Prefectural Nanbu Medical Center and Children's MC

Shimajiri-gun, Okinawa, 901-1193, Japan
Ospedale Pediatrico Bambino Gesù - Oculistica

Rome, Lazio, 00165, Italy
Saglik Bilimleri Universitesi Antalya EA Hastanesi

Antalya, 7100, Turkey (Türkiye)
Sahlgrenska Universitetssjukhuset

Gothenburg, 413 45, Sweden
Soon Chun Hyang University Cheonan Hospital

Cheonan, Chungcheongnam-do, 31151, South Korea
Spec. Hosp. of Ophthalm. Disease for Active Treatment Varna

Varna, 9000, Bulgaria
Spec. Hospital of Ophthalm. for Active Treatment Visus

Sofia, 1619, Bulgaria
Spitalul Clinic de Obstretica si Ginecologie "Cuza Voda"

Iași, 700038, Romania
Tokyo Metropolitan Bokutoh Hospital

Sumida-ku, Tokyo, 130-8575, Japan
Tokyo Metropolitan Hospital Organization Tokyo Metropolitan Children's Medical Center

Fuchū, Tokyo, 183-8561, Japan
Tokyo Metropolitan Ohtsuka Hospital

Toshima-ku, Tokyo, 170-8476, Japan
UMHAT Sveti Georgi

Plovdiv, 4002, Bulgaria
Unidade Local De Saúde De Lisboa Ocidental E.P.E.

Lisbon, 1449-005, Portugal
Unifesp/Epm

São Paulo, 04024-002, Brazil
University General Hospital of Ioannina

Ioannina, 45500, Greece
Všeobecná fakultní nemocnice v Praze

Prague, 12808, Czechia