Could a probiotic help save sight in diabetes?

NCT ID NCT07383701

Not yet recruiting Disease control Sponsor: Massachusetts Eye and Ear Infirmary Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study tests whether a daily probiotic supplement (Lactobacillus plantarum 299v) can reduce retinal swelling and improve vision in people with diabetic macular edema. Thirty-six participants will take the probiotic twice daily for four months. Researchers will measure changes in retinal thickness, visual acuity, and the need for anti-VEGF injections, comparing results to historical data.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Lactobacillus plantarum 299v probiotic
What this could lead to: If it works, this could offer a simple, safe supplement to help control diabetic macular edema and reduce the need for eye injections.
What could go wrong: This is a small, early pilot study with only 36 people, and it compares results to past data rather than a current placebo group. The probiotic may not improve vision or reduce swelling.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

diabetic macular edema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETIC MACULAR EDEMA

Contacts and locations

Locations

Mass Eye and Ear

Boston, Massachusetts, 02114, United States

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Other studies related to the condition(s) this trial covers.