Eye drops could brighten your night vision
NCT ID NCT04638660
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether Nyxol eye drops can help people who have trouble seeing in dim light, often after eye surgeries like LASIK or cataract surgery. 144 adults received either the eye drops or a placebo for 8 days. The main goal was to see if Nyxol could improve vision in low light by at least 3 lines on an eye chart.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Phentolamine ophthalmic solution (Nyxol)
What this could lead to
If it works, this could offer a simple eye drop to help people see better in dim light, especially after eye surgeries or injuries.
What could go wrong
This is a small, early-phase trial with only 144 participants. The improvement may be modest, and long-term safety is not yet known.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Clinical Site 1
Petaluma, California, 94954, United States
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Clinical Site 10
Palisades Park, New Jersey, 07650, United States
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Clinical Site 11
Memphis, Tennessee, 38119, United States
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Clinical Site 13
Pittsburg, Kansas, 66762, United States
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Clinical Site 14
Louisville, Kentucky, 41008, United States
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Clinical Site 18
Jacksonville, Florida, 32256, United States
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Clinical Site 19
Ogden, Utah, 84403, United States
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Clinical Site 2
Fargo, North Dakota, 58103, United States
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Clinical Site 20
Edgewood, Kentucky, 41017, United States
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Clinical Site 22
High Point, North Carolina, 27262, United States
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Clinical Site 3
Jacksonville, Florida, 32204, United States
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Clinical Site 4
Elizabeth City, North Carolina, 27909, United States
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Clinical Site 5
San Antonio, Texas, 78240, United States
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Clinical Site 6
Newport Beach, California, 92663, United States
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Clinical Site 8
Pennington, New Jersey, 08534, United States
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Clinical Site 9
High Point, North Carolina, 27262, United States
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Clinical Test 15
Warwick, Rhode Island, 57108, United States