Retinal disorder

This early-stage study tests whether an injection of the drug topotecan into the eye can safely prevent retinal detachment from coming back in people with a condition called proliferative vitreoretinopathy (PVR). About 50 adults having retinal detachment surgery will either recei…

This trial investigates whether faricimab, an eye injection, can help people with chronic central serous chorioretinopathy (CSCR), a condition where fluid builds up under the retina and can cause vision loss. The study includes 50 adults with persistent fluid for at least three m…

This study tests a gene therapy called OPGx-RDH12 for people with Leber Congenital Amaurosis (LCA) caused by mutations in the RDH12 gene, a rare condition that leads to severe vision loss from a young age. The treatment is given as a single injection under the retina in the worse…

This phase 3 trial tests whether NPI-001, taken twice daily for 24 months, can slow the loss of light-sensing cells in the eyes of adults with Usher syndrome, a genetic condition that causes both hearing and vision loss. About 80 participants will receive either the drug or a pla…

This trial tests a single injection of a gene therapy called ZVS101e for people with Bietti crystalline dystrophy, a rare inherited eye disease that leads to progressive vision loss. The therapy uses a harmless virus to deliver a working copy of the CYP4V2 gene to cells in the ey…

This study tests whether using cord blood, rich in fetal hemoglobin, for transfusions in preterm infants can reduce serious complications like blindness, lung disease, and gut problems. Researchers will compare outcomes in 200 very low birth weight babies who receive either cord …

This study tests whether a treat-and-extend schedule for aflibercept eye injections works better than the standard as-needed approach for people with diabetic macular edema who have not had prior treatment. About 186 participants will receive three monthly injections, then either…

This study tests an oral drug called STL303 for geographic atrophy, a form of dry age-related macular degeneration that causes a blind spot in central vision. About 300 adults aged 60 and older will receive either STL303 or a placebo pill for up to 2 years. The goal is to see if …

This study tests whether a remote dietary program can help people with early to intermediate age-related macular degeneration (AMD) lower their blood sugar and increase protective nutrients called carotenoids. About 32 participants will receive coaching to improve their eating ha…

This Phase 2a trial tests SCAI-005 eye drops in 50 adults with wet age-related macular degeneration (AMD). Participants will receive either a low dose, high dose, or placebo drops three times daily. The study aims to see if the drops can reduce retinal swelling and control the di…

This early-stage trial tests a gene therapy called AGX-08 for geographic atrophy, an advanced form of age-related macular degeneration that causes vision loss. The study will involve 24 people aged 50 and older, each receiving a single injection into one eye. The main goal is to …

This pilot study tests whether a daily probiotic supplement (Lactobacillus plantarum 299v) can reduce retinal swelling and improve vision in people with diabetic macular edema. Thirty-six participants will take the probiotic twice daily for four months. Researchers will measure c…

This study is for people with Bietti's crystalline dystrophy, a rare genetic eye disease that causes vision loss. They have already received the gene therapy VGR-R01 in one eye. Now, researchers want to test if giving the same treatment to the other eye is safe and can improve vi…

This study will test the drug faricimab, given as eye injections, in 50 people with wet age-related macular degeneration (nAMD). The goal is to see if it improves vision and eye health. Participants will receive 4 initial doses, then more as needed. The study is observational, me…

This study looks at whether a home monitoring app can help people with wet age-related macular degeneration (eAMD) safely extend the time between Aflibercept injections. About 80 adults already receiving this treatment will use the app and have regular eye exams over one to two y…

This study tests a non-invasive laser treatment called photobiomodulation for people with early age-related macular degeneration (AMD) who have a specific type of deposit in the eye called reticular pseudodrusen. The treatment uses low-energy light to stimulate cells and reduce i…

This study will test hyperbaric oxygen therapy (HBOT) — breathing pure oxygen in a pressurized chamber — for over 30 conditions, including long COVID, Crohn's disease, frostbite, and multiple sclerosis. Researchers will track 100 patients to see if HBOT improves their quality of …

This early study tests whether stimulating a nerve cluster behind the cheekbone (the pterygopalatine ganglion) is safe and doable for people with geographic atrophy, a severe form of age-related macular degeneration that causes blind spots. Sixty-two adults will receive either re…

This study tests a new medicine called AIV007 for people with wet age-related macular degeneration (AMD), a leading cause of vision loss. About 35 participants will receive either AIV007 or the standard treatment Eylea. The goal is to see if AIV007 can improve vision and reduce t…

This study tests an investigational drug called OCUL101 for people with wet age-related macular degeneration (AMD), a condition that causes blurry vision and can lead to blindness. OCUL101 targets two proteins involved in the disease to reduce abnormal blood vessel growth and inf…

This early-stage trial tests a single injection of ZM-02, a gene therapy, in 21 people aged 6 to 60 with advanced retinitis pigmentosa, a genetic condition that causes progressive vision loss. Participants are randomly assigned to receive either a low or high dose of ZM-02 or a s…

This study tests whether two dietary supplements—tauroursodeoxycholate (a bile acid) and a traditional Chinese medicine formula—can help people with diabetic macular edema, a vision-threatening complication of diabetes. The 69 participants will take the supplements or a placebo f…

This phase 3 trial tests whether adding Sanhuang Jingshiming Pills (a traditional Chinese herbal medicine) to standard ranibizumab injections can reduce the number of injections needed for wet age-related macular degeneration. About 450 adults aged 50-85 with active wet AMD will …

This study tests whether a natural supplement from Dunaliella alga, rich in 9-cis beta-carotene, can improve vision in adults with retinitis pigmentosa. Forty-one participants will take the supplement or a placebo for 3 months, then switch after a 6-month break. Researchers will …

This early-stage trial tests a single injection of AXV-101 gene therapy into one eye of 12 children and teens (ages 4-17) with Bardet-Biedl syndrome type 1, a rare genetic condition that causes progressive vision loss. The main goal is to check safety and find the right dose, whi…

This study compares transfusions using red blood cells from umbilical cord blood versus standard adult donor blood in extremely premature infants. About 176 babies born before 28 weeks or weighing under 1000 grams will be enrolled. The goal is to see if cord blood reduces the ris…

This phase 3 trial tests whether a new drug, QL1207H, works as well as the standard treatment Eylea for wet age-related macular degeneration, a leading cause of vision loss. About 356 adults aged 50 and older with active disease will receive injections every 4 weeks for 3 doses, …

This Phase 1 trial will test the safety of PRO-169, a form of bevacizumab injected into the eye, in 60 adults with diabetic macular edema. The study checks for immune reactions and side effects. It is not yet recruiting and focuses on safety, not whether it improves vision.

This study tests an oral medication, CU06-1004, for people with diabetic macular edema (DME), a condition that causes vision loss. About 156 participants will take either a low dose, high dose, or placebo pill daily for 24 weeks. The goal is to see if the drug improves vision and…

This study compares a combination of a steroid implant (dexamethasone) plus an anti-VEGF injection (aflibercept) against aflibercept alone for diabetic macular edema. Researchers will enroll 114 people with diabetes who have not had prior treatment. The goal is to see if the comb…

This study follows up 18 people who received umbilical cord stem cells or conditioned medium for retinitis pigmentosa, a rare eye disease that causes vision loss. Researchers will check vision, eye structure, and safety five years after the injection. The goal is to see if the tr…

This study tests whether stem cells from umbilical cord tissue can safely slow vision loss in people with retinitis pigmentosa, an inherited eye disease. Thirty participants will receive one of two doses injected around the eye and be monitored for six months. The main goals are …

This early-stage trial tests whether transplanting lab-grown retinal cells (made from stem cells) into the eye is safe for people with late-stage age-related macular degeneration. Nine participants will receive the cell transplant and be monitored for side effects and any improve…

This early-stage trial tests a new drug called GB10, given as an eye injection, for people with wet age-related macular degeneration (AMD). The study will include 48 participants and aims to check safety and find the right dose. It is not yet recruiting and is too early to know i…

This study tests a new, non-invasive treatment for dry age-related macular degeneration (AMD), a common cause of vision loss in older adults. About 94 people aged 50 and older with dry AMD will use a red-light device at home twice daily for three months. Researchers will check if…

This study tests whether mirabegron, a drug used for overactive bladder, can help people with dry age-related macular degeneration (AMD). Researchers will give 312 patients aged 50-80 either mirabegron or a standard bladder drug for 12 months and check for changes in the retina. …

This study tests whether glucose-lowering medications (semaglutide and possibly dapagliflozin) can reverse prediabetes and prevent complications like eye, kidney, and nerve damage in people with heart disease. About 158 participants with prediabetes and coronary artery disease wi…

This phase 4 trial will test the drug faricimab (Vabysmo) in 64 people with wet age-related macular degeneration (AMD). Participants will receive eye injections every 4 weeks for 4 doses, then a treat-and-extend schedule based on disease activity. The study also measures biomarke…

This study tests a stronger dose (8 mg) of the drug aflibercept in Chinese patients with polypoidal choroidal vasculopathy (PCV), a type of wet age-related macular degeneration that can cause rapid vision loss. About 174 people who have not been treated before will receive three …

This study will test a new pattern of retinal laser treatment combined with anti-VEGF injections for people with proliferative diabetic retinopathy (PDR), a serious eye condition that can lead to blindness. Researchers plan to enroll 300 adults aged 18–70 with stable diabetes and…

This early-stage trial tests a single injection of a gene therapy drug called UGX202 in 6 adults with advanced retinitis pigmentosa, a genetic condition that causes vision loss. The main goal is to check if the treatment is safe and tolerable over 52 weeks. Researchers will also …

This study looks at whether a single injection of the drug Aflibercept given during cataract surgery works as well as three injections (one during surgery and two more over the next two months) to stop diabetic retinopathy from getting worse. The trial will include 166 diabetic p…

This study tests whether using sterile air during eye surgery for a detached retina works as well as the standard gas bubble. About 150 patients from 10 UK centers will be randomly assigned to receive either air or a fluorinated gas. The main goal is to see if the retina stays re…

This study tests an experimental pill (EG-301) taken daily for at least 6 months in 90 people with dry age-related macular degeneration (AMD) and geographic atrophy. Participants are randomly assigned to receive either standard AREDS2 supplements alone or AREDS2 plus EG-301. The …

This study tests two different laser pulse settings (5% vs 15% duty cycle) in 50 adults with diabetic macular edema, a common cause of vision loss in diabetes. The goal is to see which setting is safer and more effective at reducing retinal swelling. Participants must have mild t…

This study tests whether a ginkgo biloba extract (EGb761) can slow or prevent diabetic retinopathy, an eye disease caused by diabetes. About 200 adults with long-standing diabetes will take either ginkgo or standard treatment for 2 years. Researchers will measure changes in eye b…

This study tests whether a powder made from a special alga can help preserve or improve vision in teenagers with retinitis pigmentosa, a genetic eye disease that causes vision loss. Thirty participants aged 12-18 will take the alga extract daily for one year. The study will measu…

This early-stage study tests a new nose spray version of the drug octreotide for people with diabetic macular edema, a condition that causes vision loss from fluid buildup in the eye. The trial will include 60 adults whose eye swelling has not improved with standard treatments. R…

This study tests an experimental drug called SNP318 in 60 people with diabetic macular edema, a condition that causes vision loss due to swelling in the retina. Participants will receive either the drug or a placebo, and researchers will monitor safety, eye thickness, and vision …

This early study tests NPDR-01 eye drops in 10 adults with non-proliferative diabetic retinopathy, a common eye complication of diabetes. Participants will use one drop daily for 6 months to see if it reduces tiny retinal bleeds (microaneurysms) and slows disease progression. The…

This study tests faricimab, a drug injected into the eye, for people with type 3 wet age-related macular degeneration (AMD), a condition that can cause rapid vision loss. Over 76 weeks, 30 participants will receive initial monthly doses, then a personalized schedule where injecti…

This early-stage trial tests EXG202, a gene therapy given as a single injection into the eye for people with wet age-related macular degeneration (AMD). The goal is to see if it is safe and can produce a protein that blocks abnormal blood vessel growth long-term, potentially redu…

This study tests whether an artificial intelligence (AI) system can help eye doctors identify urgent retinal conditions—like retinal detachment or bleeding—more accurately from wide-field eye images. Eight ophthalmologists will review images with and without AI assistance to see …

This trial tests an artificial intelligence system called QiLin that helps doctors decide when to give anti-VEGF injections for retinal diseases like wet AMD, DME, and RVO. About 200 patients who have completed initial treatment will be randomly assigned to have their doctor use …

This study tests whether using an AI program to screen for diabetic eye disease during regular primary care visits can get more people to follow up with an eye specialist. It will include 4,000 adults with diabetes who have Medicaid and haven't had an eye exam in the past year. T…

This study will develop and test an artificial intelligence system to detect common eye diseases like glaucoma, cataracts, and diabetic retinopathy using 15,000 existing eye images from Costa Rican patients. The goal is to create a tool that works accurately for local populations…

This study tests a compact, handheld eye imaging device that takes pictures of the eye in seconds. Researchers want to see if it is easy to use, mobile, and reliable. The device will be tested on 70 people with eye complaints, and the images will be compared to official diagnoses…

This study will test a software that uses artificial intelligence to analyze photos of the retina and detect diabetic retinopathy, a common eye problem in people with diabetes. About 198 adults with diabetes will have their retinal images analyzed by the AI tool, and the results …

This study will test a new, non-invasive eye scanner called wide field OCTA in 200 people with various eye diseases, including age-related macular degeneration, diabetic retinopathy, and dry eye. The goal is to see if this device can provide better images of blood vessels in the …

This study will test a new artificial intelligence (AI) system that reads eye scans (OCT) to diagnose common blinding eye diseases like diabetic retinopathy, glaucoma, and age-related macular degeneration. Researchers will collect 2000 eye scans from patients at Peking Union Medi…

This study will test whether artificial intelligence (AI) can effectively screen for diabetic retinopathy (eye damage) in 400 children with type 1 diabetes. Each child will have their eyes examined using an AI-powered camera, standard eye exams, and a detailed scan. The researche…

This study tests whether a structured referral tracking program helps adults in Pakistan complete follow-up eye care after community screenings. 500 participants will receive either standard referral or extra support like counseling and weekly reminders. The goal is to prevent bl…

This study tests whether a short course of the steroid prednisolone can prevent paradoxical immune reconstitution inflammatory syndrome (IRIS) in people with AIDS who have low CD4 counts and are starting HIV treatment. About 131 participants will receive either prednisolone or no…

This trial tests whether a fentanyl nasal spray can reduce pain during eye exams for retinopathy of prematurity (ROP) in preterm infants. About 58 babies born at or before 31 weeks will receive either fentanyl or a saltwater placebo before their routine exam, along with standard …

This study tests a new eye drop called IRX-101 to see if it reduces pain and surface damage after anti-VEGF injections for retinal disease. About 240 adults who get these injections will receive either IRX-101 or standard povidone-iodine. The goal is to make the procedure more co…

This study tests if using a cotton-tipped applicator to hold the eyelid open during eye injections is less painful and faster than the standard metal speculum. About 120 adults with certain eye conditions will take part. The goal is to improve comfort and satisfaction without com…

This clinical trial tests whether transcranial magnetic stimulation (TMS) can restore vision in adults with severe retinal degeneration. Over 100 participants will receive either real TMS or a sham (fake) treatment for five days, and their eyesight will be checked up to a year la…

This study tests whether meditation or a health education program can improve quality of life and mental health for people with irreversible age-related vision loss and their caregivers. About 150 participants will be assigned to either meditation training or health classes, both…

This early study tests whether a wearable ultrasound device can safely stimulate retinal cells and help restore vision in people with age-related macular degeneration or retinitis pigmentosa. Five participants will receive short ultrasound pulses while reporting what they see. Th…

This study tests whether Meta AI glasses, connected to the Be My Eyes network, can help people with permanent vision loss walk and move around more easily. The glasses describe scenes and objects in real time. Fifty participants will use the glasses and report changes in their qu…

This study tests a vibrating device to reduce pain during laser treatment for diabetic eye disease. About 50 people will have one eye treated with the device and the other without, then rate their pain. The goal is to see if the vibration helps make the procedure more comfortable…

This study tests a miniaturized smart contact lens in 32 people—some healthy, some with Stargardt's disease—to see if it is comfortable and easy to use. The lens tracks eye movements to help with vision tasks. Researchers will check for side effects and ask participants how they …

This trial aims to see if educational videos or audio messages can improve parents' knowledge and practices about retinopathy of prematurity (ROP) screening. About 99 parents of premature infants in Karachi will receive either a video, audio, or standard pamphlet. Their understan…

This study aims to develop new methods to help veterans with vision loss caused by age-related macular degeneration. About 20 veterans aged 50 and older with reduced vision will take part. Researchers will measure how well they recognize objects and how their brains respond befor…

This study will test a new, noninvasive camera called XyCAM CRE that measures blood flow in the back of the eye. Researchers will compare its images with standard eye tests in 350 adults with retinal disorders. The goal is to see if this camera can provide extra information to he…

This observational study will use advanced imaging techniques to measure changes in the retina and choroid (the layer beneath the retina) in people with eye diseases and healthy volunteers. Over 5 years, researchers will track thickness and blood vessel density to better understa…

This study will use artificial intelligence (AI) to analyze eye scans from 554 adults with diabetic macular edema (DME). The goal is to see if AI can predict when a person's eye treatment needs to change. Participants will not receive any new treatment; instead, researchers will …

This study tests whether a personalized care approach helps patients with chronic macular diseases (like wet age-related macular degeneration and diabetic macular edema) attend their regular eye injection appointments. Many patients skip these vital treatments, risking further vi…

This study will enroll 50 adults with a specific type of retinal detachment to look for clues in eye fluid and images that might predict a complication called PVR. Participants will receive standard surgery plus extra non-invasive eye scans and a sample of their eye fluid taken d…

This study looks at how heart rate variability (a measure of stress response) relates to emotional control and parent-teen relationships in 74 adolescents with depression. Teens will wear a Fitbit while sleeping for a week and fill out questionnaires. The goal is to better unders…

This study follows 100 adults with diabetic eye disease who are already receiving standard anti-VEGF injections for swelling in the center of the retina. Researchers will use advanced vision tests and imaging to track changes over time. The goal is not to test a new drug, but to …

This study looks at whether giving eye doctors AI-generated measurements from retinal images helps them write more accurate and complete reports. About 29 ophthalmologists and trainees will be randomly assigned to use AI tools or just the original images. A panel of senior expert…

This study will analyze eye and brain scans from over 200,000 people to see if eye images can predict brain diseases like small vessel disease and other health problems. Researchers will build computer models to map eye features to brain structure and disease diagnoses. No treatm…

This study will look back at the medical records of 150 children with retinoblastoma who received additional eye treatments after initial chemotherapy. The treatments include radioactive plaque therapy, freezing therapy, or laser therapy. The goal is to see how often each treatme…

This study will follow 450 people with diabetes (and some without) for several years to track how their eyes change. Researchers will use advanced eye tests like visual field analysis, contrast sensitivity, and retinal imaging to see which measurements best show disease progressi…

This study tests an AI tool called EyeAgent that helps eye doctors make decisions. About 300 people visiting eye clinics in Hong Kong and mainland China will take part. The AI reviews patient images and history to suggest diagnoses and treatments. The goal is to see if using the …

This study aims to see if virtual reality tests can better measure how age-related macular degeneration affects daily life compared to standard eye exams. Researchers will enroll 60 participants, including healthy adults and those with the eye condition. The goal is to develop a …

This study looks at children born prematurely who had retinopathy of prematurity (ROP), a disease that can cause blindness. Some were treated with laser, others with injections, and some had ROP but no treatment. Researchers will compare their vision and retina structure to see w…

This study aims to understand how dry eye disease and diabetic macular edema (a swelling in the back of the eye) are related in people with diabetes. About 50 adults with diabetes for over 8 years will have their eyes tested using questionnaires, tear measurements, and imaging. T…

This study will use a special type of eye scan (ultra-widefield OCTA) to measure blood vessel patterns in people with central serous chorioretinopathy (CSC), a condition that causes fluid buildup and blurry vision. Researchers aim to create a more precise way to analyze these ima…

This pilot study will test two new eye imaging devices (R1 and HighRes OCT) against a standard device in 97 adults with healthy eyes or eye diseases like macular degeneration and diabetic retinopathy. Researchers will compare image quality and how well key eye structures are seen…

This study aims to see if elderly patients with age-related macular degeneration (AMD) find a new web-based eye-tracking system easy and acceptable to use at home. The system is designed to help patients monitor their vision without frequent clinic visits. Thirty patients aged 55…

This study looks back at medical records of 200 people with inherited retinal diseases, like retinitis pigmentosa and Stargardt disease. Researchers will analyze vision tests and eye scans to see how these diseases progress and how genetics affect symptoms. The goal is to find be…

This study will look at 225 adults with diabetic retinopathy to find out how many also develop an epiretinal membrane — a thin, scar-like layer on the retina that can blur vision. Researchers will use eye scans to detect the membrane and check for related factors like age, diabet…

This study will use a special eye scan called OCT to look for early signs of retinal damage in people with diabetes who have no vision problems. Researchers want to see if these scans can detect changes before symptoms appear. About 112 participants will get a detailed eye exam, …

This study looks at whether shifting text to a different part of the eye can help people with central vision loss read faster and more accurately. Researchers will test 100 participants with conditions like macular degeneration using various reading tasks. The goal is to find bet…

This study looks at how diabetes affects small blood vessels and nerves in the eyes and brain. Researchers will use advanced imaging to detect damage and test a traditional Chinese herbal medicine called Tangshen'an Granules to see if it can help. 160 adults with diabetes will ta…

This study tests whether short animated videos, available in 25 languages, can help people with retinal detachment understand their condition and surgery better. 600 adults will either get standard counselling or counselling plus a video in their preferred language. Researchers w…

This study will look at 30 people with macular dystrophy to see how different eye tests—like OCT scans, mfERG, and standard vision tests—relate to each other. The goal is to better understand how these tests can track vision changes. No treatment is being tested; this is purely a…

This study looks at whether argon laser treatment for advanced diabetic eye disease (proliferative diabetic retinopathy) changes the number of cells in the cornea. Researchers will measure corneal cell density before and after laser treatment in 45 patients. The goal is to see if…