New combo therapy aims to improve vision in diabetic eye disease

NCT ID NCT06850922

Ongoing Disease control Sponsor: Genentech, Inc. Source: ClinicalTrials.gov ↗

First seen Oct 01, 2025 · Last updated May 14, 2026 · Updated 33 times

Summary

This study tests a new medicine (RO7446603) for people with diabetic macular edema, a condition that causes vision loss due to diabetes-related fluid buildup in the eye. The trial has two parts: first, checking safety of the drug alone or with existing treatments (aflibercept or faricimab); second, comparing two doses of the drug combined with faricimab against faricimab alone. About 546 participants are involved, and the main goals are to see if the drug is safe and if it improves vision.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Advanced Vision Research Institute

Longmont, Colorado, 80503-6499, United States
Arizona Retina and Vitreous Consultants

Phoenix, Arizona, 85020-5917, United States
Associated Retinal Consultants - Royal Oak

Royal Oak, Michigan, 48073, United States
Associated Retinal Consultants PC

Phoenix, Arizona, 85020, United States
Austin Clinical Research LLC

Austin, Texas, 78750, United States
Austin Retina Associates

Austin, Texas, 78705, United States
Bay Area Retina Associates;Study Department

Walnut Creek, California, 94598, United States
Beijing Hospital

Beijing, 100730, China
Beijing Tongren Hospital, Capital Medical University

Beijing, Beijing Municipality, 100730, China
Brown Retina Institute

San Antonio, Texas, 78251-4551, United States
Cascade Medical Research Institute LLC

Springfield, Oregon, 97477, United States
Charles Retina Institute

Germantown, Tennessee, 38138, United States
Chesapeake Retina Centers - Waldorf

Waldorf, Maryland, 20602, United States
Cincinnati Eye Institute

Blue Ash, Ohio, 45242-5537, United States
Cumberland Valley Retina Consultants

Hagerstown, Maryland, 21740, United States
Duke University Medical Center

Durham, North Carolina, 27705, United States
Emanuelli Research and Development Center LLC

Arecibo, 00612, Puerto Rico
Erie Retina Research

Erie, Pennsylvania, 16505, United States
Eye Hospital,WMU(Zhejiang Eye Hospital)

Wenzhou, Zhejiang, 325027, China
Florida Retina Institute

Jacksonville, Florida, 32216-6347, United States
Georgia Retina PC

Marietta, Georgia, 30060, United States
Graystone Eye

Hickory, North Carolina, 28602, United States
Illinois Eye and Ear Infirmary

Chicago, Illinois, 60612, United States
Johns Hopkins Hospital

Baltimore, Maryland, 21287, United States
Long Island Vitreoretinal Consultants;Opthalmology

Hauppauge, New York, 11788, United States
Macula Retina Vitreous Research Institute

Torrance, California, 90503-3270, United States
Medical Center Ophthalmology Associates

San Antonio, Texas, 78240, United States
National Ophthalmic Research Institute

Fort Myers, Florida, 33912, United States
North Carolina (NC) Retina Associates - Wake Forest Office

Wake Forest, North Carolina, 27587-3803, United States
North Carolina Retina Associates

Cary, North Carolina, 27511, United States
Northern California Retina-Vitreous Associates

Mountain View, California, 94040, United States
Ohio State Eye and Ear Institute

Columbus, Ohio, 43212, United States
Opthalmic Consultants of LI

Lynbrook, New York, 11563, United States
Palmetto Retina Center

West Columbia, South Carolina, 29169-2429, United States
Peking Union Medical College Hospital

Beijing, 100730, China
Piedmont Eye Center

Lynchburg, Virginia, 24502-4271, United States
Piedmont Retina Specialists

Winston-Salem, North Carolina, 27103-6970, United States
Raj K. Maturi, MD PC

Indianapolis, Indiana, 46290, United States
Retina & Vitreous of Texas

Bellaire, Texas, 77401, United States
Retina Associates of Florida;Retina Associates of Florida

Tampa, Florida, 33609, United States
Retina Associates of Utah, PLLC;Clinical Research

Salt Lake City, Utah, 84107, United States
Retina Consultants Minnesota

Saint Louis Park, Minnesota, 55416, United States
Retina Consultants of Hawaii

‘Aiea, Hawaii, 96701, United States
Retina Consultants of Orange County

Fullerton, California, 92835, United States
Retina Consultants of Southern Colorado PC

Colorado Springs, Colorado, 80909, United States
Retina Consultants of Texas

The Woodlands, Texas, 77384, United States
Retina Consultants of Texas - San Antonio

San Antonio, Texas, 78240, United States
Retina Group of New England

Waterford, Connecticut, 06385-1215, United States
Retina Group of Washington

Chevy Chase, Maryland, 20815, United States
Retina Institute of Virginia

Richmond, Virginia, 23235-1962, United States
Retina Research Institute of Texas

Abilene, Texas, 79606, United States
Retina Specialists of Colorado

Denver, Colorado, 80222, United States
Retina Vitreous Surgeons of CNY PC

Liverpool, New York, 13088, United States
Retinal Consultants Medical Group

Modesto, California, 95356-9412, United States
Retinal Consultants Medical Group

Sacramento, California, 95825, United States
Retinal Diagnostic Center

Campbell, California, 95008, United States
Retinal Research Institute, LLC

Phoenix, Arizona, 85053, United States
Sewickely Eye Group

Sewickley, Pennsylvania, 15143, United States
Shanghai General Hospital - North Campus

Shanghai, Shanghai Municipality, 200080, China
Southeast Retina Center

Augusta, Georgia, 30909-6440, United States
Spokane Eye Clinical Research

Spokane, Washington, 99204, United States
Strategic Clinical Research Group, LLC

Willow Park, Texas, 76087, United States
Texas Retina Associates

Arlington, Texas, 76012, United States
Texas Retina Associates

Dallas, Texas, 75231, United States
The Retina Care Center

Baltimore, Maryland, 21209, United States
Tianjin Medical University Eye Hospital

Tianjin, Tianjin Municipality, 300384, China
Tulsa Retina Consultants

Tulsa, Oklahoma, 74114, United States
University Hospitals Cleveland Medical Center

Cleveland, Ohio, 44016, United States
University Retina and Macula Associates, PC

Oak Forest, Illinois, 60452, United States
University of California San Francisco

San Francisco, California, 94158, United States
University of Colorado - Eye Center - PPDS

Aurora, Colorado, 80045-2517, United States
Valley Retina Institute P.A.

McAllen, Texas, 78550-9207, United States
Virginia Eye Institute - Richmond - 7301 Forest Ave

Richmond, Virginia, 23230, United States
Wagner Kapoor Institute

Norfolk, Virginia, 23502, United States
Western Carolina Retinal Associate PA

Asheville, North Carolina, 28803, United States
Wills Eye Hospital

Philadelphia, Pennsylvania, 19107-5109, United States

Conditions

Explore the condition pages connected to this study.

DIABETIC MACULAR EDEMA