Eye drops could brighten your night vision

NCT ID NCT04638660

Completed Symptom relief Sponsor: Ocuphire Pharma, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether Nyxol eye drops can help people who have trouble seeing in dim light, often after eye surgeries like LASIK or cataract surgery. 144 adults received either the eye drops or a placebo for 8 days. The main goal was to see if Nyxol could improve vision in low light by at least 3 lines on an eye chart.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Phentolamine ophthalmic solution (Nyxol)
What this could lead to: If it works, this could offer a simple eye drop to help people see better in dim light, especially after eye surgeries or injuries.
What could go wrong: This is a small, early-phase trial with only 144 participants. The improvement may be modest, and long-term safety is not yet known.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

night blindness

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIM LIGHT VISION DISTURBANCES

Contacts and locations

Locations

Clinical Site 1

Petaluma, California, 94954, United States
Clinical Site 10

Palisades Park, New Jersey, 07650, United States
Clinical Site 11

Memphis, Tennessee, 38119, United States
Clinical Site 13

Pittsburg, Kansas, 66762, United States
Clinical Site 14

Louisville, Kentucky, 41008, United States
Clinical Site 18

Jacksonville, Florida, 32256, United States
Clinical Site 19

Ogden, Utah, 84403, United States
Clinical Site 2

Fargo, North Dakota, 58103, United States
Clinical Site 20

Edgewood, Kentucky, 41017, United States
Clinical Site 22

High Point, North Carolina, 27262, United States
Clinical Site 3

Jacksonville, Florida, 32204, United States
Clinical Site 4

Elizabeth City, North Carolina, 27909, United States
Clinical Site 5

San Antonio, Texas, 78240, United States
Clinical Site 6

Newport Beach, California, 92663, United States
Clinical Site 8

Pennington, New Jersey, 08534, United States
Clinical Site 9

High Point, North Carolina, 27262, United States
Clinical Test 15

Warwick, Rhode Island, 57108, United States