New eye injection shows promise for Diabetes-Related vision loss
NCT ID NCT05151731
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial tested a new drug called vamikibart, given as an eye injection, for people with diabetic macular edema—a condition where diabetes causes fluid buildup in the center of the retina, leading to vision loss. The study involved 394 participants and compared vamikibart to an existing treatment (ranibizumab) or a sham procedure. The main goal was to see if vamikibart could improve vision over 48 weeks, while also checking for side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Vamikibart (also called RO7200220), an eye injection
What this could lead to
If it works, this could offer a new treatment option for diabetic macular edema, potentially improving vision with fewer injections.
What could go wrong
This is an early-phase trial with only 394 participants, so results may not apply to everyone. The drug is injected directly into the eye, which carries risks like infection or inflammation.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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AXON Clinical
Prague, Czechia
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Asan Medical Center
Seoul, 05505, South Korea
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Austin Clinical Research LLC
Austin, Texas, 78750, United States
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Bay Area Retina Associates
Walnut Creek, California, 94598, United States
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Black Hills Eye Institute
Rapid City, South Dakota, 57701, United States
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Bristol Eye Hospital
Bristol, BS1 2LX, United Kingdom
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Buenos Aires Mácula
Ciudad Autonoma Buenos Aires, C1061AAE, Argentina
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Butchertown Clinical Trials
Louisville, Kentucky, 40206, United States
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Caminomed
Tarnowskie Góry, 42-600, Poland
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Centro Oftalmologico Dr. Charles S.A.
Capital Federal, C1116, Argentina
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Centro Privado de Ojos Romagosa
Córdoba, Argentina
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Centro de ojos Loria
Lomas de Zamora, Argentina
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Centrum Diagnostyki i Mikrochirurgii Oka LENS
Olsztyn, 10-424, Poland
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Centrum Medyczne UNO-MED
Krakow, 31-070, Poland
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Charleston Neuroscience Institute
Ladson, South Carolina, 29456, United States
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Colorado Retina Associates, PC
Lakewood, Colorado, 80228, United States
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Cumberland Valley Retina PC
Hagerstown, Maryland, 21740, United States
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Deep Blue Retina PLLC
Southaven, Mississippi, 38671, United States
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Emanuelli Research and Development Center LLC
Arecibo, 00612, Puerto Rico
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Emerson Clinical Research Institute LLC
Washington D.C., District of Columbia, 20011-3010, United States
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Erie Retinal Surgery
Erie, Pennsylvania, 16507, United States
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Eye Care Specialists, PC
Kingston, Pennsylvania, 18704, United States
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EyeHealth Northwest
Portland, Oregon, 97225, United States
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Faculty Hospital Kralovske Vinohrady
Prague, 100 34, Czechia
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Faculty Hospital Ostrava
Ostrava, 708 52, Czechia
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Florida Retina Institute
Orlando, Florida, 32806-1101, United States
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General Teaching Hospital Prague
Prague, 128 08, Czechia
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Gloucestershire Hospitals NHS Foundation Trust
Gloucestershire, GL1 3NN, United Kingdom
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Grupo Laser Vision
Rosario, S2000DLA, Argentina
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Hospital General de Catalunya
Sant Cugat de Valles, Barcelona, 08190, Spain
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Hospital Universitario Miguel Servet
Zaragoza, 50009, Spain
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Hospital Universitario Puerta de Hierro
Majadahonda, Madrid, 28222, Spain
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Institut De L'Oeil Des Laurentides
Boisbriand, Quebec, J7H 0E8, Canada
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Kim's Eye Hospital
Seoul, 07301, South Korea
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LensClinic
Rybnik, 44-203, Poland
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Meridian Clinical Research
Cincinnati, Ohio, 45219, United States
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Microcirugía Ocular S.A
Rosario, S2000CTC, Argentina
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Moorfields Eye Hospital NHS Foundation Trust
London, EC1V 2PD, United Kingdom
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National Ophthalmic Research Institute
Fort Myers, Florida, 33912, United States
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Niepubliczny Zak?ad Opieki Zdrowotnej PRYZMAT-OKULISTYKA
Gliwice, 44-100, Poland
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Oftalmos
Capital Federal, C1120AAN, Argentina
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Oftalvist Valencia
Burjassot, Valencia, 46100, Spain
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Oftar
Mendoza, M5500GGK, Argentina
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Opthalmic Consultants of LI
Lynbrook, New York, 11563, United States
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Organizacion Medica de Investigacion
Buenos Aires, C1015ABO, Argentina
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Piedmont Eye Center
Lynchburg, Virginia, 24502, United States
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Rand Eye
Deerfield Beach, Florida, 33064, United States
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Retina Consultants of Nashville
Nashville, Tennessee, 37203, United States
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Retina Consultants of Texas
Bellaire, Texas, 77401, United States
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Retina Consultants of Texas
The Woodlands, Texas, 78240, United States
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Retina Consultants, San Diego
Poway, California, 92064, United States
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Retina Institute of Ottawa
Ottawa, Ontario, K2B 7E9, Canada
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Retina Specialists of Tampa
Wesley Chapel, Florida, 33544, United States
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Retina Vitreous Associates of Florida
St. Petersburg, Florida, 33607, United States
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Retinal Consultants Med Group
Sacramento, California, 95825, United States
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Royal Surrey County Hospital
Guildford, GU2 7XX, United Kingdom
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Royal Victoria Infirmary
Newcastle upon Tyne, NE1 4LP, United Kingdom
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SPSK nr 1 w Lublinie
Lublin, 20-079, Poland
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Samsung Medical Center
Seoul, 06351, South Korea
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Seoul National University Bundang Hospital
Seongnam-si, 13605, South Korea
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Sewickley Eye Group
Sewickley, Pennsylvania, 15143, United States
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Sierra Eye Associates
Reno, Nevada, 89502, United States
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Strategic Clinical Research Group, LLC
Willow Park, Texas, 76087, United States
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Texas Retina Associates
Arlington, Texas, 75075, United States
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Toronto Retina Institute
Toronto, Ontario, M3C 0G9, Canada
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University of Rochester Flaum Eye Institute
Rochester, New York, 14642, United States
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Uniwersyteckie Centrum Kliniczne
Katowice, 40-514, Poland
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Valley Retina Institute P.A.
McAllen, Texas, 78503, United States
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Verum Research LLC
Eugene, Oregon, 97401, United States
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Wagner Macula & Retina Center
Norfolk, Virginia, 23502, United States
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Wake Forest Baptist Medical Center
Winston-Salem, North Carolina, 27157, United States
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Western Carolina Retinal Associate PA
Asheville, North Carolina, 28803, United States
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Win Retina
Arcadia, California, 91006, United States
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Yeungnam University Medical Center
Daegu, 42415, South Korea